{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:54:47Z","timestamp":1790913287253,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T00:00:00Z","timestamp":1150156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogenetics"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1007\/s10048-006-0047-z","type":"journal-article","created":{"date-parts":[[2006,6,12]],"date-time":"2006-06-12T11:31:28Z","timestamp":1150111888000},"page":"157-165","source":"Crossref","is-referenced-by-count":10,"title":["Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis"],"prefix":"10.1007","volume":"7","author":[{"given":"Ping-I","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eden R.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie A.","family":"Browning-Large","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald E.","family":"Schmechel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Welsh-Bohmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Murali","family":"Doraiswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Haines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Pericak-Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,6,13]]},"reference":[{"key":"47_CR1","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","volume":"278","author":"LA Farrer","year":"1997","unstructured":"Farrer LA, Cupples LA, Haines J, Hyman B, Kukull W, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM (1997) Effects of age, gender, and ethnicity on the association between APOE genotype and Alzheimer disease. JAMA 278:1349\u20131356","journal-title":"JAMA"},{"key":"47_CR2","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","volume":"261","author":"EH Corder","year":"1993","unstructured":"Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families. Science 261:921\u2013923","journal-title":"Science"},{"key":"47_CR3","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/jama.1997.03550150041033","volume":"278","author":"MA Pericak-Vance","year":"1997","unstructured":"Pericak-Vance MA, Bass MP, Yamaoka LH, Gaskell PC, Scott WK, Terwedow HA, Menold MM, Conneally PM, Small GW, Vance JM, Saunders AM, Roses AD, Haines JL (1997) Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. JAMA 278:1237\u20131241","journal-title":"JAMA"},{"key":"47_CR4","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/S0197-4580(98)00037-2","volume":"19","author":"MA Pericak-Vance","year":"1998","unstructured":"Pericak-Vance MA, Bass ML, Yamaoka LH, Gaskell PC, Scott WK, Terwedow HA, Menold MM, Conneally PM, Small GW, Saunders AM, Roses AD, Haines JL (1998) Complete genomic screen in late-onset familial Alzheimer\u2019s disease. Neurobiol Aging 19:S39\u2013S42","journal-title":"Neurobiol Aging"},{"key":"47_CR5","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/jama.280.7.614","volume":"280","author":"E Rogaeva","year":"1998","unstructured":"Rogaeva E, Premkumar S, Song Y, Sorbi S, Brindle N, Paterson A, Duara R, Levesque G, Yu G, Nishimura M, Ikeda M, O\u2019Toole C, Kawarai T, Jorge R, Vilarino D, Bruni AC, Farrer LA, St George-Hyslop PH (1998) Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity. JAMA 280:614\u2013618","journal-title":"JAMA"},{"key":"47_CR6","first-page":"A44","volume":"63","author":"WK Scott","year":"1998","unstructured":"Scott WK, Grubber JM, Abou-donia SM, Church TD, Yamaoka LH, Conneally PM, dSmall GW, Saunders AM, Roses AD, Haines JL, Pericak-Vance MA (1998) Fine mapping and two-locus maximum lod score analysis in chromosome 12-linked late-onset familial Alzheimer disease (AD). Am J Hum Genet 63:A44","journal-title":"Am J Hum Genet"},{"key":"47_CR7","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1086\/302828","volume":"66","author":"WK Scott","year":"2000","unstructured":"Scott WK, Grubber JM, Conneally PM, Small GW, Hulette CM, Rosenberg CK, Saunders AM, Roses AD, Haines JL, Pericak-Vance MA (2000) Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity. Am J Hum Genet 66:922\u2013932","journal-title":"Am J Hum Genet"},{"key":"47_CR8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1086\/324773","volume":"70","author":"R Mayeux","year":"2002","unstructured":"Mayeux R, Lee