{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:13:41Z","timestamp":1780456421331,"version":"3.54.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012314","name":"Shinshu University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012314","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Artif Organs"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To determine the optimal perfusion volume for the celiac artery (CA) and superior mesenteric artery (SMA) in a porcine model. Fifteen Yorkshire pigs (46.7\u2009\u00b1\u20095.2\u00a0kg) underwent selective CA and SMA perfusion using a roller pump at either 400\u00a0mL\/min (G400, n\u2009=\u20095) or 800\u00a0mL\/min (G800, n\u2009=\u20096). Hemodynamic parameters, blood gas analyses, and biochemical markers were evaluated over time (T1 to T5). The intestinal tissue was assessed for edema and histological damage. Portal vein SvO2 was lower in G400 (65.0\u2009\u00b1\u200930.2% at T2) compared to G800 (87.0\u2009\u00b1\u20095.2%), indicating reduced perfusion. Lactate levels were significantly higher in G400 (7.8\u2009\u00b1\u20092.3\u00a0mmol\/L at T2) than in G800 (4.1\u2009\u00b1\u20092.1\u00a0mmol\/L), suggesting increased anaerobic metabolism. Aspartate aminotransferase levels were elevated in G400, reflecting intestinal ischemia, whereas alanine aminotransferase levels remained stable. Histological analysis revealed mucosal desquamation in G400 but not in G800. No significant differences in intestinal edema were observed between groups. A selective perfusion volume of 800\u00a0mL\/min for the CA and SMA maintains portal vein SvO2 and prevents mucosal injury, suggesting it approximates physiological blood flow. These findings indicate that increasing selective visceral perfusion during thoracoabdominal aortic surgery may reduce postoperative intestinal complications and improve patient outcomes.<\/jats:p>","DOI":"10.1007\/s10047-025-01521-y","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:23:50Z","timestamp":1753889030000},"page":"562-570","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Selective visceral perfusion in thoracoabdominal aortic surgery: optimal flow rate in a porcine model"],"prefix":"10.1007","volume":"28","author":[{"given":"Noburo","family":"Ohashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Ichimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritoshi","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Mikoshiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuichiro","family":"Seto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"1521_CR1","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.jvs.2018.03.410","volume":"68","author":"KG Moulakakis","year":"2018","unstructured":"Moulakakis KG, Karaolanis G, Antonopoulos CN, Kakisis J, Klonaris C, Preventza O, Coselli JS, Geroulakos G. Open repair of thoracoabdominal aortic aneurysms in experienced centers. J Vasc Surg. 2018;68:634-645.e12.","journal-title":"J Vasc Surg"},{"key":"1521_CR2","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/S1010-7940(99)00075-5","volume":"15","author":"K Morishita","year":"1999","unstructured":"Morishita K, Yokoyama H, Inoue S, Koshino T, Tamiya Y, Abe T. Selective visceral and renal perfusion in thoracoabdominal aneurysm repair. Eur J Cardiothorac Surg. 1999;15:502\u20137.","journal-title":"Eur J Cardiothorac Surg"},{"key":"1521_CR3","first-page":"367","volume":"10","author":"Y Kuniyoshi","year":"2004","unstructured":"Kuniyoshi Y, Koja K, Miyagi K, Uezu T, Yamashiro S, Arakaki K, Nagano T, Mabuni K, Senaha S. Selective visceral perfusion during thoracoabdominal aortic aneurysm repair. Ann Thorac Cardiovasc Surg. 2004;10:367\u201372.","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"1521_CR4","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.jvs.2006.05.018","volume":"44","author":"PE Achouh","year":"2006","unstructured":"Achouh PE, Madsen K, Miller CC 3rd, Estrera AL, Azizzadeh A, Dhareshwar J, Porat E, Safi HJ. Gastrointestinal complications after descending thoracic and thoracoabdominal aortic repairs: a 14-year experience. J Vasc Surg. 2006;44:442\u20136.","journal-title":"J Vasc Surg"},{"key":"1521_CR5","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jvs.2011.11.126","volume":"56","author":"J Kalder","year":"2012","unstructured":"Kalder J, Keschenau P, Hanssen SJ, Greiner A, Vermeulen Windsant IC, Kennes LN, Tolba R, Prinzen FW, Buurman WA, Jacobs MJ, Koeppel TA. The impact of selective visceral perfusion on intestinal macrohemodynamics and microhemodynamics in a porcine model of thoracic aortic cross-clamping. J Vasc Surg. 2012;56:149\u201358.","journal-title":"J Vasc Surg"},{"key":"1521_CR6","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.jvs.2015.05.043","volume":"64","author":"PR Keschenau","year":"2016","unstructured":"Keschenau PR, Ribbe S, Tamm M, Hanssen SJ, Tolba R, Jacobs MJ, Kalder J. Extracorporeal circulation increases proliferation in the intestinal mucosa in a large animal model. J Vasc Surg. 2016;64:1121\u201333.","journal-title":"J Vasc Surg"},{"key":"1521_CR7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12871-018-0530-8","volume":"18","author":"DC Schroeder","year":"2018","unstructured":"Schroeder DC, Maul AC, Mahabir E, Koxholt I, Yan X, Padosch SA, Herff H, Bultmann-Mellin I, Sterner-Kock A, Annecke T, Hucho T, Bottiger BW, Guschlbauer M. Evaluation of small intestinal damage in a rat model of 6 Minutes cardiac arrest. BMC Anesthesiol. 