{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:11:56Z","timestamp":1789056716556,"version":"build-2803163510"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004206","name":"The University of Osaka","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004206","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Artif Organs"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The use of left ventricular assist device (LVAD) implantation for destination therapy (DT) has been recently increased worldwide. In 2021, DT was also approved in Japan. Here, we report a single-institution experience of LVAD implantation for DT. This retrospective observational study was conducted at Osaka University Medical Hospital in Japan. Forty patients who underwent LVAD implantation for DT were included. The primary endpoint was on-device survival, and the secondary endpoint was the incidence of LVAD-related complications at five years. The on-device survival rates were 82.3%, 73.3%, and 49.8% at 1, 3, and 5 years, respectively. Most patients (90.6%) experienced rehospitalization during the follow-up period and the most common cause was LVAD-related infection. One-quarter of the patients (10 cases) required LVAD pump exchange, also most commonly due to LVAD-related infection. Comparative analysis with 213 patients who underwent LVAD implantation for bridge to transplant (BTT) revealed no significant change in the primary and secondary outcomes. Our results demonstrate favorable clinical outcomes for LVAD implantation for DT in this Japanese cohort.<\/jats:p>","DOI":"10.1007\/s10047-026-01581-8","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T17:02:23Z","timestamp":1787331743000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical differences between destination therapy and bridge-to-transplant left ventricular assist device implantation: a 17-year single-center experience in Japan"],"prefix":"10.1007","volume":"29","author":[{"given":"Koichi","family":"Inoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Misumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Yajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Miyagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"1581_CR1","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1056\/NEJMoa067758","volume":"357","author":"LW Miller","year":"2007","unstructured":"Miller LW, Pagani FD, Russel SD, John R, Boyle AJ, Aaronson KD, et al. Use of a continuous-flow device in patients awaiting heart transplantation. N Eng J Med. 2007;357:885\u201396.","journal-title":"N Eng J Med"},{"key":"1581_CR2","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1056\/NEJMoa0909938","volume":"361","author":"MS Slaughter","year":"2009","unstructured":"Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D, et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Eng J Med. 2009;361:2241\u201351.","journal-title":"N Eng J Med"},{"key":"1581_CR3","doi-asserted-by":"crossref","unstructured":"Molina EJ, Shah P, Kiernan MS, Cornwell WK 3rd, Copeland H, Takeda K et al. The society of thoracic surgeons intermacs 2020 annual report. 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N Engl J Med. 2019;380:1618\u201327.","journal-title":"N Engl J Med"},{"key":"1581_CR6","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-22-0332","author":"K Inoue","year":"2022","unstructured":"Inoue K, Fujita T, Yoshioka D, Tonai K, Yanagino Y, Kakuta T, et al. Short-term outcomes of magnetically levitated left ventricular assist device in advanced heart failure: the Japanese cohort. Circ J. 2022. https:\/\/doi.org\/10.1253\/circj.CJ-22-0332.","journal-title":"Circ J"},{"issue":"4","key":"1581_CR7","first-page":"411","volume":"5","author":"DJ Goldstein","year":"2020","unstructured":"Goldstein DJ, Naka Y, Horstmanshof D, Ravichandran AK, Schroder J, Ransom J, et al. Association of clinical outcomes with left ventricular assist device use by bridge to transplant or destination therapy intent: the multicenter study of MagLev technology in patients undergoing mechanical circulatory support therapy with HeartMate 3 (MOMENTUM 3) randomized clinical trial. JAMA Caridol. 2020;5(4):411\u20139.","journal-title":"JAMA Caridol"},{"issue":"8","key":"1581_CR8","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1002\/ejhf.2211","volume":"23","author":"MR Mehra","year":"2021","unstructured":"Mehra MR, Cleveland JC Jr, Uriel N, Cowger JA, Hall S, Horstmanshof D, et al. Primary results of long-term outcomes in the MOMENTUM 3 pivotal trial and continued access protocol study phase: a study of 2200 HeartMate3 left ventricular assist device implants. Eur J Heart Fail. 2021;23(8):1392\u2013400.","journal-title":"Eur J Heart Fail"},{"issue":"11","key":"1581_CR9","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.healun.2016.09.002","volume":"35","author":"FD Pagani","year":"2016","unstructured":"Pagani FD, Aaronson KD, Kormos R, Mann DL, Spino C, Jeffries N, et al. The NHLBI REVIVE-IT study: Understanding its discontinuation in the context of current left ventricular assist device therapy. 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ASAIO J. 2021;67(7):642\u20139.","journal-title":"ASAIO J"}],"container-title":["Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10047-026-01581-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10047-026-01581-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10047-026-01581-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:03:21Z","timestamp":1789056201000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10047-026-01581-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["1581"],"URL":"https:\/\/doi.org\/10.1007\/s10047-026-01581-8","relation":{},"ISSN":["1434-7229","1619-0904"],"issn-type":[{"value":"1434-7229","type":"print"},{"value":"1619-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]},"assertion":[{"value":"10 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there are no conflicts of interest.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"58"}}