{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T13:40:01Z","timestamp":1741614001745,"version":"3.38.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p> Long-term sequelae of Helicobacter pylori\u2013associated chronic gastritis (HpCG) have been described in adult patients. In the present study we report the histology of gastric mucosa biopsies in 6 asymptomatic pediatric patients (5 male and 1 female; mean age 9.5 years) with previous HpCG. Preceding H. pylori was histologically proved and confirmed by culture, direct visualization, and\/or serology before delivering treatment. In 5 of 6 cases the HpCG followed a protracted clinical course, with various therapeutic series needed before H. pylori eradication. Time from final treatment for HpCG to actual biopsy ranged from 3 months to almost 3 years. Gastric mucosa showed mild chronic gastritis with absence of H. pylori organisms (6 of 6), focal loss of gland units with collagenous replacement (6 of 6), serrated foveolae (3 of 6), regenerative changes at elongated glandular necks with cells having enlarged and hyper-chromatic nuclei (5 of 6), lymphoid aggregates (2 of 6), and presence of sulfomucins in isolated epithelial cells of glands and foveolae (2 of 6). None of these features were noticed in 10 normal gastric mucosa biopsies used as controls. The referred findings in \u201cex\u2013 H. pylori\u201d pediatric patients may represent very early sequelae from HpCG at this age. <\/jats:p>","DOI":"10.1007\/s10024-002-0032-y","type":"journal-article","created":{"date-parts":[[2005,7,11]],"date-time":"2005-07-11T09:48:07Z","timestamp":1121075287000},"page":"420-426","source":"Crossref","is-referenced-by-count":1,"title":["Histologic Findings in \u201cEx- <i>Helicobacter pylori<\/i>\u201d Gastric Biopsies of Pediatric Patients"],"prefix":"10.1177","volume":"8","author":[{"given":"Marta","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Pathology, Hospital de Ni\u00f1os \u201cSuperiora Sor Mar\u00eda Ludovica\u201d, 1900, La Plata, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Cueto","family":"R\u00faa","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital de Ni\u00f1os \u201cSuperiora Sor Mar\u00eda Ludovica\u201d, 1900, La Plata, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"Balcarce","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital de Ni\u00f1os \u201cSuperiora Sor Mar\u00eda Ludovica\u201d, 1900, La Plata, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Drut","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital de Ni\u00f1os \u201cSuperiora Sor Mar\u00eda Ludovica\u201d, 1900, La Plata, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,7,1]]},"reference":[{"key":"bibr1-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1159\/000061918"},{"key":"bibr2-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200007000-00014"},{"key":"bibr3-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90059-0"},{"key":"bibr4-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"bibr5-s10024-002-0032-y","first-page":"35","volume":"30","author":"Cohen M","year":"2000","journal-title":"Acta Gastroenterol Latinoam"},{"key":"bibr6-s10024-002-0032-y","doi-asserted-by":"crossref","unstructured":"PrietoG, PolancoY, LarrauriJ, RotaL, LamaR, CarrascoS. Helicobacter pylori infection in children: Clinical, endoscopic, and histologic correlations. J Pediatr Gastroenterol Nutr 1992;14:420\u2013425.","DOI":"10.1002\/j.1536-4801.1992.tb10574.x"},{"key":"bibr7-s10024-002-0032-y","unstructured":"ProphetEB, MillsB, ArringtonJB, SobinLH, eds. Laboratory methods in histotechnology. Washington, DC: American Registry of Pathology, Armed Forces Institute of Pathology, 1993;160."},{"key":"bibr8-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)80013-3"},{"key":"bibr9-s10024-002-0032-y","first-page":"208","volume-title":"Helicobacter pylori. Microbiolog\u00eda, cl\u00ednica y tratamiento.","author":"Boixeda de Miguel D","year":"1995"},{"key":"bibr10-s10024-002-0032-y","volume":"19","author":"Correa P.","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"bibr11-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)80015-7"},{"key":"bibr12-s10024-002-0032-y","first-page":"492","volume-title":"Manual of clinical microbiology.","author":"Jerris RC","year":"1995"},{"key":"bibr13-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91084-0"},{"key":"bibr14-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409105356"},{"key":"bibr15-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930915)72:6<1841::AID-CNCR2820720608>3.0.CO;2-I"},{"key":"bibr16-s10024-002-0032-y","doi-asserted-by":"crossref","unstructured":"The Eurogast Study Group. An international association between Helicobacter pylori infection and gastric cancer. Lancet 1993;341:1359\u20131362.","DOI":"10.1016\/0140-6736(93)90938-D"},{"key":"bibr17-s10024-002-0032-y","volume":"10","author":"Segura AM","year":"1997","journal-title":"Mod Pathol"},{"key":"bibr18-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1136\/fn.74.2.F141"},{"key":"bibr19-s10024-002-0032-y","doi-asserted-by":"crossref","unstructured":"BourkeB, JonesN, ShermanP. Helicobacter pylori infection and peptic ulcer disease in children. Pediatr Infect Dis J 1996;15:1\u201313.","DOI":"10.1097\/00006454-199601000-00002"},{"key":"bibr20-s10024-002-0032-y","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0065-3101(24)00287-1","volume":"39","author":"Judd RH","year":"1992","journal-title":"Adv Pediatr"},{"key":"bibr21-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199910000-00004"},{"key":"bibr22-s10024-002-0032-y","first-page":"411","volume":"31","author":"Cohen M","year":"2001","journal-title":"Acta Gastroenterol Latinam"},{"key":"bibr23-s10024-002-0032-y","first-page":"281","volume":"6","author":"Genta RM","year":"1993","journal-title":"Mod Pathol"},{"key":"bibr24-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198601000-00006"},{"key":"bibr25-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90235-9"},{"key":"bibr26-s10024-002-0032-y","doi-asserted-by":"crossref","unstructured":"WhitneyAE, GuarnerJ, HutwagnerL, GoldB. Helicobacter pylori gastritis in children and adults: comparative histopathologic study. Ann Diagn Pathol 2000;4:279\u2013285.","DOI":"10.1053\/adpa.2000.17871"},{"key":"bibr27-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199600001-00004"},{"key":"bibr28-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80082-X"},{"key":"bibr29-s10024-002-0032-y","unstructured":"MorsonBC, DawsonIM, eds. Gastrointestinal pathology. Oxford: Blackwell Scientific Publications, 1990;101."},{"key":"bibr30-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90199-4"},{"key":"bibr31-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01185.x"},{"key":"bibr32-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64006-0"},{"key":"bibr33-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750065861"},{"key":"bibr34-s10024-002-0032-y","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70365-8"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1007\/s10024-002-0032-y","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1007\/s10024-002-0032-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T12:56:33Z","timestamp":1741611393000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1007\/s10024-002-0032-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1007\/s10024-002-0032-y"],"URL":"https:\/\/doi.org\/10.1007\/s10024-002-0032-y","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"type":"print","value":"1093-5266"},{"type":"electronic","value":"1615-5742"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}