{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:27:36Z","timestamp":1786980456040,"version":"build-2736575974"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100010418","name":"Institute for Information and Communications Technology Promotion","doi-asserted-by":"publisher","award":["No.2019-0567"],"award-info":[{"award-number":["No.2019-0567"]}],"id":[{"id":"10.13039\/501100010418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Tumor Pathol"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10014-021-00420-3","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T19:04:11Z","timestamp":1642619051000},"page":"65-78","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Emerging glioneuronal and neuronal tumors: case-based review"],"prefix":"10.1007","volume":"39","author":[{"given":"So Dug","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Ik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Kyung","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hoon","family":"Phi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Kee","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongseok","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-1597","authenticated-orcid":false,"given":"Sung-Hye","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"420_CR1","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis DN, Perry A, Reifenberger G et al (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803\u2013820. https:\/\/doi.org\/10.1007\/s00401-016-1545-1","journal-title":"Acta Neuropathol"},{"key":"420_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10014-014-0187-z","volume":"32","author":"HJ Cho","year":"2015","unstructured":"Cho HJ, Myung JK, Kim H et al (2015) Primary diffuse leptomeningeal glioneuronal tumors. Brain Tumor Pathol 32:49\u201355. https:\/\/doi.org\/10.1007\/s10014-014-0187-z","journal-title":"Brain Tumor Pathol"},{"key":"420_CR3","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.humpath.2018.11.028","volume":"86","author":"E Choi","year":"2019","unstructured":"Choi E, Kim SI, Won JK et al (2019) Clinicopathological and molecular analysis of multinodular and vacuolating neuronal tumors of the cerebrum. Hum Pathol 86:203\u2013212. https:\/\/doi.org\/10.1016\/j.humpath.2018.11.028","journal-title":"Hum Pathol"},{"key":"420_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10014-020-00392-w","volume":"38","author":"T Komori","year":"2021","unstructured":"Komori T (2021) The molecular framework of pediatric-type diffuse gliomas: shifting toward the revision of the WHO classification of tumors of the central nervous system. Brain Tumor Pathol 38:1\u20133. https:\/\/doi.org\/10.1007\/s10014-020-00392-w","journal-title":"Brain Tumor Pathol"},{"key":"420_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11060-020-03529-1","volume":"150","author":"P de Blank","year":"2020","unstructured":"de Blank P, Fouladi M, Huse JT (2020) Molecular markers and targeted therapy in pediatric low-grade glioma. J Neurooncol 150:5\u201315. https:\/\/doi.org\/10.1007\/s11060-020-03529-1","journal-title":"J Neurooncol"},{"key":"420_CR6","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1007\/s00381-020-04955-2","volume":"37","author":"M Saez-Alegre","year":"2021","unstructured":"Saez-Alegre M, Saceda Gutierrez JM, Utrilla Contreras C et al (2021) Diffuse leptomeningeal glioneuronal tumour: where to biopsy? Case report and literature review. Childs Nerv Syst 37:2405\u20132408. https:\/\/doi.org\/10.1007\/s00381-020-04955-2","journal-title":"Childs Nerv Syst"},{"key":"420_CR7","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/nan.12598","volume":"46","author":"E Perez","year":"2020","unstructured":"Perez E, Capper D (2020) Invited Review: DNA methylation-based classification of paediatric brain tumours. Neuropathol Appl Neurobiol 46:28\u201347. https:\/\/doi.org\/10.1111\/nan.12598","journal-title":"Neuropathol Appl