{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:57:29Z","timestamp":1783522649633,"version":"3.55.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Health and Labor Sciences Research Grants","award":["19FC1008"],"award-info":[{"award-number":["19FC1008"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Mol Morphol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s00795-022-00314-z","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T10:03:56Z","timestamp":1646301836000},"page":"131-145","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between mitochondrial and nuclear DNA damages and cellular senescence in the patients with biliary atresia undergoing Kasai portoenterostomy and liver transplantation"],"prefix":"10.1007","volume":"55","author":[{"given":"Yudai","family":"Nakajima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Nio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoshi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiyoshi","family":"Fujishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"314_CR1","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1016\/S0140-6736(09)60946-6","volume":"374","author":"JL Hartley","year":"2009","unstructured":"Hartley JL, Davenport M, Kelly DA (2009) Biliary atresia. Lancet 374:1704\u20131713. https:\/\/doi.org\/10.1016\/S0140-6736(09)60946-6","journal-title":"Lancet"},{"key":"314_CR2","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1097\/MOP.0000000000000214","volume":"27","author":"JA Zagory","year":"2015","unstructured":"Zagory JA, Nguyen MV, Wang KS (2015) Recent advances in the pathogenesis and management of biliary atresia. Curr Opin Pediatr 27:389\u2013394. https:\/\/doi.org\/10.1097\/MOP.0000000000000214","journal-title":"Curr Opin Pediatr"},{"key":"314_CR3","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/s00383-017-4160-x","volume":"33","author":"M Nio","year":"2017","unstructured":"Nio M, Registry JBA (2017) Japanese biliary atresia registry. Pediatr Surg Int 33:1319\u20131325. https:\/\/doi.org\/10.1007\/s00383-017-4160-x","journal-title":"Pediatr Surg Int"},{"key":"314_CR4","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s00383-014-3552-4","volume":"30","author":"H Sasaki","year":"2014","unstructured":"Sasaki H, Tanaka H, Wada M, Kazama T, Nishi K, Nakamura M, Kudo H, Kawagishi N, Nio M (2014) Liver transplantation following the Kasai procedure in treatment of biliary atresia: a single institution analysis. Pediatr Surg Int 30:871\u2013875. https:\/\/doi.org\/10.1007\/s00383-014-3552-4 (Epub 2014 Jul 27)","journal-title":"Pediatr Surg Int"},{"key":"314_CR5","doi-asserted-by":"publisher","first-page":"757","DOI":"10.2147\/CIA.S158513","volume":"13","author":"I Liguori","year":"2018","unstructured":"Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P (2018) Oxidative stress, aging, and diseases. Clin Interv Aging 13:757\u2013772. https:\/\/doi.org\/10.2147\/CIA.S158513","journal-title":"Clin Interv Aging"},{"key":"314_CR6","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1172\/JCI64098","volume":"123","author":"T Tchkonia","year":"2013","unstructured":"Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL (2013) Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest 123:966\u2013972. https:\/\/doi.org\/10.1172\/JCI64098 (Epub 2013 Mar 1)","journal-title":"J Clin Invest"},{"key":"314_CR7","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.semcdb.2019.05.022","volume":"98","author":"M Abate","year":"2020","unstructured":"Abate M, Festa A, Falco M, Lombardi A, Luce A, Grimaldi A, Zappavigna S, Sperlongano P, Irace C, Caraglia M, Misso G (2020) Mitochondria as playmakers of apoptosis, autophagy and senescence. Semin Cell Dev Biol 98:139\u2013153. https:\/\/doi.org\/10.1016\/j.semcdb.2019.05.022 (Epub 2019 Jun 27)","journal-title":"Semin Cell Dev Biol"},{"key":"314_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112041","volume":"142","author":"SA Dabravolski","year":"2021","unstructured":"Dabravolski SA, Bezsonov EE, Orekhov AN (2021) The role of mitochondria dysfunction and hepatic senescence in