{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:58:15Z","timestamp":1788836295255,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oral Maxillofac Surg"],"DOI":"10.1007\/s10006-025-01419-2","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T03:40:27Z","timestamp":1750304427000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adjunctive use of posaconazole, hyperbaric oxygen therapy, and methylene blue for COVID-19-associated mucormycosis"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1444-7191","authenticated-orcid":false,"given":"Sujata","family":"Mohanty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-9599","authenticated-orcid":false,"given":"Neeraj","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemavathy","family":"S.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpit","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chayanika","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"1419_CR1","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1093\/clinids\/10.3.551","volume":"10","author":"BJ Ferguson","year":"1988","unstructured":"Ferguson BJ, Mitchell TG, Moon R, Camporesi EM, Farmer J (1988) Adjunctive hyperbaric oxygen for treatment of rhinocerebral mucormycosis. Clin Infect Dis 10:551\u2013559. https:\/\/doi.org\/10.1093\/clinids\/10.3.551","journal-title":"Clin Infect Dis"},{"key":"1419_CR2","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/j.1469-0691.2009.02986.x","volume":"15","author":"A Tragiannidis","year":"2009","unstructured":"Tragiannidis A, Groll AH (2009) Hyperbaric oxygen therapy and other adjunctive treatments for zygomycosis. Clin Microbiol Infect 15:82\u201386. https:\/\/doi.org\/10.1111\/j.1469-0691.2009.02986.x","journal-title":"Clin Microbiol Infect"},{"key":"1419_CR3","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1016\/j.jobcr.2016.10.005","volume":"6","author":"S Rai","year":"2016","unstructured":"Rai S, Yadav S, Kumar D, Kumar V, Rattan V (2016) Management of rhinomaxillary mucormycosis with posaconazole in immunocompetent patients. J Oral Biol Craniofac Res 6:S5\u20138. https:\/\/doi.org\/10.1016\/j.jobcr.2016.10.005","journal-title":"J Oral Biol Craniofac Res"},{"key":"1419_CR4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.2174\/1874285801610010012","volume":"10","author":"MA Ansari","year":"2016","unstructured":"Ansari MA, Fatima Z, Hameed S (2016) Antifungal action of methylene blue involves mitochondrial dysfunction and disruption of redox and membrane homeostasis in C. albicans. Open Microbiol J 10:12\u201322. https:\/\/doi.org\/10.2174\/1874285801610010012","journal-title":"Open Microbiol J"},{"key":"1419_CR5","doi-asserted-by":"publisher","first-page":"3620","DOI":"10.3390\/jcm11133620","volume":"11","author":"Y Madhavan","year":"2022","unstructured":"Madhavan Y, Sai KV, Shanmugam DK, Manimaran A, Guruviah K, Mohanta YK et al (2022) Current treatment options for COVID-19 associated mucormycosis: present status and future perspectives. J Clin Med 11:3620. https:\/\/doi.org\/10.3390\/jcm11133620","journal-title":"J Clin Med"},{"key":"1419_CR6","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s43163-023-00388-1","volume":"39","author":"L Pathak","year":"2023","unstructured":"Pathak L, Tripathi A, Nayyar SS, Kurkure R, Yadav A, Mishra J et al (2023) Management of post-COVID mucormycosis at a tertiary care center in Northern India. Egypt J Otolaryngol 39:19. https:\/\/doi.org\/10.1186\/s43163-023-00388-1","journal-title":"Egypt J Otolaryngol"},{"key":"1419_CR7","doi-asserted-by":"publisher","first-page":"3344","DOI":"10.1007\/s12070-022-03197-9","volume":"74","author":"KM Rao","year":"2022","unstructured":"Rao KM, Pooja N (2022) Management of mucormycosis in post COVID-19 patients and its outcome in a tertiary care center: our experience. Indian J Otolaryngol Head Neck Surg 74:3344\u20133351. https:\/\/doi.org\/10.1007\/s12070-022-03197-9","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"1419_CR8","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s15010-022-01891-y","volume":"51","author":"M Sahu","year":"2023","unstructured":"Sahu M, Shah M, Mallela VR, Kola VR, Boorugu HK, Punjani AAR et al (2023) COVID-19 associated multisystemic mucormycosis from india: a multicentric