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For 3\u00a0days after surgery, the control group was prescribed ibuprofen 400\u00a0mg every 8\u00a0h. On the other hand, the experimental group received also ibuprofen 400\u00a0mg at breakfast and lunch, replacing the dinner intake with a placebo. Pain measurements (Visual Analog Scale from 0 to 10) were recorded at baseline, 24, 48, and 72\u00a0h postoperatively. Facial swelling and trismus were also measured at baseline, 24, and 72\u00a0h postoperatively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Postoperative swelling and pain perception did not show significative difference between the control and experimental groups at 24, 48, and 72\u00a0h. Trismus was significantly lower in the control group than in the experimental group at 72\u00a0h postoperatively (<jats:italic>p<\/jats:italic>\u2009=\u20090.008). Rescue medication consumption seemed to be comparable between groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Eliminating night time ibuprofen might be insignificant for pain control after third molar extraction.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10006-022-01104-8","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T01:02:17Z","timestamp":1659488537000},"page":"699-706","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-8700","authenticated-orcid":false,"given":"Fabi\u00e1n","family":"P\u00e9rez-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0955-0055","authenticated-orcid":false,"given":"Mohammad","family":"Abusamak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-2335","authenticated-orcid":false,"given":"Luis Miguel","family":"S\u00e1ez-Alcaide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-9209","authenticated-orcid":false,"given":"Jesus Torres","family":"Garc\u00eda-Denche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4618-8374","authenticated-orcid":false,"given":"Faleh Ahmad Tamimi","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"issue":"7","key":"1104_CR1","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1259\/dmfr\/22263461","volume":"41","author":"FS Neves","year":"2012","unstructured":"Neves FS, Souza TC, Almeida SM, Haiter-Neto F, Freitas DQ, B\u00f3scolo FN (2012) Correlation of panoramic radiography and cone beam CT findings in the assessment of the relationship between impacted mandibular third molars and the mandibular canal. 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