{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:05:29Z","timestamp":1793192729529,"version":"4.5.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Postdoctoral Research Fellowship in Child & Adolescent Psychiatry supported by the Harvey L. and Maud C. Sorensen Foundation"},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["123752K23"],"award-info":[{"award-number":["123752K23"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015521","name":"Stanford Maternal and Child Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015521","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stephen Bechtel Endowed Faculty Scholar in Pediatric Translational Medicine"},{"name":"Neurofibromatosis Therapeutic Acceleration Program at the John Hopkins University School of Medicine"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Child Adolesc Psychiatry"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s00787-025-02767-w","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T05:31:20Z","timestamp":1748928680000},"page":"3497-3507","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Irritability in children with RASopathies, insights into emotional dysregulation and social impairment"],"prefix":"10.1007","volume":"34","author":[{"given":"Yaffa","family":"Serur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Fuhrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odeya","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"2767_CR1","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1002\/ajmg.c.32015","volume":"190","author":"M Zenker","year":"2022","unstructured":"Zenker M (2022) Clinical overview on rasopathies. Am J Med Genet C Semin Med Genet 190:414\u2013424","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"2767_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/sj.cr.7290105","volume":"12","author":"W Zhang","year":"2002","unstructured":"Zhang W, Liu HT (2002) MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 12:9\u201318","journal-title":"Cell Res"},{"key":"2767_CR3","doi-asserted-by":"publisher","unstructured":"Hebron KE, Hernandez ER, Yohe ME (2022) The rasopathies: from pathogenetics to therapeutics. Dis Model Mech 15. https:\/\/doi.org\/10.1242\/dmm.049107","DOI":"10.1242\/dmm.049107"},{"key":"2767_CR4","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/ajmg.c.32012","volume":"190","author":"M Tartaglia","year":"2022","unstructured":"Tartaglia M, Aoki Y, Gelb BD (2022) The molecular genetics of rasopathies: an update on novel disease genes and new disorders. Am J Med Genet C Semin Med Genet 190:425\u2013439","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"2767_CR5","doi-asserted-by":"publisher","first-page":"17004","DOI":"10.1038\/nrdp.2017.4","volume":"3","author":"DH Gutmann","year":"2017","unstructured":"Gutmann DH, Ferner RE, Listernick RH, Korf BR, Wolters PL, Johnson KJ (2017) Neurofibromatosis type 1. Nat Rev Dis Primers 3:17004","journal-title":"Nat Rev Dis Primers"},{"key":"2767_CR6","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.15627","author":"PE Naylor","year":"2023","unstructured":"Naylor PE, Bruno JL, Shrestha SB, Friedman M, Jo B, Reiss AL et al (2023) Neuropsychiatric phenotypes in children with Noonan syndrome. Dev Med Child Neurol. https:\/\/doi.org\/10.1111\/dmcn.15627","journal-title":"Dev Med Child Neurol"},{"key":"2767_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s11689-018-9239-8","volume":"10","author":"EI Pierpont","year":"2018","unstructured":"Pierpont EI, Hudock RL, Foy AM, Semrud-Clikeman M, Pierpont ME, Berry SA et al (2018) Social skills in children with rasopathies: a comparison of Noonan syndrome and neurofibromatosis type 1. J Neurodev Disord 10:21","journal-title":"J Neurodev Disord"},{"key":"2767_CR8","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1111\/dmcn.13526","volume":"59","author":"AC Vogel","year":"2017","unstructured":"Vogel AC, Gutmann DH, Morris SM (2017) Neurodevelopmental disorders in children with neurofibromatosis type 1. Dev Med Child Neurol 59:1112\u20131116","journal-title":"Dev Med Child Neurol"},{"key":"2767_CR9","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1146\/annurev-clinpsy-032816-044941","volume":"13","author":"MA