{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T04:36:54Z","timestamp":1741667814237,"version":"3.38.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p> Adrenocortical tumors are uncommon neoplasms in childhood. Most pediatric adrenal tumors are virilizing and carcinomas are more common than adenomas. Recent molecular data suggest an adenoma-to-carcinoma progression sequence in adrenal cortical neoplasms. We report a case of a 5-year-old boy who presented with virilizing symptoms secondary to an adrenal tumor that was resected laparoscopically. The bulk of the tumor was a large, yellow mass with typical features of an adrenal cortical adenoma. In the center was a well-circumscribed tan-brown nodule that was distinct from the adenoma and had oncocytic features. A third minute focus (3.0 mm) was noted that was not circumscribed or encapsulated, but showed marked pleomorphism and abundant mitoses, including atypical forms and increased Ki67 compared with the outer 2 nodules. Molecular analysis to assess the clonality and mutation rates of the 3 distinct areas showed only 2 genetic loci with allelic imbalances. <\/jats:p>","DOI":"10.1007\/s10024-005-1123-3","type":"journal-article","created":{"date-parts":[[2005,7,11]],"date-time":"2005-07-11T18:06:47Z","timestamp":1121105207000},"page":"483-488","source":"Crossref","is-referenced-by-count":2,"title":["Unusual Adrenal Cortical Tumor of Unknown Biologic Potential: A Nodule in a Nodule in a Nodule"],"prefix":"10.1177","volume":"8","author":[{"given":"Sarangarajan","family":"Ranganathan","sequence":"first","affiliation":[{"name":"Department of Pathology, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA"},{"name":"Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kecha","family":"Lynshue","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA"},{"name":"Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,7,1]]},"reference":[{"key":"bibr1-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200307000-00001"},{"key":"bibr2-s10024-005-1123-3","first-page":"1","volume":"27","author":"Lack EE","year":"1992","journal-title":"Pathol Annu"},{"key":"bibr3-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(93)90341-H"},{"key":"bibr4-s10024-005-1123-3","first-page":"1317","volume":"82","author":"Latronico AC","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr5-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.80.1.46"},{"key":"bibr6-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990129)80:3<373::AID-IJC7>3.0.CO;2-B"},{"key":"bibr7-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199702)181:2<146::AID-PATH744>3.0.CO;2-7"},{"key":"bibr8-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65205-4"},{"key":"bibr9-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000081730.72305.81"},{"key":"bibr10-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199805000-00012"},{"key":"bibr11-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02746.x"},{"key":"bibr12-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200401000-00004"},{"key":"bibr13-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850215)55:4<766::AID-CNCR2820550414>3.0.CO;2-7"},{"key":"bibr14-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198903000-00004"},{"key":"bibr15-s10024-005-1123-3","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/101.5.625"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1007\/s10024-005-1123-3","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1007\/s10024-005-1123-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T22:32:35Z","timestamp":1741645955000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1007\/s10024-005-1123-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1007\/s10024-005-1123-3"],"URL":"https:\/\/doi.org\/10.1007\/s10024-005-1123-3","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"type":"print","value":"1093-5266"},{"type":"electronic","value":"1615-5742"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}