{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:01:20Z","timestamp":1791925280312,"version":"4.3.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T00:00:00Z","timestamp":1447718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T00:00:00Z","timestamp":1447718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM030518"],"award-info":[{"award-number":["GM030518"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurogenetics"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s10048-015-0466-9","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T07:26:34Z","timestamp":1447745194000},"page":"43-49","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["De novo missense variants in PPP2R5D are associated with intellectual disability, macrocephaly, hypotonia, and autism"],"prefix":"10.1007","volume":"17","author":[{"given":"Linshan","family":"Shang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay B.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan T.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald S.","family":"Petrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-To","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina M.","family":"Haude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Shur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Carmichael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Innis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Schuette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne W.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh","family":"Asaikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandra","family":"Folk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Retterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin G.","family":"Monaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy K.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,17]]},"reference":[{"issue":"12","key":"466_CR1","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/ng.712","volume":"42","author":"LE Vissers","year":"2010","unstructured":"Vissers LE, de Ligt J, Gilissen C, Janssen I, Steehouwer M, de Vries P, van Lier B, Arts P, Wieskamp N, del Rosario M, van Bon BW, Hoischen A, de Vries BB, Brunner HG, Veltman JA (2010) A de novo paradigm for mental retardation. Nat Genet 42(12):1109\u20131112. doi:\n                    10.1038\/ng.712","journal-title":"Nat Genet"},{"issue":"2","key":"466_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/mp.2012.58","volume":"18","author":"CS Ku","year":"2013","unstructured":"Ku CS, Polychronakos C, Tan EK, Naidoo N, Pawitan Y, Roukos DH, Mort M, Cooper DN (2013) A new paradigm emerges from the study of de novo mutations in the context of neurodevelopmental disease. Mol Psychiatry 18(2):141\u2013153. doi:\n                    10.1038\/mp.2012.58","journal-title":"Mol Psychiatry"},{"key":"466_CR3","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0065-2571(94)90017-5","volume":"34","author":"AA Depaoli-Roach","year":"1994","unstructured":"Depaoli-Roach AA, Park IK, Cerovsky V, Csortos C, Durbin SD, Kuntz MJ, Sitikov A, Tang PM, Verin A, Zolnierowicz S (1994) Serine\/threonine protein phosphatases in the control of cell function. Adv Enzym Regul 34:199\u2013224","journal-title":"Adv Enzym Regul"},{"issue":"2","key":"466_CR4","doi-asserted-by":"publisher","first-page":"648","DOI":"10.3390\/cancers7020648","volume":"7","author":"M Kiely","year":"2015","unstructured":"Kiely M, Kiely PA (2015) PP2A: the wolf in sheep's clothing? Cancer 7(2):648\u2013669. doi:\n                    10.3390\/cancers7020648","journal-title":"Cancer"},{"key":"466_CR5","doi-asserted-by":"publisher","first-page":"486402","DOI":"10.1155\/2012\/486402","volume":"2012","author":"TT Gipson","year":"2012","unstructured":"Gipson TT, Johnston MV (2012) Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders. Neural Plast 2012:486402. doi:\n                    