{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:32:50Z","timestamp":1782603170848,"version":"3.54.5"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T00:00:00Z","timestamp":1535155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Tumor Pathol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s10014-018-0328-x","type":"journal-article","created":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T09:59:29Z","timestamp":1535191169000},"page":"217-223","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["NRASQ61K mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called \u201cforme fruste\u201d of neurocutaneous melanosis"],"prefix":"10.1007","volume":"35","author":[{"given":"Ilaria","family":"Girolami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ghimenton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Zannoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Mombello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Riva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Cirielli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Corradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Vogrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioia","family":"Di Stefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Novelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albino","family":"Eccher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,25]]},"reference":[{"key":"328_CR1","volume-title":"WHO classification of tumours of the central nervous system","author":"DN Louis","year":"2016","unstructured":"Louis DN, Hiroko O (2016) WHO classification of tumours of the central nervous system, 4th\u00a0edn. Lyon, France","edition":"4"},{"key":"328_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/bpa.12241","volume":"25","author":"HVN K\u00fcsters-Vandevelde","year":"2015","unstructured":"K\u00fcsters-Vandevelde HVN, K\u00fcsters B, Van Engen-Van Grunsven ACH et al (2015) Primary melanocytic tumors of the central nervous system: a review with focus on molecular aspects. Brain Pathol 25:209\u2013226. \n                    https:\/\/doi.org\/10.1111\/bpa.12241","journal-title":"Brain Pathol"},{"key":"328_CR3","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.jocn.2010.01.017","volume":"17","author":"SV Liubinas","year":"2010","unstructured":"Liubinas SV, Maartens N, Drummond KJ (2010) Primary melanocytic neoplasms of the central nervous system. J Clin Neurosci 17:1227\u20131232. \n                    https:\/\/doi.org\/10.1016\/j.jocn.2010.01.017","journal-title":"J Clin Neurosci"},{"key":"328_CR4","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1148\/rg.295095109","volume":"29","author":"AB Smith","year":"2009","unstructured":"Smith AB, Rushing EJ, Smirniotopoulos JG (2009) Pigmented lesions of the central nervous system: radiologic\u2013pathologic correlation. RadioGraphics 29:1503\u20131524. \n                    https:\/\/doi.org\/10.1148\/rg.295095109","journal-title":"RadioGraphics"},{"key":"328_CR5","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1097\/00000478-199907000-00001","volume":"23","author":"DJ Brat","year":"1999","unstructured":"Brat DJ, Giannini C, Scheithauer BW, Burger PC (1999) Primary melanocytic neoplasms of the central nervous systems. Am J Surg Pathol 23:745\u2013754","journal-title":"Am J Surg Pathol"},{"key":"328_CR6","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1212\/WNL.0000000000002396","volume":"86","author":"R Bhatia","year":"2016","unstructured":"Bhatia R, Kataria V, Vibha D et al (2016) Mystery case: neurocutaneous melanosis with diffuse leptomeningeal malignant melanoma in an adult. Neurology 86:e75\u2013e79. \n                    https:\/\/doi.org\/10.1212\/WNL.0000000000002396","journal-title":"Neurology"},{"key":"328_CR7","doi-asserted-by":"publisher","first-page":"147","DOI":"10.4103\/2152-7806.142795","volume":"5","author":"V Trinh","year":"2014","unstructured":"Trinh V, Medina-Flores R, Taylor CL et al (2014) Primary melanocytic tumors of the central nervous system: report of two cases and review of literature. Surg Neurol Int 