{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T04:30:11Z","timestamp":1741667411734,"version":"3.38.0"},"reference-count":9,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p> There is sparse information in humans on graft-versushost (GVH) lymphadenopathy. A 15-month-old male received a liver and small bowel transplant for short bowel after gastroschisis. At 21 days he developed a GVH-like skin rash. Flow cytometry demonstrated 16.1% circulating donor cells. Polymerase chain reaction for Epstein-Barr virus was negative. Two months later, the rash recurred with diffuse lymphadenopathy. Lymph node biopsy showed effaced architecture without visible follicles, large numbers of CD79a<jats:sup>+<\/jats:sup> immunoblasts interspersed with smaller CD3<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> cells, and prominent dendritic cell hyperplasia. Human herpes virus 8, cytomegalovirus, and EBER-1 probes were negative, as was polymerase chain reaction for human herpes virus 6. Allograft intestinal biopsies on days 10 and 24 had a similar infiltrate. The features appeared to be those of lymphocytes trafficking between the graft and host with a mixed lymphocyte reaction in situ, a GVH-type reaction without tissue damage. The reaction was self-limiting in the intestinal graft, and the lymphadenopathy resolved with some decrease in immunosupression. Circulating donor cells fell to 2.5% by day 62, and the child has been rejection free on low-dose immunosuppression. <\/jats:p>","DOI":"10.1007\/s10024-004-3028-y","type":"journal-article","created":{"date-parts":[[2004,10,23]],"date-time":"2004-10-23T19:40:29Z","timestamp":1098560429000},"page":"533-537","source":"Crossref","is-referenced-by-count":3,"title":["Transient Posttransplant Graft-versus-Host Lymphadenopathy"],"prefix":"10.1177","volume":"7","author":[{"given":"Laurentia","family":"Nodit","sequence":"first","affiliation":[{"name":"Department of Pathology, Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Murase","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Children's Hospital of Pittsburgh and Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge D.","family":"Reyes","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Children's Hospital of Pittsburgh and Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George V.","family":"Mazariegos","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Children's Hospital of Pittsburgh and Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Sindhi","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Children's Hospital of Pittsburgh and Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,9,1]]},"reference":[{"key":"bibr1-s10024-004-3028-y","first-page":"93","volume":"5","author":"Seemayer TA","year":"1979","journal-title":"Perspect Pediatr Pathol"},{"key":"bibr2-s10024-004-3028-y","first-page":"286","volume":"41","author":"Schraut WH","year":"1986","journal-title":"Clinical course and pathology. 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Am J Clin Pathol"},{"key":"bibr9-s10024-004-3028-y","first-page":"880","volume":"108","author":"Murase N","year":"1990","journal-title":"Surgery"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1007\/s10024-004-3028-y","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1007\/s10024-004-3028-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T18:53:09Z","timestamp":1741632789000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1007\/s10024-004-3028-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1007\/s10024-004-3028-y"],"URL":"https:\/\/doi.org\/10.1007\/s10024-004-3028-y","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"type":"print","value":"1093-5266"},{"type":"electronic","value":"1615-5742"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}