Neurobiol"},{"key":"420_CR8","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nature26000","volume":"555","author":"D Capper","year":"2018","unstructured":"Capper D, Jones DTW, Sill M et al (2018) DNA methylation-based classification of central nervous system tumours. Nature 555:469\u2013474. https:\/\/doi.org\/10.1038\/nature26000","journal-title":"Nature"},{"key":"420_CR9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s10014-019-00345-y","volume":"36","author":"K Kurozumi","year":"2019","unstructured":"Kurozumi K, Nakano Y, Ishida J et al (2019) High-grade glioneuronal tumor with an ARHGEF2-NTRK1 fusion gene. Brain Tumor Pathol 36:121\u2013128. https:\/\/doi.org\/10.1007\/s10014-019-00345-y","journal-title":"Brain Tumor Pathol"},{"key":"420_CR10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/bpa.12619","volume":"29","author":"A Siegfried","year":"2019","unstructured":"Siegfried A, Rousseau A, Maurage CA et al (2019) EWSR1-PATZ1 gene fusion may define a new glioneuronal tumor entity. Brain Pathol 29:53\u201362. https:\/\/doi.org\/10.1111\/bpa.12619","journal-title":"Brain Pathol"},{"key":"420_CR11","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","volume":"23","author":"DN Louis","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P et al (2021) The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol 23:1231\u20131251. https:\/\/doi.org\/10.1093\/neuonc\/noab106","journal-title":"Neuro Oncol"},{"key":"420_CR12","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1111\/bpa.12832","volume":"30","author":"DN Louis","year":"2020","unstructured":"Louis DN, Wesseling P, Aldape K et al (2020) cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading. Brain Pathol 30:844\u2013856. https:\/\/doi.org\/10.1111\/bpa.12832","journal-title":"Brain Pathol"},{"key":"420_CR13","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/nan.12590","volume":"46","author":"MY Deng","year":"2020","unstructured":"Deng MY, Sill M, Sturm D et al (2020) Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC)\u2014a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14. Neuropathol Appl Neurobiol 46:422\u2013430. https:\/\/doi.org\/10.1111\/nan.12590","journal-title":"Neuropathol Appl Neurobiol"},{"key":"420_CR14","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/nan.12680","volume":"47","author":"JC Pickles","year":"2021","unstructured":"Pickles JC, Mankad K, Aizpurua M et al (2021) A case series of diffuse glioneuronal tumours with oligodendroglioma-like features and nuclear clusters (DGONC). Neuropathol Appl Neurobiol 47:464\u2013467. https:\/\/doi.org\/10.1111\/nan.12680","journal-title":"Neuropathol Appl Neurobiol"},{"key":"420_CR15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s40478-017-0465-1","volume":"5","author":"Y Lee","year":"2017","unstructured":"Lee Y, Koh J, Kim SI et al (2017) The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas. Acta Neuropathol Commun 5:62. https:\/\/doi.org\/10.1186\/s40478-017-0465-1","journal-title":"Acta Neuropathol Commun"},{"key":"420_CR16","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s10014-020-00378-8","volume":"38","author":"KY Lim","year":"2021","unstructured":"Lim KY, Won JK, Park CK et al (2021) H3 G34-mutant high-grade glioma. Brain Tumor Pathol 38:4\u201313. https:\/\/doi.org\/10.1007\/s10014-020-00378-8","journal-title":"Brain Tumor Pathol"},{"key":"420_CR17","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1750-3639.2009.00285.x","volume":"20","author":"MP Gardiman","year":"2010","unstructured":"Gardiman MP, Fassan M, Orvieto E et al (2010) Diffuse leptomeningeal glioneuronal tumors: a new entity? Brain Pathol 20:361\u2013366. https:\/\/doi.org\/10.1111\/j.1750-3639.2009.00285.x","journal-title":"Brain Pathol"},{"key":"420_CR18","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00401-018-1865-4","volume":"136","author":"MY Deng","year":"2018","unstructured":"Deng MY, Sill M, Chiang J et al (2018) Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features. Acta Neuropathol 136:239\u2013253. https:\/\/doi.org\/10.1007\/s00401-018-1865-4","journal-title":"Acta Neuropathol"},{"key":"420_CR19","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1093\/brain\/65.4.352","volume":"65","author":"DJK Beck","year":"1942","unstructured":"Beck DJK, Russel DS (1942) Oligodendrogliomatosis of the cerebrospinal pathway. Brain 65:352\u2013372. https:\/\/doi.org\/10.1093\/brain\/65.4.352","journal-title":"Brain"},{"key":"420_CR20","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1097\/00000478-199603000-00014","volume":"20","author":"T Yamamoto","year":"1996","unstructured":"Yamamoto T, Komori T, Shibata N et al (1996) Multifocal neurocytoma\/gangliocytoma with extensive leptomeningeal dissemination in the brain and spinal cord. Am J Surg Pathol 20:363\u2013370. https:\/\/doi.org\/10.1097\/00000478-199603000-00014","journal-title":"Am J Surg Pathol"},{"key":"420_CR21","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.3174\/ajnr.A6737","volume":"41","author":"DA Lakhani","year":"2020","unstructured":"Lakhani DA, Mankad K, Chhabda S et al (2020) Diffuse leptomeningeal glioneuronal tumor of childhood. AJNR Am J Neuroradiol 41:2155\u20132159. https:\/\/doi.org\/10.3174\/ajnr.A6737","journal-title":"AJNR Am J Neuroradiol"},{"key":"420_CR22","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1080\/08880018.2019.1711270","volume":"37","author":"C Abongwa","year":"2020","unstructured":"Abongwa C, Cotter J, Tamrazi B et al (2020) Primary diffuse leptomeningeal glioneuronal tumors of the central nervous system: report of three cases and review of literature. Pediatr Hematol Oncol 37:248\u2013258. https:\/\/doi.org\/10.1080\/08880018.2019.1711270","journal-title":"Pediatr Hematol Oncol"},{"key":"420_CR23","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s00401-012-1037-x","volume":"124","author":"FJ Rodriguez","year":"2012","unstructured":"Rodriguez FJ, Perry A, Rosenblum MK et al (2012) Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity. Acta Neuropathol 124:627\u2013641. https:\/\/doi.org\/10.1007\/s00401-012-1037-x","journal-title":"Acta Neuropathol"},{"key":"420_CR24","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s11060-016-2109-x","volume":"128","author":"AJ Dodgshun","year":"2016","unstructured":"Dodgshun AJ, SantaCruz N, Hwang J et al (2016) Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation. J Neurooncol 128:293\u2013302. https:\/\/doi.org\/10.1007\/s11060-016-2109-x","journal-title":"J Neurooncol"},{"key":"420_CR25","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1093\/jnen\/nly053","volume":"77","author":"JH Kang","year":"2018","unstructured":"Kang JH, Buckley AF, Nagpal S et al (2018) A diffuse leptomeningeal glioneuronal tumor without diffuse leptomeningeal involvement: detailed molecular and clinical characterization. J Neuropathol Exp Neurol 77:751\u2013756. https:\/\/doi.org\/10.1093\/jnen\/nly053","journal-title":"J Neuropathol Exp Neurol"},{"key":"420_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/2329048X14567531","volume":"2","author":"MR Lyle","year":"2015","unstructured":"Lyle MR, Dolia JN, Fratkin J et al (2015) Newly identified characteristics and suggestions for diagnosis and treatment of diffuse leptomeningeal glioneuronal\/neuroepithelial tumors: a case report and review of the literature. Child Neurol Open 2:1-7. https:\/\/doi.org\/10.1177\/2329048X14567531","journal-title":"Child Neurol Open"},{"key":"420_CR27","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.wneu.2019.12.119","volume":"135","author":"S Tiwari","year":"2020","unstructured":"Tiwari S, Yadav T, Pamnani J et al (2020) Diffuse leptomeningeal glioneuronal tumor: a unique leptomeningeal tumor entity. World Neurosurg 135:297\u2013300. https:\/\/doi.org\/10.1016\/j.wneu.2019.12.119","journal-title":"World