NAFLD development and progression. Biomed Pharmacother 142:112041. https:\/\/doi.org\/10.1016\/j.biopha.2021.112041 (Epub 2021 Aug 16)","journal-title":"Biomed Pharmacother"},{"key":"314_CR9","doi-asserted-by":"publisher","first-page":"724","DOI":"10.15252\/embj.201592862","volume":"35","author":"C Correia-Melo","year":"2016","unstructured":"Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF (2016) Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J 35:724\u2013742. https:\/\/doi.org\/10.15252\/embj.201592862 (Epub 2016 Feb 4)","journal-title":"EMBO J"},{"key":"314_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050110","volume":"5","author":"JF Passos","year":"2007","unstructured":"Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H, Wappler I, Birket MJ, Harold G, Schaeuble K, Birch-Machin MA, Kirkwood TB, von Zglinicki T (2007) Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLOS Biol 5:e110. https:\/\/doi.org\/10.1371\/journal.pbio.0050110","journal-title":"PLOS Biol"},{"key":"314_CR11","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.cmet.2015.11.011","volume":"23","author":"CD Wiley","year":"2016","unstructured":"Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, Shirakawa K, Lim HW, Davis SS, Ramanathan A, Gerencser AA, Verdin E, Campisi J (2016) Mitochondrial dysfunction induces senescence with a distinct secretory phenotype. Cell Metab 23:303\u2013314. https:\/\/doi.org\/10.1016\/j.cmet.2015.11.011 (Epub 2015 Dec 10)","journal-title":"Cell Metab"},{"key":"314_CR12","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/msb.2010.5","volume":"6","author":"JF Passos","year":"2010","unstructured":"Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T (2010) Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol 6:347. https:\/\/doi.org\/10.1038\/msb.2010.5 (Epub 2010 Feb 16)","journal-title":"Mol Syst Biol"},{"key":"314_CR13","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.2741\/539","volume":"4","author":"A Arduini","year":"2012","unstructured":"Arduini A, Serviddio G, Tormos AM, Monsalve M, Sastre J (2012) Mitochondrial dysfunction in cholestatic liver diseases. Front Biosci (Elite Ed) 4:2233\u20132252. https:\/\/doi.org\/10.2741\/539","journal-title":"Front Biosci (Elite Ed)"},{"key":"314_CR14","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S1673-8527(08)60099-5","volume":"36","author":"LL Clay Montier","year":"2009","unstructured":"Clay Montier LL, Deng JJ, Bai Y (2009) Number matters: control of mammalian mitochondrial DNA copy number. J Genet Genomics 36:125\u2013131. https:\/\/doi.org\/10.1016\/S1673-8527(08)60099-5","journal-title":"J Genet Genomics"},{"key":"314_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S1567-7249(03)00053-9","volume":"3","author":"E Holmuhamedov","year":"2003","unstructured":"Holmuhamedov E, Jahangir A, Bienengraeber M, Lewis LD, Terzic A (2003) Deletion of mtDNA disrupts mitochondrial function and structure, but not biogenesis. Mitochondrion 3:13\u201319. https:\/\/doi.org\/10.1016\/S1567-7249(03)00053-9","journal-title":"Mitochondrion"},{"key":"314_CR16","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.mito.2012.10.011","volume":"13","author":"AN Malik","year":"2013","unstructured":"Malik AN, Czajka A (2013) Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction? Mitochondrion 13:481\u2013492. https:\/\/doi.org\/10.1016\/j.mito.2012.10.011 (Epub 2012 Oct 22)","journal-title":"Mitochondrion"},{"key":"314_CR17","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1002\/jcb.21625","volume":"103","author":"JY Jeng","year":"2008","unstructured":"Jeng JY, Yeh TS, Lee JW, Lin SH, Fong TH, Hsieh RH (2008) Maintenance of mitochondrial DNA copy number and expression are essential for preservation of mitochondrial function and cell growth. J Cell Biochem 103:347\u2013357. https:\/\/doi.org\/10.1002\/jcb.21625","journal-title":"J Cell Biochem"},{"key":"314_CR18","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0925-4439(95)00012-s","volume":"1271","author":"C Richter","year":"1995","unstructured":"Richter C, Gogvadze V, Laffranchi R, Schlapbach