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In order to improve decision making concerning the therapy, we examined the change of patients\u2019 quality of life (QoL) after surgical treatment of MRONJ stage III.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>The primary outcome variable was patients\u2019 QoL. It was preoperative (T0), 6 weeks postoperative (T1) and 6 months postoperative (T2) assessed by the European Organisation for Research and Treatment of Cancer QoL-H&amp;N35 (EORTC QoL-H&amp;N35) and the Oral Health Impact Factor-G14 (OHIP-G14) questionnaire in a prospective cohort study. Other variables included location, age, sex, risk factors, and recurrence. Descriptive statistics and general multivariate regression models were calculated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Forty-three patients with stage III MRONJ underwent surgery. OHIP-G14 scores decreased (improvement) statistically significant (<jats:italic>p<\/jats:italic> = .001) by 52.02% (T0-T1) and 56.45% (T1\u2013T2). EORTC QoL-H&amp;N35 showed statistical improvement for \u201cswallowing\u201d (<jats:italic>p<\/jats:italic> = .007), \u201copening mouth\u201d (<jats:italic>p<\/jats:italic> = .045), \u201cpainkiller\u201d (.005), \u201cweight loss\u201d (.004), \u201cpain\u201d (<jats:italic>p<\/jats:italic> = .001), \u201ctrouble with social eating\u201d (<jats:italic>p<\/jats:italic> = .001), \u201ctrouble with social contact\u201d (<jats:italic>p<\/jats:italic> = .001), and \u201cteeth\u201d (<jats:italic>p<\/jats:italic> = .001). Patients who developed a recurrence did not show any significant higher (worse) scores in OHIP G14 or EORTC QoL-H&amp;N35 scores compared with patients without recurrence. Twenty-nine out of 36 patients showed full mucosal healing (T2). For patients with no full mucosal healing, a downgrade to stage I was achieved.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In terms of QoL patients with stage III MRONJ do benefit from surgical treatment. The incident of a recurrence seems to have no significant impact on patients QoL.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10006-020-00927-7","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T14:03:43Z","timestamp":1606140223000},"page":"359-366","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Patients\u2019 quality of life improves after surgical intervention of stage III medication-related osteonecrosis of the jaw"],"prefix":"10.1007","volume":"25","author":[{"given":"Stefan","family":"Moll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes K.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten E.","family":"Reichert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Ettl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-9216","authenticated-orcid":false,"given":"Christoph","family":"Klingelh\u00f6ffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"927_CR1","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","volume":"61","author":"RE Marx","year":"2003","unstructured":"Marx RE (2003) Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. 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