10.1155\/2012\/486402","journal-title":"Neural Plast"},{"key":"466_CR6","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.neuroscience.2013.07.037","volume":"252","author":"KC Lim","year":"2013","unstructured":"Lim KC, Crino PB (2013) Focal malformations of cortical development: new vistas for molecular pathogenesis. Neuroscience 252:262\u2013276. doi:\n                    10.1016\/j.neuroscience.2013.07.037","journal-title":"Neuroscience"},{"issue":"3","key":"466_CR7","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1006\/bbrc.1998.8792","volume":"247","author":"J Chen","year":"1998","unstructured":"Chen J, Peterson RT, Schreiber SL (1998) Alpha 4 associates with protein phosphatases 2A, 4, and 6. Biochem Biophys Res Commun 247(3):827\u2013832. doi:\n                    10.1006\/bbrc.1998.8792","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"466_CR8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/ajmg.a.20504","volume":"123A","author":"JM Graham Jr","year":"2003","unstructured":"Graham JM Jr, Wheeler P, Tackels-Horne D, Lin AE, Hall BD, May M, Short KM, Schwartz CE, Cox TC (2003) A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13. Am J Med Genet A 123A(1):37\u201344. doi:\n                    10.1002\/ajmg.a.20504","journal-title":"Am J Med Genet A"},{"issue":"1","key":"466_CR9","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1006\/geno.1996.0438","volume":"36","author":"B McCright","year":"1996","unstructured":"McCright B, Brothman AR, Virshup DM (1996) Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 p12. Genomics 36(1):168\u2013170","journal-title":"Genomics"},{"issue":"17","key":"466_CR10","doi-asserted-by":"publisher","first-page":"6957","DOI":"10.1073\/pnas.1018777108","volume":"108","author":"JV Louis","year":"2011","unstructured":"Louis JV, Martens E, Borghgraef P, Lambrecht C, Sents W, Longin S, Zwaenepoel K, Pijnenborg R, Landrieu I, Lippens G, Ledermann B, Gotz J, Van Leuven F, Goris J, Janssens V (2011) Mice lacking phosphatase PP2A subunit PR61\/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. Proc Natl Acad Sci U S A 108(17):6957\u20136962. doi:\n                    10.1073\/pnas.1018777108","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"466_CR11","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1042\/BJ20120452","volume":"450","author":"S Zencir","year":"2013","unstructured":"Zencir S, Sike A, Dobson MJ, Ayaydin F, Boros I, Topcu Z (2013) Identification of transcriptional and phosphatase regulators as interaction partners of human ADA3, a component of histone acetyltransferase complexes. Biochem J 450(2):311\u2013320. doi:\n                    10.1042\/BJ20120452","journal-title":"Biochem J"},{"issue":"18","key":"466_CR12","doi-asserted-by":"publisher","first-page":"3730","DOI":"10.1038\/emboj.2012.226","volume":"31","author":"A Tadmouri","year":"2012","unstructured":"Tadmouri A, Kiyonaka S, Barbado M, Rousset M, Fablet K, Sawamura S, Bahembera E, Pernet-Gallay K, Arnoult C, Miki T, Sadoul K, Gory-Faure S, Lambrecht C, Lesage F, Akiyama S, Khochbin S, Baulande S, Janssens V, Andrieux A, Dolmetsch R, Ronjat M, Mori Y, De Waard M (2012) Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy. EMBO J 31(18):3730\u20133744. doi:\n                    10.1038\/emboj.2012.226","journal-title":"EMBO J"},{"issue":"7542","key":"466_CR13","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nature14135","volume":"519","author":"S Deciphering Developmental Disorders","year":"2015","unstructured":"Deciphering Developmental Disorders S (2015) Large-scale discovery of novel genetic causes of developmental disorders. Nature 519(7542):223\u2013228. doi:\n                    10.1038\/nature14135","journal-title":"Nature"},{"issue":"20","key":"466_CR14","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1056\/NEJMoa1206524","volume":"367","author":"J de Ligt","year":"2012","unstructured":"de Ligt J, Willemsen MH, van Bon BW, Kleefstra