{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:56:39Z","timestamp":1781200599211,"version":"3.54.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009757","name":"National Institute of Advanced Industrial Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009757","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Artif Organs"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lung transplantation is the definitive therapy for end-stage respiratory diseases. To expand the donor lung pool, ex vivo lung perfusion (EVLP) has been developed for the assessment of marginal donor lungs. However, current evaluation methods remain limited. This study aimed to develop non-invasive imaging and monitoring techniques for the quantitative and early assessment of pulmonary function during EVLP. Three novel approaches were established: (1) lung thermography during the initial reperfusion period to assess pulmonary function, (2) optical oxygen saturation (SaO\u2082) imaging to assess pulmonary oxygenation, and (3) real-time lung weight measurement as an early indicator of transplant suitability. Lung thermography revealed that lung surface temperature at 8\u00a0min after shunt closure was significantly lower in non-suitable cases than in suitable cases (25.1\u2009\u00b1\u20090.6\u00a0\u00b0C vs. 27.8\u2009\u00b1\u20091.2\u00a0\u00b0C,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01). Optical SaO\u2082 imaging demonstrated a strong correlation between lower lobe SaO\u2082 calculated from SaO\u2082 imaging and PaO\n                    <jats:sub>2<\/jats:sub>\n                    \/FiO\n                    <jats:sub>2<\/jats:sub>\n                    (P\/F) ratio in the lower pulmonary vein (\n                    <jats:italic>R<\/jats:italic>\n                    \u2009=\u20090.855,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01), with SaO\u2082 being significantly lower in non-suitable cases. Real-time lung weight measurement showed that lung weight gain increased significantly after 40\u00a0min in non-suitable cases compared with suitable cases (51.6\u2009\u00b1\u200946.0\u00a0g vs. \u22128.8\u2009\u00b1\u200925.7\u00a0g,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01). These three approaches proved effective for the quantitative and early assessment of pulmonary function during EVLP. This review was created based on a translation of the Japanese review written in the Japanese Journal of Artificial Organs in 2024 (Vol. 53, No. 3, pp. 216\u2013220).\n                  <\/jats:p>","DOI":"10.1007\/s10047-026-01557-8","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T09:03:15Z","timestamp":1778490195000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Special feature: \u201ccurrent status and future development of organ preservation technology\u201d novel techniques for assessing pulmonary function in cellular ex vivo lung perfusion: a republication of the review published in Japanese Journal of Artificial Organs"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4658-6196","authenticated-orcid":false,"given":"Ryo","family":"Kosaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Sakota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Niikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhito","family":"Kigata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Ohuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiki","family":"Nagaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Sakanoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"1557_CR1","unstructured":"Fact book. 2024 on organs transplantation in Japan, The Japan society for transplantation."},{"issue":"2D1","key":"1557_CR2","doi-asserted-by":"publisher","first-page":"S457","DOI":"10.1016\/j.ajt.2024.01.018","volume":"24","author":"AK Israni","year":"2024","unstructured":"Israni AK, Zaun DA, Gauntt K, et al. OPTN\/SRTR 2022 annual data report: deceased donor organ donation. Am J Transpl. 2024;24(2D1):S457\u201388.","journal-title":"Am J Transpl"},{"issue":"1","key":"1557_CR3","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/S0003-4975(03)00191-7","volume":"76","author":"S Steen","year":"2003","unstructured":"Steen S, Liao Q, Wierup P, et al. Transplantation of lungs from non-heart-beating donors after functional assessment ex vivo. Ann Thorac Surg. 2003;76(1):244\u201352.","journal-title":"Ann Thorac Surg"},{"key":"1557_CR4","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s40472-019-00258-x","volume":"6","author":"T Okamoto","year":"2019","unstructured":"Okamoto T, Niikawa H, Ayyat K, et al. Machine perfusion of lungs. Curr Transpl Rep. 2019;6:251\u201364.","journal-title":"Curr Transpl Rep"},{"key":"1557_CR5","doi-asserted-by":"crossref","unstructured":"West JB, Dollery CT. 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Optical oxygen saturation imaging in cellular ex vivo lung perfusion to assess lobular pulmonary function. Biomed Opt Express. 2022;13:328\u201343.","journal-title":"Biomed Opt Express"},{"issue":"3","key":"1557_CR15","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1097\/TP.0000000000004380","volume":"107","author":"R Kosaka","year":"2023","unstructured":"Kosaka R, Sakota D, Sakanoue I, et al. Real-time lung weight measurement during cellular ex vivo lung perfusion: an early predictor of transplant suitability. 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