Brotman","year":"2017","unstructured":"Brotman MA, Kircanski K, Leibenluft E (2017) Irritability in children and adolescents. Annu Rev Clin Psychol 13:317\u2013341","journal-title":"Annu Rev Clin Psychol"},{"key":"2767_CR10","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00787-010-0150-4","volume":"20","author":"A Stringaris","year":"2011","unstructured":"Stringaris A (2011) Irritability in children and adolescents: a challenge for DSM-5. Eur Child Adolesc Psychiatry 20:61\u201366","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"2767_CR11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1540-5834.1994.tb01278.x","volume":"59","author":"PM Cole","year":"1994","unstructured":"Cole PM, Michel MK, Teti LO (1994) The development of emotion regulation and dysregulation: a clinical perspective. Monogr Soc Res Child Dev 59:73\u2013100","journal-title":"Monogr Soc Res Child Dev"},{"key":"2767_CR12","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.jaac.2016.04.014","volume":"55","author":"P Vidal-Ribas","year":"2016","unstructured":"Vidal-Ribas P, Brotman MA, Valdivieso I, Leibenluft E, Stringaris A (2016) The status of irritability in psychiatry: A conceptual and quantitative review. J Am Acad Child Adolesc Psychiatry 55:556\u2013570","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"2767_CR13","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1176\/appi.ajp.2019.18101134","volume":"176","author":"L Riglin","year":"2019","unstructured":"Riglin L, Eyre O, Thapar AK, Stringaris A, Leibenluft E, Pine DS et al (2019) Identifying novel types of irritability using a developmental genetic approach. Am J Psychiatry 176:635\u2013642","journal-title":"Am J Psychiatry"},{"key":"2767_CR14","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1111\/jcpp.13053","volume":"60","author":"O Eyre","year":"2019","unstructured":"Eyre O, Hughes RA, Thapar AK, Leibenluft E, Stringaris A, Davey Smith G et al (2019) Childhood neurodevelopmental difficulties and risk of adolescent depression: the role of irritability. J Child Psychol Psychiatry 60:866\u2013874","journal-title":"J Child Psychol Psychiatry"},{"key":"2767_CR15","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1002\/da.22151","volume":"31","author":"J Stoddard","year":"2014","unstructured":"Stoddard J, Stringaris A, Brotman MA, Montville D, Pine DS, Leibenluft E (2014) Irritability in child and adolescent anxiety disorders. Depress Anxiety 31:566\u2013573","journal-title":"Depress Anxiety"},{"key":"2767_CR16","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1111\/j.1469-7610.2004.00387.x","volume":"46","author":"DM Fergusson","year":"2005","unstructured":"Fergusson DM, Horwood LJ, Ridder EM (2005) Show me the child at seven: the consequences of conduct problems in childhood for psychosocial functioning in adulthood. J Child Psychol Psychiatry 46:837\u2013849","journal-title":"J Child Psychol Psychiatry"},{"key":"2767_CR17","doi-asserted-by":"publisher","unstructured":"Jha MK, Schatzberg A, Minhajuddin A, Chin Fatt C, Mayes TL, Trivedi MH (2021) Cross-Sectional associations among symptoms of pain, irritability, and depression and how these symptoms relate to social functioning and quality of life: findings from the EMBARC and STRIDE studies and the VitalSign6 project. J Clin Psychiatry 82. https:\/\/doi.org\/10.4088\/JCP.20m13740","DOI":"10.4088\/JCP.20m13740"},{"key":"2767_CR18","doi-asserted-by":"crossref","unstructured":"Carter Leno V, Wright N, Pickles A, Bedford R, Zaidman-Zait A, Kerns C et al (2023) Longitudinal associations between early childhood irritability and adolescent depression symptoms in autistic children are mediated by peer relationships but not educational engagement. Dev Psychopathol:1\u201311","DOI":"10.1017\/S0954579422001316"},{"key":"2767_CR19","doi-asserted-by":"publisher","unstructured":"Edmunds SR, Jones A, Braverman Y, Fogler J, Rowland K, Faja SK Irritability as a transdiagnostic risk factor for functional impairment in autistic and Non-autistic toddlers and preschoolers. Res Child Adolesc Psychopathol 