R, Schweizer M, Suter M, Walter P, Yaffee M (1995) Oxidants in mitochondria: from physiology to diseases. Biochim Biophys Acta 1271:67\u201374. https:\/\/doi.org\/10.1016\/0925-4439(95)00012-s","journal-title":"Biochim Biophys Acta"},{"key":"314_CR19","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/hepr.13324","volume":"49","author":"J Wang","year":"2019","unstructured":"Wang J, Xu J, Xia M, Yang Y, Shen Z, Chen G, Dong R, Zheng S (2019) Correlation between hepatic oxidative damage and clinical severity and mitochondrial gene sequencing results in biliary atresia. Hepatol Res 49:695\u2013704. https:\/\/doi.org\/10.1111\/hepr.13324 (Epub 2019 Apr 1)","journal-title":"Hepatol Res"},{"key":"314_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.645593","volume":"9","author":"R Kumari","year":"2021","unstructured":"Kumari R, Jat P (2021) Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype. Front Cell Dev Biol 9:645593. https:\/\/doi.org\/10.3389\/fcell.2021.645593","journal-title":"Front Cell Dev Biol"},{"key":"314_CR21","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1309\/AJCPWMX47TREYWZG","volume":"133","author":"M Sasaki","year":"2010","unstructured":"Sasaki M, Ikeda H, Yamaguchi J, Miyakoshi M, Sato Y, Nakanuma Y (2010) Bile ductular cells undergoing cellular senescence increase in chronic liver diseases along with fibrous progression. Am J Clin Pathol 133:212\u2013223. https:\/\/doi.org\/10.1309\/AJCPWMX47TREYWZG","journal-title":"Am J Clin Pathol"},{"key":"314_CR22","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1111\/his.13476","volume":"72","author":"M Sasaki","year":"2018","unstructured":"Sasaki M, Kuo FY, Huang CC, Swanson PE, Chen CL, Chuang JH, Yeh MM (2018) Increased expression of senescence-associated cell cycle regulators in the progression of biliary atresia: an immunohistochemical study. Histopathology 72:1164\u20131171. https:\/\/doi.org\/10.1111\/his.13476 (Epub 2018 Mar 9)","journal-title":"Histopathology"},{"key":"314_CR23","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/leu.2010.6","volume":"24","author":"LJ Mah","year":"2010","unstructured":"Mah LJ, El-Osta A, Karagiannis TC (2010) gammaH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia 24:679\u2013686. https:\/\/doi.org\/10.1038\/leu.2010.6 (Epub 2010 Feb 4)","journal-title":"Leukemia"},{"key":"314_CR24","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1101\/gad.1795309","volume":"23","author":"E White","year":"2009","unstructured":"White E, Lowe SW (2009) Eating to exit: autophagy-enabled senescence revealed. Genes Dev 23:784\u2013787. https:\/\/doi.org\/10.1101\/gad.1795309","journal-title":"Genes Dev"},{"key":"314_CR25","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1083\/jcb.200507002","volume":"171","author":"G Bj\u00f8rk\u00f8y","year":"2005","unstructured":"Bj\u00f8rk\u00f8y G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T (2005) p62\/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 171:603\u2013614. https:\/\/doi.org\/10.1083\/jcb.200507002 (Epub 2005 Nov 14)","journal-title":"J Cell Biol"},{"key":"314_CR26","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1016\/j.jpedsurg.2016.09.047","volume":"51","author":"M Nio","year":"2016","unstructured":"Nio M, Wada M, Sasaki H, Kazama T, Tanaka H, Kudo H (2016) Technical standardization of Kasai portoenterostomy for biliary atresia. J Pediatr Surg 51:2105\u20132108. https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.09.047 (Epub 2016 Sep 16)","journal-title":"J Pediatr Surg"},{"key":"314_CR27","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1016\/j.humpath.2015.07.003","volume":"46","author":"FY Kuo","year":"2015","unstructured":"Kuo FY, Huang CC, Chen CL, Chuang JH, Riehle K, Swanson PE, Yeh MM (2015) Immunohistochemical characterization of the regenerative compartment in biliary atresia: a comparison between Kasai procedure and transplant cases. Hum Pathol 46:1633\u20131639. https:\/\/doi.org\/10.1016\/j.humpath.2015.07.003 (Epub 2015 Jul 15)","journal-title":"Hum