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The study analyzed the peri-implant bone around loaded and unloaded implants retrieved from human mandible after 4 months from placement.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>The composition and mineralization of human bone were analyzed through an innovative protocol technique using Environmental-Scanning-Electron-Microscopy connected with Energy-Dispersive-X-Ray-Spectroscopy (ESEM\/EDX). Two regions of interest (ROIs, approximately 750\u00d7500 \u03bcm) for each bone implant sample were analyzed at the cortical (Cortical ROI) and apical (Apical ROI) implant threads. Calcium, phosphorus, and nitrogen (atomic%) were determined using EDX, and the specific ratios (Ca\/N, P\/N, and Ca\/P) were calculated as mineralization indices.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eighteen implant biopsies from ten patients were analyzed (unloaded implants, <jats:italic>n<\/jats:italic>=10; loaded implants, <jats:italic>n<\/jats:italic>=8). For each ROI, four bone areas (defined bones 1\u20134) were detected. These areas were characterized by different mineralization degree, varied Ca, P and N content, and different ratios, and by specific grayscale intensity detectable by ESEM images. Bony tissue in contact with loaded implants at the cortical ROI showed a higher percentage of low mineralized bone (bone 1) and a lower percentage of remodeling bone (bone 2) when compared to unloaded implants. The percentage of highly mineralized bone (bone 3) was similar in all groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Cortical and apical ROIs resulted in a puzzle of different bone \u201cislands\u201d characterized by various rates of mineralization. Only the loaded implants showed a high rate of mineralization in the cortical ROI.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10006-023-01175-1","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T18:01:47Z","timestamp":1693850507000},"page":"623-637","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mineralization and morphology of peri-implant bone around loaded and unloaded dental implants retrieved from the human mandible"],"prefix":"10.1007","volume":"28","author":[{"given":"Fausto","family":"Zamparini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Gandolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Spinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Iezzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Prati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"1175_CR1","first-page":"282","volume":"20","author":"GE Romanos","year":"2005","unstructured":"Romanos GE, Johansson CB (2005) Immediate loading with complete implant-supported restorations in an edentulous heavy smoker: histologic and histomorphometric analyses. 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