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However, this surgical procedure can lead to discomfort, pain, and potentially serious complications. Full-thickness skin grafting (FTSG) could offer an alternative to SM, less prone to complications related to implantation of a foreign body in the abdominal wall. The aim of this study was to compare the use of FTSG to conventional SM in the repair of giant incisional hernia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients with a giant incisional hernia (&gt;\u200910\u00a0cm width) were randomised to repair with either FTSG or SM. 3-month and 1-year follow-ups have already been reported. A clinical follow-up was performed 3 years after repair, assessing potential complications and recurrence. SF-36, EQ-5D and VHPQ questionnaires were answered at 3 years and an average of 9\u00a0years (long-term follow-up) after surgery to assess the impact of the intervention on quality-of-life (QoL).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fifty-two patients were included. Five recurrences in the FTSG group and three in the SM group were noted at the clinical follow-up 3 years after surgery, but the difference was not significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.313). No new procedure-related complication had occurred since the one-year follow-up. There were no relevant differences in QoL between the groups. However, there were significant improvemnts in both physical, emotional, and mental domains of the SF-36 questionnaire in both groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The results of this long-term follow-up together with the results from previous follow-ups indicate that autologous FTSG as reinforcement in giant incisional hernia repair is an alternative to conventional repair with SM.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial Registration<\/jats:title>\n                <jats:p>The study was registered August 10, 2011 at ClinicalTrials.gov (ID NCT01413412), retrospectively registered.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10029-021-02544-z","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T16:19:49Z","timestamp":1639498789000},"page":"473-479","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Long-term follow-up of full-thickness skin grafting in giant incisional hernia repair: a randomised controlled trial"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8424-4883","authenticated-orcid":false,"given":"V.","family":"Holmdahl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Stark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Clay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Gunnarsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Strig\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"issue":"1","key":"2544_CR1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/bjs.1800720127","volume":"72","author":"M Mudge","year":"1985","unstructured":"Mudge M, Hughes LE (1985) Incisional hernia: a 10 year prospective study of incidence and attitudes. 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Any underlying research material can be accessed by contacting the corresponding author.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Regional Board of Ethics at the Karolinska Institute, Stockholm, (reference number: 2009\/227-31\/3 and 2012\/1775-32).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All procedures performed in the study were in accordance with the ethical standards of the Institutional Research Committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. All experiments in the study complied with current law in Sweden. No animal study was performed by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"All patients included provided a signed written consent for participation and publication after receiving verbal and printed information.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}