Neurosurg"},{"key":"420_CR28","doi-asserted-by":"publisher","first-page":"1391943","DOI":"10.1155\/2018\/1391943","volume":"2018","author":"JK Lee","year":"2018","unstructured":"Lee JK, Ko HC, Choi JG et al (2018) A case of diffuse leptomeningeal glioneuronal tumor misdiagnosed as chronic tuberculous meningitis without brain biopsy. Case Rep Neurol Med 2018:1391943. https:\/\/doi.org\/10.1155\/2018\/1391943","journal-title":"Case Rep Neurol Med"},{"key":"420_CR29","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s10014-018-0326-z","volume":"35","author":"T Yamasaki","year":"2018","unstructured":"Yamasaki T, Sakai N, Shinmura K et al (2018) Anaplastic changes of diffuse leptomeningeal glioneuronal tumor with polar spongioblastoma pattern. Brain Tumor Pathol 35:209\u2013216. https:\/\/doi.org\/10.1007\/s10014-018-0326-z","journal-title":"Brain Tumor Pathol"},{"key":"420_CR30","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.humpath.2017.06.004","volume":"70","author":"KE Schwetye","year":"2017","unstructured":"Schwetye KE, Kansagra AP, McEachern J et al (2017) Unusual high-grade features in pediatric diffuse leptomeningeal glioneuronal tumor: comparison with a typical low-grade example. Hum Pathol 70:105\u2013112. https:\/\/doi.org\/10.1016\/j.humpath.2017.06.004","journal-title":"Hum Pathol"},{"key":"420_CR31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00381-017-3584-x","volume":"34","author":"D Aguilera","year":"2018","unstructured":"Aguilera D, Castellino RC, Janss A et al (2018) Clinical responses of patients with diffuse leptomeningeal glioneuronal tumors to chemotherapy. Childs Nerv Syst 34:329\u2013334. https:\/\/doi.org\/10.1007\/s00381-017-3584-x","journal-title":"Childs Nerv Syst"},{"key":"420_CR32","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1097\/NEN.0b013e31823f2cb0","volume":"71","author":"A Lin","year":"2012","unstructured":"Lin A, Rodriguez FJ, Karajannis MA et al (2012) BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants. J Neuropathol Exp Neurol 71:66\u201372. https:\/\/doi.org\/10.1097\/NEN.0b013e31823f2cb0","journal-title":"J Neuropathol Exp Neurol"},{"key":"420_CR33","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s00401-015-1400-9","volume":"129","author":"FJ Rodriguez","year":"2015","unstructured":"Rodriguez FJ, Schniederjan MJ, Nicolaides T et al (2015) High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN). Acta Neuropathol 129:609\u2013610. https:\/\/doi.org\/10.1007\/s00401-015-1400-9","journal-title":"Acta Neuropathol"},{"key":"420_CR34","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00401-017-1728-4","volume":"134","author":"JCH Chiang","year":"2017","unstructured":"Chiang JCH, Harreld JH, Orr BA et al (2017) Low-grade spinal glioneuronal tumors with BRAF gene fusion and 1p deletion but without leptomeningeal dissemination. Acta Neuropathol 134:159\u2013162. https:\/\/doi.org\/10.1007\/s00401-017-1728-4","journal-title":"Acta Neuropathol"},{"key":"420_CR35","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.cancergen.2015.01.009","volume":"208","author":"A Kumar","year":"2015","unstructured":"Kumar A, Pathak P, Purkait S et al (2015) Oncogenic KIAA1549-BRAF fusion with activation of the MAPK\/ERK pathway in pediatric oligodendrogliomas. Cancer Genet 208:91\u201395. https:\/\/doi.org\/10.1016\/j.cancergen.2015.01.009","journal-title":"Cancer Genet"},{"key":"420_CR36","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00401-011-0802-6","volume":"121","author":"G Schindler","year":"2011","unstructured":"Schindler G, Capper D, Meyer J et al (2011) Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 121:397\u2013405. https:\/\/doi.org\/10.1007\/s00401-011-0802-6","journal-title":"Acta Neuropathol"},{"key":"420_CR37","doi-asserted-by":"publisher","first-page":"4790","DOI":"10.1158\/1078-0432.CCR-11-0034","volume":"17","author":"C Hawkins","year":"2011","unstructured":"Hawkins C, Walker E, Mohamed N et al (2011) BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma. Clin Cancer Res 17:4790\u20134798. https:\/\/doi.org\/10.1158\/1078-0432.CCR-11-0034","journal-title":"Clin Cancer Res"},{"key":"420_CR38","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00401-018-1940-x","volume":"137","author":"J Chiang","year":"2019","unstructured":"Chiang J, Dalton J, Upadhyaya SA et al (2019) Chromosome arm 1q gain is an adverse prognostic factor in localized and diffuse leptomeningeal glioneuronal tumors with BRAF gene fusion and 1p deletion. Acta Neuropathol 137:179\u2013181. https:\/\/doi.org\/10.1007\/s00401-018-1940-x","journal-title":"Acta Neuropathol"},{"key":"420_CR39","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s40478-021-01248-w","volume":"9","author":"N Manoharan","year":"2021","unstructured":"Manoharan N, Ajuyah P, Senapati A et al (2021) Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis. Acta Neuropathol Commun 9:147. https:\/\/doi.org\/10.1186\/s40478-021-01248-w","journal-title":"Acta Neuropathol Commun"},{"key":"420_CR40","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1007\/s10014-018-0325-0","volume":"35","author":"A Nambirajan","year":"2018","unstructured":"Nambirajan A, Suri V, Kedia S et al (2018) Paediatric diffuse leptomeningeal tumor with glial and neuronal differentiation harbouring chromosome 1p\/19q co-deletion and H3.3 K27M mutation: unusual molecular profile and its therapeutic implications. Brain Tumor Pathol 35:186\u2013191. https:\/\/doi.org\/10.1007\/s10014-018-0325-0","journal-title":"Brain Tumor Pathol"},{"key":"420_CR41","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jocn.2020.07.039","volume":"79","author":"D Gai","year":"2020","unstructured":"Gai D, Christie M, Gaillard F (2020) Adult diffuse leptomeningeal glioneuronal tumour with limited leptomeningeal involvement, lack of 1p deletion and BRAF V600E mutation. J Clin Neurosci 79:215\u2013218. https:\/\/doi.org\/10.1016\/j.jocn.2020.07.039","journal-title":"J Clin Neurosci"},{"key":"420_CR42","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1038\/s41379-020-0646-5","volume":"33","author":"P Argani","year":"2020","unstructured":"Argani P, Harvey I, Nielsen GP et al (2020) EWSR1\/FUS\u2013CREB fusions define a distinctive malignant epithelioid neoplasm with predilection for mesothelial-lined cavities. Mod Pathol 33:2233\u20132243. https:\/\/doi.org\/10.1038\/s41379-020-0646-5","journal-title":"Mod Pathol"},{"key":"420_CR43","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1111\/his.12983","volume":"69","author":"K Dyson","year":"2016","unstructured":"Dyson K, Rivera-Zengotita M, Kresak J et al (2016) FGFR1 N546K and H3F3A K27M mutations in a diffuse leptomeningeal tumour with glial and neuronal markers. Histopathology 69:704\u2013707. https:\/\/doi.org\/10.1111\/his.12983","journal-title":"Histopathology"},{"key":"420_CR44","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1007\/s00381-020-04892-0","volume":"37","author":"RE Navarro","year":"2021","unstructured":"Navarro RE, Golub D, Hill T et al (2021) Pediatric midline H3K27M-mutant tumor with disseminated leptomeningeal disease and glioneuronal features: case report and literature review. Childs Nerv Syst 37:2347\u20132356. https:\/\/doi.org\/10.1007\/s00381-020-04892-0","journal-title":"Childs Nerv Syst"},{"key":"420_CR45","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.humpath.2018.10.011","volume":"84","author":"K Yao","year":"2019","unstructured":"Yao K, Duan Z, Wang Y et al (2019) Detection of H3K27M mutation in cases of brain stem subependymoma. Hum Pathol 84:262\u2013269. https:\/\/doi.org\/10.1016\/j.humpath.2018.10.011","journal-title":"Hum Pathol"},{"key":"420_CR46","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00401-018-1805-3","volume":"135","author":"D Pratt","year":"2018","unstructured":"Pratt D, Natarajan SK, Banda A et al (2018) Circumscribed\/non-diffuse histology confers a better prognosis in H3K27M-mutant