{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:31:32Z","timestamp":1762421492529,"version":"build-2065373602"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Child Adolesc Psychiatry"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to assess whether a young, first-onset cohort of girls with anorexia nervosa (AN) demonstrate similar findings of reduced gray and white matter volume reductions as reported in older women with chronic AN. We compared adolescents and young adults with first-onset AN to typically developing (TD) girls and investigated associations between brain volume measures and clinical symptoms. Whole-brain T\n                    <jats:sub>1<\/jats:sub>\n                    -weighted structural imaging was performed in 58 young persons with AN and 63 age, sex-, and education-matched TD participants. Participants with AN were further divided into underweight (undAN) and restored weight (restAN) groups based on body mass index length\/weight standard deviation score (BMI-SDS). Eating disorder symptoms were measured by the Eating Disorder Examination (EDE) and the Eating Disorder Inventory-3 (EDI-3). Differences in brain volume measures were analyzed using separate linear regression analyses. Within the AN group, associations between brain volumes, BMI-SDS, and EDE\/EDI-3 scores were analyzed. The undAN group showed significant reductions in total and cortical gray matter volumes compared to the TD group, primarily in the frontal and parietal cortices. No significant associations were found between brain volume and BMI-SDS or EDE\/EDI-3 scores. Frontal and parietal cortices in adolescents and young adults with undAN are particularly affected by malnutrition, showing gray matter volume reductions even in early stages of AN. Longitudinal studies are needed to explore the effects of malnutrition on brain development and its association with clinical features of AN over time.\n                  <\/jats:p>","DOI":"10.1007\/s00787-025-02715-8","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T02:21:00Z","timestamp":1745374860000},"page":"3071-3081","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Brain morphology in adolescent girls with first-onset anorexia nervosa"],"prefix":"10.1007","volume":"34","author":[{"given":"Janneke S. P.","family":"Kovoor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0845-1749","authenticated-orcid":false,"given":"Katrien F.M.","family":"Brack\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-1896","authenticated-orcid":false,"given":"Tonya","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9700-5606","authenticated-orcid":false,"given":"Gwen C.","family":"Dieleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"issue":"1","key":"2715_CR1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41380-021-01161-7","volume":"27","author":"M Solmi","year":"2022","unstructured":"Solmi M, Radua J, Olivola M, Croce E, Soardo L, Salazar de Pablo G et al (2022) Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies. Mol Psychiatry 27(1):281\u2013295. https:\/\/doi.org\/10.1038\/s41380-021-01161-7","journal-title":"Mol Psychiatry"},{"key":"2715_CR2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787.x10_Feeding_and_Eating_Disorders","author":"Feeding and Eating Disorders","year":"2022","unstructured":"Feeding and Eating Disorders (2022) Diagnostic and statistical manual of mental disorders. Am Psychiatric Association Publishing. https:\/\/doi.org\/10.1176\/appi.books.9780890425787.x10_Feeding_and_Eating_DisordersAccessed 2023\/08\/16","journal-title":"Am Psychiatric Association Publishing"},{"issue":"4","key":"2715_CR3","doi-asserted-by":"publisher","first-page":"558","DOI":"10.5498\/wjp.v12.i4.558","volume":"12","author":"S Frostad","year":"2022","unstructured":"Frostad S, Bentz M (2022) Anorexia nervosa: outpatient treatment and medical management. World J Psychiatry 12(4):558\u2013579. https:\/\/doi.org\/10.5498\/wjp.v12.i4.558","journal-title":"World J Psychiatry"},{"key":"2715_CR4","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.pediatrneurol.2023.08.020","volume":"149","author":"A Ayaz","year":"2023","unstructured":"Ayaz A, Nisar I, Muhammad A, Ahmed K, Chand P, Jehan F (2023) Structural changes in the brain on magnetic resonance imaging in malnourished children: A scoping review of the literature. Pediatr Neurol 149:151\u2013158. