{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:42:40Z","timestamp":1776883360169,"version":"3.51.2"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K07184"],"award-info":[{"award-number":["20K07184"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K06263"],"award-info":[{"award-number":["23K06263"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Mol Morphol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s00795-024-00391-2","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T11:01:59Z","timestamp":1720522919000},"page":"268-276","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High ambient temperature may induce presbyopia via TRPV1 activation"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-1944","authenticated-orcid":false,"given":"Yosuke","family":"Nakazawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumika","family":"Kuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hibiki","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Hiramatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Funakoshi-Tago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"391_CR1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000090645","volume":"38","author":"SJ McGinty","year":"2006","unstructured":"McGinty SJ, Truscott RJW (2006) Presbyopia: the first stage of nuclear cataract? Ophthalmic Res 38:137\u2013148","journal-title":"Ophthalmic Res"},{"key":"391_CR2","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1136\/bjo.65.12.869","volume":"65","author":"RA Weale","year":"1981","unstructured":"Weale RA (1981) Human ocular aging and ambient temperature. Br J Ophthalmol 65:869\u2013870","journal-title":"Br J Ophthalmol"},{"key":"391_CR3","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.3390\/cells9122670","volume":"9","author":"N Yamamoto","year":"2020","unstructured":"Yamamoto N, Takeda S, Hatsusaka N, Hiramatsu N, Nagai N, Deguchi S, Nakazawa Y, Takata T, Kodera S, Hirata A, Kubo E, Sasaki H (2020) Effect of a lens protein in low-temperature culture of novel immortalized human lens epithelial cells (iHLEC-NY2). Cells 9:2670","journal-title":"Cells"},{"key":"391_CR4","doi-asserted-by":"publisher","first-page":"123832","DOI":"10.1007\/s11356-023-31079-2","volume":"30","author":"K Kinoshita","year":"2023","unstructured":"Kinoshita K, Hodera S, Hatsusaka N, Egawa R, Takizawa H, Kubo E, Sasaki H, Hirata A (2023) Association of nuclear cataract prevalence with UV radiation and heat load in lens of older people -five city study. Environ Sci Pollut Res Int 30:123832\u2013123842","journal-title":"Environ Sci Pollut Res Int"},{"key":"391_CR5","first-page":"226","volume":"18","author":"RG O'Neil","year":"2003","unstructured":"O\u2019Neil RG, Brown RC (2003) The vanilloid receptor family of calcium-permeable channels: molecular integrators of microenvironmental stimuli. News Physiol Sci 18:226\u2013231","journal-title":"News Physiol Sci"},{"key":"391_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2019.107707","volume":"186","author":"Y Nakazawa","year":"2019","unstructured":"Nakazawa Y, Donaldson PJ, Petrova RS (2019) Verification and spatial mapping of TRPV1 and TRPV4 expression in the embryonic and adult mouse lens. Exp Eye Res 186:107707","journal-title":"Exp Eye Res"},{"key":"391_CR7","doi-asserted-by":"publisher","first-page":"10522","DOI":"10.1038\/s41598-017-11274-1","volume":"7","author":"A Berna-Erro","year":"2017","unstructured":"Berna-Erro A, Izquierdo-Serra M, Sep\u00falveda RV, Rubio-Moscardo F, Do\u00f1ate-Maci\u00e1n P, Serra SA, Carrillo-Garcia J, Per\u00e1lvarez-Mar\u00edn A, Gonz\u00e1lez-Nilo F, Fern\u00e1ndez-Fern\u00e1ndez JM, Valverde MA (2017) Structural determinants of 5\u2019,6\u2019-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel. Sci Rep 7:10522","journal-title":"Sci Rep"},{"key":"391_CR8","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.exer.2018.04.006","volume":"172","author":"A Mandal","year":"2018","unstructured":"Mandal A, Shahidullah M, Delamere NA (2018) TRPV1-dependent ERK1\/2 activation in porcine lens epithelium. Exp Eye Res 172:128\u2013136","journal-title":"Exp Eye