{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:20:11Z","timestamp":1775607611440,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["20K09622"],"award-info":[{"award-number":["20K09622"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Mol Morphol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s00795-021-00308-3","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T18:00:23Z","timestamp":1638295223000},"page":"85-90","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Promising therapeutic targets of endometriosis obtained from microRNA studies"],"prefix":"10.1007","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4512-3325","authenticated-orcid":false,"given":"Kaei","family":"Nasu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Aoyagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruofei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamiko","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Kai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"308_CR1","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1056\/NEJMcp1000274","volume":"362","author":"LC Giudice","year":"2010","unstructured":"Giudice LC (2010) Clinical practice. Endometriosis. N Engl J Med 362:2389\u20132398","journal-title":"N Engl J Med"},{"key":"308_CR2","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","volume":"364","author":"LC Giudice","year":"2004","unstructured":"Giudice LC, Kao LC (2004) Endometriosis. Lancet 364:1789\u20131799","journal-title":"Lancet"},{"key":"308_CR3","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S1470-2045(11)70404-1","volume":"13","author":"CL Pearce","year":"2012","unstructured":"Pearce CL, Templeman C, Rossing MA, Lee A, Near AM, Webb PM, Nagle CM, Doherty JA, Cushing-Haugen KL, Wicklund KG, Chang-Claude J, Hein R, Lurie G, Wilkens LR, Carney ME, Goodman MT, Moysich K, Kjaer SK, Hogdall E, Jensen A, Goode EL, Fridley BL, Larson MC, Schildkraut JM, Palmieri RT, Cramer DW, Terry KL, Vitonis AF, Titus LJ, Ziogas A, Brewster W, Anton-Culver H, Gentry-Maharaj A, Ramus SJ, Anderson AR, Brueggmann D, Fasching PA, Gayther SA, Huntsman DG, Menon U, Ness RB, Pike MC, Risch H, Wu AH, Berchuck A, Ovarian Cancer Association Consortium (2012) Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol 13:385\u2013394","journal-title":"Lancet Oncol"},{"key":"308_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","volume":"173","author":"DP Bartel","year":"2018","unstructured":"Bartel DP (2018) Metazoan microRNAs. Cell 173:20\u201351","journal-title":"Cell"},{"key":"308_CR5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41580-018-0045-7","volume":"20","author":"LFR Gebert","year":"2019","unstructured":"Gebert LFR, MacRae IJ (2019) Regulation of microRNA function in animals. Nat Rev Mol Cell Biol 20:21\u201337","journal-title":"Nat Rev Mol Cell Biol"},{"key":"308_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-021-00303-8","author":"K Nasu","year":"2021","unstructured":"Nasu K, Aoyagi Y, Zhu R, Okamoto M, Yano M, Kai K, Kawano Y (2021) Role of repressed microRNAs in endometriosis. Med Mol Morphol. https:\/\/doi.org\/10.1007\/s00795-021-00303-8 (Online published)","journal-title":"Med Mol Morphol"},{"key":"308_CR7","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nrg3162","volume":"13","author":"AE Pasquinelli","year":"2012","unstructured":"Pasquinelli AE (2012) MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet 13:271\u2013282","journal-title":"Nat Rev Genet"},{"key":"308_CR8","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/nrg.2016.20","volume":"17","author":"DW Thomson","year":"2016","unstructured":"Thomson DW, Dinger ME (2016) Endogenous microRNA sponges: evidence and controversy. Nat Rev Genet 17:272\u2013283","journal-title":"Nat Rev Genet"},{"key":"308_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ydbio.2006.08.028","volume":"302","author":"B Zhang","year":"2007","unstructured":"Zhang B, Pan X, Cobb GP, Anderson TA (2007) microRNAs as oncogenes and tumor suppressors. Dev