{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:50:08Z","timestamp":1740142208539,"version":"3.37.3"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Mol Morphol"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s00795-022-00343-8","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T14:02:56Z","timestamp":1673877776000},"page":"94-105","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti-inflammatory and antifibrotic effects of CBP\/\u03b2-catenin inhibitor for hepatocytes: small molecular inhibitor, OP-724 possibly improves liver function"],"prefix":"10.1007","volume":"56","author":[{"given":"Hirofumi","family":"Ouchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiminori","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushi","family":"Haruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6451-0638","authenticated-orcid":false,"given":"Kenichi","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"343_CR1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","volume":"18","author":"T Kisseleva","year":"2021","unstructured":"Kisseleva T, Brenner D (2021) Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol 18:151\u2013166","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"343_CR2","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.1002\/hep4.2043","volume":"6","author":"M Kimura","year":"2022","unstructured":"Kimura M, Nishikawa K, Osawa Y, Imamura J, Yamaji K, Harada K, Yatsuhashi H, Murata K, Miura K, Tanaka A, Kanto T, Kohara M, Kamisawa T, Kimura K (2022) Inhibition of CBP\/\u03b2-catenin signaling ameliorated fibrosis in cholestatic liver disease. Hepatol Commun 6:2732\u20132747","journal-title":"Hepatol Commun"},{"key":"343_CR3","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nrd4233","volume":"13","author":"M Kahn","year":"2014","unstructured":"Kahn M (2014) Can we safely target the WNT pathway? Nat Rev Drug Discov 13:513\u2013532","journal-title":"Nat Rev Drug Discov"},{"key":"343_CR4","doi-asserted-by":"publisher","first-page":"12171","DOI":"10.1073\/pnas.0504600102","volume":"102","author":"JL Teo","year":"2005","unstructured":"Teo JL, Ma H, Nguyen C, Lam C, Kahn M (2005) Specific inhibition of CBP\/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Proc Natl Acad Sci U S A 102:12171\u201312176","journal-title":"Proc Natl Acad Sci U S A"},{"key":"343_CR5","doi-asserted-by":"publisher","first-page":"14309","DOI":"10.1073\/pnas.1001520107","volume":"107","author":"WR Henderson Jr","year":"2010","unstructured":"Henderson WR Jr, Chi EY, Ye X, Nguyen C, Tien YT, Zhou B, Borok Z, Knight DA, Kahn M (2010) Inhibition of Wnt\/beta-catenin\/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A 107:14309\u201314314","journal-title":"Proc Natl Acad Sci U S A"},{"key":"343_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.2174\/1874467212666190304121131","volume":"12","author":"KKY Lai","year":"2019","unstructured":"Lai KKY, Nguyen C, Lee KS, Lee A, Lin DP, Teo JL, Kahn M (2019) Convergence of canonical and non-canonical wnt signal: differential Kat3 coactivator usage. Curr Mol Pharmacol 12:167\u2013183","journal-title":"Curr Mol Pharmacol"},{"key":"343_CR7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s10565-016-9318-0","volume":"32","author":"PD Thomas","year":"2016","unstructured":"Thomas PD, Kahn M (2016) Kat3 coactivators in somatic stem cells and cancer stem cells: biological roles, evolution, and pharmacologic manipulation. Cell Biol Toxicol 32:61\u201381","journal-title":"Cell Biol Toxicol"},{"key":"343_CR8","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nrneph.2016.54","volume":"12","author":"M Edeling","year":"2016","unstructured":"Edeling M, Ragi G, Huang S, Pavenst\u00e4dt H, Susztak K (2016) Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog. Nat Rev Nephrol 12:426\u2013439","journal-title":"Nat Rev Nephrol"},{"key":"343_CR9","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1053\/j.gastro.2015.02.056","volume":"148","author":"SP Monga","year":"2015","unstructured":"Monga SP (2015) \u03b2-Catenin signaling and roles in liver homeostasis, injury, and tumorigenesis. Gastroenterology 148:1294\u20131310","journal-title":"Gastroenterology"},{"key":"343_CR10","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1016\/j.ebiom.2015.10.010","volume":"2","author":"Y Osawa","year":"2015","unstructured":"Osawa