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Although it is considered a benign tumor, most previous reports have focused on extracranial AS; therefore, the clinical characteristics of intracranial AS is not clear. We included 174 patients who underwent surgery for sporadic intracranial schwannoma, and 13 patients (7.5%) were diagnosed with AS. Cysts were significantly more common in patients with AS than conventional schwannomas (92.3% vs. 44.7%, p\u2009&lt;\u20090.001), as was bleeding (38.5% vs. 6.9%, p\u2009=\u20090.003) and calcification (15.4% vs. 1.3%, p\u2009=\u20090.029). The maximum tumor diameter was also larger in patients with AS (35\u00a0mm vs. 29\u00a0mm, p\u2009=\u20090.017). The median duration from symptom onset to surgery (7.0 vs. 12.5\u00a0months, p\u2009=\u20090.740) did not significantly differ between groups, nor did the probability of postoperative recurrence (p\u2009=\u20090.949). Intracranial AS was strongly associated with cyst formation and exhibited a benign clinical course with a lower rate of recurrence and need for salvage treatment. Extracranial AS is reportedly characterized by a slow progression through a long-term clinical course, whereas intracranial AS did not progress slowly in our study and exhibited different clinical features to those reported for extracranial AS.<\/jats:p>","DOI":"10.1007\/s10014-024-00482-z","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T15:02:00Z","timestamp":1712329320000},"page":"73-79","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis"],"prefix":"10.1007","volume":"41","author":[{"given":"Takahiro","family":"Tsuchiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Ikemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Miyawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Teranishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Ushiku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhito","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"482_CR1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1002\/1097-0142(195107)4:4<669::AID-CNCR2820040405>3.0.CO;2-B","volume":"4","author":"LVTF Ackerman","year":"1951","unstructured":"Ackerman LVTF (1951) Neurogenous tumors within the thorax; a clinicopathological evaluation of forty-eight cases. 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