JH, Romas SN, Mayo D, Santana V, Williamson J, Ciappa A, Rondon HZ, Estevez P, Lantigua R, Medrano M, Torres M, Stern Y, Tycko B, Knowles JA (2002) Chromosome-12 mapping of late-onset Alzheimer disease among Caribbean Hispanics. Am J Hum Genet 70:237\u2013243","journal-title":"Am J Hum Genet"},{"key":"47_CR9","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1126\/science.290.5500.2302","volume":"290","author":"L Bertram","year":"2000","unstructured":"Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE (2000) Evidence for genetic linkage of Alzheimer\u2019s disease to chromosome 10q. Science 290:2302\u20132303","journal-title":"Science"},{"key":"47_CR10","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1126\/science.290.5500.2304","volume":"290","author":"A Myers","year":"2000","unstructured":"Myers A, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D, Shears S, Booth J, DeVrieze FW, Crook R, Hamshere M, Abraham R, Tunstall N, Rice F, Carty S, Lillystone S, Kehoe P, Rudrasingham V, Jones L, Lovestone S, Perez-Tur J, Williams J, Owen MJ, Hardy J, Goate AM (2000) Susceptibility locus for Alzheimer\u2019s disease on chromosome 10. Science 290:2304\u20132305","journal-title":"Science"},{"key":"47_CR11","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1126\/science.290.5500.2303","volume":"290","author":"N Ertekin-Taner","year":"2000","unstructured":"Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J, Ronald J, Blangero J, Hutton M, Younkin SG (2000) Linkage of plasma A\u03b242 to a quantitative locus on chromosome 10 in late-onset Alzheimer\u2019s disease pedigrees. Science 290:2303\u20132304","journal-title":"Science"},{"key":"47_CR12","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1093\/hmg\/ddg343","volume":"12","author":"N Ertekin-Taner","year":"2003","unstructured":"Ertekin-Taner N, Ronald J, Asahara H, Younkin L, Hella M, Jain S, Gnida E, Younkin S, Fadale D, Ohyagi Y, Singleton A, Scanlin L, De Andrade M, Petersen R, Graff-Radford N, Hutton M, Younkin S (2003) Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer\u2019s disease pedigrees. Hum Mol Genet 12:3133\u20133143","journal-title":"Hum Mol Genet"},{"issue":"3","key":"47_CR13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/sj.mp.4001766","volume":"11","author":"X Liang","year":"2005","unstructured":"Liang X, Schnetz-Boutaud N, Kenealy SJ, Jiang L, Bartlett J, Lynch B, Gaskell PC, Gwirtsman H, McFarland L, Bembe ML, Bronson P, Gilbert JR, Martin ER, Pericak-Vance MA, Haines JL (2005) Covariate analysis of late-onset Alzheimer disease refines the chromosome 12 locus. Mol Psychiatry 11(3):280\u2013285","journal-title":"Mol Psychiatry"},{"key":"47_CR14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/gepi.20000","volume":"27","author":"ER Hauser","year":"2004","unstructured":"Hauser ER, Watanabe RM, Duren WL, Bass MP, Langefeld CD, Boehnke M (2004) Ordered subset analysis in genetic linkage mapping of complex traits. Genet Epidemiol 27:53\u201363","journal-title":"Genet Epidemiol"},{"key":"47_CR15","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1001\/archneur.1994.00540240042014","volume":"51","author":"D Blacker","year":"1994","unstructured":"Blacker D, Albert MS, Bassett SS, Go RC, Harrell LE, Folstein MF (1994) Reliability and validity of NINCDS-ADRDA criteria for Alzheimer\u2019s disease. The National Institute of Mental Health Genetics Initiative. Arch Neurol 51:1198\u20131204","journal-title":"Arch Neurol"},{"key":"47_CR16","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M (1984) Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer\u2019s Disease. Neurology 34:939\u2013944","journal-title":"Neurology"},{"key":"47_CR17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","volume":"41","author":"SS Mirra","year":"1991","unstructured":"Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, Van Belle G, Berg L (1991) The Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer\u2019s disease. Neurology 41:479\u2013486","journal-title":"Neurology"},{"key":"47_CR18","first-page":"132","volume":"117","author":"SS Mirra","year":"1993","unstructured":"Mirra SS, Hart MN, Terry RD (1993) Making the