{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:37:43Z","timestamp":1793227063139,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Tumor Pathol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>CIC<\/jats:italic>\n                    -rearranged sarcoma, a rare, undifferentiated small round cell tumor characterized by\n                    <jats:italic>CIC<\/jats:italic>\n                    gene fusions, arises in deep soft tissues of extremities and trunk, whereas an intracranial origin is rare. We report an 11-year-old girl with dural\n                    <jats:italic>CIC<\/jats:italic>\n                    -rearranged sarcoma presenting with intracranial hemorrhage at both initial diagnosis and recurrence. She presented with a sudden-onset headache and motor aphasia. Computed tomography revealed a left frontal convexity lesion with extensive acute subdural hematoma. Due to rapidly deteriorating consciousness, emergent hematoma evacuation and tumor resection were performed. Intraoperatively, the tumor was attached to the dura, suggesting a dural origin. Histopathologic examination demonstrated densely packed, atypical, small round cells within a stromal background; tumor cells were also identified in the dura mater. Comprehensive genomic profiling identified a\n                    <jats:italic>CIC<\/jats:italic>\n                    ::\n                    <jats:italic>DUX4<\/jats:italic>\n                    fusion, leading to the definitive diagnosis of\n                    <jats:italic>CIC<\/jats:italic>\n                    -rearranged sarcoma. She received adjuvant chemotherapy and radiotherapy, without recurrence evidence at 9 months postoperatively, but developed recurrent hemorrhagic lesions in the middle cranial fossa and along the tentorial edge 2 months later. Emergent surgery revealed two lesions with dural attachment; pathology confirmed recurrence. Aggressive growth and marked hemorrhagic tendency observed in this first reported case of dural\n                    <jats:italic>CIC<\/jats:italic>\n                    -rearranged sarcoma highlight the importance of vigilant follow-up and timely clinical intervention.\n                  <\/jats:p>","DOI":"10.1007\/s10014-026-00549-z","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:31:27Z","timestamp":1790782287000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dural CIC::DUX4 sarcoma presenting with intracranial hemorrhage at both initial diagnosis and recurrence: a case report and literature review"],"prefix":"10.1007","author":[{"given":"Shu","family":"Kimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3203-8655","authenticated-orcid":false,"given":"Shota","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kanamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Osada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiteru","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Niizuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"2","key":"549_CR1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.32074\/1591-951X-213","volume":"113","author":"M Sbaraglia","year":"2021","unstructured":"Sbaraglia M, Bellan E, Dei Tos AP (2021) The 2020 WHO classification of soft tissue tumours: news and perspectives. Pathologica 113(2):70\u201384. https:\/\/doi.org\/10.32074\/1591-951X-213","journal-title":"Pathologica"},{"issue":"8","key":"549_CR2","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","volume":"23","author":"DN Louis","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P et al (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23(8):1231\u20131251. https:\/\/doi.org\/10.1093\/neuonc\/noab106","journal-title":"Neuro Oncol"},{"issue":"7","key":"549_CR3","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1097\/PAS.0000000000000846","volume":"41","author":"CR Antonescu","year":"2017","unstructured":"Antonescu