retrospective study on clinical profile, predisposing factors, cumulative mortality and factors affecting outcome. Infection 51:407\u2013416. https:\/\/doi.org\/10.1007\/s15010-022-01891-y","journal-title":"Infection"},{"key":"1419_CR9","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.cmi.2023.03.008","volume":"29","author":"L \u00d6zbek","year":"2023","unstructured":"\u00d6zbek L, Top\u00e7u U, Manay M, Esen BH, Bektas SN, Ayd\u0131n S et al (2023) COVID-19\u2013associated mucormycosis: a systematic review and meta-analysis of 958 cases. Clin Microbiol Infect 29:722\u2013731. https:\/\/doi.org\/10.1016\/j.cmi.2023.03.008","journal-title":"Clin Microbiol Infect"},{"key":"1419_CR10","doi-asserted-by":"publisher","first-page":"794176","DOI":"10.3389\/fmicb.2021.794176","volume":"12","author":"S Dogra","year":"2022","unstructured":"Dogra S, Arora A, Aggarwal A, Passi G, Sharma A, Singh G et al (2022) Mucormycosis amid COVID-19 crisis: pathogenesis, diagnosis, and novel treatment strategies to combat the spread. Front Microbiol 12:794176. https:\/\/doi.org\/10.3389\/fmicb.2021.794176","journal-title":"Front Microbiol"},{"key":"1419_CR11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3390\/jof5010026","volume":"5","author":"H Prakash","year":"2019","unstructured":"Prakash H, Chakrabarti A (2019) Global epidemiology of mucormycosis. J Fungi 5:26. https:\/\/doi.org\/10.3390\/jof5010026","journal-title":"J Fungi"},{"key":"1419_CR12","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3390\/jof6040265","volume":"6","author":"A Skiada","year":"2020","unstructured":"Skiada A, Pavleas I, Drogari-Apiranthitou M (2020) Epidemiology and diagnosis of mucormycosis: an update. J Fungi 6:265. https:\/\/doi.org\/10.3390\/jof6040265","journal-title":"J Fungi"},{"key":"1419_CR13","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1007\/s12070-023-03838-7","volume":"75","author":"K Goel","year":"2023","unstructured":"Goel K, Dhillon J, Yadav V, Bhagat S, Aggarwal A (2023) Post-Covid isolated mandibular mucormycosis in a patient with chronic kidney disease: A case report. Indian J Otolaryngol Head Neck Surg 75:2538\u20132543. https:\/\/doi.org\/10.1007\/s12070-023-03838-7","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"1419_CR14","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1007\/s12070-021-02925-x","volume":"74","author":"S Dasukil","year":"2022","unstructured":"Dasukil S, Boyina KK, Sarkar S, Hallur V, Nayak A, Mishra AK et al (2022) Management of Covid associated mucormycosis of mandible: A mountain beneath a Molehill\u2014A lesson learnt. Indian J Otolaryngol Head Neck Surg 74:3481\u20133484. https:\/\/doi.org\/10.1007\/s12070-021-02925-x","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"1419_CR15","volume-title":"Oral and maxillofacial infections","author":"RG Topazian","year":"2002","unstructured":"Topazian RG, Goldberg MH, Hupp JR (2002) Oral and maxillofacial infections, 4th edn. W.B. Saunders, Philadelphia","edition":"4"},{"key":"1419_CR16","doi-asserted-by":"publisher","first-page":"218","DOI":"10.14712\/18059694.2022.5","volume":"64","author":"MK Jawanda","year":"2021","unstructured":"Jawanda MK, Narula R, Gupta S, Sharma V, Sidhu SK, Kaur N (2021) Mixed infections (Mucormycosis, actinomycosis and Candidiasis) leading to maxillary osteomyelitis in a diabetic mellitus patient in post COVID phase: first case report. Acta Med Hradec Kralove Czech Repub 64:218\u2013223. https:\/\/doi.org\/10.14712\/18059694.2022.5","journal-title":"Acta Med Hradec Kralove Czech Repub"},{"key":"1419_CR17","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3109\/1040841X.2012.711741","volume":"39","author":"JJ Vehreschild","year":"2013","unstructured":"Vehreschild JJ, Birtel A, Vehreschild MJGT, Liss B, Farowski F, Kochanek M et al (2013) Mucormycosis treated with posaconazole: review of 96 case reports. Crit Rev Microbiol 39:310\u2013324. https:\/\/doi.org\/10.3109\/1040841X.2012.711741","journal-title":"Crit Rev Microbiol"},{"key":"1419_CR18","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3109\/08880018.2013.770587","volume":"30","author":"M Almannai","year":"2013","unstructured":"Almannai M, Imran H, Estrada B, Siddiqui AH (2013) Successful treatment of Rhino-Orbital