{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:30:00Z","timestamp":1787880600622,"version":"build-2784847793"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Child Adolesc Psychiatry"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s00787-021-01860-0","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T14:02:53Z","timestamp":1628863373000},"page":"283-291","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Risk of attention deficit hyperactivity and autism spectrum disorders among the children of parents with autoimmune diseases: a nationwide birth cohort study"],"prefix":"10.1007","volume":"32","author":[{"given":"Hsuan","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Wei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Jen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Mei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung-Ping","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzeng-Ji","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-1073","authenticated-orcid":false,"given":"Mu-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"1860_CR1","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/S0140-6736(15)00238-X","volume":"387","author":"A Thapar","year":"2016","unstructured":"Thapar A, Cooper M (2016) Attention deficit hyperactivity disorder. Lancet 387:1240\u20131250","journal-title":"Lancet"},{"key":"1860_CR2","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(13)61539-1","volume":"383","author":"MC Lai","year":"2014","unstructured":"Lai MC, Lombardo MV, Baron-Cohen S (2014) Autism. Lancet 383:896\u2013910","journal-title":"Lancet"},{"key":"1860_CR3","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41398-021-01198-w","volume":"11","author":"VX Han","year":"2021","unstructured":"Han VX, Patel S, Jones HF, Nielsen TC, Mohammad SS, Hofer MJ, Gold W, Brilot F, Lain SJ, Nassar N, Dale RC (2021) Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review. Transl Psychiatry 11:71","journal-title":"Transl Psychiatry"},{"key":"1860_CR4","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.biopsych.2015.11.024","volume":"81","author":"JT Instanes","year":"2017","unstructured":"Instanes JT, Halmoy A, Engeland A, Haavik J, Furu K, Klungsoyr K (2017) Attention-deficit\/hyperactivity disorder in offspring of mothers with inflammatory and immune system diseases. Biol Psychiatry 81:452\u2013459","journal-title":"Biol Psychiatry"},{"key":"1860_CR5","doi-asserted-by":"publisher","first-page":"e420","DOI":"10.1542\/peds.112.5.e420","volume":"112","author":"TL Sweeten","year":"2003","unstructured":"Sweeten TL, Bowyer SL, Posey DJ, Halberstadt GM, McDougle CJ (2003) Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders. Pediatrics 112:e420","journal-title":"Pediatrics"},{"key":"1860_CR6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1097\/YPG.0000000000000212","volume":"29","author":"X Li","year":"2019","unstructured":"Li X, Sjostedt C, Sundquist J, Zoller B, Sundquist K (2019) Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden. Psychiatr Genet 29:37\u201343","journal-title":"Psychiatr Genet"},{"key":"1860_CR7","first-page":"151","volume":"159","author":"Croen LA, Grether JK, Yoshida CK, Odouli R, Van de Water J","year":"2005","unstructured":"Croen LA, Grether JK, Yoshida CK, Odouli R, Van de Water J (2005) Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study. Arch Pediatr Adolesc Med 159:151\u2013157","journal-title":"Arch Pediatr Adolesc Med"},{"key":"1860_CR8","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.bbr.2015.08.035","volume":"296","author":"SW Chen","year":"2016","unstructured":"Chen SW, Zhong XS, Jiang LN, Zheng XY, Xiong YQ, Ma SJ, Qiu M, Huo ST, Ge J, Chen Q (2016) Maternal autoimmune diseases and the risk of autism spectrum disorders in offspring: a systematic review and meta-analysis. Behav Brain Res 296:61\u201369","journal-title":"Behav Brain Res"},{"key":"1860_CR9","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1097\/EDE.0b013e3181f26e3f","volume":"21","author":"A Keil","year":"2010","unstructured":"Keil A, Daniels JL, Forssen U, Hultman C, Cnattingius S, Soderberg KC, Feychting M, Sparen P (2010) Parental autoimmune diseases associated with autism spectrum disorders in offspring. Epidemiology 21:805\u2013808","journal-title":"Epidemiology"},{"key":"1860_CR10","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.jaac.2016.12.010","volume":"56","author":"PR