{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:50:28Z","timestamp":1789516228019,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073571"],"award-info":[{"award-number":["82073571"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Child Adolesc Psychiatry"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s00787-024-02600-w","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T06:02:25Z","timestamp":1730354545000},"page":"1861-1871","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mediation of DNA methylation (cg04622888 and cg05037505) in the association between childhood maltreatment and non-suicidal self-injury in early adolescents"],"prefix":"10.1007","volume":"34","author":[{"given":"Yanqi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runsen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"issue":"3","key":"2600_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s11920-017-0767-9","volume":"19","author":"RC Brown","year":"2017","unstructured":"Brown RC, Plener PL (2017) Non-suicidal self-Injury in adolescence. Curr Psychiatry Rep 19(3):20. https:\/\/doi.org\/10.1007\/s11920-017-0767-9","journal-title":"Curr Psychiatry Rep"},{"issue":"10","key":"2600_CR2","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.jaac.2018.06.018","volume":"57","author":"D Gillies","year":"2018","unstructured":"Gillies D, Christou MA, Dixon AC et al (2018) Prevalence and characteristics of self-harm in adolescents: meta-analyses of community-based studies 1990\u20132015. J Am Acad Child Adolesc Psychiatry 57(10):733\u2013741. https:\/\/doi.org\/10.1016\/j.jaac.2018.06.018","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"2","key":"2600_CR3","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1192\/bjp.2021.225","volume":"221","author":"S Herzog","year":"2022","unstructured":"Herzog S, Choo TH, Galfalvy H et al (2022) Effect of non-suicidal self-injury on suicidal ideation: real-time monitoring study. Br J Psychiatry 221(2):485\u2013487. https:\/\/doi.org\/10.1192\/bjp.2021.225","journal-title":"Br J Psychiatry"},{"key":"2600_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S0033291721000040","volume":"52","author":"KX Lim","year":"2021","unstructured":"Lim KX, Krebs G, Rimfeld K et al (2021) Investigating the genetic and environmental aetiologies of non-suicidal and suicidal self-harm: a twin study. Psychol Med 52:1\u201311. https:\/\/doi.org\/10.1017\/S0033291721000040","journal-title":"Psychol Med"},{"issue":"11","key":"2600_CR5","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1176\/appi.ajp.2020.20121705","volume":"178","author":"AC Edwards","year":"2021","unstructured":"Edwards AC, Ohlsson H, Mo\u015bcicki E et al (2021) On the genetic and environmental relationship between suicide attempt and death by suicide. Am J Psychiatry 178(11):1060\u20131069. https:\/\/doi.org\/10.1176\/appi.ajp.2020.20121705","journal-title":"Am J Psychiatry"},{"issue":"11","key":"2600_CR6","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1176\/appi.ajp.2021.21090913","volume":"178","author":"JJ Mann","year":"2021","unstructured":"Mann JJ (2021) Can knowledge of genetic and environmental causal factors of fatal and nonfatal suicidal behavior be translated into better prevention? Am J Psychiatry 178(11):994\u2013997. https:\/\/doi.org\/10.1176\/appi.ajp.2021.21090913","journal-title":"Am J Psychiatry"},{"issue":"1","key":"2600_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S2215-0366(17)30469-8","volume":"5","author":"RT Liu","year":"2018","unstructured":"Liu RT, Scopelliti KM, Pittman SK, Zamora AS (2018) Childhood maltreatment and non-suicidal self-injury: a systematic review and meta-analysis. Lancet Psychiatry 5(1):51\u201364. https:\/\/doi.org\/10.1016\/S2215-0366(17)30469-8","journal-title":"Lancet Psychiatry"},{"key":"2600_CR8","doi-asserted-by":"publisher","first-page":"101350","DOI":"10.1016\/j.eclinm.2022.101350","volume":"46","author":"YJ Wang","year":"2022","unstructured":"Wang