diagnosis of Alzheimer\u2019s disease. A primer for practicing pathologists. Arch Pathol Lab Med 117:132\u2013144","journal-title":"Arch Pathol Lab Med"},{"key":"47_CR19","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1001\/archneur.60.7.975","volume":"60","author":"SA Oliveira","year":"2003","unstructured":"Oliveira SA, Scott WK, Nance MA, Watts RL, Hubble JP, Koller WC, Lyons KE, Pahwa R, Stern MB, Hiner BC, Jankovic J, Ondo WG, Allen FH Jr, Scott BL, Goetz CG, Small GW, Mastaglia FL, Stajich JM, Zhang F, Booze MW, Reaves JA, Middleton LT, Haines JL, Pericak-Vance MA, Vance JM, Martin ER (2003) Association study of Parkin gene polymorphisms with idiopathic Parkinson disease. Arch Neurol 60:975\u2013980","journal-title":"Arch Neurol"},{"key":"47_CR20","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1212\/WNL.43.8.1467","volume":"43","author":"AM Saunders","year":"1993","unstructured":"Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer\u2019s disease. Neurology 43:1467\u20131472","journal-title":"Neurology"},{"key":"47_CR21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/biomet\/73.1.13","volume":"73","author":"K Liang","year":"1986","unstructured":"Liang K, Zeger SL (1986) Longitudinal data analysis using generalized linear models. Biometrika 73:13\u201322","journal-title":"Biometrika"},{"key":"47_CR22","unstructured":"Lewis PO, Zaykin D (2000) Genetic data analysis: computer program for analysis of allelic data, version 1.0 (d15)"},{"key":"47_CR23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/bioinformatics\/16.2.182","volume":"16","author":"GR Abecasis","year":"2000","unstructured":"Abecasis GR, Cookson WO (2000) GOLD\u2014graphical overview of linkage disequilibrium. Bioinformatics 16:182\u2013183","journal-title":"Bioinformatics"},{"key":"47_CR24","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1086\/378779","volume":"73","author":"ER Martin","year":"2003","unstructured":"Martin ER, Bass MP, Hauser ER, Kaplan NL (2003) Accounting for linkage in family-based tests of association with missing parental genotypes. Am J Hum Genet 73:1016\u20131026","journal-title":"Am J Hum Genet"},{"key":"47_CR25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/gepi.10295","volume":"26","author":"S Horvath","year":"2004","unstructured":"Horvath S, Xu X, Lake SL, Silverman EK, Weiss ST, Laird NM (2004) Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol 26:61\u201369","journal-title":"Genet Epidemiol"},{"key":"47_CR26","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1101\/gr.9.8.720","volume":"9","author":"AD Long","year":"1999","unstructured":"Long AD, Langley CH (1999) The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits. Genome Res 9:720\u2013731","journal-title":"Genome Res"},{"key":"47_CR27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc 57:289\u2013300","journal-title":"J R Stat Soc"},{"key":"47_CR28","doi-asserted-by":"crossref","unstructured":"Li Y, Nowotny P, Holmans P, Smemo S, Kauwe JS, Hinrichs AL, Tacey K, Doil L, van Luchene R, Garcia V, Rowland C, Schrodi S, Leong D, Gogic G, Chan J, Cravchik A, Ross D, Lau K, Kwok S, Chang SY, Catanese J, Sninsky J, White TJ, Hardy J, Powell J, Lovestone S, Morris JC, Thal L, Owen M, Williams J, Goate A, Grupe A (2004) Association of late-onset Alzheimer\u2019s disease with genetic variation in multiple members of the GAPD gene family. Proc Natl Acad Sci USA","DOI":"10.1073\/pnas.0403535101"}],"container-title":["Neurogenetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10048-006-0047-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10048-006-0047-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10048-006-0047-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T09:55:10Z","timestamp":1736416510000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10048-006-0047-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,13]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["47"],"URL":"https:\/\/doi.org\/10.1007\/s10048-006-0047-z","relation":{},"ISSN":["1364-6745","1364-6753"],"issn-type":[{"value":"1364-6745","type":"print"},{"value":"1364-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,13]]}}}