{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:12:01Z","timestamp":1790907121199,"version":"4.1.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Artif Organs"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Two dialysis patients developed recurrent restless legs syndrome. The clinical courses and the association between the \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -microglobulin removal rate and the therapeutic effects of hemodiafiltration were analyzed. Case 1: a middle-aged woman was switched from predilution online hemodiafiltration to hemodialysis, following which the \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -microglobulin removal rate decreased from 39.1 to 29.9%. A month later, the severe restless legs syndrome occurred. The treatment was then switched to high-efficiency hemodiafiltration and 2\u00a0weeks later, these symptoms were resolved. The \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -microglobulin removal rate increased to 41.9%. Her symptoms recurred 5\u00a0years later with severity; thus, the hemodiafiltration treatment conditions were changed. Under revised conditions, the \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -microglobulin removal rate was 42.6%, and her symptoms were alleviated. Continuation of high-efficiency hemodiafiltration led to the resolution of the syndrome at 1\u00a0month after recurrence. Case 2: a middle-aged man on hemodialysis developed the restless legs syndrome in the second year of treatment. The \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -microglobulin removal rate was 23.8%. After switching to a month-long high-efficiency hemodiafiltration with a removal rate of\u2009\u2265\u200940%, his symptoms were resolved. However, the syndrome recurred after a year with severity. The symptoms were alleviated using various measures. The hemodiafilters were changed, and hemodiafiltration with an \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -microglobulin removal rate of\u2009\u2265\u200940% was continued; 2\u00a0months later, his symptoms resolved. High-efficiency online hemodiafiltration is an effective therapeutic strategy for restless legs syndrome in dialysis patients. We found, for the first time, that target removal efficiency is an \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -microglobulin removal rate of 40% or higher.\n                  <\/jats:p>","DOI":"10.1007\/s10047-020-01164-1","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T07:02:59Z","timestamp":1585551779000},"page":"296-301","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Therapeutic effect of high-efficiency online hemodiafiltration for recurrent restless legs syndrome in dialysis patients"],"prefix":"10.1007","volume":"23","author":[{"given":"Kenji","family":"Sakurai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Hosoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumi","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"issue":"Suppl","key":"1164_CR1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.0954-6820.1950.tb12291.x","volume":"246","author":"KA Akbom","year":"1950","unstructured":"Akbom KA. Restless legs: a report of 70 new cases. Acad Med Scand. 1950;246(Suppl):64\u20138.","journal-title":"Acad Med Scand"},{"issue":"6","key":"1164_CR2","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1093\/sleep\/26.6.673","volume":"26","author":"K Suzuki","year":"2003","unstructured":"Suzuki K, Ohida T, Sone T, et al. The prevalence of restless legs syndrome among pregnant women in Japan and relationship between restless legs syndrome and sleep problems. Sleep. 2003;26(6):673\u20137.","journal-title":"Sleep"},{"issue":"Suppl 1","key":"1164_CR3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1159\/000346364","volume":"35","author":"K Sakurai","year":"2013","unstructured":"Sakurai K. Biomarkers for evaluation of clinical outcomes of hemodiafiltration. 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