YJ, Li X, Ng CH et al (2022) Risk factors for non-suicidal self-injury (NSSI) in adolescents: a meta-analysis. EClinicalMedicine 46:101350. https:\/\/doi.org\/10.1016\/j.eclinm.2022.101350","journal-title":"EClinicalMedicine"},{"key":"2600_CR9","doi-asserted-by":"publisher","first-page":"112730","DOI":"10.1016\/j.psychres.2019.112730","volume":"285","author":"I Alberdi-Paramo","year":"2020","unstructured":"Alberdi-Paramo I, Saiz-Gonzalez MD, Diaz-Marsa M, Carrasco-Perera JL (2020) Bullying and childhood trauma events as predictive factors of suicidal behavior in borderline personality disorder: preliminary findings. Psychiatry Res 285:112730. https:\/\/doi.org\/10.1016\/j.psychres.2019.112730","journal-title":"Psychiatry Res"},{"key":"2600_CR10","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.neubiorev.2020.02.019","volume":"112","author":"CAM Cecil","year":"2020","unstructured":"Cecil CAM, Zhang Y, Nolte T (2020) Childhood maltreatment and DNA methylation: a systematic review. Neurosci Biobehav Rev 112:392\u2013409. https:\/\/doi.org\/10.1016\/j.neubiorev.2020.02.019","journal-title":"Neurosci Biobehav Rev"},{"issue":"20","key":"2600_CR11","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1016\/j.jmb.2014.03.016","volume":"426","author":"CJ Pena","year":"2014","unstructured":"Pena CJ, Bagot RC, Labonte B et al (2014) Epigenetic signaling in psychiatric disorders. J Mol Biol. 426(20):3389\u2013412. https:\/\/doi.org\/10.1016\/j.jmb.2014.03.016","journal-title":"J Mol Biol."},{"key":"2600_CR12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/978-981-32-9705-0_6","volume":"1191","author":"E Lin","year":"2020","unstructured":"Lin E, Tsai SJ (2020) Gene-environment interactions and role of epigenetics in anxiety disorders. Adv Exp Med Biol. 1191:93\u2013102. https:\/\/doi.org\/10.1007\/978-981-32-9705-0_6","journal-title":"Adv Exp Med Biol."},{"issue":"12","key":"2600_CR13","doi-asserted-by":"publisher","first-page":"5090","DOI":"10.1038\/s41380-023-02010-5","volume":"28","author":"A Kotsakis Ruehlmann","year":"2023","unstructured":"Kotsakis Ruehlmann A, Sammallahti S, Cortes Hidalgo AP et al (2023) Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation. Mol psychiatry 28(12):5090\u20138100. https:\/\/doi.org\/10.1038\/s41380-023-02010-5","journal-title":"Mol psychiatry"},{"issue":"1","key":"2600_CR14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41398-019-0376-y","volume":"9","author":"PR Braun","year":"2019","unstructured":"Braun PR, Han S, Hing B et al (2019) Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals. Transl Psychiatry 9(1):47. https:\/\/doi.org\/10.1038\/s41398-019-0376-y","journal-title":"Transl Psychiatry"},{"key":"2600_CR15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jpsychires.2018.07.011","volume":"104","author":"A Bani-Fatemi","year":"2018","unstructured":"Bani-Fatemi A, Jeremian R, Wang KZ et al (2018) Epigenome-wide association study of suicide attempt in schizophrenia. J Psychiatr Res 104:192\u2013197. https:\/\/doi.org\/10.1016\/j.jpsychires.2018.07.011","journal-title":"J Psychiatr Res"},{"issue":"2","key":"2600_CR16","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.jad.2013.08.001","volume":"151","author":"HJ Kang","year":"2013","unstructured":"Kang HJ, Kim JM, Lee JY et al (2013) (2013) BDNF promoter methylation and suicidal behavior in depressive patients. J Affect Disord 151(2):679\u2013685. https:\/\/doi.org\/10.1016\/j.jad.2013.08.001","journal-title":"J Affect Disord"},{"key":"2600_CR17","doi-asserted-by":"publisher","first-page":"997","DOI":"10.2147\/PRBM.S272445","volume":"13","author":"D Zheng","year":"2020","unstructured":"Zheng D, Bi X, Zhang T et al (2020) Epigenetic alterations of the promoter region of the POMC gene in adolescent depressive disorder patients with nonsuicidal self-injury behaviors. Psychol Res Behav Manag 13:997\u20131008. https:\/\/doi.org\/10.2147\/PRBM.S272445","journal-title":"Psychol Res Behav