gliomas. Acta Neuropathol 135:299\u2013301. https:\/\/doi.org\/10.1007\/s00401-018-1805-3","journal-title":"Acta Neuropathol"},{"key":"420_CR47","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/bpa.12473","volume":"28","author":"M Pages","year":"2018","unstructured":"Pages M, Beccaria K, Boddaert N et al (2018) Co-occurrence of histone H3 K27M and BRAF V600E mutations in paediatric midline grade I ganglioglioma. Brain Pathol 28:103\u2013111. https:\/\/doi.org\/10.1111\/bpa.12473","journal-title":"Brain Pathol"},{"key":"420_CR48","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/bpa.12035","volume":"23","author":"JT Huse","year":"2013","unstructured":"Huse JT, Edgar M, Halliday J et al (2013) Multinodular and vacuolating neuronal tumors of the cerebrum: 10 cases of a distinctive seizure-associated lesion. Brain Pathol 23:515\u2013524. https:\/\/doi.org\/10.1111\/bpa.12035","journal-title":"Brain Pathol"},{"key":"420_CR49","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s00401-018-1820-4","volume":"135","author":"M Pekmezci","year":"2018","unstructured":"Pekmezci M, Stevers M, Phillips JJ et al (2018) Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway. Acta Neuropathol 135:485\u2013488. https:\/\/doi.org\/10.1007\/s00401-018-1820-4","journal-title":"Acta Neuropathol"},{"key":"420_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.106149","volume":"197","author":"O Alizada","year":"2020","unstructured":"Alizada O, Ayman T, Akgun MY et al (2020) Multinodular and vacuolating neuronal tumor of the cerebrum: two cases and review of the literature. Clin Neurol Neurosurg 197:106149. https:\/\/doi.org\/10.1016\/j.clineuro.2020.106149","journal-title":"Clin Neurol Neurosurg"},{"key":"420_CR51","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1007\/s00381-019-04496-3","volume":"36","author":"L Nunes Dias","year":"2020","unstructured":"Nunes Dias L, Candela-Canto S, Jou C et al (2020) Multinodular and vacuolating neuronal tumor associated with focal cortical dysplasia in a child with refractory epilepsy: a case report and brief review of literature. Childs Nerv Syst 36:1557\u20131561. https:\/\/doi.org\/10.1007\/s00381-019-04496-3","journal-title":"Childs Nerv Syst"},{"key":"420_CR52","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1055\/s-0039-3402574","volume":"11","author":"AL Turner","year":"2020","unstructured":"Turner AL, D\u2019Souza P, Belirgen M et al (2020) Atypical presentation of multinodular and vacuolating neuronal tumor of the cerebrum in a boy. J Neurosci Rural Pract 11:214\u2013215. https:\/\/doi.org\/10.1055\/s-0039-3402574","journal-title":"J Neurosci Rural Pract"},{"key":"420_CR53","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.neurad.2019.05.010","volume":"47","author":"GB Buffa","year":"2020","unstructured":"Buffa GB, Chaves H, Serra MM et al (2020) Multinodular and vacuolating neuronal tumor of the cerebrum (MVNT): a case series and review of the literature. J Neuroradiol 47:216\u2013220. https:\/\/doi.org\/10.1016\/j.neurad.2019.05.010","journal-title":"J Neuroradiol"},{"key":"420_CR54","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/neup.12217","volume":"35","author":"M Nagaishi","year":"2015","unstructured":"Nagaishi M, Yokoo H, Nobusawa S et al (2015) Localized overexpression of alpha-internexin within nodules in multinodular and vacuolating neuronal tumors. Neuropathology 35:561\u2013568. https:\/\/doi.org\/10.1111\/neup.12217","journal-title":"Neuropathology"},{"key":"420_CR55","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/bpa.12555","volume":"28","author":"M Thom","year":"2018","unstructured":"Thom M, Liu J, Bongaarts A et al (2018) Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia? Brain Pathol 28:155\u2013171. https:\/\/doi.org\/10.1111\/bpa.12555","journal-title":"Brain Pathol"},{"key":"420_CR56","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3389\/fonc.2015.00054","volume":"5","author":"CL