{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:06:21Z","timestamp":1760216781153},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Child & Adolescent Psychiatry"],"published-print":{"date-parts":[[2000,3]]},"DOI":"10.1007\/s007870070018","type":"journal-article","created":{"date-parts":[[2003,2,12]],"date-time":"2003-02-12T18:05:56Z","timestamp":1045073156000},"page":"S44-S50","source":"Crossref","is-referenced-by-count":23,"title":["Opiate antagonists in children and adolescents"],"prefix":"10.1007","volume":"9","author":[{"given":"N.","family":"Chabane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Leboyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Mouren-Simeoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"901000044_CR1","first-page":"347","volume":"9","author":"RL Atkinson","year":"1985","unstructured":"Atkinson RL, Berke LK, Drake CR, Bibbs ML, Williams FL, Kaiser DL (1985) Effects of long term therapy with naltrexone on body weight in obesity. Clin Pharmacol Ther 9: 347\u2013353","journal-title":"Clin Pharmacol Ther"},{"key":"901000044_CR2","first-page":"644","volume":"93","author":"RP Barrett","year":"1989","unstructured":"Barrett RP, Feinstein C, Hole WT (1989) Effects of naloxone and naltrexone on self-injury: a double-blind placebo controlled analysis. American Journal of Mental Retardation 93: 644\u2013651","journal-title":"American Journal of Mental Retardation"},{"key":"901000044_CR3","volume-title":"Neurobiology of Infantile Autism","author":"MP Bouvard","year":"1992","unstructured":"Bouvard MP, Leboyer M, Launay JM, Kerdelhue B, Dugas M (1992) Opioid hypothesis in infantile autism. In: Naruse H, Ornitz EM (eds) Neurobiology of Infantile Autism. Excerpta Medica. Amsterdam, London, New-York, Tokyo"},{"key":"901000044_CR4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0165-1781(95)02601-R","volume":"58","author":"MP Bouvard","year":"1995","unstructured":"Bouvard MP, Leboyer M, Launay JM et al. (1995) Low dose naltrexone effects of on plasma chemistries and clinical symptoms in autism: a double-blind, placebo-controlled study. Psychiatry Research 58: 191\u2013201","journal-title":"Psychiatry Research"},{"key":"901000044_CR5","first-page":"130","volume":"26","author":"M Campbell","year":"1990","unstructured":"Campbell M, Anderson I, Small A, Locascio J (1990) Naltrexone in autistic children: a double blind and placebo-controlled study. Psychopharmacological bulletin 26: 130\u2013135","journal-title":"Psychopharmacological bulletin"},{"key":"901000044_CR6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/00004583-198903000-00009","volume":"28","author":"M Campbell","year":"1989","unstructured":"Campbell M, Overall JE (1989) Naltrexone in autistic children: an acute open dose range tolerance trial. Journal of the American Academy of Child and Adolescent Psychiatry 28: 200\u2013206","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"901000044_CR7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0006-8993(94)91738-8","volume":"639","author":"KD Carr","year":"1994","unstructured":"Carr KD, Papadouka V (1994) The role of multiple opiod receptors in the potentiation of reward by food restriction. Brain Research 639: 253\u2013260","journal-title":"Brain Research"},{"key":"901000044_CR8","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1001\/archpsyc.1997.01830240090013","volume":"54","author":"R Croop","year":"1997","unstructured":"Croop R, Faulkner E, Labriola D (1997) The safety profile of naltrexone in the treatment of alcoholism. Archives of General Psychiatry 54: 1130\u20131135","journal-title":"Archives of General Psychiatry"},{"key":"901000044_CR9","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1177\/009127009203201202","volume":"32","author":"M Zwaan De","year":"1992","unstructured":"De Zwaan M, Mitchell JE (1992) Opiate antagonists and eating behavior in humans. A review. Journal of Clinical Pharmacology 32: 1060\u20131072","journal-title":"Journal of Clinical Pharmacology"},{"key":"901000044_CR10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1530-0277.1999.tb04024.x","volume":"23","author":"NV Emanuele","year":"1999","unstructured":"Emanuele NV, Lapaglia N, Steiner J, Kirsteins L, Emanuele MA (1999) Reversal of chronic ethanol-induced