{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:12:34Z","timestamp":1783984354379,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2010,10,30]],"date-time":"2010-10-30T00:00:00Z","timestamp":1288396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Model"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1007\/s00894-010-0873-7","type":"journal-article","created":{"date-parts":[[2010,11,3]],"date-time":"2010-11-03T10:47:17Z","timestamp":1288781237000},"page":"1831-1840","source":"Crossref","is-referenced-by-count":15,"title":["Identification of novel 5-hydroxy-1H-indole-3-carboxylates with anti-HBV activities based on 3D QSAR studies"],"prefix":"10.1007","volume":"17","author":[{"given":"Hui-fang","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-xia","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-shen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-jie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-liang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-liang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,30]]},"reference":[{"key":"873_CR1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra031087","volume":"350","author":"D Ganem","year":"2004","unstructured":"Ganem D (2004) Hepatitis B virus infection\u2013natural history and clinical consequences. New Engl J Med 350:1118\u20131129","journal-title":"New Engl J Med"},{"key":"873_CR2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/01.mcg.0000123204.36471.be","volume":"38","author":"RMK Rerknimitr","year":"2004","unstructured":"Rerknimitr RMK, Nusont MB, Mahachai V, Kullavanijaya P (2004) Result of endoscopic biliary drainage in hilar cholangiocarcinoma. J Clin Gastroenterol 38:518\u2013523","journal-title":"J Clin Gastroenterol"},{"key":"873_CR3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1159\/000075001","volume":"46","author":"JSD Humphries","year":"2003","unstructured":"Humphries JSD (2003) Antivirals for the treatment of chronic hepatitis B:current and future options. Intervirology 46:413\u2013420","journal-title":"Intervirology"},{"key":"873_CR4","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1592\/phco.26.12.1745","volume":"26","author":"AM Woodland","year":"2006","unstructured":"Woodland AM (2006) Entecavir:a new nucleoside analog for the treatment of chronic hepatitis B Infection. Pharmacotherapy 26:1745\u20131757","journal-title":"Pharmacotherapy"},{"key":"873_CR5","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/hep.21422","volume":"44","author":"RJR Colonno","year":"2006","unstructured":"Colonno RJR, Baldick CJ, Levine S, Podornowski K, Yu CF, Walsh A, Fang J, Hsu M, Mazzucco C, Eggers B, Zhang S, Plym M, Klesczewski K, Tenney DJ (2006) Entecavir resistance is rare in nucleoside na\u00efve patients with hepatitis B. Hepatology 44:1656\u20131665","journal-title":"Hepatology"},{"key":"873_CR6","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.bmc.2005.08.041","volume":"14","author":"HF Chai","year":"2006","unstructured":"Chai HF, Zhao YF, Zhao CS, Gong P (2006) Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 6-bromo-5-hydroxy-1H-indole-3-carboxylates. Bioorg Med Chem 14:911\u2013917","journal-title":"Bioorg Med Chem"},{"key":"873_CR7","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1016\/j.bmc.2005.11.033","volume":"14","author":"CS Zhao","year":"2006","unstructured":"Zhao CS, Zhao YF, Chai HF, Gong P (2006) Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 5-hydroxy-1H-indole-3-carboxylates. Bioorg Med Chem 14:2552\u20132558","journal-title":"Bioorg Med Chem"},{"key":"873_CR8","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S1005-9040(06)60166-9","volume":"22","author":"CS Zhao","year":"2006","unstructured":"Zhao CS, Zhao YF, Chai HF, Gong P (2006) Synthesis and in vitro anti-hepatitis B virus activities of several ethyl 5-hydroxy-1H-indole-3-carboxylates. Chem Res Chin Univ 22:577\u2013583","journal-title":"Chem Res Chin Univ"},{"key":"873_CR9","unstructured":"aSYBYL [computer program]. Version 6.8. St Louis (MO):Tripos Associates"},{"key":"873_CR10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/jcc.540070419","volume":"7","author":"A Ghose","year":"1986","unstructured":"Ghose A, Crippen G (1986) Atomic Physicochemical parameters for three-dimensional structure-directed quantitative structure-activity relationships I. Partition coefficients as a measure of hydrophobicity. J Comput Chem 7:565\u2013577","journal-title":"J Comput Chem"},{"key":"873_CR11","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1021\/jo01346a503","volume":"31","author":"SA Monti","year":"1966","unstructured":"Monti SA (1966) The Nentizescu condensation of ethyl 3-aminocrotonate and 1, 4-benzoquinone. J Org Chem 31:2669\u20132672","journal-title":"J Org Chem"},{"key":"873_CR12","unstructured":"Grinev AN, Pershin GN (1990) 5-hydroxyindole-3-carboxylates derivatives and their use. WO 9008135"},{"key":"873_CR13","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1073\/pnas.84.4.1005","volume":"84","author":"MA Sells","year":"1987","unstructured":"Sells MA, Chen ML, Acs G (1987) Production of hepatitis B virus particles in Hep G2 cells transfectd with cloned hepatitis B virus DNA. Proc Natl Acad Sci USA 84:1005\u20131009","journal-title":"Proc Natl Acad Sci USA"},{"key":"873_CR14","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1128\/JVI.62.8.2836-2844.1988","volume":"62","author":"MA Sells","year":"1988","unstructured":"Sells MA, Zelent AZ, MGAcs S (1988) Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions. J Virol 62:2836\u20132844","journal-title":"J Virol"},{"key":"873_CR15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0166-3542(92)90056-B","volume":"19","author":"BE Korba","year":"1992","unstructured":"Korba BE, Gerin JL (1992) Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication. Antivir Res 19:55\u201370","journal-title":"Antivir Res"},{"key":"873_CR16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0166-3542(95)00050-V","volume":"28","author":"BE Korba","year":"1995","unstructured":"Korba BE, Gerin JL (1995) Antisense oligonucleotides are effective inhibitors of hepatitis B virus replication in vitro. Antivir Res 28:225\u2013242","journal-title":"Antivir Res"},{"key":"873_CR17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1021\/jm901237x","volume":"53","author":"ZL Lv","year":"2010","unstructured":"Lv ZL, Sheng CQ, Wang TT, Zhang YK, Liu J, Feng JL, Sun HL, Zhong HY, Niu CJ, Li K (2010) Design, synthesis, and antihepatitis B virus activities of novel 2-pyridone derivatives. J Med Chem 53:660\u2013668","journal-title":"J Med Chem"},{"key":"873_CR18","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1016\/j.bmcl.2009.02.122","volume":"19","author":"Q Zhang","year":"2009","unstructured":"Zhang Q, Jiang ZY, Luo J, Liu JF, Ma YB, Guo RH, Zhang XM, Zhou J, Chen JJ (2009) Anti-HBV agents. Part 2:synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives. Bioorg Med Chem Lett 19:2148\u20132153","journal-title":"Bioorg Med Chem Lett"}],"container-title":["Journal of Molecular Modeling"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00894-010-0873-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00894-010-0873-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00894-010-0873-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T13:35:34Z","timestamp":1592055334000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00894-010-0873-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,30]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["873"],"URL":"https:\/\/doi.org\/10.1007\/s00894-010-0873-7","relation":{},"ISSN":["1610-2940","0948-5023"],"issn-type":[{"value":"1610-2940","type":"print"},{"value":"0948-5023","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,30]]}}}