Nielsen","year":"2017","unstructured":"Nielsen PR, Benros ME, Dalsgaard S (2017) Associations between autoimmune diseases and attention-deficit\/hyperactivity disorder: a nationwide study. J Am Acad Child Adolesc Psychiatry 56:234-240.e231","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"1860_CR11","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1017\/S003329171800332X","volume":"49","author":"MH Chen","year":"2019","unstructured":"Chen MH, Hsu JW, Huang KL, Su TP, Li CT, Lin WC, Tsai SJ, Cheng CM, Chang WH, Pan TL, Chen TJ, Bai YM (2019) Risk and coaggregation of major psychiatric disorders among first-degree relatives of patients with bipolar disorder: a nationwide population-based study. Psychol Med 49:2397\u20132404","journal-title":"Psychol Med"},{"key":"1860_CR12","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1038\/mp.2017.217","volume":"23","author":"CM Cheng","year":"2018","unstructured":"Cheng CM, Chang WH, Chen MH, Tsai CF, Su TP, Li CT, Tsai SJ, Hsu JW, Huang KL, Lin WC, Chen TJ, Bai YM (2018) Co-aggregation of major psychiatric disorders in individuals with first-degree relatives with schizophrenia: a nationwide population-based study. Mol Psychiatry 23:1756\u20131763","journal-title":"Mol Psychiatry"},{"key":"1860_CR13","doi-asserted-by":"publisher","first-page":"788","DOI":"10.2337\/dc15-1807","volume":"39","author":"MH Chen","year":"2016","unstructured":"Chen MH, Lan WH, Hsu JW, Huang KL, Su TP, Li CT, Lin WC, Tsai CF, Tsai SJ, Lee YC, Chen YS, Pan TL, Chang WH, Chen TJ, Bai YM (2016) Risk of developing type 2 diabetes in adolescents and young adults with autism spectrum disorder: a nationwide longitudinal study. Diabetes Care 39:788\u2013793","journal-title":"Diabetes Care"},{"key":"1860_CR14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1136\/gutjnl-2020-320789","volume":"70","author":"B Zhang","year":"2021","unstructured":"Zhang B, Wang HE, Bai YM, Tsai SJ, Su TP, Chen TJ, Wang YP, Chen MH (2021) Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study. Gut 70:85\u201391","journal-title":"Gut"},{"key":"1860_CR15","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1002\/art.1780400928","volume":"40","author":"MC Hochberg","year":"1997","unstructured":"Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725","journal-title":"Arthritis Rheum"},{"key":"1860_CR16","first-page":"513","volume":"16","author":"CJ Chen","year":"1997","unstructured":"Chen CJ, Lin LH (1997) Use of national health insurance database in academic research: experiences from analysis of major disease certification profile. Chin J Publ Health 16:513\u2013521","journal-title":"Chin J Publ Health"},{"key":"1860_CR17","first-page":"1","volume":"4","author":"CY Liu","year":"2006","unstructured":"Liu CY, Hung YT, Chuang YL, Chen YJ, Weng WS, Liu JS (2006) Incorporating development stratification of Taiwan townships into sampling design of large scale health interview survey. J Health Manag 4:1\u201322","journal-title":"J Health Manag"},{"key":"1860_CR18","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1001\/jamapsychiatry.2019.0774","volume":"76","author":"B Leppert","year":"2019","unstructured":"Leppert B, Havdahl A, Riglin L, Jones HJ, Zheng J, Davey Smith G, Tilling K, Thapar A, Reichborn-Kjennerud T, Stergiakouli E (2019) Association of maternal neurodevelopmental risk alleles with early-life exposures. JAMA Psychiat 76:834\u2013842","journal-title":"JAMA Psychiat"},{"key":"1860_CR19","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.molmed.2018.06.008","volume":"24","author":"NM Jiang","year":"2018","unstructured":"Jiang NM, Cowan M, Moonah SN, Petri WA Jr (2018) The impact of systemic inflammation on neurodevelopment. Trends Mol Med 24:794\u2013804","journal-title":"Trends Mol Med"},{"key":"1860_CR20","doi-asserted-by":"publisher","first-page":"6041","DOI":"10.1523\/JNEUROSCI.2534-15.2016","volume":"36","author":"N Goeden","year":"2016","unstructured":"Goeden N, Velasquez J, Arnold KA, Chan Y, Lund BT, Anderson GM, Bonnin A (2016) Maternal inflammation disrupts fetal neurodevelopment via increased placental output of serotonin to the fetal brain. J Neurosci 36:6041\u20136049","journal-title":"J Neurosci"},{"key":"1860_CR21","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3389\/fncel.2018.00405","volume":"12","author":"HK Hughes","year":"2018","unstructured":"Hughes HK, Mills Ko E, Rose D, Ashwood P (2018) Immune dysfunction and autoimmunity as pathological