Pathol"},{"key":"314_CR28","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/S0928-4346(96)00325-8","volume":"6","author":"F Ichida","year":"1996","unstructured":"Ichida F, Tsuji T, Omata M, Ichida T, Inoue K, Kamimura T, Yamada G, Hino K, Yokosuka O, Suzuki H (1996) New Inuyama classification: new criteria for histological assessment of chronic hepatitis. Int Hepatol Commun 6:112\u2013119. https:\/\/doi.org\/10.1016\/S0928-4346(96)00325-8","journal-title":"Int Hepatol Commun"},{"key":"314_CR29","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.humpath.2015.10.017","volume":"53","author":"Y Yamazaki","year":"2016","unstructured":"Yamazaki Y, Nakamura Y, Shibahara Y, Konosu-Fukaya S, Sato N, Kubota-Nakayama F, Oki Y, Baba S, Midorikawa S, Morimoto R, Satoh F, Sasano H (2016) Comparison of the methods for measuring the Ki-67 labeling index in adrenocortical carcinoma: manual versus digital image analysis. Hum Pathol 53:41\u201350. https:\/\/doi.org\/10.1016\/j.humpath.2015.10.017 (Epub 2016 Mar 7)","journal-title":"Hum Pathol"},{"key":"314_CR30","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12885-020-6652-7","volume":"20","author":"S Ueki","year":"2020","unstructured":"Ueki S, Fujishima F, Kumagai T, Ishida H, Okamoto H, Takaya K, Sato C, Taniyma Y, Kamei T, Sasano H (2020) GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy. BMC Cancer 20:161. https:\/\/doi.org\/10.1186\/s12885-020-6652-7","journal-title":"BMC Cancer"},{"key":"314_CR31","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1210\/js.2017-00134","volume":"1","author":"K Omata","year":"2017","unstructured":"Omata K, Anand SK, Hovelson DH, Liu CJ, Yamazaki Y, Nakamura Y, Ito S, Satoh F, Sasano H, Rainey WE, Tomlins SA (2017) Aldosterone-producing cell clusters frequently harbor somatic mutations and accumulate with age in normal adrenals. J Endocr Soc 1:787\u2013799. https:\/\/doi.org\/10.1210\/js.2017-00134","journal-title":"J Endocr Soc"},{"key":"314_CR32","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1097\/PAS.0b013e31822da401","volume":"35","author":"E Duregon","year":"2011","unstructured":"Duregon E, Volante M, Cappia S, Cuccurullo A, Bisceglia M, Wong DD, Spagnolo DV, Szpak-Ulczok S, Bollito E, Daffara F, Berruti A, Terzolo M, Papotti M (2011) Oncocytic adrenocortical tumors: diagnostic algorithm and mitochondrial DNA profile in 27 cases. Am J Surg Pathol 35:1882\u20131893. https:\/\/doi.org\/10.1097\/PAS.0b013e31822da401","journal-title":"Am J Surg Pathol"},{"key":"314_CR33","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1001\/archophthalmol.2010.87","volume":"128","author":"A Izzotti","year":"2010","unstructured":"Izzotti A, Sacc\u00e0 SC, Longobardi M, Cartiglia C (2010) Mitochondrial damage in the trabecular meshwork of patients with glaucoma. Arch Ophthalmol 128:724\u2013730. https:\/\/doi.org\/10.1001\/archophthalmol.2010.87","journal-title":"Arch Ophthalmol"},{"key":"314_CR34","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1210\/jc.2017-01625","volume":"103","author":"D R\u00e9v\u00e9sz","year":"2018","unstructured":"R\u00e9v\u00e9sz D, Verhoeven JE, Picard M, Lin J, Sidney S, Epel ES, Penninx BWJH, Puterman E (2018) Associations between cellular aging markers and metabolic syndrome: findings from the CARDIA study. J Clin Endocrinol Metab 103:148\u2013157. https:\/\/doi.org\/10.1210\/jc.2017-01625","journal-title":"J Clin Endocrinol Metab"},{"key":"314_CR35","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s00428-020-02854-0","volume":"477","author":"Y Gokon","year":"2020","unstructured":"Gokon Y, Fujishima F, Taniyama Y, Ishida H, Yamagata T, Sawai T, Uzuki M, Ichikawa H, Itakura Y, Takahashi K, Yajima N, Hagiwara M, Nishida A, Ozawa Y, Sakuma T, Kanba R, Sakamoto K, Zuguchi M, Saito M, Kamei T, Sasano H (2020) Immune microenvironment in Barrett\u2019s esophagus adjacent to esophageal adenocarcinoma: possible influence of adjacent mucosa on cancer development and progression. Virchows Arch 477:825\u2013834. https:\/\/doi.org\/10.1007\/s00428-020-02854-0 (Epub 2020 Jun 12)","journal-title":"Virchows