{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:48:54Z","timestamp":1740142134821,"version":"3.37.3"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"JSPS KAKENHI","award":["JP15K08132"],"award-info":[{"award-number":["JP15K08132"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Mol Morphol"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s00795-023-00352-1","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T06:03:05Z","timestamp":1680156185000},"page":"177-186","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered microbiota caused by disordered gut motility leads to an overactivation of intestinal immune system in APC1638T mice"],"prefix":"10.1007","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1220-0814","authenticated-orcid":false,"given":"Nami O.","family":"Yamada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Wenduerma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Senda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"issue":"5020","key":"352_CR1","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1126\/science.1651562","volume":"253","author":"KW Kinzler","year":"1991","unstructured":"Kinzler KW, Nilbert MC, Su LK, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hedge P, McKechnie D et al (1991) Identification of FAP locus genes from chromosome 5q21. Science 253(5020):661\u2013665","journal-title":"Science"},{"issue":"3","key":"352_CR2","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/ncb0303-190","volume":"5","author":"R Fodde","year":"2003","unstructured":"Fodde R (2003) The multiple functions of tumour suppressors: it\u2019s all in APC. Nat Cell Biol 5(3):190\u2013192","journal-title":"Nat Cell Biol"},{"issue":"2","key":"352_CR3","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s00795-006-0352-5","volume":"40","author":"T Senda","year":"2007","unstructured":"Senda T, Iizuka-Kogo A, Onouchi T, Shimomura A (2007) Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia. Med Mol Morphol 40(2):68\u201381","journal-title":"Med Mol Morphol"},{"issue":"10","key":"352_CR4","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1101\/gad.13.10.1309","volume":"13","author":"R Smits","year":"1999","unstructured":"Smits R, Kielman MF, Breukel C, Zurcher C, Neufeld K, Jagmohan-Changur S, Hofland N, van Dijk J, White R, Edelmann W, Kucherlapati R, Khan PM, Fodde R (1999) Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev 13(10):1309\u20131321","journal-title":"Genes Dev"},{"key":"352_CR5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1756-6606-7-21","volume":"7","author":"T Onouchi","year":"2014","unstructured":"Onouchi T, Kobayashi K, Sakai K, Shimomura A, Smits R, Sumi-Ichinose C, Kurosumi M, Takao K, Nomura R, Iizuka-Kogo A, Suzuki H, Kondo K, Akiyama T, Miyakawa T, Fodde R, Senda T (2014) Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia. Mol Brain 7:21","journal-title":"Mol Brain"},{"issue":"1","key":"352_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00795-020-00257-3","volume":"54","author":"C Li","year":"2020","unstructured":"Li C, Onouchi T, Hirayama M, Sakai K, Matsuda S, Yamada NO, Senda T (2020) Morphological and functional abnormalities of hippocampus in APC(1638T\/1638T) mice. Med Mol Morphol 54(1):31\u201340","journal-title":"Med Mol Morphol"},{"issue":"2","key":"352_CR7","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s00795-016-0152-5","volume":"50","author":"T Wang","year":"2017","unstructured":"Wang T, Onouchi T, Yamada NO, Matsuda S, Senda T (2017) A disturbance of intestinal epithelial cell population and kinetics in APC1638T mice. Med Mol Morphol 50(2):94\u2013102","journal-title":"Med Mol Morphol"},{"key":"352_CR8","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00795-020-00279-x","volume":"54","author":"YNO Wenduerma","year":"2021","unstructured":"Wenduerma YNO, Wang T, Senda T (2021) A further study on a disturbance of intestinal epithelial cell population and kinetics in APC1638T mice. Med Mol Morphol. 54:203\u2013215","journal-title":"Med Mol Morphol."