CR, Owosho AA, Zhang L et al (2017) Sarcomas with CIC-rearrangements are a distinct pathologic entity with aggressive outcome: a clinicopathologic and molecular study of 115 cases. Am J Surg Pathol 41(7):941\u2013949. https:\/\/doi.org\/10.1097\/PAS.0000000000000846","journal-title":"Am J Surg Pathol"},{"key":"549_CR4","doi-asserted-by":"publisher","first-page":"7801","DOI":"10.1002\/cam4.5539","volume":"12","author":"M Brahmi","year":"2023","unstructured":"Brahmi M, Gaspar N, Gantzer J et al (2023) Patterns of care and outcome of CIC-rearranged sarcoma patients: a nationwide study of the French sarcoma group. Cancer Med 12:7801\u20137807. https:\/\/doi.org\/10.1002\/cam4.5539","journal-title":"Cancer Med"},{"issue":"14","key":"549_CR5","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.3390\/diagnostics15141758","volume":"15","author":"W Maaita","year":"2025","unstructured":"Maaita W, Hasasna N, Yaser S et al (2025) CIC-rearranged sarcoma: a clinical and pathological study of a peculiar entity. Diagnostics 15(14):1758. https:\/\/doi.org\/10.3390\/diagnostics15141758","journal-title":"Diagnostics"},{"key":"549_CR6","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1002\/cam4.4580","volume":"11","author":"EA Connolly","year":"2022","unstructured":"Connolly EA, Bhadri VA, Wake J et al (2022) Systemic treatments and outcomes in CIC-rearranged Sarcoma: A national multi-centre clinicopathological series and literature review. Cancer Med 11:1805\u20131816. https:\/\/doi.org\/10.1002\/cam4.4580","journal-title":"Cancer Med"},{"issue":"2","key":"549_CR7","doi-asserted-by":"publisher","first-page":"e13303","DOI":"10.1111\/bpa.13303","volume":"35","author":"A Tauzi\u00e8de-Espariat","year":"2025","unstructured":"Tauzi\u00e8de-Espariat A, Ebrahimi A, Boddaert N et al (2025) CIC\/ATXN1-rearranged tumors in the central nervous system are mainly represented by sarcomas: A comprehensive clinicopathological and epigenetic series. Brain Pathol 35(2):e13303. https:\/\/doi.org\/10.1111\/bpa.13303","journal-title":"Brain Pathol"},{"issue":"2","key":"549_CR8","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1101\/gad.14.2.224","volume":"14","author":"G Jim\u00e9nez","year":"2000","unstructured":"Jim\u00e9nez G, Guichet A, Ephrussi A, Casanova J (2000) Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning. Genes Dev 14(2):224\u2013231","journal-title":"Genes Dev"},{"issue":"1","key":"549_CR9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40478-023-01522-z","volume":"11","author":"A Tauzi\u00e8de-Espariat","year":"2023","unstructured":"Tauzi\u00e8de-Espariat A, Hasty L, M\u00e9tais A, Varlet P (2023) Mesenchymal non-meningothelial tumors of the central nervous system: a literature review and diagnostic update of novelties and emerging entities. Acta Neuropathol Commun 11(1):22. https:\/\/doi.org\/10.1186\/s40478-023-01522-z","journal-title":"Acta Neuropathol Commun"},{"issue":"4","key":"549_CR10","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s12276-020-0411-3","volume":"52","author":"Y Lee","year":"2020","unstructured":"Lee Y (2020) Regulation and function of capicua in mammals. Exp Mol Med 52(4):531\u2013537. https:\/\/doi.org\/10.1038\/s12276-020-0411-3","journal-title":"Exp Mol Med"},{"key":"549_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1006\/geno.2002.6690","volume":"79","author":"M van Geel","year":"2002","unstructured":"van Geel M, Dickson MC, Beck AF et al (2002) Genomic analysis of human chromosome 10q and 4q telomeres suggests a common origin. Genomics 79:210\u2013217. https:\/\/doi.org\/10.1006\/geno.2002.6690","journal-title":"Genomics"},{"issue":"3","key":"549_CR12","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/gcc.20945","volume":"51","author":"A Italiano","year":"2012","unstructured":"Italiano A, Sung YS, Zhang L et al (2012) High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas. Genes