Manag"},{"issue":"7\u20138","key":"2600_CR18","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/ajmg.b.32917","volume":"189","author":"S Mirza","year":"2022","unstructured":"Mirza S, Docherty AR, Bakian A et al (2022) Genetics and epigenetics of self-injurious thoughts and behaviors systematic review of the suicide literature and methodological considerations. Am J Med Genet B Neuropsychiatr Genet 189(7\u20138):221\u2013246","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"2600_CR19","doi-asserted-by":"publisher","first-page":"594244","DOI":"10.3389\/fnhum.2020.594244","volume":"14","author":"HBD Duffy","year":"2020","unstructured":"Duffy HBD, Roth TL (2020) Increases in BDNF DNA methylation in the prefrontal cortex following aversive caregiving are reflected in blood tissue. Front Hum Neurosci 14:594244. https:\/\/doi.org\/10.3389\/fnhum.2020.594244","journal-title":"Front Hum Neurosci"},{"issue":"2","key":"2600_CR20","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s40614-016-0068-3","volume":"39","author":"DS Moore","year":"2016","unstructured":"Moore DS (2016) The developmental systems approach and the analysis of behavior. Behav Anal 39(2):243\u2013258. https:\/\/doi.org\/10.1007\/s40614-016-0068-3","journal-title":"Behav Anal"},{"key":"2600_CR21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jpsychires.2014.06.011","volume":"57","author":"A Martin-Blanco","year":"2014","unstructured":"Martin-Blanco A, Ferrer M, Soler J et al (2014) Association between methylation of the glucocorticoid receptor gene, childhood maltreatment, and clinical severity in borderline personality disorder. J Psychiatr Res 57:34\u201340","journal-title":"J Psychiatr Res"},{"issue":"7","key":"2600_CR22","doi-asserted-by":"publisher","first-page":"5830593","DOI":"10.1093\/hmg\/ddad207","volume":"33","author":"Z Li","year":"2024","unstructured":"Li Z, Wang W, Li W et al (2024) Co-methylation analysis identify CpGs associated with lipid traits in Chinese discordant monozygotic twins. Hum Mol Genet 33(7):5830593. https:\/\/doi.org\/10.1093\/hmg\/ddad207","journal-title":"Hum Mol Genet"},{"key":"2600_CR23","doi-asserted-by":"publisher","first-page":"1018525","DOI":"10.3389\/fpsyt.2022.1018525","volume":"13","author":"T Jiao","year":"2022","unstructured":"Jiao T, Guo S, Zhang Y et al (2022) Associations of depressive and anxiety symptoms with non-suicidal self-injury and suicidal attempt among Chinese adolescents: The mediation role of sleep quality. Front Psychiatry 13:1018525. https:\/\/doi.org\/10.3389\/fpsyt.2022.1018525","journal-title":"Front Psychiatry"},{"key":"2600_CR24","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3390\/future1030009","volume":"1","author":"S Guo","year":"2023","unstructured":"Guo S, Jiao T, Ma Y et al (2023) Association of adverse childhood experiences with non-suicidal self-Injury and suicidality: baseline survey of the Chinese Adolescent Health Growth Cohort. Future 1:76\u201392. https:\/\/doi.org\/10.3390\/future1030009","journal-title":"Future"},{"key":"2600_CR25","first-page":"285","volume":"1","author":"F Chen","year":"2006","unstructured":"Chen F, Mi J (2006) Methods for evaluating sexual development in adolescence and its relationship with metabolic syndrome. Chin J Evid Based Pediatr 1:285\u2013291","journal-title":"Chin J Evid Based Pediatr"},{"issue":"2","key":"2600_CR26","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/s0145-2134(02)00541-0","volume":"27","author":"DP Bernstein","year":"2003","unstructured":"Bernstein DP, Stein JA, Newcomb MD et al (2003) Development and validation of a brief screening version of the childhood trauma questionnaire. Child Abuse Negl 27(2):169\u2013190. https:\/\/doi.org\/10.1016\/s0145-2134(02)00541-0","journal-title":"Child Abuse Negl"},{"issue":"3","key":"2600_CR27","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1192\/bjp.2018.263","volume":"214","author":"Y Wan","year":"2019","unstructured":"Wan Y, Chen R, Ma S et al (2019) Associations of adverse childhood