Res"},{"key":"391_CR9","doi-asserted-by":"publisher","first-page":"C969","DOI":"10.1152\/ajpcell.00391.2019","volume":"318","author":"M Shahidullah","year":"2020","unstructured":"Shahidullah M, Mandal A, Mathias RT, Gao J, Kri\u017eaj D, Redmon S, Delamere NA (2020) TRPV1 activation stimulates NKCC1 and increases hydrostatic pressure in the mouse lens. Am J Physiol Cell Physiol 318:C969\u2013C980","journal-title":"Am J Physiol Cell Physiol"},{"key":"391_CR10","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.exer.2015.08.013","volume":"140","author":"M Shahidullah","year":"2015","unstructured":"Shahidullah M, Mandal A, Delamere NA (2015) Damage to lens fibre cells causes TRPV4-dependent Src family kinase activation in the epithelium. Exp Eye Res 140:85\u201393","journal-title":"Exp Eye Res"},{"key":"391_CR11","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1016\/j.bpj.2015.09.018","volume":"109","author":"J Gao","year":"2015","unstructured":"Gao J, Sun X, White TW, Delamere NA, Mathias RT (2015) Feedback regulation of intracellular hydrostatic pressure in surface cells of the lens. Biophys J 109:1830\u20131839","journal-title":"Biophys J"},{"key":"391_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2020.104009","volume":"126","author":"S Kodera","year":"2020","unstructured":"Kodera S, Hirata A, Miura F, Rashed EA, Hatsusaka N, Yamamoto N, Kubo E, Sasaki H (2020) Model-based approach for analyzing prevalence of nuclear cataracts in elderly residents. Comput Biol Med 126:104009","journal-title":"Comput Biol Med"},{"key":"391_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108840","volume":"213","author":"Y Sugiyama","year":"2021","unstructured":"Sugiyama Y, Nakazawa Y, Sakagami T, Kawata S, Nagai N, Yamamoto N, Funakoshi-Tago M, Tamura H (2021) Capsaicin attenuates TGF\u03b22-induced epithelial-mesenchymal-transition in lens epithelial cells in vivo and in vitro. Exp Eye Res 213:108840","journal-title":"Exp Eye Res"},{"key":"391_CR14","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s00795-021-00280-y","volume":"54","author":"N Hiramatsu","year":"2021","unstructured":"Hiramatsu N, Nagai N, Kondo M, Imaizumi K, Sasaki H, Yamamoto N (2021) Morphological comparison between three-dimensional structure of immortalized human lens epithelial cells and Soemmering\u2019s ring. Med Mol Morphol 54:216\u2013226","journal-title":"Med Mol Morphol"},{"key":"391_CR15","doi-asserted-by":"publisher","first-page":"539","DOI":"10.3892\/etm.2022.11476","volume":"24","author":"N Hiramatsu","year":"2022","unstructured":"Hiramatsu N, Yamamoto N, Kato Y, Nagai N, Isogai S, Imaizumi K (2022) Formation of three-dimensional cell aggregates expressing lens-specific proteins in various cultures of human iris-derived tissue cells and iPS cells. Exp Ther Med 24:539","journal-title":"Exp Ther Med"},{"key":"391_CR16","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1248\/bpb.30.6","volume":"30","author":"N Nagai","year":"2007","unstructured":"Nagai N, Fukuhata T, Ito Y (2007) Effect of magnesium deficiency on intracellular ATP levels in human lens epithelial cells. Biol Pharm Bull 30:6\u201310","journal-title":"Biol Pharm Bull"},{"key":"391_CR17","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3892\/mmr.2023.12990","volume":"27","author":"Y Doki","year":"2023","unstructured":"Doki Y, Nakazawa Y, Morishita N, Endo S, Nagai N, Yamamoto N, Tamura H, Funakoshi-Tago M (2023) Hesperetin treatment attenuates glycation of lens proteins and advanced-glycation end products generation. Mol Med Rep 27:103","journal-title":"Mol Med Rep"},{"key":"391_CR18","volume":"25","author":"Y Nakazawa","year":"2020","unstructured":"Nakazawa Y, Aoki M, Doki Y, Morishita N, Endo S, Nagai N, Funakoshi-Tago M, Tamura H (2020) Oral consumption of \u03b1-glucosyl-hesperidin could prevent lens hardening, which causes presbyopia. Biochem Biophys Rep 25:100885","journal-title":"Biochem Biophys Rep"},{"key":"391_CR19","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3390\/cells10020382","volume":"10","author":"Y Nakazawa","year":"2021","unstructured":"Nakazawa Y, Doki Y, Sugiyama Y, Kobayashi R, Nagai N< Morisita N, Endo S, Funakoshi-Tago M, Tamura H (2021) Effect of alpha-glucosyl-hesperidin consumption on lens sclerosis and presbyopia. Cells 10:382","journal-title":"Cells"},{"issue":"83","key":"391_CR20","first-page":"95","volume":"9","author":"B Thylefors","year":"2002","unstructured":"Thylefors B, Chylack LT Jr, Konyama K, Sasaki K, Sperduto R, Taylor HR, West S, WHO Cataract Grading Group (2002) A simplified cataract grading system. Ophthalmic Epidemiol. 