{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:01:04Z","timestamp":1793055664608,"version":"4.5.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005642","name":"Universit\u00e0 degli Studi di Sassari","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005642","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oral Maxillofac Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Total maxillectomy for malignant tumors presents significant challenges for functional and aesthetic rehabilitation. Advances in digital planning and additive manufacturing have reintroduced subperiosteal implants as a promising solution for primary reconstructions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>This report details the case of a 59-year-old male with squamous cell carcinoma of the hard palate extending contralaterally, treated with a total maxillectomy and primary reconstruction using an osteomyocutaneous fibula free flap combined with a custom-made, additively manufactured subperiosteal implant. Preoperative planning integrated craniofacial CT scans, dental impressions, and lower limb angiography to design both the implant and fibula cutting guides. The implant, fabricated via direct metal laser sintering, provided a stable framework for fibular segments and future prosthetic rehabilitation. At two years post-surgery, the patient remains disease-free, with no complications and fully functional prosthetic integration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case highlights the feasibility, adaptability, and potential benefits of additively manufactured implants in reconstructing total maxillectomy defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial number<\/jats:title>\n                    <jats:p>N\/A<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10006-025-01379-7","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T22:20:31Z","timestamp":1745187631000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Primary reconstruction of total maxillectomy defect with additively manufactured subperiosteal implant and fibula free flap: a case report"],"prefix":"10.1007","volume":"29","author":[{"given":"Giacomo","family":"De Riu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Biglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Baj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Maniaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome R.","family":"Lechien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Angelo","family":"Vaira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"1379_CR1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/ger.12253","volume":"34","author":"A Yanagi","year":"2017","unstructured":"Yanagi A, Murase M, Sumita YI, Taniguchi H (2017) Investigation of nutritional status using the mini nutritional Assessment-Short form and analysis of the relevant factors in patients with head and neck tumor. 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Plast Reconstr Surg.;154(3):601e-618e. doi: 10.1097\/PRS.0000000000011476. Epub 2024 Aug 26. PMID: 39196869","DOI":"10.1097\/PRS.0000000000011476"},{"key":"1379_CR5","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1111\/joor.13043","volume":"47","author":"DJM Buurman","year":"2020","unstructured":"Buurman DJM, Speksnijder CM, de Groot RJ, Kessler P, Rieger JM (2020) Mastication in maxillectomy patients: a comparison between reconstructed maxillae and implant supported obturators: a cross-sectional study. J Oral Rehabil 47:1171\u20131177","journal-title":"J Oral Rehabil"},{"key":"1379_CR6","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.jcms.2024.06.016","volume":"52","author":"LA Vaira","year":"2024","unstructured":"Vaira LA, Biglio A, Roy M, Salzano G, Troise S, Abbate V et al (2024) Full-arch rehabilitation of severely atrophic maxilla with additively manufactured custom-made subperiosteal implants: A multicenter retrospective study. J Craniomaxillofac Surg 52:991:998","journal-title":"J Craniomaxillofac Surg"},{"key":"1379_CR7","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ijom.2024.01.003","volume":"53","author":"LA Vaira","year":"2024","unstructured":"Vaira LA, Biglio A, Favro A, Salzano G, Abbate V, Lechien JR, De Riu G (2024a) Implant-prosthetic rehabilitation of the atrophic posterior mandible with additively manufactured custom-made subperiosteal implants: a cohort study. Int J Oral Maxillofac Surg 53:533\u2013554","journal-title":"Int J Oral Maxillofac Surg"},{"key":"1379_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2024.101917","author":"LA Vaira","year":"2024","unstructured":"Vaira LA, Biglio A, Salzano G, Lechien JR, De Riu G (2024) Additively manufactured custom-made subperiosteal implant rehabilitation for severely atrophic maxillary molar area: A technical note. J Stomatol Oral Maxillofac Surg. https:\/\/doi.org\/10.1016\/j.jormas.2024.101917Epub ahead of print","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"1379_CR9","doi-asserted-by":"publisher","unstructured":"Gellrich NC, Korn P, Neuhaus M, Lentge F, Jehn P, Rahlf B (2025) Long-Term Survival of Subperiosteal Implants: Meta-Analysis and Current Status of Subperiosteal Implants for Dental Rehabilitation. Oral Maxillofac Surg Clin North Am.;37(1):163\u2013177. https:\/\/doi.org\/10.1016\/j.coms.2024.09.006. PMID: 39578012","DOI":"10.1016\/j.coms.2024.09.006"},{"key":"1379_CR10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ijom.2018.06.010","volume":"48","author":"N Vosselman","year":"2019","unstructured":"Vosselman N, Marema BJ, Schepman KP, Raghoebar GM (2019) Patient-specific sub-periosteal zygoma implant for prosthetic rehabilitation of large maxillary defects after oncological resection. 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The authors affirm that human research participant provided informed consent for publication of the images in Figs.\u00a0\n                      \n                      ,\n                      \n                      ,\n                      \n                      ,\n                      \n                      and\n                      \n                      .","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"86"}}