},{"issue":"3","key":"352_CR9","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s00795-011-0553-4","volume":"45","author":"A Yokoyama","year":"2012","unstructured":"Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A, Smits R, Fodde R, Itoh M, Senda T (2012) Some fine-structural findings on the thyroid gland in Apc1638T\/1638T mice that express a C-terminus lacking truncated Apc. Med Mol Morphol 45(3):161\u2013167","journal-title":"Med Mol Morphol"},{"key":"352_CR10","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00405-20","author":"A Nakajima","year":"2020","unstructured":"Nakajima A, Sasaki T, Itoh K, Kitahara T, Takema Y, Hiramatsu K, Ishikawa D, Shibuya T, Kobayashi O, Osada T, Watanabe S, Nagahara A (2020) A soluble fiber diet increases bacteroides fragilis group abundance and immunoglobulin a production in the gut. Appl Environ Microbiol. https:\/\/doi.org\/10.1128\/AEM.00405-20","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"352_CR11","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1271\/bbb.80612","volume":"73","author":"T Yanagibashi","year":"2009","unstructured":"Yanagibashi T, Hosono A, Oyama A, Tsuda M, Hachimura S, Takahashi Y, Itoh K, Hirayama K, Takahashi K, Kaminogawa S (2009) Bacteroides induce higher IgA production than Lactobacillus by increasing activation-induced cytidine deaminase expression in B cells in murine Peyer\u2019s patches. Biosci Biotechnol Biochem 73(2):372\u2013377","journal-title":"Biosci Biotechnol Biochem"},{"issue":"4","key":"352_CR12","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.imbio.2012.07.033","volume":"218","author":"T Yanagibashi","year":"2013","unstructured":"Yanagibashi T, Hosono A, Oyama A, Tsuda M, Suzuki A, Hachimura S, Takahashi Y, Momose Y, Itoh K, Hirayama K, Takahashi K, Kaminogawa S (2013) IgA production in the large intestine is modulated by a different mechanism than in the small intestine: Bacteroides acidifaciens promotes IgA production in the large intestine by inducing germinal center formation and increasing the number of IgA+ B cells. Immunobiology 218(4):645\u2013651","journal-title":"Immunobiology"},{"issue":"2","key":"352_CR13","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1128\/AEM.69.2.1251-1262.2003","volume":"69","author":"K Nagashima","year":"2003","unstructured":"Nagashima K, Hisada T, Sato M, Mochizuki J (2003) Application of new primer-enzyme combinations to terminal restriction fragment length polymorphism profiling of bacterial populations in human feces. Appl Environ Microbiol 69(2):1251\u20131262","journal-title":"Appl Environ Microbiol"},{"issue":"3","key":"352_CR14","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.mimet.2003.08.009","volume":"55","author":"GC Baker","year":"2003","unstructured":"Baker GC, Smith JJ, Cowan DA (2003) Review and re-analysis of domain-specific 16S primers. J Microbiol Methods 55(3):541\u2013555","journal-title":"J Microbiol Methods"},{"issue":"1","key":"352_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1348-0421.2004.tb03481.x","volume":"48","author":"H Hayashi","year":"2004","unstructured":"Hayashi H, Sakamoto M, Benno Y (2004) Evaluation of three different forward primers by terminal restriction fragment length polymorphism analysis for determination of fecal bifidobacterium spp in healthy subjects. Microbiol Immunol 48(1):1\u20136","journal-title":"Microbiol Immunol"},{"issue":"1\u20132","key":"352_CR16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jneumeth.2003.10.004","volume":"133","author":"RJ Phillips","year":"2004","unstructured":"Phillips RJ, Hargrave SL, Rhodes BS, Zopf DA, Powley TL (2004) Quantification of neurons in the myenteric plexus: an evaluation of putative pan-neuronal markers. J Neurosci Methods 133(1\u20132):99\u2013107","journal-title":"J Neurosci Methods"},{"issue":"1","key":"352_CR17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/BF00502095","volume":"82","author":"AE Bishop","year":"1985","unstructured":"Bishop AE, Carlei F, Lee V, Trojanowski J, Marangos PJ, Dahl D, Polak JM (1985) Combined immunostaining of neurofilaments, neuron specific enolase, GFAP and S-100. A possible means for assessing the morphological and functional status of the enteric nervous system. Histochemistry 