{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T22:18:31Z","timestamp":1774909111613,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hernia"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Heavyweight polypropylene (HWPP) mesh is thought to increase inflammatory response and delay tissue integration compared to mediumweight (MWPP). Reactive fluid volume (i.e., drain output) may be a reasonable surrogate for integration. We hypothesized that daily drain output is higher with HWPP compared to MWPP in open retromuscular ventral hernia repair (VHR).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This is a post-hoc analysis of a multicenter, randomized clinical trial conducted March 2017\u2013April 2019 comparing MWPP and HWPP for VHR. Retromuscular drain output in milliliters was measured at 24-h intervals up to postoperative day seven. Univariate analyses compared differences in daily drain output and time to drain removal. Multivariable analyses compared total drain output and wound morbidity within 30\u00a0days and hernia recurrence at 1\u00a0year.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>288 patients were included; 140 (48.6%) HWPP and 148 (51.4%) MWPP. Daily drain output for days 1\u20133 was higher for HWPP vs. MWPP (total volume: 837.8\u00a0mL vs. 656.5\u00a0mL) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but similar on days 4\u20137 (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Median drain removal time was 5\u00a0days for both groups. Total drain output was not predictive of 30-day wound morbidity (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) or hernia recurrence at 1 year (OR 1, <jats:italic>p<\/jats:italic>\u2009=\u20090.29).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>While HWPP mesh initially had higher drain outputs, it rapidly returned to levels similar to MWPP by postoperative day three and there was no difference in clinical outcomes. We believe that drains placed around HWPP mesh can be managed similarly to MWPP mesh.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10029-024-02972-7","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T19:02:22Z","timestamp":1708974142000},"page":"637-642","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of retromuscular drain output and postoperative outcomes for heavyweight versus mediumweight polypropylene mesh following open ventral hernia repair"],"prefix":"10.1007","volume":"28","author":[{"given":"V.","family":"Essani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7072-1944","authenticated-orcid":false,"given":"S. M.","family":"Maskal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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Clayton Petro has research grants from Central Surgical Association, American Hernia Society and SAGES and acts as a consultant for BD and Surgimatix. Michael Rosen is the medical director of Abdominal Core Health Quality Collaborative and has stock options with Ariste. Ajita Prabhu accepts speaking fees and research support paid to institution from Intuitive Surgical, consulting fees and is on the Advisory Board for CMR Surgical and is on the Advisory Board for Surgimatix. Lucas Beffa accepts honoraria from Intuitive Surgical. Sara Maskal accepted a resident research grant from ACHQC. Varisha Essani, Nir Messer, Benjamin Miller, Ryan Ellis, David Krpata, and Chao Tu have no financial disclosures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This research was conducted with ethical approval from the Cleveland Clinic Institutional Review Board in compliance with the Helsinki Declaration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval, Human and animal rights, and Informed consent"}}]}}