5:147. \n                    https:\/\/doi.org\/10.4103\/2152-7806.142795","journal-title":"Surg Neurol Int"},{"key":"328_CR8","first-page":"115","volume":"24","author":"MG Pirini","year":"2003","unstructured":"Pirini MG, Mascalchi M, Salvi F et al (2003) Primary diffuse meningeal melanomatosis: radiologic\u2013pathologic correlation. Am J Neuroradiol 24:115\u2013118","journal-title":"Am J Neuroradiol"},{"key":"328_CR9","doi-asserted-by":"publisher","first-page":"554","DOI":"10.3340\/jkns.2015.58.6.554","volume":"58","author":"DH Kim","year":"2015","unstructured":"Kim DH, Choi CY, Lee CH, Joo M (2015) Primary intracranial leptomeningeal melanomatosis. J Korean Neurosurg Soc 58:554\u2013556. \n                    https:\/\/doi.org\/10.3340\/jkns.2015.58.6.554","journal-title":"J Korean Neurosurg Soc"},{"key":"328_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-017-0914-0","author":"K Fujimori","year":"2017","unstructured":"Fujimori K, Sakai K, Higashiyama F et al (2017) Primary central nervous system malignant melanoma with leptomeningeal melanomatosis: a case report and review of the literature. Neurosurg Rev. \n                    https:\/\/doi.org\/10.1007\/s10143-017-0914-0","journal-title":"Neurosurg Rev"},{"key":"328_CR11","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s12253-014-9841-3","volume":"21","author":"HVN K\u00fcsters-Vandevelde","year":"2015","unstructured":"K\u00fcsters-Vandevelde HVN, van Engen- van Grunsven IACH, Coupland SE et al (2015) Mutations in G protein encoding genes and chromosomal alterations in primary leptomeningeal melanocytic neoplasms. Pathol Oncol Res 21:439\u2013447. \n                    https:\/\/doi.org\/10.1007\/s12253-014-9841-3","journal-title":"Pathol Oncol Res"},{"key":"328_CR12","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s11060-015-2052-2","volume":"127","author":"J Nes van de","year":"2016","unstructured":"van de Nes J, Gessi M, Sucker A et al (2016) Targeted next generation sequencing reveals unique mutation profile of primary melanocytic tumors of the central nervous system. J Neurooncol 127:435\u2013444. \n                    https:\/\/doi.org\/10.1007\/s11060-015-2052-2","journal-title":"J Neurooncol"},{"key":"328_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40478-016-0272-0","volume":"4","author":"HVN K\u00fcsters-Vandevelde","year":"2016","unstructured":"K\u00fcsters-Vandevelde HVN, Creytens D, van Engen-van Grunsven ACH et al (2016) SF3B1 and EIF1AX mutations occur in primary leptomeningeal melanocytic neoplasms; yet another similarity to uveal melanomas. Acta Neuropathol Commun 4:5. \n                    https:\/\/doi.org\/10.1186\/s40478-016-0272-0","journal-title":"Acta Neuropathol Commun"},{"key":"328_CR14","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/j.1365-2990.2012.01288.x","volume":"39","author":"M Gessi","year":"2013","unstructured":"Gessi M, Hammes J, Lauriola L et al (2013) GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system. Neuropathol Appl Neurobiol 39:417\u2013425. \n                    https:\/\/doi.org\/10.1111\/j.1365-2990.2012.01288.x","journal-title":"Neuropathol Appl Neurobiol"},{"key":"328_CR15","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1038\/jid.2013.70","volume":"133","author":"VA Kinsler","year":"2013","unstructured":"Kinsler VA, Thomas AC, Ishida M et al (2013) Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS. J Investig Dermatol 133:2229\u20132236. \n                    https:\/\/doi.org\/10.1038\/jid.2013.70","journal-title":"J Investig Dermatol"},{"key":"328_CR16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/bpa.12228","volume":"25","author":"C Koelsche","year":"2015","unstructured":"Koelsche C, Hovestadt V, Jones DTW et al (2015) Melanotic tumors of the nervous system are characterized by distinct mutational, chromosomal and epigenomic profiles. Brain Pathol 25:202\u2013208. \n                    https:\/\/doi.org\/10.1111\/bpa.12228","journal-title":"Brain Pathol"},{"key":"328_CR17","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.wneu.2018.02.007","volume":"114","author":"M Ma","year":"2018","unstructured":"Ma