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Patients were between 17 and 53\u00a0years old and diagnosed with Angle class I, II, or III malocclusion. By using the validated open-source software \u201cITK-SNAP,\u201d the volumetric measurements of 174 mandibular condyles were performed. Volumetric analysis was performed according to intra-subject side differences by paired Student t test. In accordance to inter-subject side, gender, age and type of malocclusion differences bivariate analysis and ANOVA were applied.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean volume for the right condyle was 1.378\u2009\u00b1\u20090.447 cm<jats:sup>3<\/jats:sup>, with a maximum of 2.379 cm<jats:sup>3<\/jats:sup> and a minimum of 0.121 cm<jats:sup>3<\/jats:sup>. The mean volume for the left side was 1.435\u2009\u00b1\u20090.474 cm<jats:sup>3<\/jats:sup>, with a maximum of 3.264 cm<jats:sup>3<\/jats:sup> and a minimum of 0.109 cm<jats:sup>3<\/jats:sup>. Bivariate analysis indicated a highly significant inter-subject difference between the volume of the left and right mandibular condyles (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Females had a significantly smaller condyle volume than males (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 left condyle; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01 right condyle).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The fact that shape and volume of mandibular condyles show a high susceptibility to pathological alterations and particularly malocclusions makes a precise knowledge about volumetric changes indispensable. Our results show that significant inter-subject differences in condyle volume could be found with respect to the side and gender. Larger volumes could be assessed for the left condyle and for male patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10006-021-00976-6","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T17:02:52Z","timestamp":1623344572000},"page":"205-212","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A volumetric study of mandibular condyles in orthognathic patients by semiautomatic segmentation"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2041-5687","authenticated-orcid":false,"given":"Max-Philipp","family":"Lentzen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Riekert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Buller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Grandoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Zirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim E.","family":"Zoeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kreppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"issue":"3","key":"976_CR1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1053\/j.sult.2007.02.002","volume":"28","author":"X Alomar","year":"2007","unstructured":"Alomar X, Medrano J, Cabratosa J, Clavero JA, Lorente M, Serra I, Monill JM, Salvador A (2007) Anatomy of the temporomandibular joint. 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