2018;18:61.","journal-title":"BMC Anesthesiol"},{"key":"1521_CR8","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1053\/S1043-0679(03)00090-X","volume":"15","author":"JS Coselli","year":"2003","unstructured":"Coselli JS. The use of left heart bypass in the repair of thoracoabdominal aortic aneurysms: current techniques and results. Semin Thorac Cardiovasc Surg. 2003;15:326\u201332.","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"1521_CR9","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1016\/j.jtcvs.2014.06.072","volume":"148","author":"M Aftab","year":"2014","unstructured":"Aftab M, Coselli JS. Renal and visceral protection in thoracoabdominal aortic surgery. J Thorac Cardiovasc Surg. 2014;148:2963\u20136.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1521_CR10","doi-asserted-by":"publisher","first-page":"R1790","DOI":"10.1152\/ajpregu.00553.2007","volume":"294","author":"N Someya","year":"2008","unstructured":"Someya N, Endo MY, Fukuba Y, Hayashi N. Blood flow responses in celiac and superior mesenteric arteries in the initial phase of digestion. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1790\u20136.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1521_CR11","doi-asserted-by":"publisher","first-page":"E15","DOI":"10.1055\/a-1925-1893","volume":"8","author":"K Nylund","year":"2022","unstructured":"Nylund K, Gjengst\u00f8 AJ, von Volkmann HL, Gilja OH. Assessment of small bowel motility and SMA blood flow studied with transabdominal ultrasound. Ultrasound Int Open. 2022;8:E15-21.","journal-title":"Ultrasound Int Open"},{"key":"1521_CR12","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0939-8600(03)80007-X","volume":"42","author":"MB Hubert","year":"2003","unstructured":"Hubert MB, Salazkin I, Desjardins J, Blaise G. Cardiopulmonary bypass surgery in swine: a research model. J Exp Anim Sci. 2003;42:135\u201349.","journal-title":"J Exp Anim Sci"},{"key":"1521_CR13","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.jvs.2013.10.070","volume":"61","author":"J Kalder","year":"2015","unstructured":"Kalder J, Ajah D, Keschenau P, Kennes LN, Tolba R, Kokozidou M, Jacobs MJ, Koeppel TA. Microcirculatory perfusion shift in the gut wall layers induced by extracorporeal circulation. J Vasc Surg. 2015;61:497\u2013503.","journal-title":"J Vasc Surg"},{"key":"1521_CR14","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.amjsurg.2022.03.048","volume":"224","author":"P Calame","year":"2022","unstructured":"Calame P, Winiszewski H, Lakkis Z, Verdot P, Pili-Floury S, Heyd B, Piton G, Delabrousse E, Doussot A. Prognostic factors in non-occlusive mesenteric ischemia: A pragmatic pre-operative score for the prediction of 28-day mortality. Am J Surg. 2022;224:617\u201323.","journal-title":"Am J Surg"},{"key":"1521_CR15","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13613-018-0395-5","volume":"8","author":"E Zogheib","year":"2018","unstructured":"Zogheib E, Cosse C, Sabbagh C, Marx S, Caus T, Henry M, Nader J, Fumery M, Bernasinski M, Besserve P, Trojette F, Renard C, Duhaut P, Kamel S, Regimbeau JM, Dupont H. Biological scoring system for early prediction of acute bowel ischemia after cardiac surgery: the PALM score. Ann Intensive Care. 2018;8:46.","journal-title":"Ann Intensive Care"},{"key":"1521_CR16","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1080\/00365521.2022.2131331","volume":"58","author":"T Schupp","year":"2023","unstructured":"Schupp T, Weidner K, Rusnak J, Jawhar S, Forner J, Dulatahu F, Br\u00fcck LM, Hoffmann U, Bertsch T, Wei\u00df C, Akin I, Behnes M. Diagnostic and prognostic value of the AST\/ALT ratio in patients with sepsis and septic shock. Scand J Gastroenterol. 2023;58:392\u2013402.","journal-title":"Scand J Gastroenterol"},{"key":"1521_CR17","unstructured":"LeMaitre Vascular I. Pruitt occlusion catheters. https:\/\/www.lemaitre-japan.co.jp\/pdf\/PruittCatheters.pdf."}],"container-title":["Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10047-025-01521-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10047-025-01521-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10047-025-01521-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T15:01:24Z","timestamp":1765551684000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10047-025-01521-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1521"],"URL":"https:\/\/doi.org\/10.1007\/s10047-025-01521-y","relation":{},"ISSN":["1434-7229","1619-0904"],"issn-type":[{"value":"1434-7229","type":"print"},{"value":"1619-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,30]]},"assertion":[{"value":"27 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The article note was incorrectly given as \u201cTatsuichiro Seto and Hajime Ichimura are co-first authors,\u201d but it should have been \u201cTatsuichiro Seto and Hajime Ichimura are co-corresponding authors.\u201d","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}}]}}