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Recipient sites received 0.12% iron phthalocyanine mouthrinse (test group-PHY) and 0.12% chlorhexidine (control group-CHX) during 14 postoperative days. The primary outcome was percentage of root coverage (%RC) at 6 months. Secondary outcomes included clinical parameters (probing depth, PD; recession depth and width, RD, RW; percentage of complete root coverage (CRC); clinical attachment level, CAL; keratinized tissue thickness and width, KTT, KTW), professional- and patient-reported outcomes, mechanical detection threshold (MDT) and mechanical pain threshold (MPT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PHY and CHX groups showed significant improvements in clinical parameters, including reduced RD and RW, CAL gain, and increased KTW and KTT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). %RC was similar between groups, at approximately 80%. Professional- and patient-reported outcomes, including dentin hypersensitivity and esthetic perception, as well as MPT and MDT, showed no significant differences between groups. Postoperative symptoms decreased progressively, and oral health-related quality of life remained unchanged after 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Postoperative use of phthalocyanine after CAF\u2009+\u2009SCTG resulted in clinical outcomes comparable to chlorhexidine, including similar root coverage, with no differences in professional-, patient-centered outcomes, somatosensory profile, or oral health-related quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Iron phthalocyanine may represent a promising alternative for postoperative care in periodontal plastic surgeries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10006-026-01614-9","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T03:25:50Z","timestamp":1785986750000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of a phthalocyanine mouthrinse after connective tissue graft surgery for root coverage: a randomized split-mouth clinical trial"],"prefix":"10.1007","volume":"30","author":[{"given":"Rafael Sponchiado","family":"Cavallieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caique Andrade","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Stocker","family":"Salbego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Andreotti","family":"Damante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Campos Passanesi","family":"Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heitor Marques","family":"Hon\u00f3rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Rigoldi","family":"Bonjardim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0286-7575","authenticated-orcid":false,"given":"Mariana Schutzer","family":"Ragghianti Zangrando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"1614_CR1","doi-asserted-by":"publisher","unstructured":"Armitage GC (1999) Development of a classification system for periodontal diseases and conditions. 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