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This study seeks to employ software-based voice analysis to compare the voices of girls with AN to those of female healthy controls (HC). Case-control study adopting \u201cPraat\u201d software to assess voices. Various parameters, including Acoustic Voice Quality Index (AVQI), Fundamental Frequency (F0), Yanagihara\u2019s Spectrographic Dysphonia Classifications, and \u201cGIRBAS\u201d perceptual qualitative voice rating, were investigated. Participants completed questionnaires for Vocal Fatigue Index (VFI) and the Reflux Symptoms Index (RSI). Puberty-related voice spectrum changes were considered, and Bonferroni-corrected BMI-adjusted Analyses of Covariance (ANCOVAs) were conducted. The study enrolled 15 girls with AN and 23 girls with HC. AN patients demonstrated greater impairment in voice tiredness\/voice avoidance (VFI-1, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), vocal physical discomfort (VIF-2, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), and rest as alleviation (VFI-3, <jats:italic>p<\/jats:italic>\u2009=\u20090.012). Reflux-related scores were higher in AN (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Differences were observed in voice quality (AVQI) (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), and GIRBAS scales showed alterations in multiple parameters. Spectrograms documented more frequent pathological findings in AN patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.021). No difference was observed in Fundamental Frequency. These group (AN\/HC) differences were independent of weight measures. This study is the first to connect voice irregularities in AN by employing standardized, non-invasive tools and accounting for weight-related factors. Young AN patients demonstrated substantial voice quality changes and heightened self-reported symptoms. Future research should expand on these findings with prospective designs and invasive investigations.<\/jats:p>","DOI":"10.1007\/s00787-024-02524-5","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T18:02:12Z","timestamp":1721671332000},"page":"751-761","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling vocal profiles in adolescent anorexia nervosa: a Software Based, Multiparametric Analysis"],"prefix":"10.1007","volume":"34","author":[{"given":"Jacopo","family":"Pruccoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio Rocco","family":"di Torrepadula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bergonzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Genovese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Parmeggiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"2524_CR1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013) Diagnostic and statistical Manual of Mental disorders, Fifth Edition. 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Informed consent from patients and healthy controls was obtained as well.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}