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This review on total albumin losses considers albumin \u201cleaking\u201d into the dialysate and losses due to protein\/membrane interactions (i.e. adsorption, \u201csecondary membrane formation\u201d and denaturation). The former are fairly easy to determine, usually varying at the level of ~\u20092\u00a0g to ~\u20097\u00a0g albumin loss per session. Such values, commonly accepted as representative of the total albumin losses, are often quoted as limits\/standards of permissible albumin loss per session. On albumin mass lost due to adsorption\/deposition, which is the result of complicated interactions and rather difficult to determine, scant in vivo data exist and there is great uncertainty and confusion regarding their magnitude; this is possibly responsible for neglecting their contribution to the total losses at present. Yet, many relevant in vitro studies suggest that losses of albumin due to protein\/membrane interactions are likely comparable to (or even greater than) those due to leaking, particularly in the currently favoured high-convection HDF (haemodiafiltration) treatment. Therefore, it is emphasised that top research priority should be given to resolve these issues, primarily by developing appropriate\/facile in vivo test-methods and related analytical techniques.<\/jats:p>","DOI":"10.1007\/s10047-023-01430-y","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T18:01:41Z","timestamp":1705600901000},"page":"91-99","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["On the total albumin losses during haemocatharsis"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-519X","authenticated-orcid":false,"given":"Anastasios J.","family":"Karabelas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"1430_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/s41581-018-0002-x","volume":"14","author":"C Ronco","year":"2028","unstructured":"Ronco C, Clark WR. 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