{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:33:02Z","timestamp":1778945582380,"version":"3.51.4"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T00:00:00Z","timestamp":1505520000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Artif Organs"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s10047-017-0993-2","type":"journal-article","created":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T16:01:12Z","timestamp":1505577672000},"page":"94-101","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic factors for mortality in middle-aged and older hemodialysis patients: a 5-year observational study"],"prefix":"10.1007","volume":"21","author":[{"given":"Kojiro","family":"Nagai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motokazu","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Tsuchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiro-omi","family":"Kanayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Minakuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,9,16]]},"reference":[{"key":"993_CR1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s10157-014-0978-x","volume":"19","author":"K Yamagata","year":"2015","unstructured":"Yamagata K, Yagisawa T, Nakai S, Nakayama M, Imai E, Hattori M, Iseki K, Akiba T. Prevalence and incidence of chronic kidney disease stage G5 in Japan. Clin Exp Nephrol. 2015;19:54\u201364.","journal-title":"Clin Exp Nephrol"},{"key":"993_CR2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/1744-9987.12281","volume":"18","author":"S Nakai","year":"2014","unstructured":"Nakai S, Hanafusa N, Masakane I, Taniguchi M, Hamano T, Shoji T, Hasegawa T, Itami N, Yamagata K, Shinoda T, Kazama JJ, Watanabe Y, Shigematsu T, Marubayashi S, Morita O, Wada A, Hashimoto S, Suzuki K, Nakamoto H, Kimata N, Wakai K, Fujii N, Ogata S, Tsuchida K, Nishi H, Iseki K, Tsubakihara Y. An overview of regular dialysis treatment in Japan (as of 31 December 2012). Ther Apher Dial. 2014;18:535\u2013602.","journal-title":"Ther Apher Dial"},{"key":"993_CR3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nrneph.2011.60","volume":"7","author":"K Kalantar-Zadeh","year":"2011","unstructured":"Kalantar-Zadeh K, Cano NJ, Budde K, Chazot C, Kovesdy CP, Mak RH, Mehrotra R, Raj DS, Sehgal AR, Stenvinkel P, Ikizler TA. Diets and enteral supplements for improving outcomes in chronic kidney disease. Nat Rev Nephrol. 2011;7:369 \u2013 84.","journal-title":"Nat Rev Nephrol"},{"key":"993_CR4","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/ki.2013.147","volume":"84","author":"TA Ikizler","year":"2013","unstructured":"Ikizler TA, Cano NJ, Franch H, Fouque D, Himmelfarb J, Kalantar-Zadeh K, Kuhlmann MK, Stenvinkel P, TerWee P, Teta D, Wang AY, Wanner C, International Society of Renal Nutrition and Metabolism. Prevention and treatment of protein energy wasting in chronic kidney disease patients: a consensus statement by the International Society of Renal Nutrition and Metabolism. Kidney Int. 2013;84:1096 \u2013 107.","journal-title":"Kidney Int"},{"key":"993_CR5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1542-4758.2009.00377.x","volume":"13","author":"AA Desai","year":"2009","unstructured":"Desai AA, Nissenson A, Chertow GM, Farid M, Singh I, Van Oijen MG, Esrailian E, Solomon MD, Spiegel BM. The relationship between laboratory-based outcome measures and mortality in end-stage renal disease: a systemic review. Hemodial Int. 2009;13:347 \u2013 59.","journal-title":"Hemodial Int"},{"key":"993_CR6","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1681\/ASN.2005020132","volume":"17","author":"AK Cheung","year":"2006","unstructured":"Cheung AK, Rocco MV, Yan G, Leypoldt JK, Levin NW, Greene T, Agodoa L, Bailey J, Beck GJ, Clark W, Levey AS, Ornt DB, Schulman G, Schwab S, Teehan B, Eknoyan G. Serum beta-2 microglobulin levels predict mortality in dialysis patients: results of the HEMO study. J Am Soc Nephrol. 