Chromosomes Cancer 51(3):207\u2013218. https:\/\/doi.org\/10.1002\/gcc.20945","journal-title":"Genes Chromosomes Cancer"},{"issue":"12","key":"549_CR13","doi-asserted-by":"publisher","first-page":"3322","DOI":"10.3390\/cells10123322","volume":"10","author":"E Mocciaro","year":"2021","unstructured":"Mocciaro E, Runfola V, Ghezzi P et al (2021) DUX4 role in normal physiology and in FSHD muscular dystrophy. Cells Cells 10(12):3322. https:\/\/doi.org\/10.3390\/cells10123322","journal-title":"Cells Cells"},{"issue":"10","key":"549_CR14","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/s41389-021-00357-4","volume":"10","author":"D Bosnakovski","year":"2021","unstructured":"Bosnakovski D, Ener ET, Cooper MS et al (2021) Inactivation of the CIC-DUX4 oncogene through P300\/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma. Oncogenesis 10(10):68. https:\/\/doi.org\/10.1038\/s41389-021-00357-4","journal-title":"Oncogenesis"},{"issue":"13","key":"549_CR15","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1093\/hmg\/ddl136","volume":"15","author":"M Kawamura-Saito","year":"2006","unstructured":"Kawamura-Saito M, Yamazaki Y, Kaneko K et al (2006) Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4; 19)(q35; q13) translocation. Hum Mol Genet 15(13):2125\u20132137. https:\/\/doi.org\/10.1093\/hmg\/ddl136","journal-title":"Hum Mol Genet"},{"issue":"3","key":"549_CR16","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s00256-020-03589-4","volume":"50","author":"EJ Brady","year":"2021","unstructured":"Brady EJ, Hameed M, Tap WD, Hwang S (2021) Imaging features and clinical course of undifferentiated round cell sarcomas with CIC-DUX4 and BCOR-CCNB3 translocations. Skeletal Radiol 50(3):521\u2013529. https:\/\/doi.org\/10.1007\/s00256-020-03589-4","journal-title":"Skeletal Radiol"},{"key":"549_CR17","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1002\/gcc.22172","volume":"53","author":"K Specht","year":"2014","unstructured":"Specht K, Sung Y, Zhang L et al (2014) Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion\u2013positive round cell tumors compared to EWSR1 \u2010rearranged ewing sarcomas: further evidence toward distinct pathologic entities. Genes Chromosomes Cancer 53:622\u2013633. https:\/\/doi.org\/10.1002\/gcc.22172","journal-title":"Genes Chromosomes Cancer"},{"key":"549_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/neup.12325","volume":"37","author":"C Ke","year":"2017","unstructured":"Ke C, Duan Q, Yang H et al (2017) Meningeal Ewing sarcoma\/peripheral PNET: clinicopathological, immunohistochemical and FISH study of four cases. Neuropathology 37:35\u201344. https:\/\/doi.org\/10.1111\/neup.12325","journal-title":"Neuropathology"},{"issue":"02","key":"549_CR19","doi-asserted-by":"publisher","first-page":"288","DOI":"10.4103\/1793-5482.228570","volume":"13","author":"A Singh","year":"2018","unstructured":"Singh A, Srivastava A, Pal L et al (2018) Extraosseous primary intracranial ewing sarcoma\/peripheral primitive neuroectodermal tumor: series of seven cases and review of literature. Asian J Neurosurg 13(02):288\u2013296. https:\/\/doi.org\/10.4103\/1793-5482.228570","journal-title":"Asian J Neurosurg"},{"key":"549_CR20","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s00381-018-3991-7","volume":"35","author":"AH Sohail","year":"2019","unstructured":"Sohail AH, Sachal M, Maan MA et al (2019) Primary intracranial extraosseous Ewing\u2019s sarcoma. Childs Nerv Syst 35:541\u2013545. https:\/\/doi.org\/10.1007\/s00381-018-3991-7","journal-title":"Childs Nerv Syst"},{"issue":"6","key":"549_CR21","doi-asserted-by":"publisher","first-page":"e247056","DOI":"10.1136\/bcr-2021-247056","volume":"15","author":"S Mohakud","year":"2022","unstructured":"Mohakud S, Rajasimman AS, Purkait S, Naik S (2022) Intracranial extraosseous dural-based Ewing\u2019s sarcoma with