Y, Oboki K, Imamura J, Kojika E, Hayashi Y, Hishima T, Saibara T, Shibasaki F, Kohara M, Kimura K (2015) Inhibition of cyclic adenosine monophosphate (cAMP)-response element-binding protein (CREB)-binding protein (CBP)\/beta-catenin reduces liver fibrosis in mice. EBioMedicine 2:1751\u20131758","journal-title":"EBioMedicine"},{"key":"343_CR11","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.4155\/fmc.11.126","volume":"3","author":"M Kahn","year":"2011","unstructured":"Kahn M (2011) Symmetric division versus asymmetric division: a tale of two coactivators. Future Med Chem 3:1745\u20131763","journal-title":"Future Med Chem"},{"key":"343_CR12","doi-asserted-by":"publisher","first-page":"14309","DOI":"10.1073\/pnas.1001520107","volume":"107","author":"WR Henderson","year":"2010","unstructured":"Henderson WR, Chi EY, Ye X, Nguyen C, Tien Y-T, Zhou B, Borok Z, Knight DA, Kahn M (2010) Inhibition of Wnt\/\u03b2-catenin\/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A 107:14309\u201314314","journal-title":"Proc Natl Acad Sci U S A"},{"key":"343_CR13","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1681\/ASN.2010101079","volume":"22","author":"S Hao","year":"2011","unstructured":"Hao S, He W, Li Y, Ding H, Hou Y, Nie J, Hou FF, Kahn M, Liu Y (2011) Targeted inhibition of beta-catenin\/CBP signaling ameliorates renal interstitial fibrosis. J Am Soc Nephrol 22:1642\u20131653","journal-title":"J Am Soc Nephrol"},{"key":"343_CR14","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/s41598-017-00282-w","volume":"7","author":"Y Tokunaga","year":"2017","unstructured":"Tokunaga Y, Osawa Y, Ohtsuki T, Hayashi Y, Yamaji K, Yamane D, Hara M, Munekata K, Tsukiyama-Kohara K, Hishima T, Kojima S, Kimura K, Kohara M (2017) Selective inhibitor of Wnt\/beta-catenin\/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model. Sci Rep 7:325","journal-title":"Sci Rep"},{"issue":"577\u2013594","key":"343_CR15","first-page":"e571","volume":"147","author":"F Marra","year":"2014","unstructured":"Marra F, Tacke F (2014) Roles for chemokines in liver disease. Gastroenterology 147(577\u2013594):e571","journal-title":"Gastroenterology"},{"key":"343_CR16","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1007\/s00795-005-0289-0","volume":"38","author":"H Yoneyama","year":"2005","unstructured":"Yoneyama H, Ichida T (2005) Recruitment of dendritic cells to pathological niches in inflamed liver. Med Mol Morphol 38:136\u2013141","journal-title":"Med Mol Morphol"},{"key":"343_CR17","doi-asserted-by":"publisher","first-page":"175628482110313","DOI":"10.1177\/17562848211031394","volume":"14","author":"P Middleton","year":"2021","unstructured":"Middleton P, Vergis N (2021) Mitochondrial dysfunction and liver disease: role, relevance, and potential for therapeutic modulation. Therap Adv Gastroenterol 14:17562848211031394","journal-title":"Therap Adv Gastroenterol"},{"key":"343_CR18","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1053\/j.gastro.2018.06.083","volume":"155","author":"A Mansouri","year":"2018","unstructured":"Mansouri A, Gattolliat C-H, Asselah T (2018) Mitochondrial dysfunction and signaling in chronic liver diseases. Gastroenterology 155:629\u2013647","journal-title":"Gastroenterology"},{"key":"343_CR19","doi-asserted-by":"publisher","first-page":"954","DOI":"10.3390\/v5030954","volume":"5","author":"C Brault","year":"2013","unstructured":"Brault C, Levy P, Bartosch B (2013) Hepatitis C virus-induced mitochondrial dysfunctions. Viruses 5:954\u2013980","journal-title":"Viruses"},{"key":"343_CR20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"343_CR21","doi-asserted-by":"publisher","first-page":"104069","DOI":"10.1016\/j.ebiom.2022.104069","volume":"80","author":"K Kimura","year":"2022","unstructured":"Kimura K, Kanto T, Shimoda S, Harada K, Kimura M, Nishikawa K, Imamura J, Ogawa E, Saio M, Ikura Y, Okusaka T, Inoue K, Ishikawa T, Ieiri I, Kishimoto J, Todaka K, Kamisawa T (2022) Safety, tolerability, and anti-fibrotic efficacy of the CBP\/\u03b2-catenin inhibitor PRI-724 in patients with hepatitis C and B virus-induced liver cirrhosis: An investigator-initiated, open-label, non-randomised, multicentre, phase 1\/2a study. EBioMedicine 80:104069","journal-title":"EBioMedicine"},{"key":"343_CR22","doi-asserted-by":"publisher","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","volume":"7","author":"P