{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:05:59Z","timestamp":1741752359065,"version":"3.38.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:p> A 5-year-old girl with a mild upper airways infection was admitted to the hospital because of sudden vomiting and drowsiness that evolved to stupor; she was dehydrated, hypotensive, and tachypneic; laboratory tests revealed noncompensated lactic acidosis. She also had hypoglycemia followed by hyperglycemia, and progressive bradycardia leading to reversible cardiac arrest. Her clinical condition complicated by sinus bradycardia, ventricular tachycardia, third-degree atrioventricular blockage and lethal asystole. At the final stage of her illness, the serum salicylate concentration was 383.8 mcg\/mL. Based on this single data, a retrospective toxicological analysis estimated a theoretical peak level of serum salicylate of approximately 1570 mcg\/mL (therapeutic range, 20\u2013250 mcg\/mL) although the real amount of aspirin that this child ingested is difficult to calculate because aspirin is a drug that shows a so-called zero order kinetics. At autopsy, the most striking finding was multiple foci of coagulative necrosis involving the entire thickness of the myocardium with scant inflammatory infiltrate composed mainly of macrophages and polymorphonuclear leukocytes. The morphologic characteristics of the myocardial lesion in addition to salicylate blood levels suggests the possibility of an adverse drug reaction of the type acute toxic myocarditis. <\/jats:p>","DOI":"10.1007\/s10024-001-0127-x","type":"journal-article","created":{"date-parts":[[2003,12,2]],"date-time":"2003-12-02T21:39:20Z","timestamp":1070401160000},"page":"342-347","source":"Crossref","is-referenced-by-count":13,"title":["Aspirin Intoxication in a Child Associated with Myocardial Necrosis: Is this a Drug-related Lesion?"],"prefix":"10.1177","volume":"6","author":[{"given":"Y. ROC\u00edO","family":"Pe\u00f1a-Alonso","sequence":"first","affiliation":[{"name":"Department of Pathology, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Dr. M\u00e1rquez 162, M\u00e9xico, D.F., CP 06720, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Montoya-Cabrera","sequence":"additional","affiliation":[{"name":"Universidad La Salle, Facultad Mexicana de Medicina, M\u00e9xico, D.F., M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Bustos-C\u00f3rdoba","sequence":"additional","affiliation":[{"name":"Emergency Room, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, M\u00e9xico, D.F., M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"MarroqU\u00edn-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, M\u00e9xico, D.F., M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edCTOR","family":"Olivar-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, M\u00e9xico, D.F., M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,7,1]]},"reference":[{"key":"bibr1-s10024-001-0127-x","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0733-8627(20)30432-6","volume":"12","author":"Yip L","year":"1994","journal-title":"Emerg Med Clin North Am"},{"key":"bibr2-s10024-001-0127-x","first-page":"765","volume-title":"Textbook of Pediatric Emergency Medicine","author":"Henreting FM","year":"1993"},{"key":"bibr3-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1994.tb00056.x"},{"key":"bibr4-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199605000-00005"},{"key":"bibr5-s10024-001-0127-x","first-page":"31","volume":"25","author":"Uzan S","year":"1996","journal-title":"Indications and modalities of prescription after the publication of the later trials. Presse Med"},{"key":"bibr6-s10024-001-0127-x","first-page":"661","volume-title":"Goodman and Gilman. Las Bases Farmacol\u00f3gicas de la Terap\u00e9utica","volume":"1","author":"Insel PA","year":"1996"},{"key":"bibr7-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1177\/106002809402800409"},{"key":"bibr8-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(89)90364-1"},{"key":"bibr9-s10024-001-0127-x","first-page":"675","volume-title":"Clinical Management of Poisoning and Drug Overdose","author":"Krenzolok EP","year":"1998"},{"key":"bibr10-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.51.595.344"},{"key":"bibr11-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1016\/0735-6757(94)90271-2"},{"key":"bibr12-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199307000-00027"},{"key":"bibr13-s10024-001-0127-x","first-page":"487","volume-title":"Casarett and Doull's Toxicology. The Basic Science of Poisons","author":"Ramos KS","year":"1996"},{"key":"bibr14-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1016\/0736-4679(95)00073-J"},{"key":"bibr15-s10024-001-0127-x","first-page":"201","volume-title":"Pathology of Drug-induced and Toxic Diseases","author":"McAllister HA","year":"1982"},{"key":"bibr16-s10024-001-0127-x","first-page":"764","volume":"115","author":"Burke AP","year":"1991","journal-title":"Arch Pathol Lab Med"},{"key":"bibr17-s10024-001-0127-x","first-page":"1","volume":"37","author":"Repetto MR","year":"1999","journal-title":"Clin Toxicol"},{"key":"bibr18-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199223020-00003"},{"key":"bibr19-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1993.tb04201.x"},{"key":"bibr20-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1520\/JFS13382J"},{"key":"bibr21-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)35009-X"},{"key":"bibr22-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.3109\/15513818309025871"},{"key":"bibr23-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31728-X"},{"key":"bibr24-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1987.00370030114022"},{"key":"bibr25-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(95)01719-Y"},{"key":"bibr26-s10024-001-0127-x","first-page":"338","volume":"41","author":"Das S","year":"1995","journal-title":"J Trop Med"},{"key":"bibr27-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(94)01638-L"},{"key":"bibr28-s10024-001-0127-x","first-page":"224","volume":"21","author":"Montoya CMA","year":"1983","journal-title":"Rev Med IMSS (Mex)"},{"key":"bibr29-s10024-001-0127-x","first-page":"19","volume-title":"Pathology of Drug-induced and Toxic Diseases","author":"Perrin EVDK","year":"1982"},{"key":"bibr30-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011093431908"},{"key":"bibr31-s10024-001-0127-x","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80363-5"},{"key":"bibr32-s10024-001-0127-x","first-page":"617","volume":"82","author":"Irey NS","year":"1976","journal-title":"Am J Pathol"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1007\/s10024-001-0127-x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1007\/s10024-001-0127-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T23:52:38Z","timestamp":1741650758000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1007\/s10024-001-0127-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["10.1007\/s10024-001-0127-x"],"URL":"https:\/\/doi.org\/10.1007\/s10024-001-0127-x","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"type":"print","value":"1093-5266"},{"type":"electronic","value":"1615-5742"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}