{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:40:23Z","timestamp":1787236823154,"version":"build-2736575974"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Vascular Surgery"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1007\/s10016-006-9036-9","type":"journal-article","created":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T16:52:11Z","timestamp":1144774331000},"page":"376-380","source":"Crossref","is-referenced-by-count":14,"title":["Venous Ulcer Fibroblasts Respond to Basic Fibroblast Growth Factor at the Cell Cycle Protein Level"],"prefix":"10.1016","volume":"20","author":[{"given":"Craig","family":"Seidman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Raffetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen C.","family":"Overman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James O.","family":"Menzoian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s10016-006-9036-9_bib1","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1136\/bmj.294.6584.1389","article-title":"Chronic ulcer of the leg: clinical history","volume":"294","author":"Callam","year":"1987","journal-title":"Br J Med"},{"key":"10.1007\/s10016-006-9036-9_bib2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.med.46.1.467","article-title":"Pharmacologic enhancement of wound healing","volume":"46","author":"Pierce","year":"1995","journal-title":"Annu Rev Med"},{"key":"10.1007\/s10016-006-9036-9_bib3","first-page":"864","article-title":"Venous and non-venous leg ulcers: clinical history and appearance in a population study:","volume":"78","author":"Nelzen","year":"1991","journal-title":"Br J Surg"},{"key":"10.1007\/s10016-006-9036-9_bib4","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S0741-5214(97)70012-0","article-title":"Reduced growth of dermal fibroblasts from chronic venous ulcers can be stimulated with growth factors","volume":"26","author":"Stanley","year":"1997","journal-title":"J Vasc Surg"},{"key":"10.1007\/s10016-006-9036-9_bib5","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0741-5214(98)70064-3","article-title":"Fibroblasts cultured from venous ulcers display cellular characteristics of senescence:","volume":"28","author":"Mendez","year":"1998","journal-title":"J Vasc Surg"},{"key":"10.1007\/s10016-006-9036-9_bib6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0959-8049(96)00058-5","article-title":"The biology of replicative senescence","volume":"33","author":"Campisi","year":"1997","journal-title":"Eur J Cancer"},{"key":"10.1007\/s10016-006-9036-9_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0531-5565(95)02018-7","article-title":"Molecular markers of senescence in fibroblast-like cultures","volume":"31","author":"Cristofalo","year":"1996","journal-title":"Exp Gerontol"},{"key":"10.1007\/s10016-006-9036-9_bib8","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo.","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1007\/s10016-006-9036-9_bib9","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/S0741-5214(98)70030-8","article-title":"Fibroblasts cultured from distal lower extremities in patients with venous reflux display cellular characteristics of senescence","volume":"28","author":"Mendez","year":"1998","journal-title":"J Vasc Surg"},{"key":"10.1007\/s10016-006-9036-9_bib10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/jidsp.1998.5","article-title":"Molecular mechanisms for the senescent cell cycle arrest","volume":"3","author":"Stein","year":"1998","journal-title":"J Inves Dermatol Symp Proc"},{"key":"10.1007\/s10016-006-9036-9_bib11","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.2166342","article-title":"Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts","volume":"249","author":"Stein","year":"1990","journal-title":"Science"},{"key":"10.1007\/s10016-006-9036-9_bib12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1006\/excr.1994.1063","article-title":"Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen","volume":"211","author":"Noda","year":"1994","journal-title":"Exp Cell Res"},{"key":"10.1007\/s10016-006-9036-9_bib13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0092-8674(00)00046-5","article-title":"Cellular senesence: mitotic clock or culture shock","volume":"102","author":"Sherr","year":"2000","journal-title":"Cell"},{"key":"10.1007\/s10016-006-9036-9_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/geronj\/44.6.55","article-title":"Alterations in the responsiveness of Senescent Cells to Growth Factors","volume":"44","author":"Cristofalo","year":"1989","journal-title":"J Gerentol"},{"key":"10.1007\/s10016-006-9036-9_bib15","series-title":"of Venous Disorders: Guidelines of the American Venous Forum","first-page":"652","article-title":"Classification and grading of chronic venous disease in the lower limbs: a consensus statement","author":"Bergan","year":"1996"},{"key":"10.1007\/s10016-006-9036-9_bib16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0003-2697(82)90608-X","article-title":"A simple, rapid, and sensitive method for measuring protein concentration in subcellular membrane fractions prepared by sucrose density ultracentrifugation","volume":"119","author":"Simpson","year":"1982","journal-title":"Anal Biochem"},{"key":"10.1007\/s10016-006-9036-9_bib17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0002-9610(99)00134-8","article-title":"The effect of passage number on fibroblast cellular senescence in patients with chronic venous insufficiencey with and without ulcers","volume":"178","author":"Raffeto","year":"1999","journal-title":"Am J Surg"},{"key":"10.1007\/s10016-006-9036-9_bib18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0014-4827(89)90372-8","article-title":"Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity","volume":"184","author":"West","year":"1989","journal-title":"Exp Cell Res"},{"key":"10.1007\/s10016-006-9036-9_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10016-003-0004-3","article-title":"bFGF induced alterations in cellular markers of senescence in growth rescued fibroblasts from chronic venous ulcer and venous reflux patients","volume":"17","author":"Seidman","year":"2003","journal-title":"Ann Vasc Surg"},{"key":"10.1007\/s10016-006-9036-9_bib20","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1073\/pnas.92.10.4337","article-title":"Oxidative DNA damage and senescence of human diploid fibroblast cells","volume":"92","author":"Chen","year":"1995","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Annals of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890509606613691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890509606613691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:50:06Z","timestamp":1547686206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890509606613691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0890509606613691"],"URL":"https:\/\/doi.org\/10.1007\/s10016-006-9036-9","relation":{},"ISSN":["0890-5096"],"issn-type":[{"value":"0890-5096","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}