2023. https:\/\/doi.org\/10.1007\/s10802-023-01150-0","DOI":"10.1007\/s10802-023-01150-0"},{"key":"2767_CR20","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1097\/DBP.0000000000001028","volume":"43","author":"E Fombonne","year":"2022","unstructured":"Fombonne E, Croen LA, Bulkley JE, Varga AM, Daida YG, Hatch BA et al (2022) Emotional and behavioral problems in youth with autism: high prevalence and impact on functioning. J Dev Behav Pediatr 43:140\u2013148","journal-title":"J Dev Behav Pediatr"},{"key":"2767_CR21","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/dmcn.12621","volume":"57","author":"EI Pierpont","year":"2015","unstructured":"Pierpont EI, Tworog-Dube E, Roberts AE (2015) Attention skills and executive functioning in children with Noonan syndrome and their unaffected siblings. Dev Med Child Neurol 57:385\u2013392","journal-title":"Dev Med Child Neurol"},{"key":"2767_CR22","unstructured":"Lewis AK, Porter MA, Wiliams TA, North KN, Payne JM (2016) Social competence children neurofibromatosis type 1: relationships psychopathology cognitive ability. J Child Dev Disord;2"},{"key":"2767_CR23","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1017\/S0012162204000921","volume":"46","author":"B Barton","year":"2004","unstructured":"Barton B, North K (2004) Social skills of children with neurofibromatosis type 1. Dev Med Child Neurol 46:553\u2013563","journal-title":"Dev Med Child Neurol"},{"key":"2767_CR24","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1002\/ajmg.a.31923","volume":"143A","author":"RB Noll","year":"2007","unstructured":"Noll RB, Reiter-Purtill J, Moore BD, Schorry EK, Lovell AM, Vannatta K et al (2007) Social, emotional, and behavioral functioning of children with NF1. Am J Med Genet A 143A:2261\u20132273","journal-title":"Am J Med Genet A"},{"key":"2767_CR25","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/jcpp.12899","volume":"60","author":"SV Faraone","year":"2019","unstructured":"Faraone SV, Rostain AL, Blader J, Busch B, Childress AC, Connor DF et al (2019) Practitioner review: emotional dysregulation in attention-deficit\/hyperactivity disorder - implications for clinical recognition and intervention. J Child Psychol Psychiatry 60:133\u2013150","journal-title":"J Child Psychol Psychiatry"},{"key":"2767_CR26","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1007\/s00787-022-02033-3","volume":"32","author":"T Levy","year":"2023","unstructured":"Levy T, Dupuis A, Andrade BF, Crosbie J, Kelley E, Nicolson R et al (2023) Facial emotion recognition in children and youth with attention-deficit\/hyperactivity disorder and irritability. Eur Child Adolesc Psychiatry 32:2271\u20132280","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"2767_CR27","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s40817-020-00088-1","volume":"6","author":"KS Walsh","year":"2020","unstructured":"Walsh KS, del Castillo A, Kennedy T, Karim AI, Semerjian C (2020) A review of psychological, social, and behavioral functions in the rasopathies. J Pediatr Neuropsychol 6:131\u2013142","journal-title":"J Pediatr Neuropsychol"},{"key":"2767_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ajmg.a.10003","volume":"118A","author":"P Prinzie","year":"2003","unstructured":"Prinzie P, Descheemaeker MJ, Vogels A, Cleymans T, Haselager GJT, Curfs LMG et al (2003) Personality profiles of children and adolescents with neurofibromatosis type 1. Am J Med Genet A 118A:1\u20137","journal-title":"Am J Med Genet A"},{"key":"2767_CR29","doi-asserted-by":"publisher","unstructured":"Alfieri P, Cumbo F, Serra G, Trasolini M, Frattini C, Scibelli F et al (2021) Manic and depressive symptoms in children diagnosed with Noonan syndrome. Brain Sci 11. https:\/\/doi.org\/10.3390\/brainsci11020233","DOI":"10.3390\/brainsci11020233"},{"key":"2767_CR30","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1176\/appi.ajp.2013.13070966","volume":"171","author":"P Shaw","year":"2014","unstructured":"Shaw P, Stringaris A, Nigg J, Leibenluft E (2014) Emotion dysregulation in attention deficit hyperactivity disorder. Am J Psychiatry 171:276\u2013293","journal-title":"Am J Psychiatry"},{"key":"2767_CR31","doi-asserted-by":"publisher","unstructured":"Hall JH, Chawner SJRA, IMAGINE-ID