2006;17:546 \u2013 55.","journal-title":"J Am Soc Nephrol"},{"key":"993_CR7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/ndt\/gfn521","volume":"24","author":"S Okuno","year":"2009","unstructured":"Okuno S, Ishimura E, Kohno K, Fujino-Katoh Y, Maeno Y, Yamakawa T, Inaba M, Nishizawa Y. Serum beta2-microglobulin level is a significant predictor of mortality in maintenance haemodialysis patients. Nephrol Dial Transplant. 2009;24:571\u20137.","journal-title":"Nephrol Dial Transplant"},{"key":"993_CR8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/MNH.0b013e328346f93f","volume":"20","author":"GA Block","year":"2011","unstructured":"Block GA. Therapeutic interventions for chronic kidney disease-mineral and bone disorders: focus on mortality. Curr Opin Nephrol Hypertens. 2011;20:376 \u2013 81.","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"Suppl 1","key":"993_CR9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/1744-9987.12294","volume":"19","author":"Y Watanabe","year":"2015","unstructured":"Watanabe Y, Kawanishi H, Suzuki K, Nakai S, Tsuchida K, Tabei K, Akiba T, Masakane I, Takemoto Y, Tomo T, Itami N, Komatsu Y, Hattori M, Mineshima M, Yamashita A, Saito A, Naito H, Hirakata H, Minakuchi J. \u201cMaintenance Hemodialysis: Hemodialysis Prescriptions\u201d Guideline Working Group, Japanese Society for Dialysis Therapy. Japanese society for dialysis therapy clinical guideline for \u201cMaintenance hemodialysis: hemodialysis prescriptions\u201d. Ther Apher Dial. 2015;19(Suppl 1):67\u201392.","journal-title":"Ther Apher Dial"},{"key":"993_CR10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/1744-9987.12058","volume":"17","author":"M Fukagawa","year":"2013","unstructured":"Fukagawa M, Yokoyama K, Koiwa F, Taniguchi M, Shoji T, Kazama JJ, Komaba H, Ando R, Kakuta T, Fujii H, Nakayama M, Shibagaki Y, Fukumoto S, Fujii N, Hattori M, Ashida A, Iseki K, Shigematsu T, Tsukamoto Y, Tsubakihara Y, Tomo T, Hirakata H, Akizawa T, CKD-MBD Guideline Working Group; Japanese Society for Dialysis Therapy. Clinical practice guideline for the management of chronic kidney disease-mineral and bone disorder. Ther Apher Dial. 2013;17:247\u201388.","journal-title":"Ther Apher Dial"},{"key":"993_CR11","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s12325-014-0170-4","volume":"31","author":"K Ramakrishnan","year":"2014","unstructured":"Ramakrishnan K, Braunhofer P, Newsome B, Lubeck D, Wang S, Deuson J, Claxton AJ. The economic impact of improving phosphate binder therapy adherence and attainment of guideline phosphorus goals in hemodialysis patients: a Medicare cost-offset model. Adv Ther. 2014;31:1272\u201386.","journal-title":"Adv Ther"},{"key":"993_CR12","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1097\/01.ASN.0000096373.13406.94","volume":"14","author":"AK Cheung","year":"2003","unstructured":"Cheung AK, Levin NW, Greene T, Agodoa L, Bailey J, Beck G, Clark W, Levey AS, Leypoldt JK, Ornt DB, Rocco MV, Schulman G, Schwab S, Teehan B, Eknoyan G. Effects of high-flux hemodialysis on clinical outcomes: results of the HEMO study. J Am Soc Nephrol. 2003;14:3251\u201363.","journal-title":"J Am Soc Nephrol"},{"key":"993_CR13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1159\/000187980","volume":"67","author":"T Shinzato","year":"1994","unstructured":"Shinzato T, Nakai S, Fujita Y, Takai I, Morita H, Nakane K, Maeda K. Determination of Kt\/V and protein catabolic rate using pre- and postdialysis blood urea nitrogen concentrations. Nephron. 1994;67:280 \u2013 90.","journal-title":"Nephron"},{"key":"993_CR14","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000156717","volume":"29","author":"T Shigematsu","year":"2009","unstructured":"Shigematsu T, Akizawa T, Uchida E, Tsukamoto Y, Iwasaki M, Koshikawa S, KRN1493 Study Group. Long-term cinacalcet HCl treatment improved bone metabolism in Japanese hemodialysis patients with secondary hyperparathyroidism. Am J Nephrol. 