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2023.08.020","journal-title":"Pediatr Neurol"},{"issue":"10","key":"2715_CR5","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/13158","volume":"2","author":"JN Giedd","year":"1999","unstructured":"Giedd JN, Blumenthal J, Jeffries NO, Castellanos FX, Liu H, Zijdenbos A et al (1999) Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci 2(10):861\u2013863. https:\/\/doi.org\/10.1038\/13158","journal-title":"Nat Neurosci"},{"issue":"21","key":"2715_CR6","doi-asserted-by":"publisher","first-page":"8174","DOI":"10.1073\/pnas.0402680101","volume":"101","author":"N Gogtay","year":"2004","unstructured":"Gogtay N, Giedd JN, Lusk L, Hayashi KM, Greenstein D, Vaituzis AC et al (2004) Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci U S A 101(21):8174\u20138179. https:\/\/doi.org\/10.1073\/pnas.0402680101","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"2715_CR7","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.biopsych.2022.04.022","volume":"92","author":"E Walton","year":"2022","unstructured":"Walton E, Bernardoni F, Batury VL, Bahnsen K, Lariviere S, Abbate-Daga G et al (2022) Brain structure in acutely underweight and partially Weight-Restored individuals with anorexia nervosa: A coordinated analysis by the ENIGMA eating disorders working group. Biol Psychiatry 92(9):730\u2013738. https:\/\/doi.org\/10.1016\/j.biopsych.2022.04.022","journal-title":"Biol Psychiatry"},{"key":"2715_CR8","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jpsychires.2023.05.059","volume":"163","author":"KFM Bracke","year":"2023","unstructured":"Bracke KFM, Steegers CPM, van der Harst T, Dremmen MHG, Vernooij MW, White TJH, Dieleman GC (2023) Can neuroimaging measures differentiate the disease course of anorexia nervosa? A systematic review. J Psychiatr Res 163:337\u2013349. https:\/\/doi.org\/10.1016\/j.jpsychires.2023.05.059","journal-title":"J Psychiatr Res"},{"issue":"2","key":"2715_CR9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/children8020137","volume":"8","author":"K Kappou","year":"2021","unstructured":"Kappou K, Ntougia M, Kourtesi A, Panagouli E, Vlachopapadopoulou E, Michalacos S et al (2021) Neuroimaging findings in adolescents and young adults with anorexia nervosa: A systematic review. Child (Basel) 8(2):137. https:\/\/doi.org\/10.3390\/children8020137","journal-title":"Child (Basel)"},{"issue":"8","key":"2715_CR10","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s00702-016-1567-9","volume":"123","author":"J Seitz","year":"2016","unstructured":"Seitz J, Herpertz-Dahlmann B, Konrad K (2016) Brain morphological changes in adolescent and adult patients with anorexia nervosa. J Neural Transm (Vienna) 123(8):949\u2013959. https:\/\/doi.org\/10.1007\/s00702-016-1567-9","journal-title":"J Neural Transm (Vienna)"},{"key":"2715_CR11","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.neuroimage.2016.02.003","volume":"130","author":"F Bernardoni","year":"2016","unstructured":"Bernardoni F, King JA, Geisler D, Stein E, Jaite C, Natsch D et al (2016) Weight restoration therapy rapidly reverses cortical thinning in anorexia nervosa: A longitudinal study. NeuroImage 130:214\u2013222. https:\/\/doi.org\/10.1016\/j.neuroimage.2016.02.003","journal-title":"NeuroImage"},{"key":"2715_CR12","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.jpsychires.2015.06.019","volume":"68","author":"J Seitz","year":"2015","unstructured":"Seitz J, Walter M, Mainz V, Herpertz-Dahlmann B, Konrad K, von Polier G (2015) Brain volume reduction predicts weight development in adolescent patients with anorexia nervosa. J Psychiatr Res 68:228\u2013237. https:\/\/doi.org\/10.1016\/j.jpsychires.2015.06.019","journal-title":"J Psychiatr Res"},{"issue":"1","key":"2715_CR13","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/erv.2803","volume":"29","author":"L Bang","year":"2021","unstructured":"Bang L, Tamnes CK, Norbom LB, Thomassen RA, Holm JS, Skotte LH et al (2021) Associations