experiences and social support with self-injurious behaviour and suicidality in adolescents. Br J Psychiatry 214(3):146\u2013152. https:\/\/doi.org\/10.1192\/bjp.2018.263","journal-title":"Br J Psychiatry"},{"issue":"6","key":"2600_CR28","doi-asserted-by":"publisher","first-page":"e206863","DOI":"10.1001\/jamanetworkopen.2020.6863","volume":"3","author":"J Tang","year":"2020","unstructured":"Tang J, Ma Y, Lewis SP et al (2020) Association of internet addiction with nonsuicidal self-injury among adolescents in China. JAMA Netw Open 3(6):e206863. https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.6863","journal-title":"JAMA Netw Open"},{"key":"2600_CR29","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40479-014-0024-3","volume":"2","author":"PL Plener","year":"2015","unstructured":"Plener PL, Schumacher TS, Munz LM, Groschwitz RC (2015) The longitudinal course of non-suicidal self-injury and deliberate self-harm: a systematic review of the literature. Bord Personal Disord Emot Dysregul 2:2","journal-title":"Bord Personal Disord Emot Dysregul"},{"key":"2600_CR30","doi-asserted-by":"publisher","first-page":"5633211","DOI":"10.1155\/2021\/5633211","volume":"2021","author":"F Zeng","year":"2021","unstructured":"Zeng F, Shi M, Xiao H, Chi X (2021) WGCNA-Based identification of hub genes and key pathways involved in nonalcoholic fatty liver disease. Biomed Res Int 2021:5633211. https:\/\/doi.org\/10.1155\/2021\/5633211","journal-title":"Biomed Res Int"},{"issue":"1","key":"2600_CR31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00787-012-0311-8","volume":"22","author":"R Isohookana","year":"2013","unstructured":"Isohookana R, Riala K, Hakko H, R\u00e4s\u00e4nen P (2013) Adverse childhood experiences and suicidal behavior of adolescent psychiatric inpatients. Eur Child Adolesc Psychiatry 22(1):13\u201322. https:\/\/doi.org\/10.1007\/s00787-012-0311-8","journal-title":"Eur Child Adolesc Psychiatry"},{"issue":"1","key":"2600_CR32","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1186\/s12888-021-03392-y","volume":"21","author":"L Wang","year":"2021","unstructured":"Wang L, Liu J, Yang Y, Zou H (2021) Prevalence and risk factors for non-suicidal self-injury among patients with depression or bipolar disorder in China. BMC Psychiatry 21(1):389. https:\/\/doi.org\/10.1186\/s12888-021-03392-y","journal-title":"BMC Psychiatry"},{"key":"2600_CR33","doi-asserted-by":"publisher","first-page":"1199882","DOI":"10.3389\/fpubh.2023.1199882","volume":"11","author":"L Zhang","year":"2023","unstructured":"Zhang L, Wang W, Chen Y et al (2023) Adverse childhood experiences, unhealthy lifestyle, and nonsuicidal self-injury: findings from six universities in Shaanxi province. China Front Public Health 11:1199882. https:\/\/doi.org\/10.3389\/fpubh.2023.1199882","journal-title":"China Front Public Health"},{"key":"2600_CR34","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jad.2022.09.124","volume":"320","author":"W Xiao","year":"2023","unstructured":"Xiao W, Rong F, Li S et al (2023) Co-occurrence patterns of adverse childhood experiences and their associations with non-suicidal self-injury and suicidal behaviors and gender difference among middle school students: a three-city survey in China. J Affect Disord 320:140\u2013147. https:\/\/doi.org\/10.1016\/j.jad.2022.09.124","journal-title":"J Affect Disord"},{"issue":"1","key":"2600_CR35","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1186\/s12888-023-04724-w","volume":"23","author":"N Laporte","year":"2023","unstructured":"Laporte N, Ozolins A, Westling S et al (2023) Adverse childhood experiences as a risk factor for non-suicidal self-injury and suicide attempts in forensic psychiatric patients. BMC Psychiatry 23(1):238. https:\/\/doi.org\/10.1186\/s12888-023-04724-w","journal-title":"BMC Psychiatry"},{"issue":"2","key":"2600_CR36","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/j.1467-8721.2009.01613.x","volume":"18","author":"MK