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This surge has emphasized the importance of clear therapy recommendations, improved accessibility to ECMO technology, established ECMO teams, and structured networks to ensure access to specialized care throughout the course of the disease for patients with severe ARDS. Although the initiation criteria for VV-ECMO are well defined, treatment strategies while on ECMO regarding e.g., ventilator management or ECMO weaning strategies remain variable and with lack of consensus. NAVA (Neurally Adjusted Ventilatory Assist), as an assisted mechanical ventilation modality, offers real-time electromyographic feedback, which has been shown to enhance prolonged weaning processes from mechanical ventilation. We present a case of penetrating thoracic trauma complicated by ARDS, successfully managed with VV-ECMO. NAVA was employed to monitor and facilitate ECMO. This approach integrates ECMO weaning with ventilation settings, considering both gas exchange lung function, such as carbon dioxide removal, and respiratory mechanics in the form of neuromuscular coupling. This is a new approach to VV-ECMO weaning. More research is planned to validate the efficacy of this method in conjunction with additional parameters, such as diaphragm activity evaluated sonographically in a randomized design. This case underscores the potential of NAVA in VV-ECMO weaning, offering a promising avenue for optimizing patient care and outcomes.<\/jats:p>","DOI":"10.1007\/s10047-024-01484-6","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T23:30:11Z","timestamp":1734046211000},"page":"462-467","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ECMO-weaning facilitated by neurally adjusted ventilatory assist (NAVA): a case for principal clarification"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8123-8703","authenticated-orcid":false,"given":"F.","family":"Heinold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Moerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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LOH received honoraria for educational lectures from CSL Behring, Baxter, and Shionogi, honoraria from a book project published in 2023 (Springer Book on neuro-monitoring in the ICU Book: Neuromonitoring in der Intensivmedizin 2023, ISBN: 978-3-662-65997-7), and an unrestricted research grant from Sartorius AG G\u00f6ttingen. OM is a member of the national CEOsys network Germany (Covid Ecosystem), and the Napkon-Tip (Therapeutic intervention platform for conducting ongoing assessments of new therapies), funded by the Federal Ministry of Education and Research (BMBF). Holds a research grant from Advitos for conducting experimental studies related to extracorporeal multiorgan support. OM received honoraria from a book project published in 2023. Springer Book on neuro-monitoring in the ICU Book: Neuromonitoring in der Intensivmedizin 2023, ISBN: 978-3-662-65997-7. Within the last 36\u00a0months OM received honoraria for industry sponsored lectures on congresses by Getinge (hemodynamic monitoring) and CSL Behring (coagulation). The Department of Anesthesiology holds courses and workshops supported by companies related to intensive care medicine.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}