82(1):93\u201397","journal-title":"Histochemistry"},{"issue":"1","key":"352_CR18","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/nn.3599","volume":"17","author":"O Butovsky","year":"2014","unstructured":"Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL (2014) Identification of a unique TGF-beta-dependent molecular and functional signature in microglia. Nat Neurosci 17(1):131\u2013143","journal-title":"Nat Neurosci"},{"issue":"1","key":"352_CR19","doi-asserted-by":"publisher","first-page":"11693","DOI":"10.1038\/s41598-020-68086-z","volume":"10","author":"MEV Swanson","year":"2020","unstructured":"Swanson MEV, Murray HC, Ryan B, Faull RLM, Dragunow M, Curtis MA (2020) Quantitative immunohistochemical analysis of myeloid cell marker expression in human cortex captures microglia heterogeneity with anatomical context. Sci Rep 10(1):11693","journal-title":"Sci Rep"},{"key":"352_CR20","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.3389\/fnins.2019.01291","volume":"13","author":"T Koizumi","year":"2019","unstructured":"Koizumi T, Kerkhofs D, Mizuno T, Steinbusch HWM, Foulquier S (2019) Vessel-associated immune cells in cerebrovascular diseases: from perivascular macrophages to vessel-associated microglia. Front Neurosci 13:1291","journal-title":"Front Neurosci"},{"key":"352_CR21","doi-asserted-by":"publisher","first-page":"701673","DOI":"10.3389\/fncel.2021.701673","volume":"15","author":"J Leyh","year":"2021","unstructured":"Leyh J, Paeschke S, Mages B, Michalski D, Nowicki M, Bechmann I, Winter K (2021) Classification of microglial morphological phenotypes using machine learning. Front Cell Neurosci 15:701673","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"352_CR22","doi-asserted-by":"publisher","first-page":"3250","DOI":"10.4049\/jimmunol.163.6.3250","volume":"163","author":"N Kohrgruber","year":"1999","unstructured":"Kohrgruber N, Halanek N, Groger M, Winter D, Rappersberger K, Schmitt-Egenolf M, Stingl G, Maurer D (1999) Survival, maturation, and function of CD11c- and CD11c+ peripheral blood dendritic cells are differentially regulated by cytokines. J Immunol 163(6):3250\u20133259","journal-title":"J Immunol"},{"issue":"4","key":"352_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154253","volume":"11","author":"J Qualai","year":"2016","unstructured":"Qualai J, Li LX, Cantero J, Tarrats A, Fernandez MA, Sumoy L, Rodolosse A, McSorley SJ, Genesca M (2016) Expression of CD11c Is associated with unconventional activated T cell subsets with high migratory potential. PLoS ONE 11(4):e0154253","journal-title":"PLoS ONE"},{"key":"352_CR24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.brainres.2008.09.070","volume":"1244","author":"C Freytag","year":"2008","unstructured":"Freytag C, Seeger J, Siegemund T, Grosche J, Grosche A, Freeman DE, Schusser GF, Hartig W (2008) Immunohistochemical characterization and quantitative analysis of neurons in the myenteric plexus of the equine intestine. Brain Res 1244:53\u201364","journal-title":"Brain Res"},{"issue":"2","key":"352_CR25","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1046\/j.1365-2982.2002.00317.x","volume":"14","author":"Z Lin","year":"2002","unstructured":"Lin Z, Gao N, Hu HZ, Liu S, Gao C, Kim G, Ren J, Xia Y, Peck OC, Wood JD (2002) Immunoreactivity of Hu proteins facilitates identification of myenteric neurones in guinea-pig small intestine. Neurogastroenterol Motil 14(2):197\u2013204","journal-title":"Neurogastroenterol Motil"},{"issue":"8","key":"352_CR26","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1111\/nmo.12371","volume":"26","author":"AS Desmet","year":"2014","unstructured":"Desmet AS, Cirillo C, Vanden BP (2014) Distinct subcellular localization of the neuronal marker HuC\/D reveals hypoxia-induced damage in enteric neurons. Neurogastroenterol Motil 26(8):1131\u20131143","journal-title":"Neurogastroenterol Motil"},{"issue":"8","key":"352_CR27","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.humpath.2009.12.012","volume":"41","author":"M Swaminathan","year":"2010","unstructured":"Swaminathan M, Kapur RP (2010) Counting myenteric ganglion cells in