2009;29:230\u20136.","journal-title":"Am J Nephrol"},{"key":"993_CR15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/sj.ki.5000331","volume":"70","author":"R Kakiya","year":"2006","unstructured":"Kakiya R, Shoji T, Tsujimoto Y, Tatsumi N, Hatsuda S, Shinohara K, Kimoto E, Tahara H, Koyama H, Emoto M, Ishimura E, Miki T, Tabata T, Nishizawa Y. Body fat mass and lean mass as predictors of survival in hemodialysis patients. Kidney Int. 2006;70:549\u201356.","journal-title":"Kidney Int"},{"key":"993_CR16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/ndt\/gfg513","volume":"19","author":"T Shoji","year":"2004","unstructured":"Shoji T, Shinohara K, Kimoto E, Emoto M, Tahara H, Koyama H, Inaba M, Fukumoto S, Ishimura E, Miki T, Tabata T, Nishizawa Y. Lower risk for cardiovascular mortality in oral 1alpha-hydroxy vitamin D3 users in a haemodialysis population. Nephrol Dial Transplant. 2004;19:179 \u2013 84.","journal-title":"Nephrol Dial Transplant"},{"key":"993_CR17","doi-asserted-by":"crossref","first-page":"e0127550","DOI":"10.1371\/journal.pone.0127550","volume":"10","author":"E Barron","year":"2015","unstructured":"Barron E, Lara J, White M, Mathers JC. Blood-borne biomarkers of mortality risk: systematic review of cohort studies. PLoS One. 2015;10:e0127550.","journal-title":"PLoS One"},{"key":"993_CR18","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1093\/ndt\/gfg225","volume":"18","author":"LA Szczech","year":"2003","unstructured":"Szczech LA, Reddan DN, Klassen PS, Coladonato J, Chua B, Lowrie EG, Lazarus JM, Owen WF Jr. Interactions between dialysis-related volume exposures, nutritional surrogates and mortality among ESRD patients. Nephrol Dial Transplant. 2003;18:1585\u201391.","journal-title":"Nephrol Dial Transplant"},{"key":"993_CR19","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/ejcn.2016.49","volume":"70","author":"MJ Dekker","year":"2016","unstructured":"Dekker MJ, Marcelli D, Canaud B, Konings CJ, Leunissen KM, Levin NW, Carioni P, Maheshwari V, Raimann JG, van der Sande FM, Usvyat LA, Kotanko P, Kooman JP. Unraveling the relationship between mortality, hyponatremia, inflammation and malnutrition in hemodialysis patients: results from the international MONDO initiative. Eur J Clin Nutr. 2016;70:779\u201384.","journal-title":"Eur J Clin Nutr"},{"key":"993_CR20","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/S0140-6736(13)60897-1","volume":"382","author":"SA Jamal","year":"2013","unstructured":"Jamal SA, Vandermeer B, Raggi P, Mendelssohn DC, Chatterley T, Dorgan M, Lok CE, Fitchett D, Tsuyuki RT. Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis. Lancet. 2013;382:1268\u201377.","journal-title":"Lancet"},{"key":"993_CR21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fmed.2017.00073","volume":"4","author":"CP Argyropoulos","year":"2017","unstructured":"Argyropoulos CP, Chen SS, Ng YH, Roumelioti ME, Shaffi K, Singh PP, Tzamaloukas AH. Rediscovering beta-2 microglobulin as a biomarker across the spectrum of kidney diseases. Front Med (Lausanne). 2017;4:73.","journal-title":"Front Med (Lausanne)"},{"key":"993_CR22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/1744-9987.12190","volume":"19","author":"N Nakagawa","year":"2014","unstructured":"Nakagawa N, Matsuki M, Yao N, Hirayama T, Ishida H, Kikuchi K, Hasebe N. Impact of metabolic disturbances and malnutrition-inflammation on 6-year mortality in Japanese patients undergoing hemodialysis. Ther Apher Dial. 2014;19:30\u20139.","journal-title":"Ther Apher Dial"}],"container-title":["Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10047-017-0993-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10047-017-0993-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10047-017-0993-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T16:55:38Z","timestamp":1518886538000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10047-017-0993-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,16]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["993"],"URL":"https:\/\/doi.org\/10.1007\/s10047-017-0993-2","relation":{},"ISSN":["1434-7229","1619-0904"],"issn-type":[{"value":"1434-7229","type":"print"},{"value":"1619-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,16]]}}}