consortium, Wolstencroft J, Skuse D, Holmans P et al (2023) Irritability in young people with copy number variants associated with neurodevelopmental disorders (ND-CNVs). MedRxiv. https:\/\/doi.org\/10.1101\/2023.12.05.23299440","DOI":"10.1101\/2023.12.05.23299440"},{"key":"2767_CR32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1176\/appi.ajp.20230256","volume":"181","author":"E Leibenluft","year":"2024","unstructured":"Leibenluft E, Allen LE, Althoff RR, Brotman MA, Burke JD, Carlson GA et al (2024) Irritability in youths: A critical integrative review. Am J Psychiatry 181:275\u2013290","journal-title":"Am J Psychiatry"},{"key":"2767_CR33","first-page":"265","volume":"13","author":"P Prinzie","year":"2002","unstructured":"Prinzie P, Swillen A, Vogels A, Kockuyt V, Curfs L, Haselager G et al (2002) Personality profiles of youngsters with velo-cardio-facial syndrome. Genet Couns 13:265\u2013280","journal-title":"Genet Couns"},{"key":"2767_CR34","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1017\/S0954579419000361","volume":"31","author":"E Neuhaus","year":"2019","unstructured":"Neuhaus E, Webb SJ, Bernier RA (2019) Linking social motivation with social skill: the role of emotion dysregulation in autism spectrum disorder. Dev Psychopathol 31:931\u2013943","journal-title":"Dev Psychopathol"},{"key":"2767_CR35","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1177\/10731911231161800","volume":"31","author":"AM Wycoff","year":"2024","unstructured":"Wycoff AM, Griffin SA, Helle AC, Haney AM, Watts AL, Trull TJ (2024) The brief emotion dysregulation scale: development, preliminary validation, and recommendations for use. Assessment 31:335\u2013349","journal-title":"Assessment"},{"key":"2767_CR36","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ejpn.2017.09.009","volume":"22","author":"F Perrino","year":"2018","unstructured":"Perrino F, Licchelli S, Serra G, Piccini G, Caciolo C, Pasqualetti P et al (2018) Psychopathological features in Noonan syndrome. Eur J Paediatr Neurol 22:170\u2013177","journal-title":"Eur J Paediatr Neurol"},{"key":"2767_CR37","unstructured":"Wechsler D Wechsler abbreviated scale of intelligence-(WASI-II). San antonio, TX: NCS pearson. Open Access This Article Is Licensed under a Creative n.d"},{"key":"2767_CR38","volume-title":"Wechsler preschool and primary scale of intelligence\u2014fourth edition","author":"D Wechsler","year":"2012","unstructured":"Wechsler D (2012) Wechsler preschool and primary scale of intelligence\u2014fourth edition. The Psychological Corporation San Antonio, TX"},{"key":"2767_CR39","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1177\/0734282906288389","volume":"24","author":"AS Kaufman","year":"2006","unstructured":"Kaufman AS, Flanagan DP, Alfonso VC, Mascolo JT (2006) Test review: Wechsler intelligence scale for children, fourth edition (WISC-IV). J Psychoeduc Assess 24:278\u2013295","journal-title":"J Psychoeduc Assess"},{"key":"2767_CR40","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1177\/1357633X18776095","volume":"25","author":"MA Hodge","year":"2019","unstructured":"Hodge MA, Sutherland R, Jeng K, Bale G, Batta P, Cambridge A et al (2019) Agreement between telehealth and face-to-face assessment of intellectual ability in children with specific learning disorder. J Telemed Telecare 25:431\u2013437","journal-title":"J Telemed Telecare"},{"key":"2767_CR41","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1542\/pir.21.8.265","volume":"21","author":"TM Achenbach","year":"2000","unstructured":"Achenbach TM, Ruffle TM (2000) The child behavior checklist and related forms for assessing behavioral\/emotional problems and competencies. Pediatr Rev 21:265\u2013271","journal-title":"Pediatr Rev"},{"key":"2767_CR42","unstructured":"Achenbach TM Manual for ASEBA school-age forms & profiles 2001"},{"key":"2767_CR43","unstructured":"Constantino JN (2012) Social responsiveness scale second edition (SRS-2): manual. Western Psychological Services (WPS)"},{"key":"2767_CR44","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jaac.2015.10.007","volume":"55","author":"D Cornacchio","year":"2016","unstructured":"Cornacchio D, Crum KI, Coxe S, Pincus