{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T04:36:50Z","timestamp":1741667810343,"version":"3.38.0"},"reference-count":54,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:p> Anencephaly is a human fetal malformation with absence of brain and calvarium superior to the orbits. The consequent absence of hypothalamus provides a unique model for studying human development, and therefore skeletal growth, in the absence of hypothalamic hormones and their regulatory functions. To assess the influence of hypothalamic insufficiency on cartilage development, we studied costochondral cartilage sections from eight anencephalic fetuses (18\u201322 weeks old) and seven controls (16\u201322 weeks old) with pathologies not directly related to skeletal growth. We found a previously undescribed anomalous organization of the cartilage in the anencephalic. The proliferative chondrocytes showed a disordered appearance with an increased proliferative zonal length (156 \u00b1 28 \u03bcm in anencephalic fetuses vs. 103 \u00b1 14 \u03bcm in controls, p = 0.006) and a concomitant decrease in the maturing portion, where cells form ordered isogenic groups (58 \u00b1 13 \u03bcm in anencephalic fetuses vs. 93 \u00b1 19 \u03bcm in controls, p = 0.003). In addition, cell density was significantly decreased in the proliferating and maturing zones in the anencephalic cases (84 \u00b121 vs. 130 \u00b1 21 cells\/40 \u03bcm<jats:sup>2<\/jats:sup> in proliferating zone; 53 \u00b1 8 vs. 94 \u00b1 8 in maturing portion, p &lt; 0.005). These alterations in the developing cartilage of the anencephalic may contribute to the observed growth retardation in these fetuses and reflect modifications in pituitary hormones and growth factors resulting from reduction in hypothalamopituitary function. <\/jats:p>","DOI":"10.1007\/s100249910033","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T06:40:57Z","timestamp":1027579257000},"page":"256-263","source":"Crossref","is-referenced-by-count":0,"title":["Anomalous Costochondral Cartilage in Fetal Anencephaly"],"prefix":"10.1177","volume":"3","author":[{"given":"Marta","family":"Garcia-Ramirez","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Hospitals Vall d'Hebron, Passeig Vall'Hebron, 119-129, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Toran","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospitals Vall d'Hebron, Passeig Vall'Hebron, 119-129, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Carrascosa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospitals Vall d'Hebron, Passeig Vall'Hebron, 119-129, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Audi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospitals Vall d'Hebron, Passeig Vall'Hebron, 119-129, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,5,1]]},"reference":[{"key":"bibr1-s100249910033","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.151.3.547"},{"key":"bibr2-s100249910033","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(88)80531-1"},{"key":"bibr3-s100249910033","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320440116"},{"key":"bibr4-s100249910033","doi-asserted-by":"publisher","DOI":"10.3109\/15513818809022280"},{"key":"bibr5-s100249910033","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.2.107"},{"key":"bibr6-s100249910033","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320360119"},{"key":"bibr7-s100249910033","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320360112"},{"key":"bibr8-s100249910033","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320560119"},{"key":"bibr9-s100249910033","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960628)63:4<610::AID-AJMG15>3.0.CO;2-L"},{"key":"bibr10-s100249910033","first-page":"161","volume":"32","author":"Kaplan SL","year":"1976","journal-title":"Recent Prog Horm Res"},{"key":"bibr11-s100249910033","doi-asserted-by":"publisher","DOI":"10.1159\/000127177"},{"key":"bibr12-s100249910033","doi-asserted-by":"publisher","DOI":"10.3109\/15513819009064724"},{"key":"bibr13-s100249910033","first-page":"311","volume":"12","author":"Bocian-Sobkowska J","year":"1997","journal-title":"I. 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