{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:08:09Z","timestamp":1790082489948,"version":"4.0.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100011104","name":"Universitat Aut\u00f2noma de Barcelona","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011104","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hernia"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Short-term results have been reported regarding parastomal hernia (PH) prevention with a permanent mesh. Long-term results are scarce. The objective was to assess the long-term PH occurrence after a prophylactic synthetic non-absorbable mesh.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Long-term data of three randomized controlled trials (RCTs) were collected. The primary outcome was the detection of PH based exclusively on a radiological diagnosis by computed tomography (CT) performed during the long-term follow-up. The Kaplan\u2013Meier method was used for the comparison of time to diagnosis of PH according to the presence of mesh vs. no-mesh and the technique of mesh insertion: open retromuscular, laparoscopic keyhole, and laparoscopic modified Sugarbaker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We studied 121 patients (87 men, median age 70\u00a0years), 82 (67.8%) of which developed a PH. The median overall length of follow-up was 48.5\u00a0months [interquartile range (IQR) 14.4\u2013104.9], with a median time until PH diagnosis of 17.7\u00a0months (IQR 9.3\u201349.0). The survival analysis did not show significant differences in the time to development of a PH according to the presence or absence of a prophylactic mesh neither in the overall study population (log-rank,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.094) nor in the groups of each technique of mesh insertion, although according to the surgical technique, a higher reduction in the appearance of PH for the open retromuscular technique was found (log-rank,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the long-term follow-up placement of a non-absorbable synthetic prophylactic mesh in the context of an elective end colostomy does not seem effective for preventing PH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10029-023-02781-4","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T14:02:30Z","timestamp":1679752950000},"page":"657-664","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Parastomal hernia prevention with permanent mesh in end colostomy: failure with late follow-up of cohorts in three randomized trials"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3337-0756","authenticated-orcid":false,"given":"M.","family":"L\u00f3pez-Cano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Adell-Trap\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Verdaguer-Tremolosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rodrigues-Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Badia-Closa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Serra-Aracil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"key":"2781_CR1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/WON.0000000000000261","volume":"43","author":"B Temple","year":"2016","unstructured":"Temple B, Farley T, Popik K, Ewanyshyn C, Beyer E, Dufault B (2016) Prevalence of parastomal hernia and factors associated with its development. 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Cir Esp (Engl Ed) 99:527\u2013534","journal-title":"Cir Esp (Engl Ed)"},{"key":"2781_CR4","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1007\/s00268-021-05990-z","volume":"45","author":"E M\u00e4k\u00e4r\u00e4inen-Uhlb\u00e4ck","year":"2021","unstructured":"M\u00e4k\u00e4r\u00e4inen-Uhlb\u00e4ck E, Vironen J, Falenius V, Nordstr\u00f6m P, V\u00e4likoski A, K\u00f6ssi J et al (2021) Parastomal hernia: a retrospective nationwide cohort study comparing different techniques with long-term follow-up. World J Surg 45:1742\u20131749","journal-title":"World J Surg"},{"key":"2781_CR5","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s10029-016-1563-x","volume":"21","author":"M L\u00f3pez-Cano","year":"2017","unstructured":"L\u00f3pez-Cano M, Brandsma HT, Bury K, Hansson B, Kyle-Leinhase I, Alamino JG et al (2017) Prophylactic mesh to prevent parastomal hernia after end colostomy: a meta-analysis and trial sequential analysis. 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L\u00f3pez-Cano has received honoraria for consultancy, lectures, support for travels and participation in review activities from BD, Medtronic and Gore and is a member of the Board of the European Hernia Society (unpaid). All other authors have no conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study design, the surgical procedure, and approval by the institutional review board of the three trials were reported in the corresponding publications of short-term results. Patients included in the three trials were initially informed of the possibility of participating in a retrospective study aimed to collect long-term follow-up data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Patients were requested to sign the written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This article does not contain any study with animals performed by any of the authors.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}}]}}