DB, Comer JS (2016) Irritability and severity of anxious symptomatology among youth with anxiety disorders. J Am Acad Child Adolesc Psychiatry 55:54\u201361","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"2767_CR45","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1176\/appi.ajp.2015.14040509","volume":"172","author":"R Roberson-Nay","year":"2015","unstructured":"Roberson-Nay R, Leibenluft E, Brotman MA, Myers J, Larsson H, Lichtenstein P et al (2015) Longitudinal stability of genetic and environmental influences on irritability: from childhood to young adulthood. Am J Psychiatry 172:657\u2013664","journal-title":"Am J Psychiatry"},{"key":"2767_CR46","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1111\/jcpp.12039","volume":"54","author":"M Aebi","year":"2013","unstructured":"Aebi M, Plattner B, Metzke CW, Bessler C, Steinhausen H-C (2013) Parent- and self-reported dimensions of oppositionality in youth: construct validity, concurrent validity, and the prediction of criminal outcomes in adulthood. J Child Psychol Psychiatry 54:941\u2013949","journal-title":"J Child Psychol Psychiatry"},{"key":"2767_CR47","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1111\/jcpp.12233","volume":"55","author":"RR Althoff","year":"2014","unstructured":"Althoff RR, Kuny-Slock AV, Verhulst FC, Hudziak JJ, van der Ende J (2014) Classes of oppositional-defiant behavior: concurrent and predictive validity. J Child Psychol Psychiatry 55:1162\u20131171","journal-title":"J Child Psychol Psychiatry"},{"key":"2767_CR48","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1080\/15374416.2019.1622119","volume":"49","author":"SC Evans","year":"2020","unstructured":"Evans SC, Bonadio FT, Bearman SK, Ugueto AM, Chorpita BF, Weisz JR (2020) Assessing the irritable and defiant dimensions of youth oppositional behavior using CBCL and YSR items. J Clin Child Adolesc Psychol 49:804\u2013819","journal-title":"J Clin Child Adolesc Psychol"},{"key":"2767_CR49","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1080\/15374416.2023.2292041","volume":"53","author":"SC Evans","year":"2024","unstructured":"Evans SC, Karlovich AR, Khurana S, Edelman A, Buza B, Riddle W et al (2024) Evidence base update on the assessment of irritability, anger, and aggression in youth. J Clin Child Adolesc Psychol 53:277\u2013308","journal-title":"J Clin Child Adolesc Psychol"},{"key":"2767_CR50","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/s11920-012-0262-2","volume":"14","author":"JM Cisler","year":"2012","unstructured":"Cisler JM, Olatunji BO (2012) Emotion regulation and anxiety disorders. Curr Psychiatry Rep 14:182\u2013187","journal-title":"Curr Psychiatry Rep"},{"key":"2767_CR51","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/ceo.12358","volume":"42","author":"RJ Casson","year":"2014","unstructured":"Casson RJ, Farmer LDM (2014) Understanding and checking the assumptions of linear regression: a primer for medical researchers: assumptions of linear regression. Clin Exp Ophthalmol 42:590\u2013596","journal-title":"Clin Exp Ophthalmol"},{"key":"2767_CR52","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41398-023-02504-4","volume":"13","author":"B Rai","year":"2023","unstructured":"Rai B, Naylor PE, Siqueiros-Sanchez M, Wintermark M, Raman MM, Jo B et al (2023) Novel effects of Ras-MAPK pathogenic variants on the developing human brain and their link to gene expression and Inhibition abilities. Transl Psychiatry 13:245","journal-title":"Transl Psychiatry"},{"key":"2767_CR53","doi-asserted-by":"publisher","unstructured":"Stringaris A, Goodman R (2009) Mood lability and psychopathology in youth. Psychol Med 39. https:\/\/doi.org\/10.1017\/S0033291708004662","DOI":"10.1017\/S0033291708004662"},{"key":"2767_CR54","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1017\/S0954579405050376","volume":"17","author":"JT Nigg","year":"2005","unstructured":"Nigg JT, Casey BJ (2005) An integrative theory of attention-deficit\/ hyperactivity disorder based on the cognitive and affective neurosciences. Dev Psychopathol 17:785\u2013806","journal-title":"Dev Psychopathol"},{"key":"2767_CR55","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/mp.2008.82","volume":"13","author":"ML