Arch"},{"key":"314_CR36","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1196\/annals.1395.036","volume":"1100","author":"Z Ju","year":"2007","unstructured":"Ju Z, Choudhury AR, Rudolph KL (2007) A dual role of p21 in stem cell aging. Ann N Y Acad Sci 1100:333\u2013344. https:\/\/doi.org\/10.1196\/annals.1395.036","journal-title":"Ann N Y Acad Sci"},{"key":"314_CR37","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1038\/sj.onc.1207518","volume":"23","author":"JW Shay","year":"2004","unstructured":"Shay JW, Roninson IB (2004) Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23:2919\u20132933. https:\/\/doi.org\/10.1038\/sj.onc.1207518","journal-title":"Oncogene"},{"key":"314_CR38","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","volume":"179","author":"V Gorgoulis","year":"2019","unstructured":"Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M (2019) Cellular senescence: defining a path forward. Cell 179:813\u2013827. https:\/\/doi.org\/10.1016\/j.cell.2019.10.005","journal-title":"Cell"},{"issue":"5","key":"314_CR39","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.90780","volume":"2","author":"SY Cai","year":"2017","unstructured":"Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL (2017) Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight 2(5):e90780. https:\/\/doi.org\/10.1172\/jci.insight.90780","journal-title":"JCI Insight"},{"key":"314_CR40","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1101\/gad.13.12.1501","volume":"13","author":"CJ Sherr","year":"1999","unstructured":"Sherr CJ, Roberts JM (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501\u20131512. https:\/\/doi.org\/10.1101\/gad.13.12.1501","journal-title":"Genes Dev"},{"key":"314_CR41","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1128\/MCB.19.3.2109","volume":"19","author":"GH Stein","year":"1999","unstructured":"Stein GH, Drullinger LF, Soulard A, Duli\u0107 V (1999) Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 19:2109\u20132117. https:\/\/doi.org\/10.1128\/MCB.19.3.2109","journal-title":"Mol Cell Biol"},{"key":"314_CR42","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1016\/j.cub.2017.07.033","volume":"27","author":"A Hernandez-Segura","year":"2017","unstructured":"Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M (2017) Unmasking transcriptional heterogeneity in senescent cells. Curr Biol 27:2652-2660.e4. https:\/\/doi.org\/10.1016\/j.cub.2017.07.033 (Epub 2017 Aug 30)","journal-title":"Curr Biol"},{"key":"314_CR43","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1111\/acel.12518","volume":"15","author":"NV Petrova","year":"2016","unstructured":"Petrova NV, Velichko AK, Razin SV, Kantidze OL (2016) Small molecule compounds that induce cellular senescence. Aging Cell 15:999\u20131017. https:\/\/doi.org\/10.1111\/acel.12518 (Epub 2016 Sep 14)","journal-title":"Aging Cell"},{"key":"314_CR44","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1016\/j.humpath.2009.06.009","volume":"40","author":"H Ikeda","year":"2009","unstructured":"Ikeda H, Sasaki M, Sato Y, Harada K, Zen Y, Mitsui T, Nakanuma Y (2009) Large cell change of hepatocytes in chronic viral hepatitis represents a senescent-related lesion. Hum Pathol 40:1774\u20131782. https:\/\/doi.org\/10.1016\/j.humpath.2009.06.009 (Epub 2009 Sep 4)","journal-title":"Hum Pathol"},{"key":"314_CR45","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1007\/s00204-019-02511-9","volume":"93","author":"B Kopp","year":"2019","unstructured":"Kopp B, Khoury L, Audebert M (2019) Validation of the \u03b3H2AX biomarker for genotoxicity assessment: a review. Arch Toxicol 93:2103\u20132114. https:\/\/doi.org\/10.1007\/s00204-019-02511-9 (Epub 2019 Jul 9)","journal-title":"Arch Toxicol"},{"key":"314_CR46","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/febs.15570","volume":"288","author":"E Gonz\u00e1lez-Gualda","year":"2021","unstructured":"Gonz\u00e1lez-Gualda E, Baker AG, Fruk L, Mu\u00f1oz-Esp\u00edn D (2021) A guide to assessing cellular senescence in vitro and in vivo. FEBS J 288:56\u201380. https:\/\/doi.org\/10.1111\/febs.15570 (Epub 2020 Oct 10)","journal-title":"FEBS