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Maxillofacial findings can be diagnostic, especially in the evaluation of discrete facial dysmorphia. Diagnostic landmark findings of therapeutic relevance for the jaws such as central giant cell granuloma (CGCG) are rare in NS. However, recent molecular genetic studies indicate that these rare, benign lesions are neoplasms and more common in specific syndromes grouped under the umbrella term RASopathies. A specialist surgical diagnosis can be helpful in identifying the underlying disease. This report outlines diagnosis and treatment of a case of CGCG for which jaw diagnosis became the key to identifying a syndromic disease.<\/jats:p>","DOI":"10.1007\/s10006-024-01209-2","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T01:02:51Z","timestamp":1707786171000},"page":"991-997","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multiple central giant cell granuloma of the jaws: diagnostic signposts of Noonan syndrome and RASopathy"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-9636","authenticated-orcid":false,"given":"Reinhard E.","family":"Friedrich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rico","family":"Rutkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Gosau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"1209_CR1","volume-title":"GeneReviews\u00ae","author":"AE Roberts","year":"2001","unstructured":"Roberts AE (2001) Noonan Syndrome. 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