Phillips","year":"2008","unstructured":"Phillips ML, Ladouceur CD, Drevets WC (2008) A neural model of voluntary and automatic emotion regulation: implications for Understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry 13:829","journal-title":"Mol Psychiatry"},{"key":"2767_CR56","doi-asserted-by":"publisher","first-page":"e1241","DOI":"10.1038\/tp.2017.212","volume":"7","author":"L Riglin","year":"2017","unstructured":"Riglin L, Eyre O, Cooper M, Collishaw S, Martin J, Langley K et al (2017) Investigating the genetic underpinnings of early-life irritability. Transl Psychiatry 7:e1241","journal-title":"Transl Psychiatry"},{"key":"2767_CR57","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/jcpp.13132","volume":"61","author":"JT Nigg","year":"2020","unstructured":"Nigg JT, Karalunas SL, Gustafsson HC, Bhatt P, Ryabinin P, Mooney MA et al (2020) Evaluating chronic emotional dysregulation and irritability in relation to ADHD and depression genetic risk in children with ADHD. J Child Psychol Psychiatry 61:205\u2013214","journal-title":"J Child Psychol Psychiatry"},{"key":"2767_CR58","doi-asserted-by":"publisher","unstructured":"McGhee CA, Honari H, Siqueiros-Sanchez M, Serur Y, van Staalduinen EK, Stevenson D et al Influences of rasopathies on neuroanatomical variation in children. Biol Psychiatry Cogn Neurosci Neuroimaging 2024. https:\/\/doi.org\/10.1016\/j.bpsc.2024.04.003","DOI":"10.1016\/j.bpsc.2024.04.003"},{"key":"2767_CR59","doi-asserted-by":"publisher","first-page":"13141","DOI":"10.1073\/pnas.1004829107","volume":"107","author":"C Shilyansky","year":"2010","unstructured":"Shilyansky C, Karlsgodt KH, Cummings DM, Sidiropoulou K, Hardt M, James AS et al (2010) Neurofibromin regulates corticostriatal inhibitory networks during working memory performance. Proc Natl Acad Sci U S A 107:13141\u201313146","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2767_CR60","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cpr.2017.01.004","volume":"53","author":"SC Evans","year":"2017","unstructured":"Evans SC, Burke JD, Roberts MC, Fite PJ, Lochman JE, de la Pe\u00f1a FR et al (2017) Irritability in child and adolescent psychopathology: an integrative review for ICD-11. Clin Psychol Rev 53:29\u201345","journal-title":"Clin Psychol Rev"},{"key":"2767_CR61","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s00787-007-0624-1","volume":"16","author":"K Boylan","year":"2007","unstructured":"Boylan K, Vaillancourt T, Boyle M, Szatmari P (2007) Comorbidity of internalizing disorders in children with oppositional defiant disorder. Eur Child Adolesc Psychiatry 16:484\u2013494","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"2767_CR62","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1176\/appi.ajp.2013.13070864","volume":"171","author":"M Schneider","year":"2014","unstructured":"Schneider M, Debban\u00e9 M, Bassett AS, Chow EWC, Fung WLA, van den Bree M et al (2014) Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the international consortium on brain and behavior in 22q11.2 deletion syndrome. Am J Psychiatry 171:627\u2013639","journal-title":"Am J Psychiatry"},{"key":"2767_CR63","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/S2215-0366(22)00207-3","volume":"9","author":"J Wolstencroft","year":"2022","unstructured":"Wolstencroft J, Wicks F, Srinivasan R, Wynn S, Ford T, Baker K et al (2022) Neuropsychiatric risk in children with intellectual disability of genetic origin: IMAGINE, a UK National cohort study. Lancet Psychiatry 9:715\u2013724","journal-title":"Lancet Psychiatry"},{"key":"2767_CR64","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/1098-2779(2000)6:2<117::AID-MRDD5>3.0.CO;2-X","volume":"6","author":"AE Kayl","year":"2000","unstructured":"Kayl AE, Moore BD 3rd (2000) Behavioral phenotype of neurofibromatosis, type 1. Ment Retard Dev Disabil Res Rev 6:117\u2013124","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"2767_CR65","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/s41380-018-0294-z","volume":"26","author":"ID Waldman","year":"2021","unstructured":"Waldman ID, Rowe R, Boylan K, Burke JD (2021) External validation