M, Ding ZL, Cheng ZQ et al (2018) Neurocutaneous melanosis in an adult patient with intracranial primary malignant melanoma: case report and review of the literature. World Neurosurg 114:76\u201383. \n                    https:\/\/doi.org\/10.1016\/j.wneu.2018.02.007","journal-title":"World Neurosurg"},{"key":"328_CR18","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1111\/j.1365-2133.2008.08775.x","volume":"159","author":"VA Kinsler","year":"2008","unstructured":"Kinsler VA, Chong WK, Aylett SE, Atherton DJ (2008) Complications of congenital melanocytic naevi in children: analysis of 16 years\u2019 experience and clinical practice. Br J Dermatol 159:907\u2013914. \n                    https:\/\/doi.org\/10.1111\/j.1365-2133.2008.08775.x","journal-title":"Br J Dermatol"},{"key":"328_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1001\/archderm.140.2.171","volume":"140","author":"AA Marghoob","year":"2004","unstructured":"Marghoob AA, Dusza S, Oliveria S, Halpern AC (2004) Number of satellite nevi as a correlate for neurocutaneous melanocytosis in patients with large congenital melanocytic nevi. Arch Dermatol 140:171\u2013175. \n                    https:\/\/doi.org\/10.1001\/archderm.140.2.171","journal-title":"Arch Dermatol"},{"key":"328_CR20","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1177\/0883073811409749","volume":"26","author":"KL Brunsvig","year":"2011","unstructured":"Brunsvig KL, Zenobi M, Rilliet B et al (2011) Primary leptomeningeal melanocytosis in a 10-year-old girl: a challenging diagnosis with a poor prognosis. J Child Neurol 26:1444\u20131448. \n                    https:\/\/doi.org\/10.1177\/0883073811409749","journal-title":"J Child Neurol"},{"key":"328_CR21","doi-asserted-by":"publisher","first-page":"178","DOI":"10.5414\/NP300363","volume":"30","author":"BJ Sutton","year":"2011","unstructured":"Sutton BJ, Tatter SB, Stanton CA, Mott RT (2011) Leptomeningeal melanocytosis in an adult male without large congenital nevi: a rare and atypical case of neurocutaneous melanosis. Clin Neuropathol 30:178\u2013182","journal-title":"Clin Neuropathol"},{"key":"328_CR22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/cyt.12366","volume":"28","author":"DL Kolin","year":"2017","unstructured":"Kolin DL, Geddie WR, Ko HM (2017) CSF cytology diagnosis of NRAS-mutated primary leptomeningeal melanomatosis with neurocutaneous melanosis. Cytopathology 28:235\u2013238. \n                    https:\/\/doi.org\/10.1111\/cyt.12366","journal-title":"Cytopathology"},{"key":"328_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2556-y","author":"G Angelino","year":"2016","unstructured":"Angelino G, De Pasquale MD, De Sio L et al (2016) NRASQ61K mutated primary leptomeningeal melanoma in a child: case presentation and discussion on clinical and diagnostic implications. BMC Cancer. \n                    https:\/\/doi.org\/10.1186\/s12885-016-2556-y","journal-title":"BMC Cancer"}],"container-title":["Brain Tumor Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10014-018-0328-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10014-018-0328-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10014-018-0328-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T23:19:59Z","timestamp":1566688799000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10014-018-0328-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,25]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["328"],"URL":"https:\/\/doi.org\/10.1007\/s10014-018-0328-x","relation":{},"ISSN":["1433-7398","1861-387X"],"issn-type":[{"value":"1433-7398","type":"print"},{"value":"1861-387X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,25]]},"assertion":[{"value":"16 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the institutional review board of the University of Verona in accordance with the ethical standards of the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"Informed consent was acquired from the family of the patient in order to perform autopsy and subsequent investigations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}