mechanisms in autism spectrum disorders. Front Cell Neurosci 12:405","journal-title":"Front Cell Neurosci"},{"key":"1860_CR22","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1038\/s41386-020-0640-0","volume":"45","author":"SB Gumusoglu","year":"2020","unstructured":"Gumusoglu SB, Hing BWQ, Chilukuri ASS, Dewitt JJ, Scroggins SM, Stevens HE (2020) Chronic maternal interleukin-17 and autism-related cortical gene expression, neurobiology, and behavior. Neuropsychopharmacology 45:1008\u20131017","journal-title":"Neuropsychopharmacology"},{"key":"1860_CR23","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41398-018-0112-z","volume":"8","author":"A Ghassabian","year":"2018","unstructured":"Ghassabian A, Albert PS, Hornig M, Yeung E, Cherkerzian S, Goldstein RB, Buka SL, Goldstein JM, Gilman SE (2018) Gestational cytokine concentrations and neurocognitive development at 7 years. Transl Psychiatry 8:64","journal-title":"Transl Psychiatry"},{"key":"1860_CR24","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.bbi.2020.07.019","volume":"89","author":"HC Gustafsson","year":"2020","unstructured":"Gustafsson HC, Sullivan EL, Battison EAJ, Holton KF, Graham AM, Karalunas SL, Fair DA, Loftis JM, Nigg JT (2020) Evaluation of maternal inflammation as a marker of future offspring ADHD symptoms: a prospective investigation. Brain Behav Immun 89:350\u2013356","journal-title":"Brain Behav Immun"},{"key":"1860_CR25","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.neuroimage.2018.04.020","volume":"185","author":"JM Rasmussen","year":"2019","unstructured":"Rasmussen JM, Graham AM, Entringer S, Gilmore JH, Styner M, Fair DA, Wadhwa PD, Buss C (2019) Maternal Interleukin-6 concentration during pregnancy is associated with variation in frontolimbic white matter and cognitive development in early life. Neuroimage 185:825\u2013835","journal-title":"Neuroimage"},{"key":"1860_CR26","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.bbi.2020.09.033","volume":"91","author":"R Tamouza","year":"2021","unstructured":"Tamouza R, Krishnamoorthy R, Leboyer M (2021) Understanding the genetic contribution of the human leukocyte antigen system to common major psychiatric disorders in a world pandemic context. Brain Behav Immun 91:731\u2013739","journal-title":"Brain Behav Immun"},{"key":"1860_CR27","doi-asserted-by":"crossref","unstructured":"Tylee DS, Sun J, Hess JL, Tahir MA, Sharma E, Malik R, Worrall BB, Levine AJ, Martinson JJ, Nejentsev S, Speed D, Fischer A, Mick E, Walker BR, Crawford A, Grant SFA, Polychronakos C, Bradfield JP, Sleiman PMA, Hakonarson H, Ellinghaus E, Elder JT, Tsoi LC, Trembath RC, Barker JN, Franke A, Dehghan A, Me Research T, Inflammation Working Group of the CC, Consortium MCotISG, Netherlands Twin R, neuro CWG, Obsessive C, Tourette Syndrome Working Group of the Psychiatric Genomics C, Faraone SV, Glatt SJ. Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data. Am J Med Genet B Neuropsychiatr Genet. 2018;177:641\u2013657.","DOI":"10.1002\/ajmg.b.32652"},{"key":"1860_CR28","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1002\/aur.2217","volume":"13","author":"R Tamouza","year":"2020","unstructured":"Tamouza R, Fernell E, Eriksson MA, Anderlid BM, Manier C, Mariaselvam CM, Boukouaci W, Leboyer M, Gillberg C (2020) HLA polymorphism in regressive and non-regressive autism: a preliminary study. Autism Res 13:182\u2013186","journal-title":"Autism Res"},{"key":"1860_CR29","first-page":"959073","volume":"2012","author":"AR Torres","year":"2012","unstructured":"Torres AR, Westover JB, Rosenspire AJ (2012) HLA immune function genes in autism. Autism Res Treat 2012:959073","journal-title":"Autism Res Treat"}],"container-title":["European Child &amp; Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-021-01860-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00787-021-01860-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-021-01860-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T06:05:22Z","timestamp":1677477922000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00787-021-01860-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["1860"],"URL":"https:\/\/doi.org\/10.1007\/s00787-021-01860-0","relation":{},"ISSN":["1018-8827","1435-165X"],"issn-type":[{"value":"1018-8827","type":"print"},{"value":"1435-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,13]]},"assertion":[{"value":"21 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}