of a bifactor model of oppositional defiant disorder. Mol Psychiatry 26:682\u2013693","journal-title":"Mol Psychiatry"},{"key":"2767_CR66","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1080\/10409289.2017.1409606","volume":"29","author":"JM Dollar","year":"2018","unstructured":"Dollar JM, Perry NB, Calkins SD, Keane SP, Shanahan L (2018) Temperamental anger and positive reactivity and the development of social skills: implications for academic competence during preadolescence. Early Educ Dev 29:747\u2013761","journal-title":"Early Educ Dev"},{"key":"2767_CR67","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.chc.2013.07.002","volume":"23","author":"CA Mazefsky","year":"2014","unstructured":"Mazefsky CA, White SW (2014) Emotion regulation: concepts & practice in autism spectrum disorder. Child Adolesc Psychiatr Clin N Am 23:15\u201324","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"key":"2767_CR68","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.cpr.2010.05.007","volume":"30","author":"E Neuhaus","year":"2010","unstructured":"Neuhaus E, Beauchaine TP, Bernier R (2010) Neurobiological correlates of social functioning in autism. Clin Psychol Rev 30:733\u2013748","journal-title":"Clin Psychol Rev"},{"key":"2767_CR69","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1080\/15374416.2015.1038827","volume":"44","author":"TP Beauchaine","year":"2015","unstructured":"Beauchaine TP (2015) Future directions in emotion dysregulation and youth psychopathology. J Clin Child Adolesc Psychol 44:875\u2013896","journal-title":"J Clin Child Adolesc Psychol"},{"key":"2767_CR70","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ijpsycho.2016.12.014","volume":"119","author":"TP Beauchaine","year":"2017","unstructured":"Beauchaine TP, Zisner A (2017) Motivation, emotion regulation, and the latent structure of psychopathology: an integrative and convergent historical perspective. Int J Psychophysiol 119:108\u2013118","journal-title":"Int J Psychophysiol"},{"key":"2767_CR71","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s11689-021-09414-w","volume":"14","author":"AMH Foy","year":"2022","unstructured":"Foy AMH, Hudock RL, Shanley R, Pierpont EI (2022) Social behavior in rasopathies and idiopathic autism. J Neurodev Disord 14:5","journal-title":"J Neurodev Disord"},{"key":"2767_CR72","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.jaac.2014.08.005","volume":"53","author":"JL Wiggins","year":"2014","unstructured":"Wiggins JL, Mitchell C, Stringaris A, Leibenluft E (2014) Developmental trajectories of irritability and bidirectional associations with maternal depression. J Am Acad Child Adolesc Psychiatry 53:1191\u20131205 1205.e1-4","journal-title":"J Am Acad Child Adolesc Psychiatry"}],"container-title":["European Child &amp; Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-025-02767-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00787-025-02767-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00787-025-02767-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T11:02:40Z","timestamp":1764068560000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00787-025-02767-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":72,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["2767"],"URL":"https:\/\/doi.org\/10.1007\/s00787-025-02767-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5428038\/v1","asserted-by":"object"}]},"ISSN":["1018-8827","1435-165X"],"issn-type":[{"value":"1018-8827","type":"print"},{"value":"1435-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]},"assertion":[{"value":"11 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, approved by the Stanford University School of Medicine Institutional Review Board, and followed during all study components. IRB Protocol # 57403, date of last approval: 09\/03\/2024.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"Informed consent was obtained from all subjects involved in the study. Parents or legal guardians provided informed written consent for their child\u2019s participation in the study; participants over age 7 submitted an additional written assent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}