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Systematic reviews with or without meta-analysis investigating the effect of different interventions on soft and hard tissue healing after third molar surgery were considered. Methodological quality of included reviews was assessed with AMSTAR-2 tool. The degree of overlapping of index publications in the eligible reviews was presented and calculated with the GROOVE tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-three reviews were included, collectively encompassing 191 distinct primary studies that evaluated flap design, extraction socket management, and postsurgical care. Quantitative data retrieved from the methodologically rigorous MAs revealed that the application of autologous platelet concentrates (APCs) is the best choice to improve soft tissue healing [MD\u2009=\u20091.01; 95% CI (0.77, 1.24), 7 days follow-up] and bone mineral density [SMD\u2009=\u20092.34; 95% CI (0.18,4.51), 4 months follow-up] and alleviate pain [SMD= -0.86; 95% CI (-1.26, -0.46), 3 days follow-up], trismus [SMD= -0.26; 95% CI (-0.48, -0.03), 7 days follow-up], alveolar osteitis [RR\u2009=\u20090.43; 95% CI (0.28, 0.65)] and swelling [MD= -1.66; 95% CI (-2.43, -0.90), 3 days follow-up]. Ridge preservation is the most effective intervention in improving pocket probing depth [MD= -1.42; 95% CI (-2.01, -0.83), 6\u201372 months follow-up], clinical attachment level [MD\u2009=\u20091.98; 95% CI (1.44, 2.52), 4.5-72months follow-up] and alveolar bone height [MD\u2009=\u20091.21; 95% CI (0.21, 2.21), 6\u201312 months follow-up] distal to mandibular second molar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Minimizing tissue trauma is key in surgical extractions. Our overview found that triangular flaps reduce PPD, while envelope flaps lower postoperative pain. APCs improved healing and reduced adverse events, and HyA mainly alleviated pain. All regenerative techniques enhanced periodontal outcomes, though high heterogeneity and variable study quality urge cautious interpretation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10006-025-01432-5","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T03:19:49Z","timestamp":1755832789000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interventions to minimize periodontal defect distal to second molar after mandibular third molar surgery: an overview of systematic reviews"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4085-6378","authenticated-orcid":false,"given":"Ioulianos","family":"Apessos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christodoulos","family":"Dovas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon","family":"Mantalenakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9029-8714","authenticated-orcid":false,"given":"Theodoros","family":"Lillis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-5471","authenticated-orcid":false,"given":"Georgios","family":"Antonoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"1432_CR1","volume-title":"White paper on the management of third molar teeth","author":"American Association of Oral and Maxillofacial Surgeons","year":"2016","unstructured":"American Association of Oral and Maxillofacial Surgeons (2016) White paper on the management of third molar teeth. 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