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To assess serum levels of folate and B<jats:sub>12<\/jats:sub> in child and adolescent psychiatric inpatients and examine possible links between these levels and different psychiatric disorders. Child and adolescent psychiatric inpatients admitted in a general hospital during a 3-year period were included for analysis. Folate and B<jats:sub>12<\/jats:sub> levels were measured when the subjects were admitted. Psychiatric diagnoses were made following DSM-5 criteria and grouped into categories. Logistic regression analysis was used to study the effects of socio-demographic variables as well as folate and B<jats:sub>12<\/jats:sub> levels, insufficiencies and deficits as possible predictors of outcome (psychiatric diagnostic category). 729 inpatients (60.6% female, mean age: 15.1\u2009\u00b1\u20092 years) were included. A total of 42.9% presented insufficient folate levels and 19.4% insufficient B<jats:sub>12<\/jats:sub> levels. Insufficient B<jats:sub>12<\/jats:sub> levels were associated with depressive disorders in the multivariate model (OR\u2009=\u20090.82, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) as was female sex (OR\u2009=\u20091.65, <jats:italic>p<\/jats:italic>\u2009=\u20090.007). Moreover, low vitamin B<jats:sub>12<\/jats:sub> levels were linked to schizophrenia spectrum disorders (SSD, OR\u2009=\u20090.9982, <jats:italic>p<\/jats:italic>\u2009=\u20090.024). In contrast, higher folate (OR\u2009=\u20091.15, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and vitamin B<jats:sub>12<\/jats:sub> levels (1.0024, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) as well as female sex (OR\u2009=\u20097.86, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were associated with eating disorders. Insufficient or low B<jats:sub>12<\/jats:sub> levels could help predict depressive and SSD respectively in child and adolescent psychiatric inpatients. Further study could help us better understand the impact of this insufficiency during the neurodevelopmental period and the potential benefits of nutritional interventions.<\/jats:p>","DOI":"10.1007\/s00787-025-02662-4","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T06:53:42Z","timestamp":1742280822000},"page":"2753-2762","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of low vitamin B12 levels with depressive and schizophrenia spectrum disorders in child and adolescent psychiatric inpatients"],"prefix":"10.1007","volume":"34","author":[{"given":"Gerard","family":"Anmella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Prades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gim\u00e9nez-Palomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"de Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Deulofeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Solerdelcoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1strid","family":"Morer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Baeza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"2662_CR1","doi-asserted-by":"publisher","first-page":"570","DOI":"10.5546\/aap.2016.eng.570","volume":"114","author":"HF Gonz\u00e1lez","year":"2016","unstructured":"Gonz\u00e1lez HF, Visentin S (2016) Micronutrients and neurodevelopment: an update (. 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EV has received honoraria and travel support from Otsuka-Lundbeck, Shire and Janssen. AG-P has received support from Janssen-Cilag and Otsuka-Lundbeck, and declares no support related to the subject of this article. LE has received support from Janssen-Cilag and Otsuka-Lundbeck, and declares no support related to the subject of this article. NP has received grants, personal fees and\/or non-financial support from Janssen-Cilag and Otsuka and reports no financial or other relationship relevant to the subject of this article. MS was a grant-holder from Fundaci\u00f3n Alicia Koplowitz. IB has received honoraria or travel support from Otsuka-Lundbeck and Angelini, research support from Fundaci\u00f3n Alicia Koplowitz and grants from Spanish Ministry of Health, Instituto de Salud Carlos III (PI18\/00242, PI21\/00391) and National Drugs Plan (2022I053). 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