testosterone suppression in peripubertal male rats by opiate blockade. Alcohol Clin Exp Res 23: 60\u201366","journal-title":"Alcohol Clin Exp Res"},{"key":"901000044_CR11","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1001\/jama.281.14.1318","volume":"14","author":"JC Garbutt","year":"1999","unstructured":"Garbutt JC, West S, Carey TS, Lorh K, Fulton TC (1999) Pharmacological treatment of alcohol dependence, a review of evidence. JAMA 14: 1318\u20131325","journal-title":"JAMA"},{"key":"901000044_CR12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1469-8749.1995.tb11998.x","volume":"37","author":"C Gillberg","year":"1995","unstructured":"Gillberg C (1995) Endogenous opioids and opiate antagonists in autism: brief review of empirical findings and implications for clinicians. Developmental Medicine and Child Neurology 37: 239\u2013245","journal-title":"Developmental Medicine and Child Neurology"},{"key":"901000044_CR13","first-page":"203","volume":"30","author":"NM Gonzalez","year":"1994","unstructured":"Gonzalez NM, Campbell M, Smalla AM, Bluhm LD, Adams PB, Foltz RL (1994) Naltrexone plasma levels, clinical response and effect on weight in autistic children. Psychopharmacology Bulletin 30: 203\u2013208","journal-title":"Psychopharmacology Bulletin"},{"key":"901000044_CR14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0006-291X(77)80205-2","volume":"77","author":"R Guillemin","year":"1977","unstructured":"Guillemin R, Ling N, Vargo T (1977) Radioimmunoassays for alpha-endorphin and beta-endorphin. Biochem Biophys Res Commun 77: 361","journal-title":"Biochem Biophys Res Commun"},{"key":"901000044_CR15","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/ana.410220419","volume":"22","author":"BH Herman","year":"1987","unstructured":"Herman BH, Hammock, MK, Arthur Smith A, Egan J, Chatoor I, Werner A, Zelneck N (1987) Naltrexone decreases self-injurious behavior. Annals of Neurology 22: 550\u2013552","journal-title":"Annals of Neurology"},{"issue":"7","key":"901000044_CR16","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/0006-3223(90)90589-T","volume":"27","author":"H Kars","year":"1990","unstructured":"Kars H, Broekema W, Glaudemans-van Gelderen I, Verhoeven WM, van Ree JM (1990) Naltrexone attenuates self-injurious behavior in mentally retarded subjects. Biol Psychiatry 27 (7): 741\u2013746","journal-title":"Biol Psychiatry"},{"key":"901000044_CR17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00004583-199502000-00018","volume":"34","author":"BK Kolmen","year":"1995","unstructured":"Kolmen BK, Feldman HM, Handen BL, Janosky JE (1995) Naltrexone in young autistic children, a double blind placebo-controlled crossover study. Journal of the American Academy of Child and Adolescent Psychiatry 34: 223\u2013231","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"901000044_CR18","first-page":"1570","volume":"36","author":"BK Kolmen","year":"1997","unstructured":"Kolmen BK, Feldman HM, Handen BL, Janosky JE (1997) Naltrexone in young autistic children: replication study and learning measures. Journal of the American Academy of Child and Adolescent Psychiatry 36: 1570\u20131578","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"901000044_CR19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF01058158","volume":"22","author":"M Leboyer","year":"1992","unstructured":"Leboyer M, Bouvard MP, Launay JM, Tabuteau F, Waller D, Dugas M, Kerdelhue B, Lensing P, Panksepp J (1992) A double blind study of naltrexone in infantile autism. Journal of Autism Developmental Disorders 22: 309\u2013319","journal-title":"Journal of Autism Developmental Disorders"},{"key":"901000044_CR20","first-page":"285","volume":"3","author":"M Leboyer","year":"1990","unstructured":"Leboyer M, Bouvard MP, Lensing P, Launay JM, Tabuteau F, Arnaud P, Waller D, Plumet MH, Recasens C, Kerdelhue B, Dugas M, Panksepp J (1990) Opioid excess hypothesis of autism: a double-blind study of naltrexone. Brain Dysfunction 3: 285\u2013298","journal-title":"Brain Dysfunction"},{"key":"901000044_CR21","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1176\/ajp.151.12.1797","volume":"151","author":"M Leboyer","year":"1994","unstructured":"Leboyer M, Bouvard MP, Recassens C, Philippe A, Guilloud-Bataille M, Bondoux