Bankhead","year":"2017","unstructured":"Bankhead P, Loughrey MB, Fern\u00e1ndez JA, Dombrowski Y, McArt DG, Dunne PD, McQuaid S, Gray RT, Murray LJ, Coleman HG, James JA, Salto-Tellez M, Hamilton PW (2017) QuPath: open source software for digital pathology image analysis. Sci Rep 7:16878","journal-title":"Sci Rep"},{"key":"343_CR23","first-page":"79","volume":"23","author":"K Kimura","year":"2017","unstructured":"Kimura K, Ikoma A, Shibakawa M, Shimoda S, Harada K, Saio M, Imamura J, Osawa Y, Kimura M, Nishikawa K, Okusaka T, Morita S, Inoue K, Kanto T, Todaka K, Nakanishi Y, Kohara M, Mizokami M (2017) Safety, tolerability, and preliminary efficacy of the anti-fibrotic small molecule PRI-724, a CBP\/beta-catenin inhibitor, in patients with hepatitis c virus-related cirrhosis: a single-center, open-label, dose escalation phase 1 trial. E BioMedicine 23:79\u201387","journal-title":"E BioMedicine"},{"key":"343_CR24","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1002\/hep.27332","volume":"61","author":"E Seki","year":"2015","unstructured":"Seki E, Schwabe RF (2015) Hepatic inflammation and fibrosis: Functional links and key pathways. Hepatology 61:1066\u20131079","journal-title":"Hepatology"},{"key":"343_CR25","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.1172\/JCI41732","volume":"120","author":"M-L Berres","year":"2010","unstructured":"Berres M-L, Koenen RR, Rueland A, Zaldivar MM, Heinrichs D, Sahin H, Schmitz P, Streetz KL, Berg T, Gassler N, Weiskirchen R, Proudfoot A, Weber C, Trautwein C, Wasmuth HE (2010) Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. J Clin Invest 120:4129\u20134140","journal-title":"J Clin Invest"},{"issue":"103\u2013117","key":"343_CR26","first-page":"e104","volume":"180","author":"BH Li","year":"2017","unstructured":"Li BH, He FP, Yang X, Chen YW, Fan JG (2017) Steatosis induced CCL5 contributes to early-stage liver fibrosis in nonalcoholic fatty liver disease progress. Transl Res 180(103\u2013117):e104","journal-title":"Transl Res"},{"key":"343_CR27","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.3390\/ijms19041145","volume":"19","author":"W-P Shi","year":"2018","unstructured":"Shi W-P, Ju D, Li H, Yuan L, Cui J, Luo D, Chen Z-N, Bian H (2018) CD147 Promotes CXCL1 expression and modulates liver fibrogenesis. Int J Mol Sci 19:1145","journal-title":"Int J Mol Sci"},{"key":"343_CR28","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.jaut.2010.09.003","volume":"35","author":"E Hintermann","year":"2010","unstructured":"Hintermann E, Bayer M, Pfeilschifter JM, Luster AD, Christen U (2010) CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation. J Autoimmun 35:424\u2013435","journal-title":"J Autoimmun"},{"key":"343_CR29","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1002\/hep.29652","volume":"67","author":"E Kaffe","year":"2018","unstructured":"Kaffe E, Fiorotto R, Pellegrino F, Mariotti V, Amenduni M, Cadamuro M, Fabris L, Strazzabosco M, Spirli C (2018) \u03b2-Catenin and interleukin-1\u03b2-dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis. Hepatology 67:1903\u20131919","journal-title":"Hepatology"},{"key":"343_CR30","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s00795-007-0371-x","volume":"40","author":"H Yoneyama","year":"2007","unstructured":"Yoneyama H, Kai Y, Koyama J, Suzuki K, Kawachi H, Narumi S, Ichida T (2007) Neutralization of CXCL10 accelerates liver regeneration in carbon tetrachloride-induced acute liver injury. Med Mol Morphol 40:191\u2013197","journal-title":"Med Mol Morphol"},{"key":"343_CR31","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.jcmgh.2020.01.002","volume":"9","author":"A Filliol","year":"2020","unstructured":"Filliol A, Schwabe RF (2020) FoxM1 induces CCl2 secretion from hepatocytes triggering hepatic inflammation, injury, fibrosis, and liver cancer. Cell Mol Gastroenterol Hepatol 9:555\u2013556","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"343_CR32","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s00795-005-0292-5","volume":"38","author":"T Nagata","year":"2005","unstructured":"Nagata T, Kudo H, Nishino T, Doi Y, Itoh H, Fujimoto S (2005) Increased immunoreactivities against endothelin-converting enzyme-1 and monocyte chemotactic protein-1 in hepatic stellate cells of