of age, body mass index and biochemical parameters with brain morphology in patients with anorexia nervosa. Eur Eat Disord Rev 29(1):74\u201385. https:\/\/doi.org\/10.1002\/erv.2803","journal-title":"Eur Eat Disord Rev"},{"issue":"7","key":"2715_CR14","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1111\/ejn.13659","volume":"46","author":"B Martin Monzon","year":"2017","unstructured":"Martin Monzon B, Henderson LA, Madden S, Macefield VG, Touyz S, Kohn MR et al (2017) Grey matter volume in adolescents with anorexia nervosa and associated eating disorder symptoms. Eur J Neurosci 46(7):2297\u20132307. https:\/\/doi.org\/10.1111\/ejn.13659","journal-title":"Eur J Neurosci"},{"issue":"15","key":"2715_CR15","doi-asserted-by":"publisher","first-page":"5154","DOI":"10.1002\/hbm.25602","volume":"42","author":"T Su","year":"2021","unstructured":"Su T, Gong J, Tang G, Qiu S, Chen P, Chen G et al (2021) Structural and functional brain alterations in anorexia nervosa:a multimodal meta-analysis of neuroimaging studies. Hum Brain Mapp 42(15):5154\u20135169. https:\/\/doi.org\/10.1002\/hbm.25602","journal-title":"Hum Brain Mapp"},{"issue":"9","key":"2715_CR16","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.biopsych.2014.12.016","volume":"78","author":"JH Decker","year":"2015","unstructured":"Decker JH, Figner B, Steinglass JE (2015) On weight and waiting: delay discounting in anorexia nervosa pretreatment and posttreatment. Biol Psychiatry 78(9):606\u2013614. https:\/\/doi.org\/10.1016\/j.biopsych.2014.12.016","journal-title":"Biol Psychiatry"},{"issue":"6","key":"2715_CR17","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1097\/PSY.0b013e31824ef10e","volume":"74","author":"V Mainz","year":"2012","unstructured":"Mainz V, Schulte-Ruther M, Fink GR, Herpertz-Dahlmann B, Konrad K (2012) Structural brain abnormalities in adolescent anorexia nervosa before and after weight recovery and associated hormonal changes. Psychosom Med 74(6):574\u2013582. https:\/\/doi.org\/10.1097\/PSY.0b013e31824ef10e","journal-title":"Psychosom Med"},{"key":"2715_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02378-4","author":"K Tose","year":"2024","unstructured":"Tose K, Takamura T, Isobe M, Hirano Y, Sato Y, Kodama N et al (2024) Systematic reduction of Gray matter volume in anorexia nervosa, but relative enlargement with clinical symptoms in the prefrontal and posterior insular cortices: a multicenter neuroimaging study. Mol Psychiatry. https:\/\/doi.org\/10.1038\/s41380-023-02378-4","journal-title":"Mol Psychiatry"},{"key":"2715_CR19","doi-asserted-by":"publisher","first-page":"104480","DOI":"10.1016\/j.appet.2019.104480","volume":"144","author":"J Leppanen","year":"2020","unstructured":"Leppanen J, Cardi V, Sedgewick F, Treasure J, Tchanturia K (2020) Basal ganglia volume and shape in anorexia nervosa. Appetite 144:104480. https:\/\/doi.org\/10.1016\/j.appet.2019.104480","journal-title":"Appetite"},{"issue":"3","key":"2715_CR20","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1080\/08039488.2016.1250948","volume":"71","author":"L Solstrand Dahlberg","year":"2017","unstructured":"Solstrand Dahlberg L, Wiemerslage L, Swenne I, Larsen A, Stark J, Rask-Andersen M et al (2017) Adolescents newly diagnosed with eating disorders have structural differences in brain regions linked with eating disorder symptoms. Nord J Psychiatry 71(3):188\u2013196. https:\/\/doi.org\/10.1080\/08039488.2016.1250948","journal-title":"Nord J Psychiatry"},{"issue":"2","key":"2715_CR21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/ejn.13793","volume":"47","author":"A Phillipou","year":"2018","unstructured":"Phillipou A, Rossell SL, Gurvich C, Castle DJ, Abel LA, Nibbs RG, Hughes ME (2018) Differences in regional grey matter volumes in currently ill patients with anorexia nervosa. Eur J Neurosci 47(2):177\u2013183. https:\/\/doi.org\/10.1111\/ejn.13793","journal-title":"Eur J Neurosci"},{"issue":"22","key":"2715_CR22","doi-asserted-by":"publisher","first-page":"8819","DOI":"10.1523\/JNEUROSCI.21-22-08819.2001","volume":"21","author":"ER Sowell","year":"2001","unstructured":"Sowell ER, Thompson PM, Tessner KD, Toga AW (2001) Mapping continued