T, Yntema HG, Kroes T, Vulto-van Silfhout AT, Koolen DA, de Vries P, Gilissen C, del Rosario M, Hoischen A, Scheffer H, de Vries BB, Brunner HG, Veltman JA, Vissers LE (2012) Diagnostic exome sequencing in persons with severe intellectual disability. N Engl J Med 367(20):1921\u20131929. doi:\n                    10.1056\/NEJMoa1206524","journal-title":"N Engl J Med"},{"key":"466_CR15","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv182","author":"C Loveday","year":"2015","unstructured":"Loveday C, Tatton-Brown K, Clarke M, Westwood I, Renwick A, Ramsay E, Nemeth A, Campbell J, Joss S, Gardner M, Zachariou A, Elliott A, Ruark E, van Montfort R, Childhood Overgrowth C, Rahman N (2015) Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth. Hum Mol Genet. doi:\n                    10.1093\/hmg\/ddv182","journal-title":"Hum Mol Genet"},{"issue":"7526","key":"466_CR16","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature13908","volume":"515","author":"I Iossifov","year":"2014","unstructured":"Iossifov I, O'Roak BJ, Sanders SJ, Ronemus M, Krumm N, Levy D, Stessman HA, Witherspoon KT, Vives L, Patterson KE, Smith JD, Paeper B, Nickerson DA, Dea J, Dong S, Gonzalez LE, Mandell JD, Mane SM, Murtha MT, Sullivan CA, Walker MF, Waqar Z, Wei L, Willsey AJ, Yamrom B, Lee YH, Grabowska E, Dalkic E, Wang Z, Marks S, Andrews P, Leotta A, Kendall J, Hakker I, Rosenbaum J, Ma B, Rodgers L, Troge J, Narzisi G, Yoon S, Schatz MC, Ye K, McCombie WR, Shendure J, Eichler EE, State MW, Wigler M (2014) The contribution of de novo coding mutations to autism spectrum disorder. Nature 515(7526):216\u2013221. doi:\n                    10.1038\/nature13908","journal-title":"Nature"},{"issue":"8","key":"466_CR17","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1172\/JCI79860","volume":"125","author":"G Houge","year":"2015","unstructured":"Houge G, Haesen D, Vissers LE, Mehta S, Parker MJ, Wright M, Vogt J, McKee S, Tolmie JL, Cordeiro N, Kleefstra T, Willemsen MH, Reijnders MR, Berland S, Hayman E, Lahat E, Brilstra EH, van Gassen KL, Zonneveld-Huijssoon E, de Bie CI, Hoischen A, Eichler EE, Holdhus R, Steen VM, Doskeland SO, Hurles ME, FitzPatrick DR, Janssens V (2015) B56delta-related protein phosphatase 2A dysfunction identified in patients with intellectual disability. J Clin Invest 125(8):3051\u20133062. doi:\n                    10.1172\/JCI79860","journal-title":"J Clin Invest"},{"issue":"4","key":"466_CR18","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s10048-015-0454-0","volume":"16","author":"L Shang","year":"2015","unstructured":"Shang L, Cho MT, Retterer K, Folk L, Humberson J, Rohena L, Sidhu A, Saliganan S, Iglesias A, Vitazka P, Juusola J, O'Donnell-Luria AH, Shen Y, Chung WK (2015) Mutations in ARID2 are associated with intellectual disabilities. Neurogenetics 16(4):307\u2013314. doi:\n                    10.1007\/s10048-015-0454-0","journal-title":"Neurogenetics"},{"issue":"14","key":"466_CR19","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Durbin R (2009) Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25(14):1754\u20131760. doi:\n                    10.1093\/bioinformatics\/btp324","journal-title":"Bioinformatics"},{"issue":"5","key":"466_CR20","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/ng.806","volume":"43","author":"MA DePristo","year":"2011","unstructured":"DePristo MA, Banks E, Poplin R, Garimella KV, Maguire JR, Hartl C, Philippakis AA, del Angel G, Rivas MA, Hanna M, McKenna A, Fennell TJ, Kernytsky AM, Sivachenko AY, Cibulskis K, Gabriel SB, Altshuler D, Daly MJ (2011) A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet 43(5):491\u2013498. doi:\n                    10.1038\/ng.806","journal-title":"Nat Genet"},{"issue":"13","key":"466_CR21","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1093\/nar\/gkg543","volume":"31","author":"N Eswar","year":"2003","unstructured":"Eswar N, John B, Mirkovic N, Fiser A, Ilyin