{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:16:35Z","timestamp":1783667795537,"version":"3.55.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oral Maxillofac Surg"],"DOI":"10.1007\/s10006-026-01593-x","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:50:34Z","timestamp":1783666234000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative neoadjuvant chemotherapy was associated with improved local control in selected cases of locally advanced or invasive oral squamous cell carcinoma: a retrospective single-center study"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4066-4237","authenticated-orcid":false,"given":"Hironori","family":"Sakai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiriko","family":"Matsuzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kusafuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"issue":"9208","key":"1593_CR1","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S0140-6736(00)90011-4","volume":"355","author":"JP Pignon","year":"2000","unstructured":"Pignon JP, Bourhis J, Domenge C, Design\u00e9 L (2000) Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet 355(9208):949\u2013955","journal-title":"Lancet"},{"issue":"1","key":"1593_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","volume":"92","author":"JP Pignon","year":"2009","unstructured":"Pignon JP, le Ma\u00eetre A, Maillard E, Bourhis J, MACH-NC Collaborative Group (2009) Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol 92(1):4\u201314. https:\/\/doi.org\/10.1016\/j.radonc.2009.04.014","journal-title":"Radiother Oncol"},{"key":"1593_CR3","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.radonc.2021.01.013","volume":"156","author":"B Lacas","year":"2021","unstructured":"Lacas B, Carmel A, Landais C, Wong SJ, Licitra L, Tobias JS, Burtness B, Ghi MG, Cohen EEW, Grau C, Wolf G, Hitt R, Corv\u00f2 R, Budach V, Kumar S, Laskar SG, Mazeron JJ, Zhong LP, Dobrowsky W, Ghadjar P, Fallai C, Zakotnik B, Sharma A, Bensadoun RJ, Ruo Redda MG, Racadot S, Fountzilas G, Brizel D, Rovea P, Argiris A, Nagy ZT, Lee JW, Fortpied C, Harris J, Bourhis J, Aup\u00e9rin A, Blanchard P, Pignon JP, MACH-NC Collaborative Group (2021) Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group. Radiother Oncol 156:281\u2013293. https:\/\/doi.org\/10.1016\/j.radonc.2021.01.013","journal-title":"Radiother Oncol"},{"issue":"11","key":"1593_CR4","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.oraloncology.2012.06.014","volume":"48","author":"J Ma","year":"2012","unstructured":"Ma J, Liu Y, Huang XL, Zhang ZY, Myers JN, Neskey DM, Zhong LP (2012) Induction chemotherapy decreases the rate of distant metastasis in patients with head and neck squamous cell carcinoma but does not improve survival or locoregional control: a meta-analysis. Oral Oncol 48(11):1076\u20131084. https:\/\/doi.org\/10.1016\/j.oraloncology.2012.06.014","journal-title":"Oral Oncol"},{"issue":"17","key":"1593_CR5","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1016\/j.ejca.2015.08.007","volume":"51","author":"GN Marta","year":"2015","unstructured":"Marta GN, Riera R, Bossi P, Zhong LP, Licitra L, Macedo CR, de Castro Junior G, Carvalho AL, William WN Jr, Kowalski LP (2015) Induction chemotherapy prior to surgery with or without postoperative radiotherapy for oral cavity cancer patients: Systematic review and meta-analysis. Eur J Cancer 51(17):2596\u20132603. https:\/\/doi.org\/10.1016\/j.ejca.2015.08.007","journal-title":"Eur J Cancer"},{"key":"1593_CR6","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.oraloncology.2019.06.001","volume":"95","author":"E Dauzier","year":"2024","unstructured":"Dauzier E, Lacas B, Blanchard P, Le QT, Simon C, Wolf G, Janot F, Horiuchi M, Tobias JS, Moon J, Simes J, Deshmane V, Mazeron JJ, Mehta S, Zaktonik B, Tamura M, Moyal E, Licitra L, Fortpied C, Haffty BG, Ghi MG, Gregoire V, Harris J, Bourhis J, Aup\u00e9rin A, Pignon JP, MACH-NC Collaborative Group (2024) Role of chemotherapy in 5000 patients with head and neck cancer treated by curative surgery: A subgroup analysis of the meta-analysis of chemotherapy in head and neck cancer. Oral Oncol 95:106\u2013114. https:\/\/doi.org\/10.1016\/j.oraloncology.2019.06.001","journal-title":"Oral Oncol"},{"issue":"1","key":"1593_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijom.2023.03.007","volume":"53","author":"P Kende","year":"2024","unstructured":"Kende P, Mathur Y, Varte V, Tayal S, Patyal N, Landge J (2024) The efficacy of neoadjuvant chemotherapy as compared to upfront surgery for the management of oral squamous cell carcinoma: a systematic review and meta-analysis. Int J Oral Maxillofac Surg 53(1):1\u201310. https:\/\/doi.org\/10.1016\/j.ijom.2023.03.007","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"5","key":"1593_CR8","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.ijom.2024.11.012","volume":"54","author":"H Kurita","year":"2025","unstructured":"Kurita H, Uzawa N, Nakayama H, Abe T, Ibaraki S, Ohyama Y, Uchida K, Sato H, Miyabe S, Ab\u00e9 T, Kakimoto N, Kaida A, Sugiura T, Kioi M, Danjo A, Kitamura N, Hasegawa O, Tanaka T, Ueda N, Hasegawa T, Asoda S, Katsuta H, Yanamoto S, Yamada S, Takeda D, Suzuki T, Ohta Y, Kirita T (2025) Japanese clinical practice guidelines for oral cancer, 2023. Int J Oral Maxillofac Surg 54(5):461\u2013476. https:\/\/doi.org\/10.1016\/j.ijom.2024.11.012","journal-title":"Int