brain growth and Gray matter density reduction in dorsal frontal cortex: inverse relationships during postadolescent brain maturation. J Neurosci 21(22):8819\u20138829. https:\/\/doi.org\/10.1523\/JNEUROSCI.21-22-08819.2001","journal-title":"J Neurosci"},{"key":"2715_CR23","doi-asserted-by":"publisher","unstructured":"Cathelijne Steegers KB, Stefan Ehrlich T, van der Harst J, Legerstee et al (2024) Brain, behavior, cognition, and physical health in first-onset adolescent anorexia nervosa: The BRAVE Study design and cohort profile. Aperture Neuro 4:25. https:\/\/doi.org\/10.52294\/001c.116180d","DOI":"10.52294\/001c.116180d"},{"key":"2715_CR24","unstructured":"JGZ-Richtlijn Lengtegroei (2022) https:\/\/tnochildhealthstatistics.shinyapps.io\/JGZRichtlijnLengtegroei\/ Accessed."},{"issue":"7612","key":"2715_CR25","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1136\/bmj.39238.399444.55","volume":"335","author":"TJ Cole","year":"2007","unstructured":"Cole TJ, Flegal KM, Nicholls D, Jackson AA (2007) Body mass index cut offs to define thinness in children and adolescents: international survey. BMJ 335(7612):194. https:\/\/doi.org\/10.1136\/bmj.39238.399444.55","journal-title":"BMJ"},{"key":"2715_CR26","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/2050-2974-1-42","volume":"1","author":"JS Rose","year":"2013","unstructured":"Rose JS, Vaewsorn A, Rosselli-Navarra F, Wilson GT, Weissman RS (2013) Test-retest reliability of the eating disorder examination-questionnaire (EDE-Q) in a college sample. J Eat Disord 1:42. https:\/\/doi.org\/10.1186\/2050-2974-1-42","journal-title":"J Eat Disord"},{"key":"2715_CR27","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.3389\/fpsyg.2018.02145","volume":"9","author":"JA de Vos","year":"2018","unstructured":"de Vos JA, Radstaak M, Bohlmeijer ET, Westerhof GJ (2018) Having an eating disorder and still being able to flourish?? Examination of pathological symptoms and Well-Being as two continua of mental health in a clinical sample. Front Psychol 9:2145. https:\/\/doi.org\/10.3389\/fpsyg.2018.02145","journal-title":"Front Psychol"},{"issue":"1","key":"2715_CR28","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s10862-010-9207-4","volume":"33","author":"L Clausen","year":"2011","unstructured":"Clausen L, Rosenvinge JH, Friborg O, Rokkedal K (2011) Validating the eating disorder Inventory-3 (EDI-3): A comparison between 561 female eating disorders patients and 878 females from the general population. J Psychopathol Behav Assess 33(1):101\u2013110. https:\/\/doi.org\/10.1007\/s10862-010-9207-4","journal-title":"J Psychopathol Behav Assess"},{"key":"2715_CR29","volume-title":"Beck depression inventory manual 1996","author":"ASR Beck","year":"1996","unstructured":"Beck ASR, Brown GK (1996) Beck depression inventory manual 1996. The Psychological Corporation, San Antonio, TX"},{"issue":"4","key":"2715_CR30","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1590\/1516-4446-2012-1048","volume":"35","author":"YP Wang","year":"2013","unstructured":"Wang YP, Gorenstein C (2013) Psychometric properties of the Beck depression Inventory-II: a comprehensive review. Braz J Psychiatry 35(4):416\u2013431. https:\/\/doi.org\/10.1590\/1516-4446-2012-1048","journal-title":"Braz J Psychiatry"},{"issue":"4","key":"2715_CR31","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0005-7916(98)00023-8","volume":"29","author":"P Muris","year":"1998","unstructured":"Muris P, Merckelbach H, Mayer B, van Brakel A, Thissen S, Moulaert V, Gadet B (1998) The screen for child anxiety related emotional disorders (SCARED) and traditional childhood anxiety measures. J Behav Ther Exp Psychiatry 29(4):327\u2013339 doi: S0005-7916(98)00023-8 [pii] https:\/\/doi.org\/10.1016\/s0005-7916(98)00023-8","journal-title":"J Behav Ther Exp Psychiatry"},{"issue":"4","key":"2715_CR32","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1097\/00004583-199704000-00018","volume":"36","author":"B Birmaher","year":"1997","unstructured":"Birmaher B, Khetarpal S, Brent D, Cully M, Balach L, Kaufman J, Neer SM (1997) The screen for child anxiety related emotional disorders (SCARED): scale construction and psychometric