Nock","year":"2009","unstructured":"Nock MK (2009) Why do people hurt themselves? New insights into the nature and functions of self-injury. Curr Dir Psychol Sci 18(2):78\u201383. https:\/\/doi.org\/10.1111\/j.1467-8721.2009.01613.x","journal-title":"Curr Dir Psychol Sci"},{"issue":"9834","key":"2600_CR37","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1016\/S0140-6736(12)60322-5","volume":"379","author":"K Hawton","year":"2012","unstructured":"Hawton K, Saunders KE, O\u2019Connor RC (2012) Self-harm and suicide in adolescents. Lancet 379(9834):2373\u20132382. https:\/\/doi.org\/10.1016\/S0140-6736(12)60322-5","journal-title":"Lancet"},{"key":"2600_CR38","doi-asserted-by":"publisher","first-page":"S144","DOI":"10.1016\/j.amepre.2014.06.011","volume":"47","author":"G Turecki","year":"2014","unstructured":"Turecki G (2014) Epigenetics and suicidal behavior research pathways. Am J Prev Med 47:S144\u2013S151. https:\/\/doi.org\/10.1016\/j.amepre.2014.06.011","journal-title":"Am J Prev Med"},{"key":"2600_CR39","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jpsychires.2017.02.005","volume":"89","author":"B Roy","year":"2017","unstructured":"Roy B, Shelton RC, Dwivedi Y (2017) DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideation. J Psychiatr Res 89:115\u2013124. https:\/\/doi.org\/10.1016\/j.jpsychires.2017.02.005","journal-title":"J Psychiatr Res"},{"key":"2600_CR40","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/YPG.0000000000000183","volume":"27","author":"A Bani-Fatemi","year":"2017","unstructured":"Bani-Fatemi A, Strauss J, Zai C et al (2017) Multiple tissue methylation analysis of HTR2A exon I in suicidal behavior. Psychiatr Genet 27:219\u2013224. https:\/\/doi.org\/10.1097\/YPG.0000000000000183","journal-title":"Psychiatr Genet"},{"issue":"6","key":"2600_CR41","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/YPG.0000000000000273","volume":"27","author":"A Bani-Fatemi","year":"2017","unstructured":"Bani-Fatemi A, Raymond R, Adanty C et al (2017) Global DNA methylation in suicidal ideation and suicide attempt in schizophrenia. Psychiatr Genet 27(6):219\u2013224. https:\/\/doi.org\/10.1097\/YPG.0000000000000273","journal-title":"Psychiatr Genet"},{"issue":"4","key":"2600_CR42","doi-asserted-by":"publisher","first-page":"584","DOI":"10.3390\/brainsci13040584","volume":"13","author":"DM Dionisio-Garc\u00eda","year":"2023","unstructured":"Dionisio-Garc\u00eda DM, Genis-Mendoza AD, Gonz\u00e1lez-Castro TB et al (2023) DNA methylation of genes involved in the HPA axis in presence of suicide behavior: a systematic review. Brain Sci 13(4):584. https:\/\/doi.org\/10.3390\/brainsci13040584","journal-title":"Brain Sci"},{"issue":"2","key":"2600_CR43","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1074\/mcp.M113.035600","volume":"13","author":"L Fagerberg","year":"2014","unstructured":"Fagerberg L, Hallstr\u00f6m BM, Oksvold P et al (2014) Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics 13(2):397\u2013406. https:\/\/doi.org\/10.1074\/mcp.M113.035600","journal-title":"Mol Cell Proteomics"},{"issue":"7669","key":"2600_CR44","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/nature23663","volume":"548","author":"K Liu","year":"2017","unstructured":"Liu K, Kim J, Kim DW et al (2017) Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep. Nature 548(7669):582\u2013587. https:\/\/doi.org\/10.1038\/nature23663","journal-title":"Nature"},{"key":"2600_CR45","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3389\/fgene.2019.00694","volume":"10","author":"WJ Lim","year":"2019","unstructured":"Lim WJ, Kim KH, Kim JY et al (2019) Investigation of gene expression and DNA methylation from seven different brain regions of a crab-eating monkey as determined by RNA-Seq and whole-genome bisulfite sequencing. Front Genet 10:694. https:\/\/doi.org\/10.3389\/fgene.2019.00694","journal-title":"Front Genet"},{"key":"2600_CR46","doi-asserted-by":"publisher","first-page":"106627","DOI":"10.1016\/j.chiabu.2023.106627","volume":"149","author":"F