J"},{"issue":"3","key":"314_CR47","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/s1383-5742(97)00035-5","volume":"387","author":"H Kasai","year":"1997","unstructured":"Kasai H (1997) Analysis of a form of oxidative DNA damage, 8-hydroxy-2\u2019-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat Res 387(3):147\u2013163. https:\/\/doi.org\/10.1016\/s1383-5742(97)00035-5","journal-title":"Mutat Res"},{"issue":"3","key":"314_CR48","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1097\/MPG.0b013e3180cc2c0f","volume":"45","author":"MM Tiao","year":"2007","unstructured":"Tiao MM, Lin TK, Kuo FY, Huang CC, Du YY, Chen CL, Chuang JH (2007) Early stage of biliary atresia is associated with significant changes in 8-hydroxydeoxyguanosine and mitochondrial copy number. J Pediatr Gastroenterol Nutr 45(3):329\u2013334. https:\/\/doi.org\/10.1097\/MPG.0b013e3180cc2c0f","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6308","key":"314_CR49","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/349431a0","volume":"349","author":"S Shibutani","year":"1991","unstructured":"Shibutani S, Takeshita M, Grollman AP (1991) Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349(6308):431\u2013434. https:\/\/doi.org\/10.1038\/349431a0","journal-title":"Nature"},{"key":"314_CR50","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.4161\/cc.8.13.8892","volume":"8","author":"T Lamark","year":"2009","unstructured":"Lamark T, Kirkin V, Dikic I, Johansen T (2009) NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle 8:1986\u20131990. https:\/\/doi.org\/10.4161\/cc.8.13.8892 (Epub 2009 Jul 30)","journal-title":"Cell Cycle"},{"key":"314_CR51","doi-asserted-by":"publisher","first-page":"22847","DOI":"10.1074\/jbc.M802182200","volume":"283","author":"Y Ichimura","year":"2008","unstructured":"Ichimura Y, Kumanomidou T, Sou YS, Mizushima T, Ezaki J, Ueno T, Kominami E, Yamane T, Tanaka K, Komatsu M (2008) Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem 283:22847\u201322857. https:\/\/doi.org\/10.1074\/jbc.M802182200 (Epub 2008 Jun 4)","journal-title":"J Biol Chem"},{"key":"314_CR52","doi-asserted-by":"publisher","first-page":"24131","DOI":"10.1074\/jbc.M702824200","volume":"282","author":"S Pankiv","year":"2007","unstructured":"Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, \u00d8vervatn A, Bj\u00f8rk\u00f8y G, Johansen T (2007) p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 282:24131\u201324145. https:\/\/doi.org\/10.1074\/jbc.M702824200 (Epub 2007 Jun 19)","journal-title":"J Biol Chem"},{"key":"314_CR53","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/ncb2021","volume":"12","author":"M Komatsu","year":"2010","unstructured":"Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M (2010) The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12:213\u2013223. https:\/\/doi.org\/10.1038\/ncb2021 (Epub 2010 Feb 21)","journal-title":"Nat Cell Biol"},{"key":"314_CR54","doi-asserted-by":"publisher","first-page":"5425","DOI":"10.4049\/jimmunol.1001603","volume":"185","author":"MM Monick","year":"2010","unstructured":"Monick MM, Powers LS, Walters K, Lovan N, Zhang M, Gerke A, Hansdottir S, Hunninghake GW (2010) Identification of an autophagy defect in smokers\u2019 alveolar macrophages. J Immunol 185:5425\u20135435. https:\/\/doi.org\/10.4049\/jimmunol.1001603 (Epub 2010 Oct 4)","journal-title":"J Immunol"},{"key":"314_CR55","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/j.1478-3231.2011.02656.x","volume":"32","author":"M Sasaki","year":"2012","unstructured":"Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y (2012) A possible involvement of p62\/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis. Liver Int 32:487\u2013499. https:\/\/doi.org\/10.1111\/j.1478-3231.2011.02656.x (Epub 2011 Sep 27)","journal-title":"Liver Int"},{"key":"314_CR56","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fendo.2019.00086","volume":"10","author":"F Copped\u00e8","year":"2019","unstructured":"Copped\u00e8 F, Stoccoro A (2019) Mitoepigenetics and neurodegenerative diseases. Front Endocrinol (Lausanne) 