characteristics. J Am Acad Child Adolesc Psychiatry 36(4):545\u2013553. https:\/\/doi.org\/10.1097\/00004583-199704000-00018","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"3","key":"2715_CR33","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1002\/hbm.23911","volume":"39","author":"T White","year":"2018","unstructured":"White T, Jansen PR, Muetzel RL, Sudre G, El Marroun H, Tiemeier H et al (2018) Automated quality assessment of structural magnetic resonance images in children: comparison with visual inspection and surface-based reconstruction. Hum Brain Mapp 39(3):1218\u20131231. https:\/\/doi.org\/10.1002\/hbm.23911","journal-title":"Hum Brain Mapp"},{"issue":"3","key":"2715_CR34","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","volume":"31","author":"RS Desikan","year":"2006","unstructured":"Desikan RS, Segonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D et al (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage 31(3):968\u2013980. https:\/\/doi.org\/10.1016\/j.neuroimage.2006.01.021","journal-title":"NeuroImage"},{"key":"2715_CR35","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1007\/978-1-4419-9863-7_223","volume-title":"Encyclopedia of systems biology","author":"S Rouam","year":"2013","unstructured":"Rouam S (2013) False discovery rate (FDR). In: Dubitzky W, Wolkenhauer O, Cho K-H, Yokota H (eds) Encyclopedia of systems biology. Springer New York, New York, NY, pp 731\u2013732"},{"issue":"1","key":"2715_CR36","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1024\/1422-4917\/a000265","volume":"42","author":"J Seitz","year":"2014","unstructured":"Seitz J, Buhren K, von Polier GG, Heussen N, Herpertz-Dahlmann B, Konrad K (2014) Morphological changes in the brain of acutely ill and weight-recovered patients with anorexia nervosa. A meta-analysis and qualitative review. Z Kinder Jugendpsychiatr Psychother 42(1):7\u201317 quiz\u2013\u20098. https:\/\/doi.org\/10.1024\/1422-4917\/a000265","journal-title":"Z Kinder Jugendpsychiatr Psychother"},{"issue":"1","key":"2715_CR37","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.pscychresns.2010.06.007","volume":"191","author":"S Gaudio","year":"2011","unstructured":"Gaudio S, Nocchi F, Franchin T, Genovese E, Cannata V, Longo D, Fariello G (2011) Gray matter decrease distribution in the early stages of anorexia nervosa restrictive type in adolescents. Psychiatry Res 191(1):24\u201330. https:\/\/doi.org\/10.1016\/j.pscychresns.2010.06.007","journal-title":"Psychiatry Res"},{"key":"2715_CR38","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/1471-244X-13-110","volume":"13","author":"OE Titova","year":"2013","unstructured":"Titova OE, Hjorth OC, Schioth HB, Brooks SJ (2013) Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies. BMC Psychiatry 13:110. https:\/\/doi.org\/10.1186\/1471-244X-13-110","journal-title":"BMC Psychiatry"},{"issue":"4","key":"2715_CR39","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1503\/jpn.140193","volume":"40","author":"KJ Bar","year":"2015","unstructured":"Bar KJ, de la Cruz F, Berger S, Schultz CC, Wagner G (2015) Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa. J Psychiatry Neurosci 40(4):269\u2013279. https:\/\/doi.org\/10.1503\/jpn.140193","journal-title":"J Psychiatry Neurosci"},{"issue":"1","key":"2715_CR40","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.neuron.2015.09.029","volume":"88","author":"O Blanke","year":"2015","unstructured":"Blanke O, Slater M, Serino A, Behavioral (2015) Neural, and computational principles of bodily Self-Consciousness. Neuron 88(1):145\u2013166. https:\/\/doi.org\/10.1016\/j.neuron.2015.09.029","journal-title":"Neuron"},{"key":"2715_CR41","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2147\/NDT.S39776","volume":"9","author":"M Arain","year":"2013","unstructured":"Arain M, Haque M, Johal L, Mathur P, Nel W, Rais A et al (2013) Maturation of the adolescent brain. Neuropsychiatr Dis Treat 9:449\u2013461. https:\/\/doi.org\/10.2147\/NDT.S39776","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2715_CR42","doi-asserted-by":"publisher","first-page":"1047545","DOI":"10.3389\/fendo.2022.1047545","volume":"13","author":"M