{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:07:54Z","timestamp":1786122474426,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","award":["Prime Award Grant"],"award-info":[{"award-number":["Prime Award Grant"]}],"id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hernia"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Evaluate the impact of sugammadex on gastrointestinal recovery following complex AWR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center, double-blinded, randomized controlled trial randomized 184 patients undergoing open retromuscular AWR to receive either sugammadex or neostigmine\/glycopyrrolate for neuromuscular blockade reversal per drug packaging protocol. The primary outcome was time to gastrointestinal recovery (GI-2), defined as tolerance of solid food and first bowel movement and univariate and multivariate analysis was used to compare sugammadex and neostigmine\/glycopyrrolate cohorts. Secondary outcomes included incidence of POI, hospital length of stay, and opioid consumption among our two cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The final analysis included 177 patients (88 sugammadex, 89 neostigmine\/glycopyrrolate). Median time to GI-2 recovery was similar between groups (89 vs. 87\u00a0h, Wilcoxon rank-sum\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.637). No significant differences were observed in POI incidence (21% vs. 25%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.52) or length of stay (5 vs. 4 days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.90). Multivariable analysis confirmed sugammadex did not significantly affect time to GI-2 recovery (HR 0.96, 95% CI 0.69\u20131.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.79). Independent predictors of delayed recovery included POI development and greater opioid consumption.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sugammadex did not result in faster return to gastrointestinal function when compared with neostigmine\/glycopyrrolate when used for neuromuscular blockade reversal. Thus, avoidance of neostigmine\/glycopyrrolate did not reduce POI incidence or hospital length of stay in patients undergoing complex AWR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10029-026-03814-4","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T10:12:22Z","timestamp":1786097542000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of neuromuscular blockade reversal strategy on gastrointestinal recovery following abdominal wall reconstruction: a randomized controlled trial"],"prefix":"10.1007","volume":"30","author":[{"given":"Daphne","family":"Remulla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah X.","family":"Tocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Carvhalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alparslan","family":"Turan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Tastaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajita S.","family":"Prabhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Krpata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas R.","family":"Beffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin T.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton C.","family":"Petro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"3814_CR1","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1007\/s10029-022-02687-7","volume":"26","author":"CD Greco","year":"2022","unstructured":"Greco CD, Petro CC, Thomas JD et al (2022) Ileus rate after abdominal wall reconstruction: a retrospective analysis of two clinical trials. 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The use of data and materials was carried out with proper authorization and in compliance with all applicable laws and regulations.","order":2,"name":"Ethics","label":"Ethical Considerations","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":3,"name":"Ethics","label":"Prior presentation","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There are no conflicts of interest related to the analysis of the data or the presentation of this manuscript. The authors note the following conflicts of interest: David M. Krpata MD serves as a consultant for Gore and has received a research grant from TelaBio. Lucas R. Beffa MD serves as a consultant for Gore and Abbvie and is on the advisory board for Vertex Pharmaceuticals. Benjamin T. Miller MD serves as a consultant for Boston Scientific and Medtronic, has received speaking fees from BG Medical, and received a research grant from the American Hernia Society and research funding from Integra. Michael J. Rosen MD serves as the medical director of the ACHQC and receives salary support. Clayton C. Petro MD serves as a consultant for Advanced Medical Solutions, TelaBio, Medtronic, and Gore, and has received an institutional research grant from Merck.","order":4,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":5,"name":"Ethics","label":"Reprint publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"313"}}