Biol 302:1\u201312","journal-title":"Dev Biol"},{"key":"308_CR10","first-page":"2735","volume":"15","author":"W Tan","year":"2018","unstructured":"Tan W, Liu B, Qu S, Liang G, Luo W, Gong C (2018) MicroRNAs and cancer: key paradigms in molecular therapy. Oncol Lett 15:2735\u20132742","journal-title":"Oncol Lett"},{"key":"308_CR11","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nrc3932","volume":"15","author":"S Lin","year":"2015","unstructured":"Lin S, Gregory RI (2015) MicroRNA biogenesis pathways in cancer. Nat Rev Cancer 15:321\u2013333","journal-title":"Nat Rev Cancer"},{"key":"308_CR12","doi-asserted-by":"publisher","first-page":"15004","DOI":"10.1038\/sigtrans.2015.4","volume":"1","author":"Y Peng","year":"2016","unstructured":"Peng Y, Croce CM (2016) The role of microRNAs in human cancer. Signal Transduct Target Ther 1:15004","journal-title":"Signal Transduct Target Ther"},{"key":"308_CR13","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1093\/molehr\/gap068","volume":"15","author":"RO Burney","year":"2009","unstructured":"Burney RO, Hamilton AE, Aghajanova L, Vo KC, Nezhat CN, Lessey BA, Giudice LC (2009) MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis. Mol Hum Reprod 15:625\u2013631","journal-title":"Mol Hum Reprod"},{"key":"308_CR14","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1210\/me.2008-0387","volume":"23","author":"EMC Teague","year":"2009","unstructured":"Teague EMC, Van der Hoek KH, Van der Hoek MB, Perry N, Wagaarachchi P, Robertson SA, Print CG, Hull LM (2009) MicroRNA-regulated pathways associated with endometriosis. Mol Endocrinol 23:265\u2013275","journal-title":"Mol Endocrinol"},{"key":"308_CR15","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1093\/humupd\/dmp034","volume":"16","author":"EMC Teague","year":"2010","unstructured":"Teague EMC, Print CG, Hull ML (2010) The role of microRNAs in endometriosis and associated reproductive conditions. Hum Reprod Update 16:142\u2013165","journal-title":"Hum Reprod Update"},{"key":"308_CR16","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/369549","author":"N Filigheddu","year":"2010","unstructured":"Filigheddu N, Gregnanin I, Porporato PE, Surico D, Perego B, Galli L, Patrignani C, Graziani A, Surico N (2010) Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis. J Biomed Biotechnol. https:\/\/doi.org\/10.1155\/2010\/369549","journal-title":"J Biomed Biotechnol"},{"key":"308_CR17","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1095\/biolreprod.109.081059","volume":"82","author":"S Kuokkanen","year":"2010","unstructured":"Kuokkanen S, Chen B, Ojalvo L, Benard L, Santoro N, Pollard JW (2010) Genomic profiling of microRNAs and messenger RNAs reveals hormonal regulation in microRNA expression in human endometrium. Biol Reprod 82:791\u2013801","journal-title":"Biol Reprod"},{"key":"308_CR18","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1210\/me.2010-0371","volume":"25","author":"SM Hawkins","year":"2011","unstructured":"Hawkins SM, Creighton CJ, Han DY, Zariff A, Anderson ML, Gunaratne PH, Matzuk MM (2011) Functional microRNA involved in endometriosis. Mol Endocrinol 25:821\u2013832","journal-title":"Mol Endocrinol"},{"key":"308_CR19","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1093\/humrep\/des446","volume":"28","author":"W Abe","year":"2013","unstructured":"Abe W, Nasu K, Nakada C, Kawano Y, Moriyama M, Narahara H (2013) miR-196b targets c-myc and Bcl-2 expression, inhibits proliferation and induces apoptosis in endometriotic stromal cells. Hum Reprod 28:750\u2013761","journal-title":"Hum Reprod"},{"key":"308_CR20","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1093\/humrep\/deu019","volume":"29","author":"A Braza-Bo\u00efs","year":"2014","unstructured":"Braza-Bo\u00efs A, Mar\u00ed-Alexandre J, Gilabert J, S\u00e1nchez-Izquierdo D, Espa\u00f1a F, Estell\u00e9s A, Gilabert-Estell\u00e9s J (2014) MicroRNA expression profile in endometriosis: its relation to angiogenesis and fibrinolytic factors. Hum Reprod 