rat fibrous liver induced by thioacetamide. Med Mol Morphol 38:161\u2013172","journal-title":"Med Mol Morphol"},{"key":"343_CR33","doi-asserted-by":"publisher","first-page":"5854","DOI":"10.1038\/s41388-021-01986-0","volume":"40","author":"F Zhang","year":"2021","unstructured":"Zhang F, Li P, Liu S, Yang M, Zeng S, Deng J, Chen D, Yi Y, Liu H (2021) \u03b2-Catenin-CCL2 feedback loop mediates crosstalk between cancer cells and macrophages that regulates breast cancer stem cells. Oncogene 40:5854\u20135865","journal-title":"Oncogene"},{"key":"343_CR34","first-page":"4845","volume":"18","author":"X Song","year":"2019","unstructured":"Song X, Shen Y, Lao Y, Tao Z, Zeng J, Wang J, Wu H (2019) CXCL9 regulates acetaminophen-induced liver injury via CXCR3. Exp Ther Med 18:4845\u20134851","journal-title":"Exp Ther Med"},{"key":"343_CR35","doi-asserted-by":"publisher","first-page":"18961","DOI":"10.1074\/jbc.M117.793794","volume":"292","author":"M Sato-Matsubara","year":"2017","unstructured":"Sato-Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, Thuy LTT, Adachi J, Tomonaga T, Ikeda K, Yoshizato K, Pinzani M, Kawada N (2017) Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling. J Biol Chem 292:18961\u201318972","journal-title":"J Biol Chem"},{"key":"343_CR36","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1053\/j.gastro.2014.01.061","volume":"146","author":"L Yang","year":"2014","unstructured":"Yang L, Kwon J, Popov Y, Gajdos GB, Ordog T, Brekken RA, Mukhopadhyay D, Schuppan D, Bi Y, Simonetto D, Shah VH (2014) Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology 146:1339-1350.e1331","journal-title":"Gastroenterology"},{"key":"343_CR37","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1126\/science.283.5407.1488","volume":"283","author":"M Saraste","year":"1999","unstructured":"Saraste M (1999) Oxidative phosphorylation at the fin de si\u00e8cle. Science 283:1488\u20131493","journal-title":"Science"},{"key":"343_CR38","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1002\/prca.201000049","volume":"4","author":"MP Simula","year":"2010","unstructured":"Simula MP, De Re V (2010) Hepatitis C virus-induced oxidative stress and mitochondrial dysfunction: a focus on recent advances in proteomics. Proteomics Clin Appl 4:782\u2013793","journal-title":"Proteomics Clin Appl"},{"key":"343_CR39","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","volume":"552","author":"LD Zorova","year":"2018","unstructured":"Zorova LD, Popkov VA, Plotnikov EY, Silachev DN, Pevzner IB, Jankauskas SS, Babenko VA, Zorov SD, Balakireva AV, Juhaszova M, Sollott SJ, Zorov DB (2018) Mitochondrial membrane potential. Anal Biochem 552:50\u201359","journal-title":"Anal Biochem"},{"key":"343_CR40","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-1-4939-6346-1_2","volume":"1473","author":"S Sakamuru","year":"2016","unstructured":"Sakamuru S, Attene-Ramos MS, Xia M (2016) Mitochondrial membrane potential assay. Methods Mol Biol 1473:17\u201322","journal-title":"Methods Mol Biol"},{"key":"343_CR41","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s12012-021-09643-4","volume":"21","author":"P Sen","year":"2021","unstructured":"Sen P, Gupta K, Kumari A, Singh G, Pandey S, Singh R (2021) Wnt\/\u03b2-catenin antagonist pyrvinium exerts cardioprotective effects in polymicrobial sepsis model by attenuating calcium dyshomeostasis and mitochondrial dysfunction. Cardiovasc Toxicol 21:517\u2013532","journal-title":"Cardiovasc Toxicol"}],"container-title":["Medical Molecular Morphology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00795-022-00343-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00795-022-00343-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00795-022-00343-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T15:07:33Z","timestamp":1684249653000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00795-022-00343-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,16]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["343"],"URL":"https:\/\/doi.org\/10.1007\/s00795-022-00343-8","relation":{},"ISSN":["1860-1480","1860-1499"],"issn-type":[{"type":"print","value":"1860-1480"},{"type":"electronic","value":"1860-1499"}],"subject":[],"published":{"date-parts":[[2023,1,16]]},"assertion":[{"value":"20 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}