Rong","year":"2024","unstructured":"Rong F, Wang M, Peng C et al (2024) Specific and cumulative effects of childhood maltreatment on nonsuicidal self-injury in Chinese adolescents: The moderating effect of sleep disturbance. Child Abuse Negl 149:106627. https:\/\/doi.org\/10.1016\/j.chiabu.2023.106627","journal-title":"Child Abuse Negl"},{"issue":"5","key":"2600_CR47","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1093\/schbul\/sbu068","volume":"40","author":"DW Volk","year":"2014","unstructured":"Volk DW, Edelson JR, Lewis DA (2014) Cortical inhibitory neuron disturbances in schizophrenia: role of the ontogenetic transcription factor Lhx6. Schizoph Bull 40(5):1053\u20131061. https:\/\/doi.org\/10.1093\/schbul\/sbu068","journal-title":"Schizoph Bull"},{"issue":"6","key":"2600_CR48","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nrg2341","volume":"9","author":"MM Suzuki","year":"2008","unstructured":"Suzuki MM, Bird A (2008) DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 9(6):465\u2013476. https:\/\/doi.org\/10.1038\/nrg2341","journal-title":"Nat Rev Genet"},{"key":"2600_CR49","doi-asserted-by":"publisher","first-page":"105079","DOI":"10.1016\/j.neubiorev.2023.105079","volume":"147","author":"M Rubens","year":"2023","unstructured":"Rubens M, Bruenig D, Adams JAM et al (2023) Childhood maltreatment and DNA methylation: a systematic review. Neurosci Biobehav Rev 147:105079. https:\/\/doi.org\/10.1016\/j.neubiorev.2023.105079","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"2600_CR50","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/s41398-021-01207-y","volume":"11","author":"SH Parade","year":"2021","unstructured":"Parade SH, Huffhines L, Daniels TE et al (2021) A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches. Transl Psychiatry 11(1):134. https:\/\/doi.org\/10.1038\/s41398-021-01207-y","journal-title":"Transl Psychiatry"},{"issue":"1","key":"2600_CR51","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41398-018-0307-3","volume":"8","author":"LC Houtepen","year":"2018","unstructured":"Houtepen LC, Hardy R, Maddock J et al (2018) Childhood adversity and DNA methylation in two population-based cohorts. Transl Psychiatry 8(1):266","journal-title":"Transl Psychiatry"},{"issue":"1","key":"2600_CR52","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/cdev.13972","volume":"95","author":"M Chen","year":"2024","unstructured":"Chen M, Cao C (2024) The mediation effect of glucocorticoid receptor gene (NR3C1) methylation between childhood maltreatment and depressive symptoms in Chinese adolescents: a 2-year longitudinal study. Child Dev 95(1):144\u2013159","journal-title":"Child Dev"}],"container-title":["European Child & Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-024-02600-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00787-024-02600-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-024-02600-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T01:07:49Z","timestamp":1750813669000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00787-024-02600-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["2600"],"URL":"https:\/\/doi.org\/10.1007\/s00787-024-02600-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4859977\/v1","asserted-by":"object"}]},"ISSN":["1018-8827","1435-165X"],"issn-type":[{"value":"1018-8827","type":"print"},{"value":"1435-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]},"assertion":[{"value":"5 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The proposal of CAHGC study and the case\u2013control study have been approved by the Institutional Review Board of Guangzhou Medical University (NO.2021010002) and therefore been performed in accordance with ethical standard laid down in the 1964 Declaration of Helsinki and its later amendments. All parents\/guardians of the participants provided written informed consent prior to their inclusion in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}