D, Tabuteau F, Dugas M, Panksepp J, Launay JM (1994) Dissociation between N and C terminal \u03b2-endorphines in autistic, Rett syndrome and controls children. American Journal of Psychiatry 151: 1797\u20131801","journal-title":"American Journal of Psychiatry"},{"key":"901000044_CR22","first-page":"439","volume":"154","author":"E Lifrak","year":"1997","unstructured":"Lifrak E, Alterman A, O\u2019Brien C, Volpicell J (1997) Naltrexone for alcoholic adolescents. American Journal of Psychiatry 154: 439\u2013440","journal-title":"American Journal of Psychiatry"},{"key":"901000044_CR23","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1126\/science.715455","volume":"202","author":"DL Margules","year":"1978","unstructured":"Margules DL, Moisset B, Lewis MJ, Shibuya H (1978) Beta-endorphine is associated with overeating in genetically obese mice (ob\/ob) and rats (fa-fa). Science 202: 988\u2013991","journal-title":"Science"},{"key":"901000044_CR24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00004850-199510030-00005","volume":"10","author":"MA Marrazzi","year":"1995","unstructured":"Marrazzi MA, Bacon JP, Kinzie J, Luby ED (1995) Naltrexone use in the treatment of anorexia and bulimia nervosa. International Clinical Psychopharmacology 10: 163\u2013172","journal-title":"International Clinical Psychopharmacology"},{"key":"901000044_CR25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1521-0391.1997.tb00388.x","volume":"6","author":"MA Marrazzi","year":"1997","unstructured":"Marrazzi MA, Wroblewski JM, Kinzie J, Luby ED (1997) High dose naltrexone and liver function. American Journal of Addiction 6: 21\u201329","journal-title":"American Journal of Addiction"},{"key":"901000044_CR26","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0091-3057(90)90375-R","volume":"35","author":"JC Melchior","year":"1990","unstructured":"Melchior JC, Rigaud D, Colas-Linhart N, Rozen R, Fantino M, Apfelbaum M (1990) Negative allesthesia and decreased endogenous opiate system activity in anorexia nervosa. Pharmacology, Biochemistry and Behaviour 35: 885\u2013888","journal-title":"Pharmacology, Biochemistry and Behaviour"},{"key":"901000044_CR27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/archpsyc.1996.01830030039007","volume":"53","author":"SS O\u2019Malley","year":"1996","unstructured":"O\u2019Malley SS, Jaffe AJ, Chang G et al. (1996) Follow-up of naltrexone and psychotherapy for alcohol dependenc. Archives of General Psychiatry 53: 217\u2013224","journal-title":"Archives of General Psychiatry"},{"key":"901000044_CR28","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0166-2236(79)90071-7","volume":"2","author":"J Panksepp","year":"1979","unstructured":"Panksepp J (1979). A neurochemical theory of autism. Trends Neurosci 2: 174\u2013177","journal-title":"Trends Neurosci"},{"key":"901000044_CR29","first-page":"39","volume-title":"The psychobiology of social attachements and separation","author":"J Panksepp","year":"1985","unstructured":"Panksepp J, Siviy S (1985) Brain opioid and social emotions. In: Reite M, Field R (eds) The psychobiology of social attachements and separation. Academic Press, Orlando, pp 39\u201349"},{"key":"901000044_CR30","first-page":"181","volume-title":"Naltrexone therapy of autistic children","author":"J Panksepp","year":"1990","unstructured":"Panksepp J, Lensing P (1990) Naltrexone therapy of autistic children. In: Van Ree JM, Mulder AW, Wiegant VM, Van Wimersma Greidanus TB (eds) Elsevier, Amsterdam, pp 181\u2013182"},{"key":"901000044_CR31","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF02284764","volume":"21","author":"J Panksepp","year":"1991","unstructured":"Panksepp J, Lensing P (1991) Naltrexone treatment of autism: a synopsis of an opentrial with four children. Journal of Autism and Development Disorders 21: 135\u2013141","journal-title":"Journal of Autism and Development Disorders"},{"key":"901000044_CR32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF01495056","volume":"17","author":"TL Sahley","year":"1987","unstructured":"Sahley TL, Panksepp J (1987) Brain opioids in autism: an uptade analysis of possible linkage. Journal of Autism and Developmental Disorders 17: 