9(83):95","journal-title":"Ophthalmic Epidemiol."},{"key":"391_CR21","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1001\/archopht.1965.00970040239022","volume":"74","author":"B Schwartz","year":"1965","unstructured":"Schwartz B (1965) Environmental temperature and the ocular temperature gradient. Arch Ophthalmol 74:237\u2013243","journal-title":"Arch Ophthalmol"},{"key":"391_CR22","doi-asserted-by":"publisher","first-page":"123832","DOI":"10.1007\/s11356-023-31079-2","volume":"30","author":"K Kinoshita","year":"2023","unstructured":"Kinoshita K, Kodera S, Hatsusaka N, Egawa R, Takizawa H, Kubo E, Sasaki H, Hirata A (2023) Association of nuclear cataract prevalence with UV radiation and heat load in lens of older people -five city study. Environ Sci Pollut Res Int 30:123832\u2013123842","journal-title":"Environ Sci Pollut Res Int"},{"key":"391_CR23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/cosmetics7020047","volume":"7","author":"SR Swa","year":"2020","unstructured":"Swa SR, Jeong-Yeon C, Kyeong-Sun L, Jung-No L, Chun ML, Sung-Min P (2020) Inhibitory effect of Manassantin B isolated from saururus chinensis on skin heat aging. Cosmetics 7:47","journal-title":"Cosmetics"},{"key":"391_CR24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12974-021-02162-7","volume":"18","author":"G-M Fakihd","year":"2021","unstructured":"Fakihd G-M, Baudouin C, Goazigo AR-L, Parsadaniantz SM (2021) Capsazepine decreases corneal pain syndrome in severe dry eye disease. J Neuroinflammation 18:111","journal-title":"J Neuroinflammation"},{"key":"391_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024535","volume":"6","author":"SF Ang","year":"2011","unstructured":"Ang SF, Moochhala SM, MacAry PA, Bhatia M (2011) Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-\u03baB signaling. PLoS ONE 6:e24535","journal-title":"PLoS ONE"},{"key":"391_CR26","doi-asserted-by":"publisher","first-page":"C793","DOI":"10.1152\/ajpcell.00252.2018","volume":"315","author":"M Shahidullah","year":"2018","unstructured":"Shahidullah M, Mandal A, Delamere NA (2018) Activation of TRPV1 channels leads to stimulation of NKCC1 cotransport in the lens. Am J Physiol Cell Physiol 315:C793\u2013C802","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Medical Molecular Morphology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00795-024-00391-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00795-024-00391-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00795-024-00391-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T13:07:15Z","timestamp":1730984835000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00795-024-00391-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["391"],"URL":"https:\/\/doi.org\/10.1007\/s00795-024-00391-2","relation":{},"ISSN":["1860-1480","1860-1499"],"issn-type":[{"value":"1860-1480","type":"print"},{"value":"1860-1499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]},"assertion":[{"value":"22 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Human samples were obtained after surgery at Kanazawa Medical University Hospital with informed consent. All human procedures were performed following the ethical guidelines set forth by the Kanazawa Medical University Research Ethics Committee (No. G101) and the Keio University Faculty of Pharmacy Research Ethics Committee (211117\u20131). All animal experiments were performed following the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research and were approved by the Kanazawa Medical University Animal Research Committee (No. 2021\u201308) and the Keio University Animal Research Committee (09061\u201310).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}