10:86. https:\/\/doi.org\/10.3389\/fendo.2019.00086","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"314_CR57","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s00401-020-02252-5","volume":"141","author":"AR Mehta","year":"2021","unstructured":"Mehta AR, Gregory JM, Dando O, Carter RN, Burr K, Nanda J, Story D, McDade K, Smith C, Morton NM, Mahad DJ, Hardingham GE, Chandran S, Selvaraj BT (2021) Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis. Acta Neuropathol 141(2):257\u2013279. https:\/\/doi.org\/10.1007\/s00401-020-02252-5 (Epub 2021 Jan 4)","journal-title":"Acta Neuropathol"},{"key":"314_CR58","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.mito.2021.01.004","volume":"57","author":"IO Bychkov","year":"2021","unstructured":"Bychkov IO, Itkis YS, Tsygankova PG, Krylova TD, Mikhaylova SV, Klyushnikov SA, Pechatnikova NL, Degtyareva AV, Nikolaeva EA, Seliverstov YA, Kurbatov SA, Dadali EL, Rudenskaya GE, Illarioshkin SN, Zakharova EY (2021) Mitochondrial DNA maintenance disorders in 102 patients from different parts of Russia: mutational spectrum and phenotypes. Mitochondrion 57:205\u2013212. https:\/\/doi.org\/10.1016\/j.mito.2021.01.004 (Epub 2021 Jan 21)","journal-title":"Mitochondrion"},{"key":"314_CR59","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/joim.13242","volume":"290","author":"F Fazzini","year":"2021","unstructured":"Fazzini F, Lamina C, Raftopoulou A, Koller A, Fuchsberger C, Pattaro C, Del Greco FM, D\u00f6ttelmayer P, Fendt L, Fritz J, Meiselbach H, Sch\u00f6nherr S, Forer L, Weissensteiner H, Pramstaller PP, Eckardt KU, Hicks AA, Kronenberg F, Investigators GCKD (2021) Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14 176 individuals. J Intern Med 290:190\u2013202. https:\/\/doi.org\/10.1111\/joim.13242 (Epub 2021 Feb 20)","journal-title":"J Intern Med"},{"key":"314_CR60","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1073\/pnas.94.2.514","volume":"94","author":"FM Yakes","year":"1997","unstructured":"Yakes FM, Van Houten B (1997) Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci U S A 94:514\u2013519. https:\/\/doi.org\/10.1073\/pnas.94.2.514","journal-title":"Proc Natl Acad Sci U S A"},{"key":"314_CR61","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.mad.2008.03.002","volume":"129","author":"NM Druzhyna","year":"2008","unstructured":"Druzhyna NM, Wilson GL, LeDoux SP (2008) Mitochondrial DNA repair in aging and disease. Mech Ageing Dev 129:383\u2013390. https:\/\/doi.org\/10.1016\/j.mad.2008.03.002 (Epub 2008 Mar 13)","journal-title":"Mech Ageing Dev"},{"key":"314_CR62","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/cphy.c130024","volume":"4","author":"L Rui","year":"2014","unstructured":"Rui L (2014) Energy metabolism in the liver. Compr Physiol 4:177\u2013197. https:\/\/doi.org\/10.1002\/cphy.c130024","journal-title":"Compr Physiol"},{"key":"314_CR63","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fcell.2015.00040","volume":"3","author":"C Auger","year":"2015","unstructured":"Auger C, Alhasawi A, Contavadoo M, Appanna VD (2015) Dysfunctional mitochondrial bioenergetics and the pathogenesis of hepatic disorders. Front Cell Dev Biol 3:40. https:\/\/doi.org\/10.3389\/fcell.2015.00040","journal-title":"Front Cell Dev Biol"}],"container-title":["Medical Molecular Morphology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00795-022-00314-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00795-022-00314-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00795-022-00314-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T14:14:43Z","timestamp":1653488083000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00795-022-00314-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,3]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["314"],"URL":"https:\/\/doi.org\/10.1007\/s00795-022-00314-z","relation":{},"ISSN":["1860-1480","1860-1499"],"issn-type":[{"value":"1860-1480","type":"print"},{"value":"1860-1499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,3]]},"assertion":[{"value":"17 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}