{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:01:32Z","timestamp":1790892092715,"version":"4.1.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hernia"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Managing postoperative pain remains a significant challenge in hernia operations. With ventral hernia repair (VHR) being one of the most commonly performed procedures, this study aimed to compare the effectiveness of non-opioid analgesia to opioid-based regimens for postoperative pain management.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The Abdominal Core Health Quality Collaborative was queried for elective VHR patients between 2019\u20132022. Subjects prescribed opioid or non-opioid analgesics at discharge were matched using a propensity score. Postoperative Hernia-Related Quality of Life Survey (HerQLes) summary scores, Patient-Reported Outcome Measurement Information System (PROMIS) 3a questionnaire, and clinical outcomes were compared between the two groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>1,051 patients who underwent VHR met the study criteria. The 2:1 matched demographics were opioids (n\u2009=\u2009188) and non-opioids (n\u2009=\u200994) (median age 63, 48% females, 91% white, and 6.5\u00a0cm hernia length). Long-term (1-year post-operation) patients\u2019 pain levels were similar between opioids vs non-opioids (median (IQR): 31(31\u201340) vs. 31(31\u201340), p\u2009=\u20090.46), and HerQLes summary scores were similar (92(78\u2013100) vs. 90(59\u201395), p\u2009=\u20090.052).<\/jats:p>\n                <jats:p>Clinical short-term (30-days post-operation) outcomes between opioid vs non-opioid patients had similar length-of-stay (1(0\u20135) vs 2(0\u20136), P\u2009=\u20090.089), readmissions (3% vs. 1%, P\u2009=\u20090.28), recurrences (0% vs. 0%, P\u2009=\u20091), reoperations (1% vs. 0%, P\u2009=\u20090.55), surgical site infections (3% vs. 7%, P\u2009=\u20090.11), surgical site occurrences (5% vs. 6%, P\u2009=\u20090.57), and surgical site occurrences requiring procedural intervention (3% vs. 6%, P\u2009=\u20090.13). Finally, long-term recurrence rates were similar (12% vs. 12%, P\u2009=\u20091).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Non-opioid postoperative regimens for analgesia are non-inferior to opioids in VHR patients with similar outcomes. Aggressive efforts should be undertaken to reduce opioid use in this population.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10029-024-02968-3","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T17:02:26Z","timestamp":1706720546000},"page":"1599-1607","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The impact of opioid versus non-opioid analgesics on postoperative pain level, quality of life, and outcomes in ventral hernia repair"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3145-2547","authenticated-orcid":false,"given":"Ramez","family":"Alzatari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ching","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin K.","family":"Poulose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"issue":"2","key":"2968_CR1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s10029-022-02707-6","volume":"27","author":"KA Schlosser","year":"2022","unstructured":"Schlosser KA, Renshaw SM, Tamer RM, Strassels SA, Poulose BK (2022) Ventral hernia repair: an increasing burden affecting abdominal core health. 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Ramez Alzatari and Li-Ching Huang declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This research study was conducted retrospectively from de-identified nationally database. The institutional review board of The Ohio State University determined that the study did not need ethical approval. An institutional review board official waiver of ethical approval was granted from the institutional review board of The Ohio State University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This analysis was determined from obtaining informed consent by the IRB at The Ohio State University.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This analysis did not directly involve humans. The data was obtained from a national hernia database.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}}]}}