29:978\u2013988","journal-title":"Hum Reprod"},{"key":"308_CR21","doi-asserted-by":"publisher","first-page":"E1515","DOI":"10.1210\/jc.2012-1450","volume":"97","author":"SC Lin","year":"2012","unstructured":"Lin SC, Wang CC, Wu MH, Yang SH, Li YH, Tsai SJ (2012) Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. J Clin Endocrinol Metab 97:E1515\u2013E1523","journal-title":"J Clin Endocrinol Metab"},{"key":"308_CR22","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12958-020-00590-3","volume":"18","author":"K Takebayashi","year":"2020","unstructured":"Takebayashi K, Nasu K, Okamoto M, Aoyagi Y, Hirakawa T, Narahara H (2020) hsa-miR-100-5p, an overexpressed miRNA in human ovarian endometriotic stromal cells, promotes invasion through attenuation of SMARCD1 expression. Reprod Biol Endocrinol 18:31","journal-title":"Reprod Biol Endocrinol"},{"key":"308_CR23","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3892\/mmr.2021.11995","volume":"23","author":"H Yang","year":"2021","unstructured":"Yang H, Hu T, Hu P, Qi C, Qian L (2021) miR-143-3p inhibits endometriotic stromal cell proliferation and invasion by inactivating autophagy in endometriosis. Mol Med Rep 23:356","journal-title":"Mol Med Rep"},{"key":"308_CR24","first-page":"4933","volume":"8","author":"X Tian","year":"2015","unstructured":"Tian X, Xu L, Wang P (2015) MiR-191 inhibits TNF-alpha induced apoptosis of ovarian endometriosis and endometrioid carcinoma cells by targeting DAPK1. Int J Clin Exp Pathol 8:4933\u20134942","journal-title":"Int J Clin Exp Pathol"},{"key":"308_CR25","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1093\/humrep\/deu332","volume":"30","author":"M Okamoto","year":"2015","unstructured":"Okamoto M, Nasu K, Abe W, Aoyagi Y, Kawano Y, Kai K, Moriyama M, Narahara H (2015) Enhanced miR-210 expression promotes the pathogenesis of endometriosis through activation of signal transducer and activator of transcription 3. Hum Reprod 30:632\u2013641","journal-title":"Hum Reprod"},{"key":"308_CR26","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/s41419-019-1395-6","volume":"10","author":"Y Dai","year":"2019","unstructured":"Dai Y, Lin X, Xu W, Lin X, Huang Q, Shi L, Pan Y, Zhang Y, Zhu Y, Li C, Liu L, Zhang S (2019) MiR-210-3p protects endometriotic cells from oxidative stress-induced cell cycle arrest by targeting BARD1. Cell Death Dis 10:144","journal-title":"Cell Death Dis"},{"key":"308_CR27","doi-asserted-by":"publisher","first-page":"E427","DOI":"10.1210\/jc.2013-3717","volume":"99","author":"SC Lin","year":"2014","unstructured":"Lin SC, Li YH, Wu MH, Chang YF, Lee DK, Tsai SY, Tsai MJ, Tsai SJ (2014) Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. J Clin Endocrinol Metab 99:E427\u2013E437","journal-title":"J Clin Endocrinol Metab"},{"key":"308_CR28","first-page":"1328682","volume":"2021","author":"D Sun","year":"2021","unstructured":"Sun D, Wang Y, Wang L, Guo X (2021) MicroRNA-342 promotes the malignant-like phenotype of endometrial stromal cells via regulation of annexin A2. Anal Cell Pathol (Amst) 2021:1328682","journal-title":"Anal Cell Pathol (Amst)"},{"key":"308_CR29","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1093\/humrep\/dev005","volume":"30","author":"A Graham","year":"2015","unstructured":"Graham A, Falcone T, Nothnick WB (2015) The expression of microRNA-451 in human endometriotic lesions is inversely related to that of macrophage migration inhibitory factor (MIF) and regulates MIF expression and modulation of epithelial cell survival. Hum Reprod 30:642\u2013652","journal-title":"Hum Reprod"},{"key":"308_CR30","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/rmb2.12028","volume":"16","author":"S Sultana","year":"2017","unstructured":"Sultana S, Kajihara T, Mizuno Y, Sato T, Oguro T, Kimura M, Akita M, Ishihara O (2017) Overexpression of microRNA-542-3p attenuates the differentiating capacity of endometriotic stromal cells. Reprod Med Biol 16:170\u2013178","journal-title":"Reprod Med