201\u2013216","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"901000044_CR33","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0006-3223(87)90088-6","volume":"22","author":"CA Sandman","year":"1987","unstructured":"Sandman CA, Barron JL (1987) Influence of naloxone on brain and behavior of a self-injurious woman. Biological Psychiatry 22: 899\u2013906","journal-title":"Biological Psychiatry"},{"key":"901000044_CR34","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ana.410170521","volume":"17","author":"R Sandyk","year":"1985","unstructured":"Sandyk R (1985) Naloxone abolishes self-injuring in a mentally retarded child. Annals of Neurology 17: 520","journal-title":"Annals of Neurology"},{"key":"901000044_CR35","first-page":"351","volume":"32","author":"R Scifo","year":"1996","unstructured":"Scifo R, Cioni M, Nicolosi A, Batticane N, Tirolo C, Testa N, Quattropani MC et al. (1996) Opioid-immune interactions in autism: behavioral and immuological assesment during a double blind treatment with naltrexone. Ann Ist Super Sanita 32: 351\u2013359","journal-title":"Ann Ist Super Sanita"},{"key":"901000044_CR36","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0891-4222(87)90002-3","volume":"2","author":"L Szymansky","year":"1987","unstructured":"Szymansky L, Kedesky J, Sulkes S, Cutler A, Stevens-Ours P (1987) Naltrexone in treatment of self-injury behavior: a clinical study. Research in Developmental Disabilities 2: 179\u2013190","journal-title":"Research in Developmental Disabilities"},{"key":"901000044_CR37","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1001\/archpsyc.1992.01820110040006","volume":"49","author":"JR Volpicelli","year":"1992","unstructured":"Volpicelli JR, Alterman AI, Hayashida M, O\u2019Brien CP (1992) Naltrexone in the treatment of alcohol dependence. Archives of General Psychiatry 49: 881\u2013887","journal-title":"Archives of General Psychiatry"},{"key":"901000044_CR38","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF02284716","volume":"20","author":"AS Walters","year":"1990","unstructured":"Walters AS, Rowland P (1990) A case report of naltrexone treatment of self-injury and social withdrawal in autism. Journal of Autism and Development Disorders 20: 169\u2013176","journal-title":"Journal of Autism and Development Disorders"},{"key":"901000044_CR39","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1001\/archpsyc.1995.03950210060011","volume":"52","author":"SH Willemsen-Swinkels","year":"1995","unstructured":"Willemsen-Swinkels SH, Buitelaar JK, Nijhof GF, Van Engeland H (1995) Failure of naltrexone hypochloride to reduce self-injurious and autistic behavior in mentally retarded adults. Double blind placebo-controlled study. Archives of General Psychiatry 52: 766\u2013773","journal-title":"Archives of General Psychiatry"},{"key":"901000044_CR40","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/0006-3223(95)00297-9","volume":"39","author":"SH Willemsen-Swinkels","year":"1996","unstructured":"Willemsen-Swinkels SH, Buitelaar JK, Van Engeland H (1996) The effects of chronic naltrexone treatment in young autistic children: a double blind placebo-controlled crossover study. Biological Psychiatry 39: 1023\u20131031","journal-title":"Biological Psychiatry"},{"key":"901000044_CR41","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00004583-199701000-00010","volume":"36","author":"M Wold","year":"1997","unstructured":"Wold M, Kaminer Y (1997) Naltrexone for alcohol abuse. Journal of the American Academy of Child and Adolescent Psychiatry 36: 6\u20137","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"}],"container-title":["European Child & Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s007870070018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s007870070018\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s007870070018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T22:02:19Z","timestamp":1682373739000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s007870070018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":41,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["901000044"],"URL":"https:\/\/doi.org\/10.1007\/s007870070018","relation":{},"ISSN":["1018-8827","1435-165X"],"issn-type":[{"value":"1018-8827","type":"print"},{"value":"1435-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}