J Oral Maxillofac Surg"},{"key":"1593_CR9","unstructured":"National Comprehensive Cancer Network (2025) NCCN guidelines: head and neck cancers. Updated Febr https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf"},{"issue":"5","key":"1593_CR10","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1002\/hed.2890060508","volume":"6","author":"E Yamamoto","year":"1984","unstructured":"Yamamoto E, Miyakawa A, Kohama G (1984) Mode of invasion and lymph node metastasis in squamous cell carcinoma of the oral cavity. Head Neck Surg 6(5):938\u2013947. https:\/\/doi.org\/10.1002\/hed.2890060508","journal-title":"Head Neck Surg"},{"issue":"10","key":"1593_CR11","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.oraloncology.2004.05.002","volume":"40","author":"H Kurita","year":"2004","unstructured":"Kurita H, Yamamoto E, Nozaki S, Wada S, Furuta I, Kurashina K (2004) Multicenter phase I trial of induction chemotherapy with docetaxel and nedaplatin for oral squamous cell carcinoma. Oral Oncol 40(10):1000\u20131006. https:\/\/doi.org\/10.1016\/j.oraloncology.2004.05.002","journal-title":"Oral Oncol"},{"issue":"3","key":"1593_CR12","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s00280-009-1056-z","volume":"65","author":"H Kurita","year":"2010","unstructured":"Kurita H, Yamamoto E, Nozaki S, Wada S, Furuta I, Miyata M, Kurashina K (2010) Multicenter phase 2 study of induction chemotherapy with docetaxel and nedaplatin for oral squamous cell carcinoma. Cancer Chemother Pharmacol 65(3):503\u2013508. https:\/\/doi.org\/10.1007\/s00280-009-1056-z","journal-title":"Cancer Chemother Pharmacol"},{"issue":"4","key":"1593_CR13","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/j.1749-4486.2010.02141.x","volume":"35","author":"V Paleri","year":"2010","unstructured":"Paleri V, Mehanna H, Wight RG (2010) TNM classification of malignant tumours 7th edition: what\u2019s new for head and neck? Clin Otolaryngol 35(4):270\u2013272. https:\/\/doi.org\/10.1111\/j.1749-4486.2010.02141.x","journal-title":"Clin Otolaryngol"},{"issue":"2","key":"1593_CR14","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","volume":"45","author":"EA Eisenhauer","year":"2009","unstructured":"Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D, Verweij J (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45(2):228\u2013247. https:\/\/doi.org\/10.1016\/j.ejca.2008.10.026","journal-title":"Eur J Cancer"},{"issue":"5","key":"1593_CR15","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1200\/JCO.1996.14.5.1672","volume":"14","author":"AI Dreyfuss","year":"1996","unstructured":"Dreyfuss AI, Clark JR, Norris CM, Rossi RM, Lucarini JW, Busse PM, Poulin MD, Thornhill L, Costello R, Posner MR (1996) Docetaxel: an active drug for squamous cell carcinoma of the head and neck. J Clin Oncol 14(5):1672\u20131678. https:\/\/doi.org\/10.1200\/JCO.1996.14.5.1672","journal-title":"J Clin Oncol"},{"issue":"6","key":"1593_CR16","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s002800050604","volume":"39","author":"DS Alberts","year":"1997","unstructured":"Alberts DS, Fanta PT, Running KL, Adair LP Jr, Garcia DJ, Liu-Stevens R, Salmon SE (1997) In vitro phase II comparison of the cytotoxicity of a novel platinum analog, nedaplatin (254-S), with that of cisplatin and carboplatin against fresh, human ovarian cancers. Cancer Chemother Pharmacol 39(6):493\u2013497. https:\/\/doi.org\/10.1007\/s002800050604","journal-title":"Cancer Chemother Pharmacol"},{"issue":"6","key":"1593_CR17","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1200\/JCO.2012.43.8820","volume":"31","author":"CP Zhang","year":"2013","unstructured":"Zhang CP, Zhang ZY, Ren GX, Guo W, William WN Jr, Sun J, Zhu HG, Tu WY, Li J, Cai YL, Wang LZ, Fan XD, Wang ZH, Hu YJ, Ji T, Yang WJ, Ye WM, Li J, He Y, Wang YA, Xu LQ, Wang BS, Kies MS, Lee JJ, Myers JN, Zhong LP (2013) Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma. J Clin Oncol 31(6):744\u2013751. https:\/\/doi.org\/10.1200\/JCO.2012.43.8820","journal-title":"J Clin Oncol"}],"container-title":["Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10006-026-01593-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10006-026-01593-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10006-026-01593-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:50:36Z","timestamp":1783666236000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10006-026-01593-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1593"],"URL":"https:\/\/doi.org\/10.1007\/s10006-026-01593-x","relation":{},"ISSN":["1865-1569"],"issn-type":[{"value":"1865-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"assertion":[{"value":"26 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in accordance with the Declaration of Helsinki (2013 Fortaleza revision) and Ethical Guidelines for Medical Research for Humans. The study protocol was approved by the Ethics Committee of Shinshu University School of Medicine (Approval number #5212).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The requirement for informed consent was waived by the Ethics Committee due to the retrospective nature of the study. However, the consent process guaranteed participation in the study and the opportunity to refuse participation in an opt-out format.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate\/publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"110"}}