Biol"},{"key":"308_CR31","doi-asserted-by":"publisher","first-page":"5784","DOI":"10.1074\/jbc.AC119.007855","volume":"294","author":"O Mohtar","year":"2019","unstructured":"Mohtar O, Ozdemir C, Roy D, Shantaram D, Emili A, Kandror KV (2019) Egr1 mediates the effect of insulin on leptin transcription in adipocytes. J Biol Chem 294:5784\u20135789","journal-title":"J Biol Chem"},{"key":"308_CR32","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1158\/1535-7163.MCT-07-0231","volume":"6","author":"BR Davies","year":"2007","unstructured":"Davies BR, Logie A, McKay JS, Martin P, Steele S, Jenkins R, Cockerill M, Cartlidge S, Smith PD (2007) AZD6244 (ARRY-142886), a potent inhibitor of mitogenactivated protein kinase\/extracellular signal-regulated kinase kinase 1\/2 kinases: mechanism of action in vivo, pharmacokinetic\/pharmacodynamic relationship, and potential for combination in preclinical models. Mol Cancer Ther 6:2209\u20132219","journal-title":"Mol Cancer Ther"},{"key":"308_CR33","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/1476-4598-13-194","volume":"13","author":"DJ Wong","year":"2014","unstructured":"Wong DJ, Robert L, Atefi MS, Lassen A, Avarappatt G, Cerniglia M, Avramis E, Tsoi J, Foulad D, Graeber TG, Comin-Anduix B, Samatar A, Lo RS, Ribas A (2014) Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma. Mol Cancer 13:194","journal-title":"Mol Cancer"},{"key":"308_CR34","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1056\/NEJMoa1912735","volume":"382","author":"AM Gross","year":"2020","unstructured":"Gross AM, Wolters PL, Dombi E, Baldwin A, Whitcomb P, Fisher MJ, Weiss B, Kim A, Bornhorst M, Shah AC, Martin S, Roderick MC, Pichard DC, Carbonell A, Paul SM, Therrien J, Kapustina O, Heisey K, Clapp DW, Zhang C, Peer CJ, Figg WD, Smith M, Glod J, Blakeley JO, Steinberg SM, Venzon DJ, Doyle LA, Widemann BC (2020) Selumetinib in children with inoperable plexiform neurofibromas. N Engl J Med 382:1430\u20131442","journal-title":"N Engl J Med"},{"key":"308_CR35","doi-asserted-by":"publisher","first-page":"12389","DOI":"10.18632\/oncotarget.13310","volume":"8","author":"L Rossi","year":"2017","unstructured":"Rossi L, Verrico M, Zaccarelli E, Papa A, Colonna M, Strudel M, Vici P, Bianco V, Tomao F (2017) Bevacizumab in ovarian cancer: a critical review of phase III studies. Oncotarget 8:12389\u201312405","journal-title":"Oncotarget"},{"key":"308_CR36","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1097\/00006254-200211000-00023","volume":"57","author":"EC Hayes","year":"2002","unstructured":"Hayes EC, Rock JA (2002) COX-2 inhibitors and their role in gynecology. Obstet Gynecol Surv 57:768\u2013780","journal-title":"Obstet Gynecol Surv"},{"key":"308_CR37","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.gmit.2014.07.001","volume":"3","author":"W Abe","year":"2015","unstructured":"Abe W, Nasu K, Tsuno A, Kawano Y, Narahara H (2015) Phosphatidylinositol-3 kinase-Akt-mammalian target of rapamycin signaling pathway mediates contractility of human endometriotic stromal cells: promising targets for the treatment of endometriosis-associated fibrosis. Gynecol Minimally Invasive Ther 3:115\u2013118","journal-title":"Gynecol Minimally Invasive Ther"}],"container-title":["Medical Molecular Morphology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00795-021-00308-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00795-021-00308-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00795-021-00308-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T14:13:15Z","timestamp":1653487995000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00795-021-00308-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,30]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["308"],"URL":"https:\/\/doi.org\/10.1007\/s00795-021-00308-3","relation":{},"ISSN":["1860-1480","1860-1499"],"issn-type":[{"value":"1860-1480","type":"print"},{"value":"1860-1499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,30]]},"assertion":[{"value":"8 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}