fluid-haematocrit levels: imaging findings of a rare tumour. BMJ Case Rep 15(6):e247056. https:\/\/doi.org\/10.1136\/bcr-2021-247056","journal-title":"BMJ Case Rep"},{"issue":"4","key":"549_CR22","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s00381-022-05767-2","volume":"39","author":"A Guler","year":"2023","unstructured":"Guler A, Senol YC (2023) Primary, dural-based, Ewing sarcoma in a pediatric patient: presentation of a rare tumor entity with literature review. Childs Nerv Syst 39(4):1071\u20131075. https:\/\/doi.org\/10.1007\/s00381-022-05767-2","journal-title":"Childs Nerv Syst"},{"key":"549_CR23","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3171\/2013.3.JNS121707","volume":"119","author":"H Takei","year":"2013","unstructured":"Takei H, Powell S, Rivera A (2013) Concurrent occurrence of primary intracranial Epstein-Barr virus\u2013associated leiomyosarcoma and Hodgkin lymphoma in a young adult: Case report. JNS 119:499\u2013503. https:\/\/doi.org\/10.3171\/2013.3.JNS121707","journal-title":"JNS"},{"key":"549_CR24","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.wneu.2018.10.132","volume":"122","author":"A Saito","year":"2019","unstructured":"Saito A, Ninomiya A, Ishida T et al (2019) Intractable repeated intracerebral hemorrhage due to primary dural leiomyosarcoma: case report and literature review. World Neurosurg 122:116\u2013122. https:\/\/doi.org\/10.1016\/j.wneu.2018.10.132","journal-title":"World Neurosurg"},{"issue":"1","key":"549_CR25","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1440-1789.2012.01320.x","volume":"33","author":"Y Lin","year":"2013","unstructured":"Lin Y, Yang Q, Tian X et al (2013) Unusual primary intracranial dural-based poorly differentiated synovial sarcoma with t(X; 18)(p11; q11). Neuropathology 33(1):75\u201382. https:\/\/doi.org\/10.1111\/j.1440-1789.2012.01320.x","journal-title":"Neuropathology"},{"key":"549_CR26","doi-asserted-by":"publisher","first-page":"447","DOI":"10.25259\/SNI_665_2022","volume":"13","author":"TK Vora","year":"2022","unstructured":"Vora TK, Lath R, Swain M, Ray A (2022) Primary intracranial synovial sarcoma: A case report and review of literature. Surg Neurol Int 13:447. https:\/\/doi.org\/10.25259\/SNI_665_2022","journal-title":"Surg Neurol Int"},{"issue":"2","key":"549_CR27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1159\/000380901","volume":"59","author":"S Lee","year":"2015","unstructured":"Lee S, Kim NR, Chung DH et al (2015) Squash cytology of a dural-based high-grade chondrosarcoma may mimic that of glioblastoma in the central nervous system. Acta Cytol 59(2):219\u2013224. https:\/\/doi.org\/10.1159\/000380901","journal-title":"Acta Cytol"},{"issue":"1","key":"549_CR28","doi-asserted-by":"publisher","first-page":"128","DOI":"10.4103\/0028-3886.60428","volume":"58","author":"N Ghosal","year":"2010","unstructured":"Ghosal N, Dadlani R, Furtado S et al (2010) Dural based primary osteosarcoma in right fronto-temporal region: Case report with review of literature. Neurol India 58(1):128\u2013130. https:\/\/doi.org\/10.4103\/0028-3886.60428","journal-title":"Neurol India"},{"issue":"3","key":"549_CR29","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1097\/PAS.0000000000000570","volume":"40","author":"A Yoshida","year":"2016","unstructured":"Yoshida A, Goto K, Kodaira M et al (2016) CIC-rearranged sarcomas: a study of 20 cases and comparisons with Ewing sarcomas. Am J Surg Pathol 40(3):313\u2013323. https:\/\/doi.org\/10.1097\/PAS.0000000000000570","journal-title":"Am J Surg Pathol"},{"key":"549_CR30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ejca.2023.01.003","volume":"183","author":"E Palmerini","year":"2023","unstructured":"Palmerini E, Gambarotti M, Italiano A et al (2023) A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl). Eur J Cancer 183:11\u201323. https:\/\/doi.org\/10.1016\/j.ejca.2023.01.003","journal-title":"Eur