VA, Pieper U, Stuart AC, Marti-Renom MA, Madhusudhan MS, Yerkovich B, Sali A (2003) Tools for comparative protein structure modeling and analysis. Nucleic Acids Res 31(13):3375\u20133380","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"466_CR22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nmeth.1818","volume":"9","author":"M Remmert","year":"2012","unstructured":"Remmert M, Biegert A, Hauser A, Soding J (2012) HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment. Nat Methods 9(2):173\u2013175. doi:\n                    10.1038\/nmeth.1818","journal-title":"Nat Methods"},{"issue":"2","key":"466_CR23","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1006\/jmbi.2001.4865","volume":"311","author":"Z Xiang","year":"2001","unstructured":"Xiang Z, Honig B (2001) Extending the accuracy limits of prediction for side-chain conformations. J Mol Biol 311(2):421\u2013430. doi:\n                    10.1006\/jmbi.2001.4865","journal-title":"J Mol Biol"},{"key":"466_CR24","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/S0076-6879(03)74021-X","volume":"374","author":"D Petrey","year":"2003","unstructured":"Petrey D, Honig B (2003) GRASP2: visualization, surface properties, and electrostatics of macromolecular structures and sequences. Methods Enzymol 374:492\u2013509. doi:\n                    10.1016\/S0076-6879(03)74021-X","journal-title":"Methods Enzymol"},{"issue":"1","key":"466_CR25","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/ng1939","volume":"39","author":"M Tartaglia","year":"2007","unstructured":"Tartaglia M, Pennacchio LA, Zhao C, Yadav KK, Fodale V, Sarkozy A, Pandit B, Oishi K, Martinelli S, Schackwitz W, Ustaszewska A, Martin J, Bristow J, Carta C, Lepri F, Neri C, Vasta I, Gibson K, Curry CJ, Siguero JP, Digilio MC, Zampino G, Dallapiccola B, Bar-Sagi D, Gelb BD (2007) Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nat Genet 39(1):75\u201379. doi:\n                    10.1038\/ng1939","journal-title":"Nat Genet"},{"issue":"1","key":"466_CR26","doi-asserted-by":"publisher","first-page":"e54363","DOI":"10.1371\/journal.pone.0054363","volume":"8","author":"B Wang","year":"2013","unstructured":"Wang B, Doan D, Roman Petersen Y, Alvarado E, Alvarado G, Bhandari A, Mohanty A, Mohanty S, Nissen RM (2013) Wdr68 requires nuclear access for craniofacial development. PLoS One 8(1):e54363. doi:\n                    10.1371\/journal.pone.0054363","journal-title":"PLoS One"},{"issue":"2","key":"466_CR27","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/ana.10607","volume":"54","author":"Y Chen","year":"2003","unstructured":"Chen Y, Lu J, Pan H, Zhang Y, Wu H, Xu K, Liu X, Jiang Y, Bao X, Yao Z, Ding K, Lo WH, Qiang B, Chan P, Shen Y, Wu X (2003) Association between genetic variation of CACNA1H and childhood absence epilepsy. Ann Neurol 54(2):239\u2013243. doi:\n                    10.1002\/ana.10607","journal-title":"Ann Neurol"},{"issue":"4","key":"466_CR28","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/ana.20028","volume":"55","author":"SE Heron","year":"2004","unstructured":"Heron SE, Phillips HA, Mulley JC, Mazarib A, Neufeld MY, Berkovic SF, Scheffer IE (2004) Genetic variation of CACNA1H in idiopathic generalized epilepsy. Ann Neurol 55(4):595\u2013596. doi:\n                    10.1002\/ana.20028","journal-title":"Ann Neurol"},{"issue":"44","key":"466_CR29","doi-asserted-by":"publisher","first-page":"26123","DOI":"10.1074\/jbc.270.44.26123","volume":"270","author":"B McCright","year":"1995","unstructured":"McCright B, Virshup DM (1995) Identification of a new family of protein phosphatase 2A regulatory subunits. J Biol Chem 270(44):26123\u201326128","journal-title":"J Biol Chem"},{"issue":"36","key":"466_CR30","doi-asserted-by":"publisher","first-page":"22081","DOI":"10.1074\/jbc.271.36.22081","volume":"271","author":"B McCright","year":"1996","unstructured":"McCright B, Rivers AM, Audlin S, Virshup DM (1996) The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J Biol Chem 271(36):22081\u201322089","journal-title":"J Biol Chem"},{"issue":"4","key":"466_CR31","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.jmb.2003.12.047","volume":"336","author":"E Martens","year":"2004","unstructured":"Martens E, Stevens I, Janssens V, Vermeesch J, Gotz J, Goris J, Van Hoof C (2004) Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61\/B' regulatory subunits of protein phosphatase 2A in mice. J Mol Biol 336(4):971\u2013986. doi:\n                    10.1016\/j.jmb.2003.12.047","journal-title":"J Mol Biol"},{"issue":"2","key":"466_CR32","doi-asserted-by":"publisher","first-page":"155","DOI":"10.4196\/kjpp.2014.18.2.155","volume":"18","author":"UY Yu","year":"2014","unstructured":"Yu UY, Yoo BC, Ahn JH (2014) Regulatory B Subunits of Protein Phosphatase 2A Are Involved in Site-specific Regulation of Tau Protein Phosphorylation. Korean J Physiol Pharmacol Off J Korean Physiol Soc Kor Soc Pharmacol 18(2):155\u2013161. doi:\n                    10.4196\/kjpp.2014.18.2.155","journal-title":"Korean J Physiol Pharmacol Off J Korean Physiol Soc Kor Soc Pharmacol"},{"issue":"2","key":"466_CR33","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4161\/chan.23895","volume":"7","author":"M Ronjat","year":"2013","unstructured":"Ronjat M, Kiyonaka S, Barbado M, De Waard M, Mori Y (2013) Nuclear life of the voltage-gated Cacnb4 subunit and its role in gene transcription regulation. Channels 7(2):119\u2013125. doi:\n                    10.4161\/chan.23895","journal-title":"Channels"},{"issue":"7089","key":"466_CR34","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nature04663","volume":"441","author":"TS Kitajima","year":"2006","unstructured":"Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y (2006) Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature 441(7089):46\u201352. doi:\n                    10.1038\/nature04663","journal-title":"Nature"},{"issue":"50","key":"466_CR35","doi-asserted-by":"publisher","first-page":"19867","DOI":"10.1073\/pnas.0709879104","volume":"104","author":"CM Forester","year":"2007","unstructured":"Forester CM, Maddox J, Louis JV, Goris J, Virshup DM (2007) Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. Proc Natl Acad Sci U S A 104(50):19867\u201319872. doi:\n                    10.1073\/pnas.0709879104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"466_CR36","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1073\/pnas.0611532104","volume":"104","author":"JH Ahn","year":"2007","unstructured":"Ahn JH, McAvoy T, Rakhilin SV, Nishi A, Greengard P, Nairn AC (2007) Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit. Proc Natl Acad Sci U S A 104(8):2979\u20132984. doi:\n                    10.1073\/pnas.0611532104","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["neurogenetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10048-015-0466-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10048-015-0466-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10048-015-0466-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10048-015-0466-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T15:34:10Z","timestamp":1589643250000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10048-015-0466-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,17]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["466"],"URL":"https:\/\/doi.org\/10.1007\/s10048-015-0466-9","relation":{},"ISSN":["1364-6745","1364-6753"],"issn-type":[{"value":"1364-6745","type":"print"},{"value":"1364-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,17]]},"assertion":[{"value":"19 August 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Lindsay Henderson, Megan Cho, Leandra Folk, Kyle Retterer, and Kristin Monaghan are employees of GeneDx.Wendy Chung is a consultant to BioReference Laboratories.The other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}