mucormycosis with posaconazole and hyperbaric oxygen therapy. Pediatr Hematol Oncol 30:184\u2013186. https:\/\/doi.org\/10.3109\/08880018.2013.770587","journal-title":"Pediatr Hematol Oncol"},{"key":"1419_CR19","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.1093\/jac\/dkz344","volume":"74","author":"J Salmanton-Garc\u00eda","year":"2019","unstructured":"Salmanton-Garc\u00eda J, Seidel D, Koehler P, Mellinghoff SC, Herbrecht R, Klimko N et al (2019) Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn). J Antimicrob Chemother 74:3315\u20133327. https:\/\/doi.org\/10.1093\/jac\/dkz344","journal-title":"J Antimicrob Chemother"},{"key":"1419_CR20","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s40265-020-01306-y","volume":"80","author":"L Chen","year":"2020","unstructured":"Chen L, Krekels EHJ, Verweij PE, Buil JB, Knibbe CAJ, Br\u00fcggemann RJM (2020) Pharmacokinetics and pharmacodynamics of posaconazole. Drugs 80:671\u2013695. https:\/\/doi.org\/10.1007\/s40265-020-01306-y","journal-title":"Drugs"},{"key":"1419_CR21","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/j.1469-0691.2005.01170.x","volume":"11","author":"BV John","year":"2005","unstructured":"John BV, Chamilos G, Kontoyiannis DP (2005) Hyperbaric oxygen as an adjunctive treatment for zygomycosis. Clin Microbiol Infect 11:515\u2013517. https:\/\/doi.org\/10.1111\/j.1469-0691.2005.01170.x","journal-title":"Clin Microbiol Infect"},{"key":"1419_CR22","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1001\/archotol.1988.01860190095032","volume":"114","author":"L Couch","year":"1988","unstructured":"Couch L, Theilen F, Mader JT (1988) Rhinocerebral mucormycosis with cerebral extension successfully treated with adjunctive hyperbaric oxygen therapy. Arch Otolaryngol - Head Neck Surg 114:791\u2013794. https:\/\/doi.org\/10.1001\/archotol.1988.01860190095032","journal-title":"Arch Otolaryngol - Head Neck Surg"},{"key":"1419_CR23","first-page":"355","volume":"9","author":"E Segal","year":"2007","unstructured":"Segal E, Menhusen MJ, Simmons S (2007) Hyperbaric oxygen in the treatment of invasive fungal infections: A Single-Center experience. Isr Med Assoc J 9:355\u2013357","journal-title":"Isr Med Assoc J"},{"key":"1419_CR24","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s11046-019-00321-2","volume":"184","author":"Z Liu","year":"2019","unstructured":"Liu Z, Tang J, Sun Y, Gao L (2019) Effects of photodynamic inactivation on the growth and antifungal susceptibility of rhizopus oryzae. Mycopathologia 184:315\u2013319. https:\/\/doi.org\/10.1007\/s11046-019-00321-2","journal-title":"Mycopathologia"},{"key":"1419_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/3759704","volume":"2018","author":"R Pal","year":"2018","unstructured":"Pal R, Ansari MA, Saibabu V, Das S, Fatima Z, Hameed S (2018) Nonphotodynamic roles of methylene blue: display of distinct antimycobacterial and anticandidal mode of actions. J Pathog 2018:1\u201313. https:\/\/doi.org\/10.1155\/2018\/3759704","journal-title":"J Pathog"},{"key":"1419_CR26","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.ajem.2020.09.032","volume":"42","author":"A Werthman-Ehrenreich","year":"2021","unstructured":"Werthman-Ehrenreich A (2021) Mucormycosis with orbital compartment syndrome in a patient with COVID-19. Am J Emerg Med 42:264.e5-264.e8","journal-title":"Am J Emerg Med"}],"container-title":["Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10006-025-01419-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10006-025-01419-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10006-025-01419-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T02:11:36Z","timestamp":1765159896000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10006-025-01419-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,19]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1419"],"URL":"https:\/\/doi.org\/10.1007\/s10006-025-01419-2","relation":{},"ISSN":["1865-1569"],"issn-type":[{"value":"1865-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,19]]},"assertion":[{"value":"30 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Institutional Review Board (IRB) approval was taken for this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"126"}}