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This study was designed to analyze, in the short and medium term, the biological and mechanical behavior of two self-fixing meshes compared to that of a polypropylene (PP) mesh fixed with a cyanoacrylate (CA) tissue adhesive.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Partial abdominal wall defects (6\u2009\u00d7\u20094\u00a0cm) were created in New Zealand rabbits (<jats:italic>n<\/jats:italic>\u2009=\u200936) and repaired using a self-adhesive hydrogel mesh (Adhesix\u2122), a self-gripping mesh (ProGrip\u2122) or a PP mesh fixed with CA (Surgipro\u2122 CA). After 14 and 90\u00a0days, the host tissue incorporation, macrophage response and biomechanical strength were examined.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At 14 and 90\u00a0days, the ProGrip and Surgipro CA meshes showed good host tissue incorporation; however, the Adhesix implants presented poor integration, seroma formation and a higher degree of shrinkage. The Adhesix hydrogel was completely reabsorbed at 14\u00a0days, whereas ProGrip microhooks were observed at all study times. The macrophage response was higher in the ProGrip and Surgipro CA groups at 14 and 90\u00a0days, respectively, and decreased over time. At 90\u00a0days, the ProGrip implants showed the highest tensile strength values and the Adhesix implants showed the highest failure stretch.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Meshes with mechanical microgrip self-fixation (ProGrip) show better biological and mechanical behavior than those with adhesive hydrogel (Adhesix) in a preclinical model of abdominal hernia repair in rabbits.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10029-021-02552-z","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T10:02:43Z","timestamp":1641549763000},"page":"543-555","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Self-adhesive hydrogel meshes reduce tissue incorporation and mechanical behavior versus microgrips self-fixation: a preclinical study"],"prefix":"10.1007","volume":"26","author":[{"given":"Selma","family":"Benito-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Garc\u00eda-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"P\u00e9rez-K\u00f6hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1623-4384","authenticated-orcid":false,"given":"Gemma","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Bell\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"2552_CR1","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/S0140-6736(03)14746-0","volume":"362","author":"A Kigsnorth","year":"2003","unstructured":"Kigsnorth A, LeBlanc K (2003) Hernias: inguinal and incisional. 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All\u00a0procedures were performed at the Animal Research Centre of the Universidad de Alcal\u00e1 (Madrid, Spain), which is\u00a0registered with the Directorate General for Agriculture of the Ministry of Economy and Technology Innovation of the\u00a0Community of Madrid (ES280050001165) ensuring all facilities legally cover the needs and requirements of the\u00a0research.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}}]}}