{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:31:41Z","timestamp":1770823901972,"version":"3.50.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:p> This retrospective study compared the prenatal ultrasound (US) diagnosis with autopsy findings in 61 intact fetuses following induced abortion and 36 fragmented fetuses from dilatation and evacuation (D&amp;E). In intact fetuses, complete agreement between US diagnosis and autopsy findings was achieved in 65.6% of cases in the central nervous system (CNS) and 47.5% in other somatic organ systems (SOS). There were major differences between US and autopsy findings involving the CNS in 6.5% of cases and SOS in 27.9%. Correlation was better for evaluation of renal anomalies (complete agreement in 63.6% of 11 suspected cases, 2 false-positive and no false-negative cases) than congenital heart disease (complete agreement in 27.3% of 11 suspected cases, 5 false-positive and 3 false-negative cases). In D&amp;E specimens, a prenatal diagnosis of neural tube defect (NTD) was confirmed in 90% of cases. However, due to fragmentation of fetal parts, the US diagnosis in the CNS could not be confirmed totally (69.4%) or partially (2.8%) in fetuses with chromosomal abnormalities (ChA) or multiple congenital anomalies (MCA). Nonetheless, the US diagnosis of SOS was confirmed in six cases on D&amp;E, including Meckel-Gruber syndrome, cystic hygroma, renal agenesis with contralateral renal dysplasia, cardiac defect, fetal hydrops, and tracheal atresia. Our results show that a thorough autopsy of an intact fetus after abortion is necessary to confirm prenatal diagnosis and allow proper management and counseling. The pathologic examination of D&amp;E specimens can reliably confirm the US diagnosis of NTD, but it is very limited in identifying other fetal anomalies. <\/jats:p>","DOI":"10.1007\/s100249900101","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T06:40:57Z","timestamp":1027579257000},"page":"131-142","source":"Crossref","is-referenced-by-count":46,"title":["Correlation of Prenatal Ultrasound Diagnosis and Pathologic Findings in Fetal Anomalies"],"prefix":"10.1177","volume":"2","author":[{"given":"Chen-Chih J.","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pathology and Pediatrics, School of Medicine, University of Maryland, 655 W. Baltimore Street, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Grumbach","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, School of Medicine, University of Maryland, 655 W. Baltimore Street, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna T.","family":"DeCosta","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, School of Medicine, University of Maryland, 655 W. Baltimore Street, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol M.","family":"Meyers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Maryland, 655 W. Baltimore Street, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Dungan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Maryland, 655 W. Baltimore Street, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,3,1]]},"reference":[{"key":"bibr1-s100249900101","first-page":"101","volume-title":"Operative procedures and technique","author":"Warren M.","year":"1990"},{"key":"bibr2-s100249900101","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(85)80070-3"},{"key":"bibr3-s100249900101","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970080205"},{"key":"bibr4-s100249900101","doi-asserted-by":"publisher","DOI":"10.3109\/15513818909022327"},{"key":"bibr5-s100249900101","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6720.295"},{"key":"bibr6-s100249900101","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999258"},{"key":"bibr7-s100249900101","doi-asserted-by":"publisher","DOI":"10.3109\/00016349409015765"},{"key":"bibr8-s100249900101","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1994.13.6.451"},{"key":"bibr9-s100249900101","first-page":"5p","volume":"8","author":"Magee JF","year":"1995","journal-title":"Mod Pathol"},{"key":"bibr10-s100249900101","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05030168.x"},{"key":"bibr11-s100249900101","volume-title":"Importance of complete genetic evaluation in pregnancies aborted for multiple congenital anomalies","author":"Meyers CM","year":"1994"},{"key":"bibr12-s100249900101","first-page":"11","volume":"5","author":"Shulman LP","year":"1991","journal-title":"Am J Gynecol Health"},{"key":"bibr13-s100249900101","first-page":"356","volume":"16","author":"Debich-Spicer DE","year":"1996","journal-title":"Pediatr Pathol Lab Med"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1007\/s100249900101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1007\/s100249900101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T02:26:41Z","timestamp":1741660001000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1007\/s100249900101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["10.1007\/s100249900101"],"URL":"https:\/\/doi.org\/10.1007\/s100249900101","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,3]]}}}