histologic sections: an empirical approach. Hum Pathol 41(8):1097\u20131108","journal-title":"Hum Pathol"},{"issue":"2","key":"352_CR28","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/cne.901010212","volume":"101","author":"CL Yntema","year":"1954","unstructured":"Yntema CL, Hammond WS (1954) The origin of intrinsic ganglia of trunk viscera from vagal neural crest in the chick embryo. J Comp Neurol 101(2):515\u2013541","journal-title":"J Comp Neurol"},{"issue":"1","key":"352_CR29","doi-asserted-by":"publisher","first-page":"G1","DOI":"10.1152\/ajpgi.00452.2012","volume":"305","author":"JI Lake","year":"2013","unstructured":"Lake JI, Heuckeroth RO (2013) Enteric nervous system development: migration, differentiation, and disease. Am J Physiol Gastrointest Liver Physiol 305(1):G1-24","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"352_CR30","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.neuron.2005.04.013","volume":"46","author":"LH Tsai","year":"2005","unstructured":"Tsai LH, Gleeson JG (2005) Nucleokinesis in neuronal migration. Neuron 46(3):383\u2013388","journal-title":"Neuron"},{"issue":"3","key":"352_CR31","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.neuron.2015.05.046","volume":"87","author":"LC Kapitein","year":"2015","unstructured":"Kapitein LC, Hoogenraad CC (2015) Building the neuronal microtubule cytoskeleton. Neuron 87(3):492\u2013506","journal-title":"Neuron"},{"key":"352_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105172","volume":"148","author":"ML Bennett","year":"2021","unstructured":"Bennett ML, Viaene AN (2021) What are activated and reactive glia and what is their role in neurodegeneration? Neurobiol Dis 148:105172","journal-title":"Neurobiol Dis"},{"issue":"1","key":"352_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/dnares\/dsn033","volume":"16","author":"M Hattori","year":"2009","unstructured":"Hattori M, Taylor TD (2009) The human intestinal microbiome: a new frontier of human biology. DNA Res 16(1):1\u201312","journal-title":"DNA Res"},{"issue":"4","key":"352_CR34","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/mi.2013.30","volume":"6","author":"NA Mabbott","year":"2013","unstructured":"Mabbott NA, Donaldson DS, Ohno H, Williams IR, Mahajan A (2013) Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium. Mucosal Immunol 6(4):666\u2013677","journal-title":"Mucosal Immunol"},{"issue":"7415","key":"352_CR35","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature11551","volume":"489","author":"CL Maynard","year":"2012","unstructured":"Maynard CL, Elson CO, Hatton RD, Weaver CT (2012) Reciprocal interactions of the intestinal microbiota and immune system. Nature 489(7415):231\u2013241","journal-title":"Nature"},{"issue":"6","key":"352_CR36","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","volume":"150","author":"F Mearin","year":"2016","unstructured":"Mearin F, Lacy BE, Chang L, Chey WD, Lembo AJ, Simren M, Spiller R (2016) Bowel disorders. Gastroenterology 150(6):1393\u20131407","journal-title":"Gastroenterology"}],"container-title":["Medical Molecular Morphology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00795-023-00352-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00795-023-00352-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00795-023-00352-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T16:12:42Z","timestamp":1691683962000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00795-023-00352-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["352"],"URL":"https:\/\/doi.org\/10.1007\/s00795-023-00352-1","relation":{},"ISSN":["1860-1480","1860-1499"],"issn-type":[{"type":"print","value":"1860-1480"},{"type":"electronic","value":"1860-1499"}],"subject":[],"published":{"date-parts":[[2023,3,30]]},"assertion":[{"value":"12 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The animal study proposal was approved by the Committee for Ethics in Animal Experimentation at Gifu University (permission number: 2019-004). All experiments were conducted in accordance with the relevant guidelines and regulations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}