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However, it is unclear if persistent sleep problems in childhood are associated with enduring depression symptoms in emerging adulthood and the mechanisms underlying this. Data from the Avon Longitudinal Study of Parents and Children birth cohort were used to examine associations between persistent sleep problems across childhood and persistent depression across adolescence and emerging adulthood, and whether inflammation mediates this link. Predictors were parental report of the child\u2019s nighttime sleep duration and midpoint of sleep (MPS), from 6 months to 6\u20137 years old. Our outcome was self-reported persistent higher depression symptoms, between 13 and 22 years. Latent Class Growth Analysis (LCGA) was used to detect trajectories for sleep duration, MPS, and depression symptoms and used in subsequent logistic regression analyses. Path analyses explored whether C-Reactive Protein [CRP] and Interleukin-6 [IL-6] at age 9 mediated the relationships between exposures and outcome. Data were available on 6,785 participants. Three separate LCGAs revealed distinct trajectories of interest: (a) persistent shorter nighttime sleep, (b) persistent later MPS, and (c) persistent higher depression symptoms. Children with persistent shorter nighttime sleep were at higher risk of persistent higher depression (OR\u2009=\u20091.94, 95%CI\u2009=\u20091.01\u20133.73,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.046) and was partially mediated by increased IL-6 levels (bias-corrected estimate\u2009=\u20090\u00b7002, 95%CI\u2009=\u20090.001\u20130.003,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Persistent shorter nighttime sleep duration across childhood is longitudinally associated with persistent higher depression in adolescence into emerging adulthood, and inflammation is part of the mechanism. Addressing short sleep duration and inflammatory responses in childhood may prevent the development of depression in young people.\n                  <\/jats:p>","DOI":"10.1007\/s00787-026-03053-z","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:06:03Z","timestamp":1779105963000},"page":"2865-2880","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the prospective associations of childhood sleep problems with persistent depression in emerging adulthood: the mediating role of inflammation"],"prefix":"10.1007","volume":"35","author":[{"given":"R.","family":"Amos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. B.","family":"Durdurak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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She was a consultant for Perrigo (2021+). She receives royalties for two books Nodding Off (Bloomsbury Sigma, 2018) and The Sleepy Pebble (Flying Eye, 2019) and a sleep gift (The Gift of Sleep, Lawrence King Publishers, 2023). She was previously a CEO of Sleep Universal LTD (2022). She is a regular contributor to BBC Focus Magazine and has contributed to other outlets (such as The Conversation, The Guardian, Balance Magazine, Psyche Aeon). She occasionally receives sample products related to sleep (e.g. blue light blocking glasses) and has given a paid talk to a business (Investec). She has contributed a paid article to Neurodiem and is sometimes given small fees and expenses for presenting.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}