J Cancer"},{"issue":"3","key":"549_CR31","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s00432-024-05631-7","volume":"150","author":"J Murphy","year":"2024","unstructured":"Murphy J, Resch EE, Leland C et al (2024) Clinical outcomes of patients with CIC-rearranged sarcoma: a single institution retrospective analysis. J Cancer Res Clin Oncol 150(3):112. https:\/\/doi.org\/10.1007\/s00432-024-05631-7","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"549_CR32","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s40478-024-01824-w","volume":"12","author":"Y Hou","year":"2024","unstructured":"Hou Y, Du Y, Wang J et al (2024) Pediatric central nervous system tumor with CIC::LEUTX fusion: a diagnostic challenge. Acta neuropathol commun 12(1):106. https:\/\/doi.org\/10.1186\/s40478-024-01824-w","journal-title":"Acta neuropathol commun"},{"issue":"5","key":"549_CR33","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s00428-026-04437-x","volume":"488","author":"J Balko","year":"2026","unstructured":"Balko J, Kukla F, Krskova L et al (2026) Clinicopathological features of CIC-rearranged sarcomas: a retrospective study including novel visceral locations and methylation profile analysis. Virchows Arch 488(5):1067\u20131076. https:\/\/doi.org\/10.1007\/s00428-026-04437-x","journal-title":"Virchows Arch"},{"issue":"2","key":"549_CR34","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/PAS.0000000000001187","volume":"43","author":"F Le Loarer","year":"2019","unstructured":"Le Loarer F, Pissaloux D, Watson S et al (2019) Clinicopathologic features of CIC-NUTM1 sarcomas, a new molecular variant of the family of CIC-fused sarcomas. Am J Surg Pathol 43(2):268\u2013276. 10.1097\/ PAS.0000000000001187","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"549_CR35","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1002\/dc.23520","volume":"44","author":"M Ito","year":"2016","unstructured":"Ito M, Ishikawa M, Kitajima M et al (2016) A case report of CIC-rearranged undifferentiated small round cell sarcoma in the cerebrum. Diagn Cytopathol 44(10):828\u2013832. https:\/\/doi.org\/10.1002\/dc.23520","journal-title":"Diagn Cytopathol"},{"issue":"2","key":"549_CR36","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00401-014-1312-0","volume":"128","author":"F Bielle","year":"2014","unstructured":"Bielle F, Zanello M, Guillemot D et al (2014) Unusual primary cerebral localization of a CIC\u2013DUX4 translocation tumor of the Ewing sarcoma family. Acta Neuropathol 128(2):309\u2013311. https:\/\/doi.org\/10.1007\/s00401-014-1312-0","journal-title":"Acta Neuropathol"},{"key":"549_CR37","doi-asserted-by":"publisher","first-page":"1519335","DOI":"10.3389\/fonc.2025.1519335","volume":"15","author":"W Jin","year":"2025","unstructured":"Jin W, Dong K, Yang F et al (2025) Cerebral CIC-NUTM1 rearrangement sarcoma- case report and review of the literature. Front Oncol 15:1519335. https:\/\/doi.org\/10.3389\/fonc.2025.1519335","journal-title":"Front Oncol"}],"container-title":["Brain Tumor Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10014-026-00549-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10014-026-00549-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10014-026-00549-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:31:28Z","timestamp":1790782288000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10014-026-00549-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":37,"alternative-id":["549"],"URL":"https:\/\/doi.org\/10.1007\/s10014-026-00549-z","relation":{},"ISSN":["1433-7398","1861-387X"],"issn-type":[{"value":"1433-7398","type":"print"},{"value":"1861-387X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"4 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest directly related to the topic of this article.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}