Penman","year":"2015","unstructured":"Penman CL, Faulkner C, Lowis SP et al (2015) Current understanding of BRAF alterations in diagnosis, prognosis, and therapeutic targeting in pediatric low-grade gliomas. Front Oncol 5:54. https:\/\/doi.org\/10.3389\/fonc.2015.00054","journal-title":"Front Oncol"},{"key":"420_CR57","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s00401-016-1549-x","volume":"131","author":"B Rivera","year":"2016","unstructured":"Rivera B, Gayden T, Carrot-Zhang J et al (2016) Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors. Acta Neuropathol 131:847\u2013863. https:\/\/doi.org\/10.1007\/s00401-016-1549-x","journal-title":"Acta Neuropathol"},{"key":"420_CR58","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s40478-019-0763-x","volume":"7","author":"B Cheaney 2nd","year":"2019","unstructured":"Cheaney B 2nd, Bowden S, Krause K et al (2019) An unusual recurrent high-grade glioneuronal tumor with MAP2K1 mutation and CDKN2A\/B homozygous deletion. Acta Neuropathol Commun 7:110. https:\/\/doi.org\/10.1186\/s40478-019-0763-x","journal-title":"Acta Neuropathol Commun"},{"key":"420_CR59","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s00401-020-02127-9","volume":"139","author":"DJ Brat","year":"2020","unstructured":"Brat DJ, Aldape K, Colman H et al (2020) cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas. Acta Neuropathol 139:603\u2013608. https:\/\/doi.org\/10.1007\/s00401-020-02127-9","journal-title":"Acta Neuropathol"},{"key":"420_CR60","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1182\/blood-2014-05-577361","volume":"124","author":"NA Brown","year":"2014","unstructured":"Brown NA, Furtado LV, Betz BL et al (2014) High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis. Blood 124:1655\u20131658. https:\/\/doi.org\/10.1182\/blood-2014-05-577361","journal-title":"Blood"},{"key":"420_CR61","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1002\/pro.4125","volume":"30","author":"DE Heppner","year":"2021","unstructured":"Heppner DE, Eck MJ (2021) A structural perspective on targeting the RTK\/Ras\/MAP kinase pathway in cancer. Protein Sci 30:1535\u20131553. https:\/\/doi.org\/10.1002\/pro.4125","journal-title":"Protein Sci"},{"key":"420_CR62","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1215\/15228517-2007-026","volume":"9","author":"A Maillo","year":"2007","unstructured":"Maillo A, Orfao A, Espinosa AB et al (2007) Early recurrences in histologically benign\/grade I meningiomas are associated with large tumors and coexistence of monosomy 14 and del(1p36) in the ancestral tumor cell clone. Neuro Oncol 9:438\u2013446. https:\/\/doi.org\/10.1215\/15228517-2007-026","journal-title":"Neuro Oncol"},{"key":"420_CR63","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.cancergencyto.2004.12.010","volume":"160","author":"L Fuzesi","year":"2005","unstructured":"Fuzesi L, Frank D, Nguyen C et al (2005) Losses of 1p and chromosome 14 in renal oncocytomas. Cancer Genet Cytogenet 160:120\u2013125. https:\/\/doi.org\/10.1016\/j.cancergencyto.2004.12.010","journal-title":"Cancer Genet Cytogenet"},{"key":"420_CR64","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1007\/s10350-007-9040-3","volume":"50","author":"N Mourra","year":"2007","unstructured":"Mourra N, Zeitoun G, Buecher B et al (2007) High frequency of chromosome 14 deletion in early-onset colon cancer. Dis Colon Rectum 50:1881\u20131886. https:\/\/doi.org\/10.1007\/s10350-007-9040-3","journal-title":"Dis Colon Rectum"},{"key":"420_CR65","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/sj.onc.1200853","volume":"14","author":"AG Menon","year":"1997","unstructured":"Menon AG, Rutter JL, von Sattel JP et al (1997) Frequent loss of chromosome 14 in atypical and malignant meningioma: identification of a putative \u2018tumor progression\u2019 locus. Oncogene 