Cacciatore","year":"2022","unstructured":"Cacciatore M, Grasso EA, Tripodi R, Chiarelli F (2022) Impact of glucose metabolism on the developing brain. Front Endocrinol (Lausanne) 13:1047545. https:\/\/doi.org\/10.3389\/fendo.2022.1047545","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"2715_CR43","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1002\/hbm.23223","volume":"37","author":"N Trotta","year":"2016","unstructured":"Trotta N, Archambaud F, Goldman S, Baete K, Van Laere K, Wens V et al (2016) Functional integration changes in regional brain glucose metabolism from childhood to adulthood. Hum Brain Mapp 37(8):3017\u20133030. https:\/\/doi.org\/10.1002\/hbm.23223","journal-title":"Hum Brain Mapp"},{"issue":"9","key":"2715_CR44","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1016\/j.jaac.2022.03.026","volume":"61","author":"K Bahnsen","year":"2022","unstructured":"Bahnsen K, Bernardoni F, King JA, Geisler D, Weidner K, Roessner V et al (2022) Dynamic structural brain changes in anorexia nervosa: A replication study, Mega-analysis, and virtual histology approach. J Am Acad Child Adolesc Psychiatry 61(9):1168\u20131181. https:\/\/doi.org\/10.1016\/j.jaac.2022.03.026","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"8","key":"2715_CR45","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.2174\/1570159X15666171109145651","volume":"16","author":"J Seitz","year":"2018","unstructured":"Seitz J, Konrad K, Herpertz-Dahlmann B (2018) Extend, pathomechanism and clinical consequences of brain volume changes in anorexia nervosa. Curr Neuropharmacol 16(8):1164\u20131173. https:\/\/doi.org\/10.2174\/1570159X15666171109145651","journal-title":"Curr Neuropharmacol"},{"issue":"25","key":"2715_CR46","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3238\/arztebl.2013.0425","volume":"110","author":"K Konrad","year":"2013","unstructured":"Konrad K, Firk C, Uhlhaas PJ (2013) Brain development during adolescence: neuroscientific insights into this developmental period. Dtsch Arztebl Int 110(25):425\u2013431. https:\/\/doi.org\/10.3238\/arztebl.2013.0425","journal-title":"Dtsch Arztebl Int"},{"issue":"1","key":"2715_CR47","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/eat.10111","volume":"33","author":"VW Swayze","year":"2003","unstructured":"Swayze VW 2nd, Andersen AE, Andreasen NC, Arndt S, Sato Y, Ziebell S (2003) Brain tissue volume segmentation in patients with anorexia nervosa before and after weight normalization. Int J Eat Disord 33(1):33\u201344. https:\/\/doi.org\/10.1002\/eat.10111","journal-title":"Int J Eat Disord"},{"issue":"2","key":"2715_CR48","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/erv.2965","volume":"31","author":"E Collantoni","year":"2023","unstructured":"Collantoni E, Meregalli V, Manara R, Meneguzzo P, Tenconi E, Favaro A (2023) Volume and complexity of the thalamus in anorexia nervosa: an exploratory evaluation. Eur Eat Disord Rev 31(2):349\u2013359. https:\/\/doi.org\/10.1002\/erv.2965","journal-title":"Eur Eat Disord Rev"}],"container-title":["European Child &amp; Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-025-02715-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00787-025-02715-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-025-02715-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:27:19Z","timestamp":1762421239000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00787-025-02715-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["2715"],"URL":"https:\/\/doi.org\/10.1007\/s00787-025-02715-8","relation":{},"ISSN":["1018-8827","1435-165X"],"issn-type":[{"type":"print","value":"1018-8827"},{"type":"electronic","value":"1435-165X"}],"subject":[],"published":{"date-parts":[[2025,4,23]]},"assertion":[{"value":"18 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The BRAVE study was approved by the Medical Ethical Committee of the Erasmus MC-Sophia (MEC 2016\u2013194\/NL55175.078.16) and conducted in agreement with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all participants. When the participant was younger than 16 years of age informed consent was obtained from both parents.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}