14:611\u2013616. https:\/\/doi.org\/10.1038\/sj.onc.1200853","journal-title":"Oncogene"},{"key":"420_CR66","doi-asserted-by":"publisher","first-page":"14478","DOI":"10.1073\/pnas.0900198106","volume":"106","author":"AK Cheung","year":"2009","unstructured":"Cheung AK, Lung HL, Ko JM et al (2009) Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma. Proc Natl Acad Sci USA 106:14478\u201314483. https:\/\/doi.org\/10.1073\/pnas.0900198106","journal-title":"Proc Natl Acad Sci USA"},{"key":"420_CR67","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/gcc.20190","volume":"43","author":"JM Ko","year":"2005","unstructured":"Ko JM, Yau WL, Chan PL et al (2005) Functional evidence of decreased tumorigenicity associated with monochromosome transfer of chromosome 14 in esophageal cancer and the mapping of tumor-suppressive regions to 14q32. Genes Chromosom Cancer 43:284\u2013293. https:\/\/doi.org\/10.1002\/gcc.20190","journal-title":"Genes Chromosom Cancer"},{"key":"420_CR68","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/s0165-4608(03)00279-6","volume":"148","author":"C Lopez-Gines","year":"2004","unstructured":"Lopez-Gines C, Cerda-Nicolas M, Gil-Benso R et al (2004) Association of loss of 1p and alterations of chromosome 14 in meningioma progression. Cancer Genet Cytogenet 148:123\u2013128. https:\/\/doi.org\/10.1016\/s0165-4608(03)00279-6","journal-title":"Cancer Genet Cytogenet"},{"key":"420_CR69","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1002\/cncr.27947","volume":"119","author":"N Kroeger","year":"2013","unstructured":"Kroeger N, Klatte T, Chamie K et al (2013) Deletions of chromosomes 3p and 14q molecularly subclassify clear cell renal cell carcinoma. Cancer 119:1547\u20131554. https:\/\/doi.org\/10.1002\/cncr.27947","journal-title":"Cancer"},{"key":"420_CR70","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1309\/D7U997XD2PHBCQCN","volume":"123","author":"MD Tabernero","year":"2005","unstructured":"Tabernero MD, Espinosa AB, Maillo A et al (2005) Characterization of chromosome 14 abnormalities by interphase in situ hybridization and comparative genomic hybridization in 124 meningiomas: correlation with clinical, histopathologic, and prognostic features. Am J Clin Pathol 123:744\u2013751","journal-title":"Am J Clin Pathol"},{"key":"420_CR71","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1023\/b:neon.0000024218.68120.8d","volume":"67","author":"C Dichamp","year":"2004","unstructured":"Dichamp C, Taillibert S, Aguirre-Cruz L et al (2004) Loss of 14q chromosome in oligodendroglial and astrocytic tumors. J Neurooncol 67:281\u2013285. https:\/\/doi.org\/10.1023\/b:neon.0000024218.68120.8d","journal-title":"J Neurooncol"}],"container-title":["Brain Tumor Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10014-021-00420-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10014-021-00420-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10014-021-00420-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T23:43:58Z","timestamp":1652226238000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10014-021-00420-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,20]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["420"],"URL":"https:\/\/doi.org\/10.1007\/s10014-021-00420-3","relation":{},"ISSN":["1433-7398","1861-387X"],"issn-type":[{"value":"1433-7398","type":"print"},{"value":"1861-387X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,20]]},"assertion":[{"value":"15 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest or disclosures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved from the IRB of Seoul National University Hospital (1906\u2013020-1037) and was conducted under the Helsinki declaration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Because this study is a retrospective clinicopathological analysis using anonymized data, informed consent and publication consent were exempted by the Korean Bioethical and Safety Act.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and publication"}}]}}